Professor of Biomedical Engineering
Tatiana Segura is a Professor of Biomedical Engineering, Neurology, and Dermatology at Duke University. She received her B.S. degree in Bioengineering from the University of California, Berkeley (UC Berkeley) and her doctorate in Chemical Engineering from Northwestern University. She began her career in Biomaterials research during her doctoral work working with Prof. Lonnie Shea. She designed hydrogels for local non-viral gene delivery, a topic that she still works on today. She continued her Biomaterials training during her postdoctoral work with Jeffrey Hubbell. There she worked on the design of hydrogels and self-assembled polysulfides for gene delivery. She began her independent career at the University of California, Los Angeles (UCLA) in the Department of Chemical and Biomolecular Engineering reaching the title of Professor. At UCLA she participated actively in service culminating with her election as department Vice Chair and running the Graduate Program. At Duke she has continued to be heavily involved in service at the department, school, and university level. In only 5 years, she has Chaired 6 committees, and participated in at least 6 more, is the direct mentor to two young assistant professors, is the Co-director of the Center for Biotechnology and Tissue Engineering and serves as MPI of the T32 Biotechnology Training grant. Notably she is currently the Chair of the BME department Diversity Equity and Inclusion Committee.
Prof. Segura’s research is centered on biomaterials and in engineering biomaterial-soft tissue interactions to promote repair and regeneration. Together with her lab members, she designs new biomaterial interventions that can promote brain plasticity after stroke, promote scarless healing in skin wounds, induce tolerance of transplanted skin, and promote constructive immune responses after biomaterial implantation. Currently, her lab has 12 graduate students, 4 postdoctoral scholars, 2 master students, 1 plastic surgery resident, 16 undergraduate students, one high school student, and one research associate.
Professor Segura has received numerous awards and distinctions during her career, including being named a Senior Member of the National Academy of Inventors, receiving the Acta Biomaterialia Silver Medal, a CAREER Award from the National Science Foundation, a Outstanding Young Investigator Award from the American Society of Gene and Cell Therapy, and a National Scientist Development Grant from the American Heart Association. She was also named a Fellow of the American Institute for Medical and Biological Engineers (AIMBE). Professor Segura has published over 100 peer-reviewed papers and reviews and has over 10,000 citations. Her laboratory has been continuously funded since 2008 with several grants from the National Institutes of Health (NIH).
Appointments and Affiliations
- Professor of Biomedical Engineering
- Professor in Neurology
- Professor in Dermatology
- Affiliate of the Duke Regeneration Center
- Office Location: 534 Research Drive, Durham, NC 27708
- Office Phone: (919) 660-2901
- Email Address: email@example.com
- B.S. University of California - Berkeley, 1999
- Ph.D. Northwestern University, 2004
Research InterestsThe design of biomaterials to promote endogenous repair and reducing inflammation through the design of the geometry of the material, and delivering genes, proteins and drugs.
- BME 394: Projects in Biomedical Engineering (GE)
- BME 493: Projects in Biomedical Engineering (GE)
- BME 494: Projects in Biomedical Engineering (GE)
- BME 771: Bioconjugation in drug biomaterials and drug delivery systems
- BME 790: Advanced Topics for Graduate Students in Biomedical Engineering
- BME 791: Graduate Independent Study
- EGR 393: Research Projects in Engineering
- NEUROSCI 493: Research Independent Study 1
- NEUROSCI 494: Research Independent Study 2
- NEUROSCI 495: Research Independent Study 3
In the News
- A Gel That Regrows the Brain (Mar 2, 2022)
- Antimicrobial Coating for Orthopedic Implants Prevents Dangerous Infections (Se…
- Duke Celebrates Women and Girls in Science Day (Feb 10, 2021)
- Wound-Healing Biomaterials Activate Immune System for Stronger Skin (Nov 11, 20…
- No Ordinary Gel: New Tools to Help the Body Repair Brain and Muscle Tissue (Nov…
- New Biomaterial Helps Regrow Brain Tissue After Stroke in Mice (May 21, 2018 | …
- Tatiana Segura: Promoting Healing and Healthy Tissue (Aug 22, 2017 | Pratt Scho…
- Liu, Yining, Alejandra Suarez-Arnedo, Shamitha Shetty, Yaoying Wu, Michelle Schneider, Joel H. Collier, and Tatiana Segura. “A Balance between Pro-Inflammatory and Pro-Reparative Macrophages is Observed in Regenerative D-MAPS.” Advanced Science (Weinheim, Baden Wurttemberg, Germany), February 2023, e2204882. https://doi.org/10.1002/advs.202204882.
- Anderson, Alexa R., and Tatiana Segura. “Controlling Particle Fraction in Microporous Annealed Particle Scaffolds for 3D Cell Culture.” Journal of Visualized Experiments : Jove, no. 188 (October 2022). https://doi.org/10.3791/64554.
- Anderson, Alexa R., Ethan Nicklow, and Tatiana Segura. “Particle fraction is a bioactive cue in granular scaffolds.” Acta Biomaterialia 150 (September 2022): 111–27. https://doi.org/10.1016/j.actbio.2022.07.051.
- Wilson, Katrina L., Sasha Cai Lesher Pérez, Moawiah M. Naffaa, Sean H. Kelly, and Tatiana Segura. “Stoichiometric Post-Modification of Hydrogel Microparticles Dictates Neural Stem Cell Fate in Microporous Annealed Particle Scaffolds.” Advanced Materials (Deerfield Beach, Fla.) 34, no. 33 (August 2022): e2201921. https://doi.org/10.1002/adma.202201921.
- Sideris, Elias, Sophia Kioulaphides, Katrina Wilson, Aaron Yu, Jun Chen, S Thomas Carmichael, and Tatiana Segura. “Particle hydrogels decrease cerebral atrophy and attenuate astrocyte and microglia/macrophage reactivity after stroke.” Advanced Therapeutics 5, no. 8 (August 2022): 2200048. https://doi.org/10.1002/adtp.202200048.