Mark W Dewhirst

Mark Wesley Dewhirst

Gustavo S. Montana Professor of Radiation Oncology, in the School of Medicine

Mark W. Dewhirst, DVM, PhD is the Gustavo S. Montana Professor of Radiation Oncology and Vice Director for Basic Science in the Duke Cancer Institute. Dr. Dewhirst has research interests in tumor hypoxia, angiogenesis, hyperthermia and drug transport. He has spent 30 years studying causes of tumor hypoxia and the use of hyperthermia to treat cancer. In collaboration with Professor David Needham in the Pratt School of Engineering, he has developed a novel thermally sensitive drug carrying liposome that has been successfully translated to human clinical trials. He has utilized the thermal characteristics of this liposome to develop an MR imageable form that can accurately reflect drug concentrations in tumors, which then is related to the extent of anti-tumor effect in pre-clinical models. This property has been widely used by other investigators, world-wide, particularly in the area of high intensity focused ultrasound, where it would be possible to literally paint drug to a target zone and visualize this process in real time, during heating. For his work in this area, Dr. Dewhirst was named a Fellow in the AAAS. Dr. Dewhirst has well over 500 peer-reviewed publications, book chapters and reviews, with >20,000 citations and an H-index of 73. He has given named lectures at the University of Western Ontario, Thomas Jefferson University and the New Zealand Cancer Society. He was awarded the Failla Medal and Lecture at the Radiation Research Society in 2008, the Eugene Robinson award for excellence hyperthermia research in 1992 and a similar award from the European Society for Hyperthermic Oncology in 2009. He was named a fellow of ASTRO in 2009 and was awarded the prestigious Gold Medal from the same society in 2012. He is a Senior Editor of Cancer Research and Editor-in-Chief of the International Journal of Hyperthermia. He has mentored 24 graduate students, and many postdoctoral fellows, residents, junior faculty and medical students. He has been particularly skillful in assisting those he has mentored to obtain DOD and NIH fellowships, K awards and first R01 grants. His skill in mentoring has been recognized by the Duke Comprehensive Cancer Center, the Medical Physics Graduate Training programs and the School of Medicine, where he has received “Mentor of the Year” awards. In 2011 he was selected to become the first Associate Dean of Faculty Mentoring in the Duke School of Medicine. In this position, he is implementing a comprehensive program to enhance success in obtaining NIH funding. He graduated from the University of Arizona in 1971 with a degree in Chemistry and Colorado State University in 1975 and 1979 with DVM and PhD degrees, respectively.

Appointments and Affiliations

  • Gustavo S. Montana Professor of Radiation Oncology, in the School of Medicine
  • Professor of Radiation Oncology
  • Professor of Biomedical Engineering
  • Professor in Pathology
  • Member of the Duke Cancer Institute
  • Associate Dean for Faculty Mentoring

Contact Information

  • Office Phone: (919) 684-4180
  • Email Address: mark.dewhirst@duke.edu

Education

  • Ph.D. Colorado State University at Fort Collins, 1979

Research Interests

Dr. Dewhirst's research interests focus on the tumor microenvironment and how it influences treatment responses. Areas of particular focus are hypoxia, acidosis, angiogenesis and oxidative stress.

Specialties

Medical Imaging

Awards, Honors, and Distinctions

  • AAAS Fellows. American Association for the Advancement of Science, The. 2010

Courses Taught

  • BME 494: Projects in Biomedical Engineering (GE)
  • MEDPHY 507: Radiation Biology
  • PATHOL 293: Research Independent Study
  • PATHOL 793: Research Independent Study

