Kathryn R Nightingale

Theo Pilkington Distinguished Professor of Biomedical Engineering

The goals of our laboratory are to investigate and improve ultrasonic imaging methods for clinically-relevant problems. We do this through theoretical, experimental, and simulation methods. The main focus of our recent work is the development of novel, acoustic radiation force impulse (ARFI)-based elasticity imaging methods to generate images of the mechanical properties of tissue, involving interdisciplinary research in ultrasonics and tissue biomechanics. We have access to the engineering interfaces of several commercial ultrasound systems which allows us to design, rapidly prototype, and experimentally demonstrate custom sequences to explore novel beamforming and imaging concepts. We employ FEM modeling methods to simulate the behavior of tissues during mechanical excitation, and we have integrated these tools with ultrasonic imaging modeling tools to simulate the ARFI imaging process. We maintain strong collaborations with the Duke University Medical Center where we work to translate our technologies to clinical practice. The ARFI imaging technologies we have developed have served as the basis for commercial imaging technologies that are now being used in clinics throughout the world.  We are also studying the risks and benefits of increasing acoustic output energy for specific clinical imaging scenarios, with the goal of improving ultrasonic image quality in the difficult-to-image patient.

Appointments and Affiliations

• Theo Pilkington Distinguished Professor of Biomedical Engineering
• Professor in the Department of Biomedical Engineering
• Member of the Duke Cancer Institute
• Bass Fellow

Contact Information

• Office Location: 277 Hudson Hall Annex, Durham, NC 27708
• Office Phone: (919) 660-5175
• Email Address: kathy.nightingale@duke.edu
• Websites:
  • Google Scholar
  • http://kathynightingalelab.pratt.duke.edu/

Education

• Ph.D. Duke University, 1997
• B.S. Duke University, 1989

Research Interests

Ultrasonic and elasticity imaging, specifically nonlinear propagation, acoustic streaming and radiation force; the intentional generation of these phenomena for the purpose of tissue characterization; finite element modeling of normal and diseased tissue when exposed to ultrasound, and performing both phantom and clinical experiments investigating these phenomena. Other areas of interest include prostate imaging, abdominal imaging, image-guided therapies, and the bioeffects of ultrasound.

Awards, Honors, and Distinctions

• Joseph H. Holmes Basic Science Pioneer Award. American Institute of Ultrasound in Medicine. 2022
• Lois and John L. Imhoff Distinguished Teaching Award. Pratt School of Engineering. 2018
• Fellow. American Institute for Medical and Biological Engineering. 2016
• Capers and Marion McDonald Teaching and Research Award. Pratt School of Engineering. 2015
• Klein Family Distinguished Teaching Award. Pratt School of Engineering. 2007

Courses Taught

• BME 354L: Introduction to Medical Instrumentation
• BME 493-1: Projects in Biomedical Engineering (GE)
• BME 493: Projects in Biomedical Engineering (GE)
• BME 494: Projects in Biomedical Engineering (GE)
• BME 542: Principles of Ultrasound Imaging (GE, IM)
• BME 791: Graduate Independent Study

In the News

• Nightingale, Wilson Elected Fellows of the National Academy of Inventors (Dec 6, 2019 | Pratt School of Engineering)
• Duke Adds 21 Faculty to Distinguished Faculty Rank (May 7, 2019)
• Bringing Scholarship to the Classroom (Nov 19, 2013)

Representative Publications

• McCune, EP; Le, DQ; Lindholm, P; Nightingale, KR; Dayton, PA; Papadopoulou, V, Perspective on ultrasound bioeffects and possible implications for continuous post-dive monitoring safety., Diving and Hyperbaric Medicine, vol 52 no. 2 (2022), pp. 136-148 [10.28920/dhm52.2.136-148] [abs].
• Rouze, NC; Caenen, A; Nightingale, KR, Phase and group velocities for shear wave propagation in an incompressible, hyperelastic material with uniaxial stretch., Physics in Medicine and Biology, vol 67 no. 9 (2022) [10.1088/1361-6560/ac5bfc] [abs].
• Geoghegan, R; Ter Haar, G; Nightingale, K; Marks, L; Natarajan, S, Methods of monitoring thermal ablation of soft tissue tumors - A comprehensive review., Medical Physics, vol 49 no. 2 (2022), pp. 769-791 [10.1002/mp.15439] [abs].
• Knight, AE; Jin, FQ; Trutna Paley, CT; Rouze, NC; Moavenzadeh, SR; Pietrosimone, LS; Palmeri, ML; Nightingale, KR, Parametric Analysis of SV Mode Shear Waves in Transversely Isotropic Materials Using Ultrasonic Rotational 3D SWEI, Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control (2022) [10.1109/TUFFC.2022.3203935] [abs].
• Knight, AE; Trutna, CA; Rouze, NC; Hobson-Webb, LD; Caenen, A; Jin, FQ; Palmeri, ML; Nightingale, KR, Full Characterization of in vivo Muscle as an Elastic, Incompressible, Transversely Isotropic Material Using Ultrasonic Rotational 3D Shear Wave Elasticity Imaging., Ieee Trans Med Imaging, vol 41 no. 1 (2022), pp. 133-144 [10.1109/TMI.2021.3106278] [abs].