Tatiana Segura


Professor of Biomedical Engineering

Professor Tatiana Segura received her BS degree in Bioengineering from the University of California Berkeley and her doctorate in Chemical Engineering from Northwestern University. Her graduate work in designing and understanding non-viral gene delivery from hydrogel scaffolds was supervised by Prof. Lonnie Shea. She pursued post-doctoral training at the Swiss Federal Institute of Technology, Lausanne under the guidance of Prof. Jeffrey Hubbell, where her focus was self-assembled polymer systems for gene and drug delivery. Professor Segura's Laboratory studies the use of materials for minimally invasive in situ tissue repair.   On this topic, she has published over 60 peered reviewed publications. She has been recognized with the Outstanding Young Investigator Award from the American Society of Gene and Cell Therapy, the American Heart Association National Scientist Development Grant, and the CAREER award from National Science Foundation.  She was Elected to the College of Fellows at the American Institute for Medical and Biological Engineers (AIMBE) in 2017. She spent the first 11 years of her career at UCLA department of Chemical and Biomolecular Engineering and has recently relocated to Duke University, where she holds appointments in Biomedical Engineering, Neurology and Dermatology.

Appointments and Affiliations

  • Professor of Biomedical Engineering
  • Affiliate of the Regeneration Next Initiative

Contact Information

  • Office Location:
  • Office Phone:
  • Email Address: tatiana.segura@duke.edu
  • Websites:


  • Ph.D. Northwestern University, 2004

Research Interests

Dr. Segura’s research interest are in the design of biomaterials to promote endogenous repair and reducing inflammation through the design of the geometry of the material, and delivering genes, proteins and drugs.

Awards, Honors, and Distinctions

  • Fellow. American Institute for Medical and Biological Engineers. 2017
  • National Scientist Development Grant. American Heart Association. 2009
  • Outstanding Young Investigator Award. American Society of Gene and Cell Therapy. 2009
  • CAREER Award. National Science Foundation. 2008

Courses Taught

  • BME 791: Graduate Independent Study

In the News

Representative Publications

  • Darling, NJ; Sideris, E; Hamada, N; Carmichael, ST; Segura, T, Injectable and Spatially Patterned Microporous Annealed Particle (MAP) Hydrogels for Tissue Repair Applications., Advanced Science (Weinheim, Baden Wurttemberg, Germany), vol 5 no. 11 (2018) [10.1002/advs.201801046] [abs].
  • Villate-Beitia, I; Truong, NF; Gallego, I; Zárate, J; Puras, G; Pedraz, JL; Segura, T, Hyaluronic acid hydrogel scaffolds loaded with cationic niosomes for efficient non-viral gene delivery., Rsc Adv., vol 8 no. 56 (2018), pp. 31934-31942 [10.1039/c8ra05125a] [abs].
  • Youngblood, RL; Truong, NF; Segura, T; Shea, LD, It's All in the Delivery: Designing Hydrogels for Cell and Non-viral Gene Therapies., Molecular Therapy, vol 26 no. 9 (2018), pp. 2087-2106 [10.1016/j.ymthe.2018.07.022] [abs].
  • Nih, LR; Gojgini, S; Carmichael, ST; Segura, T, Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke., Nature Materials, vol 17 no. 7 (2018), pp. 642-651 [10.1038/s41563-018-0083-8] [abs].
  • Zhu, S; Li, S; Escuin-Ordinas, H; Dimatteo, R; Xi, W; Ribas, A; Segura, T, Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs., Journal of Controlled Release : Official Journal of the Controlled Release Society, vol 282 (2018), pp. 156-165 [10.1016/j.jconrel.2018.05.006] [abs].