In the News

Representative Publications

  • Zhong, J; Rajaram, N; Brizel, DM; Frees, AE; Ramanujam, N; Batinic-Haberle, I; Dewhirst, MW, Radiation induces aerobic glycolysis through reactive oxygen species., Radiotherapy and Oncology, vol 106 no. 3 (2013), pp. 390-396 [10.1016/j.radonc.2013.02.013] [abs].
  • Hanna, G; Fontanella, A; Palmer, G; Shan, S; Radiloff, DR; Zhao, Y; Irwin, D; Hamilton, K; Boico, A; Piantadosi, CA; Blueschke, G; Dewhirst, M; McMahon, T; Schroeder, T, Automated measurement of blood flow velocity and direction and hemoglobin oxygen saturation in the rat lung using intravital microscopy., American journal of physiology. Lung cellular and molecular physiology, vol 304 no. 2 (2013), pp. L86-L91 [10.1152/ajplung.00178.2012] [abs].
  • Palmer, GM; Boruta, RJ; Viglianti, BL; Lan, L; Spasojevic, I; Dewhirst, MW, Non-invasive monitoring of intra-tumor drug concentration and therapeutic response using optical spectroscopy., Journal of Controlled Release, vol 142 no. 3 (2010), pp. 457-464 [10.1016/j.jconrel.2009.10.034] [abs].
  • Jones, LW; Viglianti, BL; Tashjian, JA; Kothadia, SM; Keir, ST; Freedland, SJ; Potter, MQ; Moon, EJ; Schroeder, T; Herndon, JE; Dewhirst, MW, Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer., Journal of applied physiology (Bethesda, Md. : 1985), vol 108 no. 2 (2010), pp. 343-348 [10.1152/japplphysiol.00424.2009] [abs].
  • Kennedy, KM; Dewhirst, MW, Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation., Future oncology (London, England), vol 6 no. 1 (2010), pp. 127-148 [10.2217/fon.09.145] [abs].
  • Dewhirst, MW, Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress., Radiation Research, vol 172 no. 6 (2009), pp. 653-665 [10.1667/RR1926.1] [abs].
  • Craciunescu, OI; Stauffer, PR; Soher, BJ; Wyatt, CR; Arabe, O; Maccarini, P; Das, SK; Cheng, KS; Wong, TZ; Jones, EL; Dewhirst, MW; Vujaskovic, Z; MacFall, JR, Accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas., Medical physics, vol 36 no. 11 (2009), pp. 4848-4858 [10.1118/1.3227506] [abs].
  • Vishwanath, K; Klein, D; Chang, K; Schroeder, T; Dewhirst, MW; Ramanujam, N, Quantitative optical spectroscopy can identify long-term local tumor control in irradiated murine head and neck xenografts., Journal of Biomedical Optics, vol 14 no. 5 (2009) [10.1117/1.3251013] [abs].
  • Zhang, G; Palmer, GM; Dewhirst, MW; Fraser, CL, A dual-emissive-materials design concept enables tumour hypoxia imaging., Nature Materials, vol 8 no. 9 (2009), pp. 747-751 [10.1038/nmat2509] [abs].
  • Viglianti, BL; Lora-Michiels, M; Poulson, JM; Lan, L; Yu, D; Sanders, L; Craciunescu, O; Vujaskovic, Z; Thrall, DE; Macfall, J; Charles, CH; Wong, T; Dewhirst, MW, Dynamic contrast-enhanced magnetic resonance imaging as a predictor of clinical outcome in canine spontaneous soft tissue sarcomas treated with thermoradiotherapy., Clinical cancer research : an official journal of the American Association for Cancer Research, vol 15 no. 15 (2009), pp. 4993-5001 [10.1158/1078-0432.CCR-08-2222] [abs].
  • Hardee, ME; Dewhirst, MW; Agarwal, N; Sorg, BS, Novel imaging provides new insights into mechanisms of oxygen transport in tumors., Current molecular medicine, vol 9 no. 4 (2009), pp. 435-441 [abs].
  • Pries, AR; Cornelissen, AJ; Sloot, AA; Hinkeldey, M; Dreher, MR; Höpfner, M; Dewhirst, MW; Secomb, TW, Structural adaptation and heterogeneity of normal and tumor microvascular networks., PLoS computational biology, vol 5 no. 5 (2009) [10.1371/journal.pcbi.1000394] [abs].
