Michael D. Lynch


Assistant Professor in the Department of Biomedical Engineering

Appointments and Affiliations

  • Assistant Professor in the Department of Biomedical Engineering
  • Faculty Fellow in The Energy Initiative
  • Associate of the Duke Initiative for Science & Society

Contact Information


  • M.D. University of Colorado School of Medicine, 2007
  • Ph.D. University of Colorado - Boulder, 2005

Research Interests

Focused on genetically engineering microbes to shut off their growth circuits and turn on new pathways to produce different compounds—improving production of biofuels, pharmacological molecules and industrial chemicals.

Courses Taught

  • BME 490L: Special Topics in Biomedical Engineering Design (DR)
  • BME 590D: Special Topics with Discussion
  • BME 590L: Special Topics with Lab
  • BME 703S: Engineering Management Seminar for Master of Science Students
  • BME 790L: Advanced Topics with the Lab for Graduate Students in Biomedical Engineering

In the News

Representative Publications

  • Yang, T; Ye, Z; Lynch, MD, "Multiagent" Screening Improves Directed Enzyme Evolution by Identifying Epistatic Mutations., Acs Synthetic Biology, vol 11 no. 5 (2022), pp. 1971-1983 [10.1021/acssynbio.2c00136] [abs].
  • Decker, JS; Menacho-Melgar, R; Lynch, MD, Integrated autolysis, DNA hydrolysis and precipitation enables an improved bioprocess for Q-Griffithsin, a broad-spectrum antiviral and clinical-stage anti-COVID-19 candidate., Biochemical Engineering Journal, vol 181 (2022) [10.1016/j.bej.2022.108403] [abs].
  • Moreb, EA; Lynch, MD, A Meta-Analysis of gRNA Library Screens Enables an Improved Understanding of the Impact of gRNA Folding and Structural Stability on CRISPR-Cas9 Activity., The Crispr Journal, vol 5 no. 1 (2022), pp. 146-154 [10.1089/crispr.2021.0084] [abs].
  • Menacho-Melgar, R; Lynch, MD, Simple Scalable Protein Expression and Extraction Using Two-stage Autoinducible Cell Autolysis and DNA/RNA Autohydrolysis in Escherichia coli., Bio Protocol, vol 12 no. 2 (2022) [10.21769/bioprotoc.4297] [abs].
  • Menacho-Melgar, R; Lynch, MD, Measuring Oligonucleotide Hydrolysis in Cellular Lysates via Viscosity Measurements., Bio Protocol, vol 12 no. 2 (2022) [10.21769/bioprotoc.4304] [abs].