Michael D Lynch

W. H. Gardner, Jr. Associate Professor of Biomedical Engineering

Appointments and Affiliations

  • W. H. Gardner, Jr. Associate Professor of Biomedical Engineering
  • Associate Professor in the Department of Biomedical Engineering
  • Associate Professor in Chemistry
  • Associate of the Duke Initiative for Science & Society

Contact Information


  • Ph.D. University of Colorado - Boulder, 2005
  • M.D. University of Colorado School of Medicine, 2007

Research Interests

Focused on genetically engineering microbes to shut off their growth circuits and turn on new pathways to produce different compounds—improving production of biofuels, pharmacological molecules and industrial chemicals.

Courses Taught

  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 590L: Special Topics with Lab
  • BME 790L: Advanced Topics with the Lab for Graduate Students in Biomedical Engineering
  • BME 791: Graduate Independent Study
  • BME 792: Continuation of Graduate Independent Study
  • EGR 393: Research Projects in Engineering

In the News

Representative Publications

  • Hennigan, Jennifer, Romel Menacho-Melgar, Payel Sarkar, and Michael Lynch. “Scalable, Robust, High-throughput Expression, Purification & Characterization of Nanobodies Enabled by 2-Stage Dynamic Control.” BioRxiv, 2023. https://doi.org/10.1101/2023.12.14.571655.
  • Decker, John, Utsuki Yano, Romel Menacho Melgar, and Michael Lynch. “Precipitation and Extraction Methods for Protein Purification: A Meta-Analysis of Purification Performance and Cost-Effectiveness.” BioRxiv, 2023. https://doi.org/10.1101/2023.12.14.571684.
  • Yang, Tian, Zhixia Ye, and Michael D. Lynch. “"Multiagent" Screening Improves Directed Enzyme Evolution by Identifying Epistatic Mutations.” ACS Synthetic Biology 11, no. 5 (May 2022): 1971–83. https://doi.org/10.1021/acssynbio.2c00136.
  • Decker, John S., Romel Menacho-Melgar, and Michael D. Lynch. “Integrated autolysis, DNA hydrolysis and precipitation enables an improved bioprocess for Q-Griffithsin, a broad-spectrum antiviral and clinical-stage anti-COVID-19 candidate.” Biochemical Engineering Journal 181 (April 2022): 108403. https://doi.org/10.1016/j.bej.2022.108403.
  • Moreb, Eirik A., and Michael D. Lynch. “A Meta-Analysis of gRNA Library Screens Enables an Improved Understanding of the Impact of gRNA Folding and Structural Stability on CRISPR-Cas9 Activity.” The CRISPR Journal 5, no. 1 (February 2022): 146–54. https://doi.org/10.1089/crispr.2021.0084.