  • Palmer, GM; Viola, RJ; Schroeder, T; Yarmolenko, PS; Dewhirst, MW; Ramanujam, N, Quantitative diffuse reflectance and fluorescence spectroscopy: tool to monitor tumor physiology in vivo., Journal of Biomedical Optics, vol 14 no. 2 (2009) [10.1117/1.3103586] [abs].
  • Skala, MC; Fontanella, A; Hendargo, H; Dewhirst, MW; Izatt, JA, Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging., Optics Letters, vol 34 no. 3 (2009), pp. 289-291 [abs].
  • Craciunescu, OI; Blackwell, KL; Jones, EL; Macfall, JR; Yu, D; Vujaskovic, Z; Wong, TZ; Liotcheva, V; Rosen, EL; Prosnitz, LR; Samulski, TV; Dewhirst, MW, DCE-MRI parameters have potential to predict response of locally advanced breast cancer patients to neoadjuvant chemotherapy and hyperthermia: a pilot study., International Journal of Hyperthermia (Informa), vol 25 no. 6 (2009), pp. 405-415 [10.1080/02656730903022700] [abs].
  • Sonveaux, P; Végran, F; Schroeder, T; Wergin, MC; Verrax, J; Rabbani, ZN; De Saedeleer, CJ; Kennedy, KM; Diepart, C; Jordan, BF; Kelley, MJ; Gallez, B; Wahl, ML; Feron, O; Dewhirst, MW, Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice., Journal of Clinical Investigation, vol 118 no. 12 (2008), pp. 3930-3942 [10.1172/JCI36843] [abs].
  • Viola, RJ; Provenzale, JM; Li, F; Li, CY; Yuan, H; Tashjian, J; Dewhirst, MW, In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy., AJR. American journal of roentgenology, vol 191 no. 6 (2008), pp. 1779-1784 [10.2214/AJR.07.4060] [abs].
  • Cárdenas-Navia, LI; Mace, D; Richardson, RA; Wilson, DF; Shan, S; Dewhirst, MW, The pervasive presence of fluctuating oxygenation in tumors., Cancer Research, vol 68 no. 14 (2008), pp. 5812-5819 [10.1158/0008-5472.CAN-07-6387] [abs].
  • Dewhirst, MW; Cao, Y; Moeller, B, Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response., Nature Reviews Cancer, vol 8 no. 6 (2008), pp. 425-437 [10.1038/nrc2397] [abs].
  • Manzoor, AA; Schroeder, T; Dewhirst, MW, One-stop-shop tumor imaging: buy hypoxia, get lactate free., Journal of Clinical Investigation, vol 118 no. 5 (2008), pp. 1616-1619 [10.1172/JCI35543] [abs].
  • Sorg, BS; Hardee, ME; Agarwal, N; Moeller, BJ; Dewhirst, MW, Spectral imaging facilitates visualization and measurements of unstable and abnormal microvascular oxygen transport in tumors., Journal of Biomedical Optics, vol 13 no. 1 (2008) [10.1117/1.2837439] [abs].
  • Vlahovic, G; Ponce, AM; Rabbani, Z; Salahuddin, FK; Zgonjanin, L; Spasojevic, I; Vujaskovic, Z; Dewhirst, MW, Treatment with imatinib improves drug delivery and efficacy in NSCLC xenografts., British Journal of Cancer, vol 97 no. 6 (2007), pp. 735-740 [10.1038/sj.bjc.6603941] [abs].
  • Dreher, MR; Liu, W; Michelich, CR; Dewhirst, MW; Chilkoti, A, Thermal cycling enhances the accumulation of a temperature-sensitive biopolymer in solid tumors., Cancer Research, vol 67 no. 9 (2007), pp. 4418-4424 [10.1158/0008-5472.CAN-06-4444] [abs].
  • Cao, Y; Sonveaux, P; Liu, S; Zhao, Y; Mi, J; Clary, BM; Li, CY; Kontos, CD; Dewhirst, MW, Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth., Cancer Research, vol 67 no. 8 (2007), pp. 3835-3844 [10.1158/0008-5472.CAN-06-4056] [abs].
  • Li, F; Sonveaux, P; Rabbani, ZN; Liu, S; Yan, B; Huang, Q; Vujaskovic, Z; Dewhirst, MW; Li, CY, Regulation of HIF-1alpha stability through S-nitrosylation., Molecular Cell, vol 26 no. 1 (2007), pp. 63-74 [10.1016/j.molcel.2007.02.024] [abs].
  • Dewhirst, MW, Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting., Cancer Research, vol 67 no. 3 (2007), pp. 854-855 [10.1158/0008-5472.CAN-06-4744] [abs].
