Geoffrey Steven Ginsburg

Adjunct Professor in the Department of Medicine

Dr. Geoffrey S. Ginsburg's research interests are in the development of novel paradigms for developing and translating genomic information into medical practice and the integration of personalized medicine into health care.

Appointments and Affiliations

  • Adjunct Professor in the Department of Medicine
  • Professor in Pathology
  • Professor of Biostatistics and Bioinformatics
  • Professor in the School of Nursing
  • Member of the Duke Cancer Institute

Contact Information

  • Office Location: 101 Science Dr, Rm 2111, CIEMAS Bldg, Durham, NC 27708
  • Office Phone: (919) 668-6210
  • Websites:

Education

  • M.D. Boston University, 1984
  • Ph.D. Boston University, 1984
  • Beth Israel Deaconess Medical Center, 1987
  • Beth Israel Deaconess Medical Center, 1990
  • Children's Hospital Boston, 1990

Courses Taught

  • BME 493: Projects in Biomedical Engineering (GE)

In the News

Representative Publications

  • Manolio, Teri A., Marc Abramowicz, Fahd Al-Mulla, Warwick Anderson, Rudi Balling, Adam C. Berger, Steven Bleyl, et al. “Global implementation of genomic medicine: We are not alone.” Sci Transl Med 7, no. 290 (June 3, 2015): 290ps13. https://doi.org/10.1126/scitranslmed.aab0194.
  • Dzau, Victor J., Geoffrey S. Ginsburg, Karen Van Nuys, David Agus, and Dana Goldman. “Aligning incentives to fulfil the promise of personalised medicine.” Lancet 385, no. 9982 (May 23, 2015): 2118–19. https://doi.org/10.1016/S0140-6736(15)60722-X.
  • Benjamin, Ashlee M., Marshall Nichols, Thomas W. Burke, Geoffrey S. Ginsburg, and Joseph E. Lucas. “Comparing reference-based RNA-Seq mapping methods for non-human primate data.” Bmc Genomics 15, no. 1 (July 7, 2014): 570. https://doi.org/10.1186/1471-2164-15-570.
  • Kraft, Bryan D., Claude A. Piantadosi, Ashlee M. Benjamin, Joseph E. Lucas, Aimee K. Zaas, Marisol Betancourt-Quiroz, Christopher W. Woods, et al. “Development of a novel preclinical model of pneumococcal pneumonia in nonhuman primates.” Am J Respir Cell Mol Biol 50, no. 5 (May 2014): 995–1004. https://doi.org/10.1165/rcmb.2013-0340OC.
  • Ngo, Hoan T., Hsin-Neng Wang, Thomas Burke, Geoffrey S. Ginsburg, and Tuan Vo-Dinh. “Multiplex detection of disease biomarkers using SERS molecular sentinel-on-chip.” Anal Bioanal Chem 406, no. 14 (May 2014): 3335–44. https://doi.org/10.1007/s00216-014-7648-4.
  • Power, Aidan, Adam C. Berger, and Geoffrey S. Ginsburg. “Genomics-enabled drug repositioning and repurposing: insights from an IOM Roundtable activity.” Jama 311, no. 20 (May 2014): 2063–64. https://doi.org/10.1001/jama.2014.3002.
  • Ginsburg, Geoffrey. “Medical genomics: Gather and use genetic data in health care.” Nature 508, no. 7497 (April 24, 2014): 451–53. https://doi.org/10.1038/508451a.
  • Tsalik, Ephraim L., Raymond J. Langley, Darrell L. Dinwiddie, Neil A. Miller, Byunggil Yoo, Jennifer C. van Velkinburgh, Laurie D. Smith, et al. “An integrated transcriptome and expressed variant analysis of sepsis survival and death.” Genome Med 6, no. 11 (2014): 111. https://doi.org/10.1186/s13073-014-0111-5.
  • Voora, Deepak, Derek Cyr, Joseph Lucas, Jen-Tsan Chi, Jennifer Dungan, Timothy A. McCaffrey, Richard Katz, et al. “Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events.” J Am Coll Cardiol 62, no. 14 (October 1, 2013): 1267–76. https://doi.org/10.1016/j.jacc.2013.05.073.
  • Zaas, Aimee K., Thomas Burke, Minhua Chen, Micah McClain, Bradly Nicholson, Timothy Veldman, Ephraim L. Tsalik, et al. “A host-based RT-PCR gene expression signature to identify acute respiratory viral infection.” Sci Transl Med 5, no. 203 (September 18, 2013): 203ra126. https://doi.org/10.1126/scitranslmed.3006280.
  • Langley, Raymond J., Ephraim L. Tsalik, Jennifer C. van Velkinburgh, Seth W. Glickman, Brandon J. Rice, Chunping Wang, Bo Chen, et al. “An integrated clinico-metabolomic model improves prediction of death in sepsis.” Sci Transl Med 5, no. 195 (July 24, 2013): 195ra95. https://doi.org/10.1126/scitranslmed.3005893.
  • Wang, Hsin-Neng, Andrew M. Fales, Aimee K. Zaas, Christopher W. Woods, Thomas Burke, Geoffrey S. Ginsburg, and Tuan Vo-Dinh. “Surface-enhanced Raman scattering molecular sentinel nanoprobes for viral infection diagnostics.” Anal Chim Acta 786 (July 5, 2013): 153–58. https://doi.org/10.1016/j.aca.2013.05.017.
  • Ginsburg, Geoffrey S. “Realizing the opportunities of genomics in health care.” Jama 309, no. 14 (April 10, 2013): 1463–64. https://doi.org/10.1001/jama.2013.1465.
