Tatiana Segura

Professor of Biomedical Engineering

Tatiana Segura is a Professor of Biomedical Engineering, Neurology, and Dermatology at Duke University. She received her B.S. degree in Bioengineering from the University of California, Berkeley (UC Berkeley) and her doctorate in Chemical Engineering from Northwestern University.  She began her career in Biomaterials research during her doctoral work working with Prof. Lonnie Shea. She designed hydrogels for local non-viral gene delivery, a topic that she still works on today. She continued her Biomaterials training during her postdoctoral work with Jeffrey Hubbell. There she worked on the design of hydrogels and self-assembled polysulfides for gene delivery. She began her independent career at the University of California, Los Angeles (UCLA) in the Department of Chemical and Biomolecular Engineering reaching the title of Professor. At UCLA she participated actively in service culminating with her election as department Vice Chair and running the Graduate Program. At Duke she has continued to be heavily involved in service at the department, school, and university level. In only 5 years, she has Chaired 6 committees, and participated in at least 6 more, is the direct mentor to two young assistant professors, is the Co-director of the Center for Biotechnology and Tissue Engineering and serves as MPI of the T32 Biotechnology Training grant. Notably she is currently the Chair of the BME department Diversity Equity and Inclusion Committee. 


Prof. Segura’s research is centered on biomaterials and in engineering biomaterial-soft tissue interactions to promote repair and regeneration. Together with her lab members, she designs new biomaterial interventions that can promote brain plasticity after stroke, promote scarless healing in skin wounds, induce tolerance of transplanted skin, and promote constructive immune responses after biomaterial implantation. Currently, her lab has 12 graduate students, 4 postdoctoral scholars, 2 master students, 1 plastic surgery resident, 16 undergraduate students, one high school student, and one research associate. 


Professor Segura has received numerous awards and distinctions during her career, including being named a Senior Member of the National Academy of Inventors, receiving the Acta Biomaterialia Silver Medal, a CAREER Award from the National Science Foundation, a Outstanding Young Investigator Award from the American Society of Gene and Cell Therapy, and a National Scientist Development Grant from the American Heart Association. She was also named a Fellow of the American Institute for Medical and Biological Engineers (AIMBE). Professor Segura has published over 100 peer-reviewed papers and reviews and has over 10,000 citations. Her laboratory has been continuously funded since 2008 with several grants from the National Institutes of Health (NIH). 

Appointments and Affiliations

  • Professor of Biomedical Engineering
  • Professor in Neurology
  • Professor in Dermatology
  • Affiliate of the Duke Regeneration Center

Contact Information


  • B.S. University of California - Berkeley, 1999
  • Ph.D. Northwestern University, 2004

Research Interests

The design of biomaterials to promote endogenous repair and reducing inflammation through the design of the geometry of the material, and delivering genes, proteins and drugs.

Courses Taught

  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 771: Bioconjugation in drug biomaterials and drug delivery systems
  • BME 789: Internship in Biomedical Engineering
  • BME 790: Advanced Topics for Graduate Students in Biomedical Engineering
  • BME 791: Graduate Independent Study
  • EGR 393: Research Projects in Engineering
  • EGR 491: Projects in Engineering
  • NEUROSCI 493: Research Independent Study 1
  • NEUROSCI 494: Research Independent Study 2
  • NEUROSCI 495: Research Independent Study 3

In the News

Representative Publications

  • Liu, Yining, Alejandra Suarez-Arnedo, Eleanor L. P. Caston, Lindsay Riley, Michelle Schneider, and Tatiana Segura. “Exploring the Role of Spatial Confinement in Immune Cell Recruitment and Regeneration of Skin Wounds.” Advanced Materials (Deerfield Beach, Fla.), September 2023, e2304049. https://doi.org/10.1002/adma.202304049.
  • Wilson, Katrina L., Lauren A. Onweller, Neica I. Joseph, Jennifer David-Bercholz, Nicole J. Darling, and Tatiana Segura. “SDF-1 Bound Heparin Nanoparticles Recruit Progenitor Cells for Their Differentiation and Promotion of Angiogenesis After Stroke.” Biorxiv, July 5, 2023. https://doi.org/10.1101/2023.07.05.547800.
  • Samal, Juhi, Tana V. Palomino, Judy Chen, David C. Muddiman, and Tatiana Segura. “Enhanced Detection of Charged N-Glycans in the Brain by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometric Imaging.” Analytical Chemistry 95, no. 29 (July 2023): 10913–20. https://doi.org/10.1021/acs.analchem.3c00494.
  • Riley, Lindsay, Grace Wei, Yijun Bao, Peter Cheng, Katrina L. Wilson, Yining Liu, Yiyang Gong, and Tatiana Segura. “Void Volume Fraction of Granular Scaffolds.” Small (Weinheim an Der Bergstrasse, Germany), June 2023, e2303466. https://doi.org/10.1002/smll.202303466.
  • Wang, Mary F., Alexandria L. Sohn, Juhi Samal, Kevin Erning, Tatiana Segura, and David C. Muddiman. “Lipidomic Analysis of Mouse Brain to Evaluate the Efficacy and Preservation of Different Tissue Preparatory Techniques by IR-MALDESI-MSI.” Journal of the American Society for Mass Spectrometry 34, no. 5 (May 2023): 869–77. https://doi.org/10.1021/jasms.2c00353.