  • Dewhirst, MW; Navia, IC; Brizel, DM; Willett, C; Secomb, TW, Multiple etiologies of tumor hypoxia require multifaceted solutions., Clinical cancer research : an official journal of the American Association for Cancer Research, vol 13 no. 2 Pt 1 (2007), pp. 375-377 [10.1158/1078-0432.CCR-06-2629] [abs].
  • Ponce, AM; Viglianti, BL; Yu, D; Yarmolenko, PS; Michelich, CR; Woo, J; Bally, MB; Dewhirst, MW, Magnetic resonance imaging of temperature-sensitive liposome release: drug dose painting and antitumor effects., Journal of the National Cancer Institute, vol 99 no. 1 (2007), pp. 53-63 [10.1093/jnci/djk005] [abs].
  • Hardee, ME; Cao, Y; Fu, P; Jiang, X; Zhao, Y; Rabbani, ZN; Vujaskovic, Z; Dewhirst, MW; Arcasoy, MO, Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression., PloS one, vol 2 no. 6 (2007) [10.1371/journal.pone.0000549] [abs].
  • Lora-Michiels, M; Yu, D; Sanders, L; Poulson, JM; Azuma, C; Case, B; Vujaskovic, Z; Thrall, DE; Charles, HC; Dewhirst, MW, Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy., Clinical cancer research : an official journal of the American Association for Cancer Research, vol 12 no. 19 (2006), pp. 5733-5740 [10.1158/1078-0432.CCR-05-2669] [abs].
  • Hicks, KO; Pruijn, FB; Secomb, TW; Hay, MP; Hsu, R; Brown, JM; Denny, WA; Dewhirst, MW; Wilson, WR, Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs., Journal of the National Cancer Institute, vol 98 no. 16 (2006), pp. 1118-1128 [10.1093/jnci/djj306] [abs].
  • Thrall, DE; Larue, SM; Pruitt, AF; Case, B; Dewhirst, MW, Changes in tumour oxygenation during fractionated hyperthermia and radiation therapy in spontaneous canine sarcomas., International Journal of Hyperthermia (Informa), vol 22 no. 5 (2006), pp. 365-373 [10.1080/02656730600836386] [abs].
  • Hauck, ML; LaRue, SM; Petros, WP; Poulson, JM; Yu, D; Spasojevic, I; Pruitt, AF; Klein, A; Case, B; Thrall, DE; Needham, D; Dewhirst, MW, Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumors., Clinical cancer research : an official journal of the American Association for Cancer Research, vol 12 no. 13 (2006), pp. 4004-4010 [10.1158/1078-0432.CCR-06-0226] [abs].
  • Yuan, H; Schroeder, T; Bowsher, JE; Hedlund, LW; Wong, T; Dewhirst, MW, Intertumoral differences in hypoxia selectivity of the PET imaging agent 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone)., Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol 47 no. 6 (2006), pp. 989-998 [abs].
  • Dreher, MR; Liu, W; Michelich, CR; Dewhirst, MW; Yuan, F; Chilkoti, A, Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers., Journal of the National Cancer Institute, vol 98 no. 5 (2006), pp. 335-344 [10.1093/jnci/djj070] [abs].
  • Lanzen, J; Braun, RD; Klitzman, B; Brizel, D; Secomb, TW; Dewhirst, MW, Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor., Cancer Research, vol 66 no. 4 (2006), pp. 2219-2223 [10.1158/0008-5472.CAN-03-2958] [abs].
  • Dressman, HK; Hans, C; Bild, A; Olson, JA; Rosen, E; Marcom, PK; Liotcheva, VB; Jones, EL; Vujaskovic, Z; Marks, J; Dewhirst, MW; West, M; Nevins, JR; Blackwell, K, Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy., Clinical cancer research : an official journal of the American Association for Cancer Research, vol 12 no. 3 Pt 1 (2006), pp. 819-826 [10.1158/1078-0432.CCR-05-1447] [abs].
  • Das, SK; Macfall, J; McCauley, R; Craciunescu, O; Dewhirst, MW; Samulski, TV, Improved magnetic resonance thermal imaging by combining proton resonance frequency shift (PRFS) and apparent diffusion coefficient (ADC) data., International Journal of Hyperthermia (Informa), vol 21 no. 7 (2005), pp. 657-667 [10.1080/02656730500186346] [abs].
