Kathryn R Nightingale

Professor in the Department of Biomedical Engineering

The goals of our laboratory are to investigate and improve ultrasonic imaging methods for clinically-relevant problems. We do this through theoretical, experimental, and simulation methods. The main focus of our recent work is the development of novel, acoustic radiation force impulse (ARFI)-based elasticity imaging methods to generate images of the mechanical properties of tissue, involving interdisciplinary research in ultrasonics and tissue biomechanics. We have access to the engineering interfaces of several commercial ultrasound systems which allows us to design, rapidly prototype, and experimentally demonstrate custom sequences to explore novel beamforming and imaging concepts. We employ FEM modeling methods to simulate the behavior of tissues during mechanical excitation, and we have integrated these tools with ultrasonic imaging modeling tools to simulate the ARFI imaging process. We maintain strong collaborations with the Duke University Medical Center where we work to translate our technologies to clinical practice. The ARFI imaging technologies we have developed have served as the basis for commercial imaging technologies that are now being used in clinics throughout the world.  We are also studying the risks and benefits of increasing acoustic output energy for specific clinical imaging scenarios, with the goal of improving ultrasonic image quality in the difficult-to-image patient.

Appointments and Affiliations

• Professor in the Department of Biomedical Engineering
• Member of the Duke Cancer Institute
• Bass Fellow

Contact Information

• Office Location: 277 Hudson Hall Annex, Durham, NC 27708
• Office Phone: (919) 660-5175
• Email Address: kathy.nightingale@duke.edu
• Websites:
  • Google Scholar
  • http://kathynightingalelab.pratt.duke.edu/

Education

• Ph.D. Duke University, 1997
• B.S. Duke University, 1989

Research Interests

Ultrasonic and elasticity imaging, specifically nonlinear propagation, acoustic streaming and radiation force; the intentional generation of these phenomena for the purpose of tissue characterization; finite element modeling of normal and diseased tissue when exposed to ultrasound, and performing both phantom and clinical experiments investigating these phenomena. Other areas of interest include prostate imaging, abdominal imaging, image-guided therapies, and the bioeffects of ultrasound.

Awards, Honors, and Distinctions

• Lois and John L. Imhoff Distinguished Teaching Award. Pratt School of Engineering. 2018
• Fellow. American Institute for Medical and Biological Engineering. 2016
• Capers and Marion McDonald Teaching and Research Award. Pratt School of Engineering. 2015
• Klein Family Distinguished Teaching Award. Pratt School of Engineering. 2007

Courses Taught

• BME 354L: Introduction to Medical Instrumentation
• BME 394: Projects in Biomedical Engineering (GE)
• BME 494: Projects in Biomedical Engineering (GE)
• BME 542: Principles of Ultrasound Imaging (GE, IM)
• BME 790L: Advanced Topics with the Lab for Graduate Students in Biomedical Engineering
• BME 791: Graduate Independent Study
• BME 792: Continuation of Graduate Independent Study
• BME 845: Elasticity Imaging

In the News

• Bringing Scholarship to the Classroom (Nov 19, 2013)

Representative Publications

• Rouze, NC; Deng, Y; Trutna, CA; Palmeri, ML; Nightingale, KR, Characterization of Viscoelastic Materials Using Group Shear Wave Speeds., Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol 65 no. 5 (2018), pp. 780-794 [10.1109/tuffc.2018.2815505] [abs].
• Lipman, SL; Rouze, NC; Palmeri, ML; Nightingale, KR, Impact of Acoustic Radiation Force Excitation Geometry on Shear Wave Dispersion and Attenuation Estimates., Ultrasound in Medicine & Biology, vol 44 no. 4 (2018), pp. 897-908 [10.1016/j.ultrasmedbio.2017.12.019] [abs].
• Deng, Y; Palmeri, ML; Rouze, NC; Haystead, CM; Nightingale, KR, Evaluating the Benefit of Elevated Acoustic Output in Harmonic Motion Estimation in Ultrasonic Shear Wave Elasticity Imaging., Ultrasound in Medicine & Biology, vol 44 no. 2 (2018), pp. 303-310 [10.1016/j.ultrasmedbio.2017.10.003] [abs].
• Rouze, NC; Deng, Y; Palmeri, ML; Nightingale, KR, Accounting for the Spatial Observation Window in the 2-D Fourier Transform Analysis of Shear Wave Attenuation., Ultrasound in Medicine & Biology, vol 43 no. 10 (2017), pp. 2500-2506 [10.1016/j.ultrasmedbio.2017.06.006] [abs].
• Deng, Y; Palmeri, ML; Rouze, NC; Trahey, GE; Haystead, CM; Nightingale, KR, Quantifying Image Quality Improvement Using Elevated Acoustic Output in B-Mode Harmonic Imaging., Ultrasound in Medicine & Biology, vol 43 no. 10 (2017), pp. 2416-2425 [10.1016/j.ultrasmedbio.2017.06.024] [abs].