  • Moeller, BJ; Dreher, MR; Rabbani, ZN; Schroeder, T; Cao, Y; Li, CY; Dewhirst, MW, Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity., Cancer Cell, vol 8 no. 2 (2005), pp. 99-110 [10.1016/j.ccr.2005.06.016] [abs].
  • Thrall, DE; LaRue, SM; Yu, D; Samulski, T; Sanders, L; Case, B; Rosner, G; Azuma, C; Poulson, J; Pruitt, AF; Stanley, W; Hauck, ML; Williams, L; Hess, P; Dewhirst, MW, Thermal dose is related to duration of local control in canine sarcomas treated with thermoradiotherapy., Clinical cancer research : an official journal of the American Association for Cancer Research, vol 11 no. 14 (2005), pp. 5206-5214 [10.1158/1078-0432.CCR-05-0091] [abs].
  • Cao, Y; Li, CY; Moeller, BJ; Yu, D; Zhao, Y; Dreher, MR; Shan, S; Dewhirst, MW, Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation., Cancer Research, vol 65 no. 13 (2005), pp. 5498-5505 [10.1158/0008-5472.CAN-04-4553] [abs].
  • Sorg, BS; Moeller, BJ; Donovan, O; Cao, Y; Dewhirst, MW, Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development., Journal of Biomedical Optics, vol 10 no. 4 (2005) [10.1117/1.2003369] [abs].
  • Jones, EL; Oleson, JR; Prosnitz, LR; Samulski, TV; Vujaskovic, Z; Yu, D; Sanders, LL; Dewhirst, MW, Randomized trial of hyperthermia and radiation for superficial tumors., Journal of Clinical Oncology, vol 23 no. 13 (2005), pp. 3079-3085 [10.1200/JCO.2005.05.520] [abs].
  • Dewhirst, MW; Poulson, JM; Yu, D; Sanders, L; Lora-Michiels, M; Vujaskovic, Z; Jones, EL; Samulski, TV; Powers, BE; Brizel, DM; Prosnitz, LR; Charles, HC, Relation between pO2, 31P magnetic resonance spectroscopy parameters and treatment outcome in patients with high-grade soft tissue sarcomas treated with thermoradiotherapy., International Journal of Radiation Oncology, Biology, Physics, vol 61 no. 2 (2005), pp. 480-491 [10.1016/j.ijrobp.2004.06.211] [abs].
  • Lockhart, AC; Braun, RD; Yu, D; Ross, JR; Dewhirst, MW; Humphrey, JS; Thompson, S; Williams, KM; Klitzman, B; Yuan, F; Grichnik, JM; Proia, AD; Conway, DA; Hurwitz, HI, Reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor., Clinical cancer research : an official journal of the American Association for Cancer Research, vol 9 no. 2 (2003), pp. 586-593 [abs].
  • Dewhirst, MW, Mechanisms underlying hypoxia development in tumors., Advances in experimental medicine and biology, vol 510 (2003), pp. 51-56 [abs].
  • Richardson, RA; Dewhirst, MW, The effect of nicotinamide & hyperoxic gases on blood glucose., Advances in experimental medicine and biology, vol 510 (2003), pp. 375-378 [abs].
  • Zeman, EM; Dynlacht, JR; Rosenstein, BS; Dewhirst, MW; ASTRO Joint Working Group on Radiobiology Teaching, , Toward a national consensus: teaching radiobiology to radiation oncology residents., International Journal of Radiation Oncology, Biology, Physics, vol 54 no. 3 (2002), pp. 861-872 [abs].
  • Vujaskovic, Z; Batinic-Haberle, I; Rabbani, ZN; Feng, QF; Kang, SK; Spasojevic, I; Samulski, TV; Fridovich, I; Dewhirst, MW; Anscher, MS, A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury., Free Radical Biology & Medicine, vol 33 no. 6 (2002), pp. 857-863 [abs].
  • Wong, CW; Song, C; Grimes, MM; Fu, W; Dewhirst, MW; Muschel, RJ; Al-Mehdi, AB, Intravascular location of breast cancer cells after spontaneous metastasis to the lung., The American journal of pathology, vol 161 no. 3 (2002), pp. 749-753 [10.1016/S0002-9440(10)64233-2] [abs].
  • Kavanagh, BD; Secomb, TW; Hsu, R; Lin, PS; Venitz, J; Dewhirst, MW, A theoretical model for the effects of reduced hemoglobin-oxygen affinity on tumor oxygenation., International Journal of Radiation Oncology, Biology, Physics, vol 53 no. 1 (2002), pp. 172-179 [abs].
  • Dynlacht, JR; Dewhirst, MW; Hall, EJ; Rosenstein, BS; Zeman, EM, Toward a consensus on radiobiology teaching to radiation oncology residents., Radiation Research, vol 157 no. 5 (2002), pp. 599-606 [abs].
  • Hale, LP; Braun, RD; Gwinn, WM; Greer, PK; Dewhirst, MW, Hypoxia in the thymus: role of oxygen tension in thymocyte survival., American journal of physiology. Heart and circulatory physiology, vol 282 no. 4 (2002), pp. H1467-H1477 [10.1152/ajpheart.00682.2001] [abs].
  • Haroon, ZA; Amin, K; Saito, W; Wilson, W; Greenberg, CS; Dewhirst, MW, SU5416 delays wound healing through inhibition of TGF-beta 1 activation., Cancer Biology and Therapy, vol 1 no. 2 (2002), pp. 121-126 [abs].
  • Needham, D; Dewhirst, MW, The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors., Advanced Drug Delivery Reviews, vol 53 no. 3 (2001), pp. 285-305 [abs].
  • Ettinger, SN; Poellmann, CC; Wisniewski, NA; Gaskin, AA; Shoemaker, JS; Poulson, JM; Dewhirst, MW; Klitzman, B, Urea as a recovery marker for quantitative assessment of tumor interstitial solutes with microdialysis., Cancer Research, vol 61 no. 21 (2001), pp. 7964-7970 [abs].
  • Walenta, S; Snyder, S; Haroon, ZA; Braun, RD; Amin, K; Brizel, D; Mueller-Klieser, W; Chance, B; Dewhirst, MW, Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model., International Journal of Radiation Oncology, Biology, Physics, vol 51 no. 3 (2001), pp. 840-848 [abs].
  • Pogue, BW; Braun, RD; Lanzen, JL; Erickson, C; Dewhirst, MW, Analysis of the heterogeneity of pO2 dynamics during photodynamic therapy with verteporfin., Photochemistry & Photobiology, vol 74 no. 5 (2001), pp. 700-706 [abs].
  • Lohr, F; Huang, Q; Hu, K; Dewhirst, MW; Li, CY, Systemic vector leakage and transgene expression by intratumorally injected recombinant adenovirus vectors., Clinical cancer research : an official journal of the American Association for Cancer Research, vol 7 no. 11 (2001), pp. 3625-3628 [abs].
  • Brizel, DM; Schroeder, T; Scher, RL; Walenta, S; Clough, RW; Dewhirst, MW; Mueller-Klieser, W, Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer., International Journal of Radiation Oncology, Biology, Physics, vol 51 no. 2 (2001), pp. 349-353 [abs].
  • Snyder, SA; Lanzen, JL; Braun, RD; Rosner, G; Secomb, TW; Biaglow, J; Brizel, DM; Dewhirst, MW, Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone., International Journal of Radiation Oncology, Biology, Physics, vol 51 no. 2 (2001), pp. 494-506 [abs].
  • Lal, A; Peters, H; St Croix, B; Haroon, ZA; Dewhirst, MW; Strausberg, RL; Kaanders, JH; van der Kogel, AJ; Riggins, GJ, Transcriptional response to hypoxia in human tumors., Journal of the National Cancer Institute, vol 93 no. 17 (2001), pp. 1337-1343 [abs].
  • Tozer, GM; Prise, VE; Wilson, J; Cemazar, M; Shan, S; Dewhirst, MW; Barber, PR; Vojnovic, B; Chaplin, DJ, Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability., Cancer Research, vol 61 no. 17 (2001), pp. 6413-6422 [abs].
  • Shan, S; Lockhart, AC; Saito, WY; Knapp, AM; Laderoute, KR; Dewhirst, MW, The novel tubulin-binding drug BTO-956 inhibits R3230AC mammary carcinoma growth and angiogenesis in Fischer 344 rats., Clinical cancer research : an official journal of the American Association for Cancer Research, vol 7 no. 8 (2001), pp. 2590-2596 [abs].
  • Vujaskovic, Z; Anscher, MS; Feng, QF; Rabbani, ZN; Amin, K; Samulski, TS; Dewhirst, MW; Haroon, ZA, Radiation-induced hypoxia may perpetuate late normal tissue injury., International Journal of Radiation Oncology, Biology, Physics, vol 50 no. 4 (2001), pp. 851-855 [abs].
  • Meyer, DE; Shin, BC; Kong, GA; Dewhirst, MW; Chilkoti, A, Drug targeting using thermally responsive polymers and local hyperthermia., Journal of Controlled Release, vol 74 no. 1-3 (2001), pp. 213-224 [abs].
  • Maguire, PD; Samulski, TV; Prosnitz, LR; Jones, EL; Rosner, GL; Powers, B; Layfield, LW; Brizel, DM; Scully, SP; Harrelson, JM; Dewhirst, MW, A phase II trial testing the thermal dose parameter CEM43 degrees T90 as a predictor of response in soft tissue sarcomas treated with pre-operative thermoradiotherapy., International Journal of Hyperthermia (Informa), vol 17 no. 4 (2001), pp. 283-290 [abs].
  • Braun, RD; Lanzen, JL; Snyder, SA; Dewhirst, MW, Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents., American journal of physiology. Heart and circulatory physiology, vol 280 no. 6 (2001), pp. H2533-H2544 [abs].
  • Braun, RD; Lanzen, JL; Turnage, JA; Rosner, G; Dewhirst, MW, Effects of the interaction between carbogen and nicotinamide on R3230 Ac tumor blood flow in Fischer 344 rats., Radiation Research, vol 155 no. 5 (2001), pp. 724-733 [abs].
  • Neeman, M; Dafni, H; Bukhari, O; Braun, RD; Dewhirst, MW, In vivo BOLD contrast MRI mapping of subcutaneous vascular function and maturation: validation by intravital microscopy., Magnetic Resonance in Medicine, vol 45 no. 5 (2001), pp. 887-898 [abs].
  • Lohr, F; Lo, DY; Zaharoff, DA; Hu, K; Zhang, X; Li, Y; Zhao, Y; Dewhirst, MW; Yuan, F; Li, CY, Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation., Cancer Research, vol 61 no. 8 (2001), pp. 3281-3284 [abs].
  • Kong, G; Braun, RD; Dewhirst, MW, Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature., Cancer Research, vol 61 no. 7 (2001), pp. 3027-3032 [abs].
  • Connor, CE; Norris, JD; Broadwater, G; Willson, TM; Gottardis, MM; Dewhirst, MW; McDonnell, DP, Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor., Cancer Research, vol 61 no. 7 (2001), pp. 2917-2922 [abs].
  • Meyer, DE; Kong, GA; Dewhirst, MW; Zalutsky, MR; Chilkoti, A, Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia., Cancer Research, vol 61 no. 4 (2001), pp. 1548-1554 [abs].
  • Li, CY; Little, JB; Hu, K; Zhang, W; Zhang, L; Dewhirst, MW; Huang, Q, Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures., Cancer Research, vol 61 no. 2 (2001), pp. 428-432 [abs].
  • Neeman, M; Provenzale, JM; Dewhirst, MW, Magnetic resonance imaging applications in the evaluation of tumor angiogenesis., Seminars in Radiation Oncology, vol 11 no. 1 (2001), pp. 70-82 [abs].
  • Dewhirst, MW; Kimura, H; Rehmus, SW; Braun, RD; Papahadjopoulos, D; Hong, K; Secomb, TW, Microvascular studies on the origins of perfusion-limited hypoxia., The British journal of cancer. Supplement, vol 27 (1996), pp. S247-S251 [abs].
  • Brizel, DM; Scully, SP; Harrelson, JM; Layfield, LJ; Bean, JM; Prosnitz, LR; Dewhirst, MW, Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma., Cancer Research, vol 56 no. 5 (1996), pp. 941-943 [abs].
  • Kimura, H; Wu, NZ; Dodge, R; Spencer, DP; Klitzman, BM; McIntyre, TM; Dewhirst, MW, Inhibition of radiation-induced up-regulation of leukocyte adhesion to endothelial cells with the platelet-activating factor inhibitor, BN52021., International Journal of Radiation Oncology, Biology, Physics, vol 33 no. 3 (1995), pp. 627-633 [10.1016/0360-3016(95)00205-D] [abs].
  • Sostman, HD; Prescott, DM; Dewhirst, MW; Dodge, RK; Thrall, DE; Page, RL; Tucker, JA; Harrelson, JM; Reece, G; Leopold, KA, MR imaging and spectroscopy for prognostic evaluation in soft-tissue sarcomas., Radiology, vol 190 no. 1 (1994), pp. 269-275 [10.1148/radiology.190.1.8259418] [abs].