  • Khoury, Muin J., Tram Kim Lam, John P. A. Ioannidis, Patricia Hartge, Margaret R. Spitz, Julie E. Buring, Stephen J. Chanock, et al. “Transforming epidemiology for 21st century medicine and public health.” Cancer Epidemiol Biomarkers Prev 22, no. 4 (April 2013): 508–16. https://doi.org/10.1158/1055-9965.EPI-13-0146.
  • Henao, Ricardo, Jared Murray, Geoffrey Ginsburg, Lawrence Carin, and Joseph E. Lucas. “Patient clustering with uncoded text in electronic medical records.” Amia Annu Symp Proc 2013 (2013): 592–99.
  • Orlando, Lori A., Adam H. Buchanan, Susan E. Hahn, Carol A. Christianson, Karen P. Powell, Celette Sugg Skinner, Blair Chesnut, et al. “Development and validation of a primary care-based family health history and decision support program (MeTree).” N C Med J 74, no. 4 (2013): 287–96.
  • Ginsburg, Geoffrey S., and Nicole M. Kuderer. “Comparative effectiveness research, genomics-enabled personalized medicine, and rapid learning health care: a common bond.” J Clin Oncol 30, no. 34 (December 1, 2012): 4233–42. https://doi.org/10.1200/JCO.2012.42.6114.
  • Zarco, M. F., T. J. Vess, and G. S. Ginsburg. “The oral microbiome in health and disease and the potential impact on personalized dental medicine.” Oral Dis 18, no. 2 (March 2012): 109–20. https://doi.org/10.1111/j.1601-0825.2011.01851.x.
  • Orlando, Lori A., Elizabeth R. Hauser, Carol Christianson, Karen P. Powell, Adam H. Buchanan, Blair Chesnut, Astrid B. Agbaje, Vincent C. Henrich, and Geoffrey Ginsburg. “Protocol for implementation of family health history collection and decision support into primary care using a computerized family health history system.” Bmc Health Serv Res 11 (October 11, 2011): 264. https://doi.org/10.1186/1472-6963-11-264.
  • Ginsburg, Geoffrey S., Judd Staples, and Amy P. Abernethy. “Academic medical centers: ripe for rapid-learning personalized health care.” Sci Transl Med 3, no. 101 (September 21, 2011): 101cm27. https://doi.org/10.1126/scitranslmed.3002386.
  • Chen, Minhua, Aimee Zaas, Christopher Woods, Geoffrey S. Ginsburg, Joseph Lucas, David Dunson, and Lawrence Carin. “Predicting Viral Infection From High-Dimensional Biomarker Trajectories.” J Am Stat Assoc 106, no. 496 (January 1, 2011): 1259–79. https://doi.org/10.1198/jasa.2011.ap10611.
  • Chan, Isaac S., and Geoffrey S. Ginsburg. “Personalized medicine: progress and promise.” Annu Rev Genomics Hum Genet 12 (2011): 217–44. https://doi.org/10.1146/annurev-genom-082410-101446.
  • Altshuler, Jill S., Erin Balogh, Anna D. Barker, Stephen L. Eck, Stephen H. Friend, Geoffrey S. Ginsburg, Roy S. Herbst, Sharyl J. Nass, Christopher M. Streeter, and John A. Wagner. “Opening up to precompetitive collaboration.” Sci Transl Med 2, no. 52 (October 6, 2010): 52cm26. https://doi.org/10.1126/scitranslmed.3001515.
  • Ginsburg, Geoffrey S. “Regression of atherosclerosis with therapeutic antibodies pipe cleaner or pipe dream?” J Am Coll Cardiol 50, no. 24 (December 11, 2007): 2319–21. https://doi.org/10.1016/j.jacc.2007.08.039.
  • Lugogo, Njira L., Geoffrey S. Ginsburg, and Loretta G. Que. “Genetic profiling and tailored therapy in asthma: are we there yet?” Curr Opin Mol Ther 9, no. 6 (December 2007): 528–37.
  • Ginsburg, Geoffrey S., Svati H. Shah, and Jeanette J. McCarthy. “Taking cardiovascular genetic association studies to the next level.” J Am Coll Cardiol 50, no. 10 (September 4, 2007): 930–32. https://doi.org/10.1016/j.jacc.2007.05.025.
  • Parker, Alex, Elena S. Izmailova, Jigna Narang, Sunita Badola, Tinh Le, Ronenn Roubenoff, Geoffrey S. Ginsburg, et al. “Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate.” J Rheumatol 34, no. 9 (September 2007): 1817–22.
  • Dressman, Holly K., Garrett G. Muramoto, Nelson J. Chao, Sarah Meadows, Dawn Marshall, Geoffrey S. Ginsburg, Joseph R. Nevins, and John P. Chute. “Gene expression signatures that predict radiation exposure in mice and humans.” Plos Med 4, no. 4 (April 2007): e106. https://doi.org/10.1371/journal.pmed.0040106.
  • Dressman, Holly K., Andrew Berchuck, Gina Chan, Jun Zhai, Andrea Bild, Robyn Sayer, Janiel Cragun, et al. “An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer.” J Clin Oncol, February 10, 2007. https://doi.org/10.1200/JCO.2006.06.3743.
  • Potti, Anil, Holly K. Dressman, Andrea Bild, Richard F. Riedel, Gina Chan, Robyn Sayer, Janiel Cragun, et al. “Genomic signatures to guide the use of chemotherapeutics.” Nat Med, November 2006. https://doi.org/10.1038/nm1491.
  • Ginsburg, Geoffrey S., David Seo, and Camille Frazier. “Microarrays coming of age in cardiovascular medicine: standards, predictions, and biology.” J Am Coll Cardiol 48, no. 8 (October 17, 2006): 1618–20. https://doi.org/10.1016/j.jacc.2006.07.025.
  • Ginsburg, Geoffrey S., Misha Angrist, and Robert Cook-Deegan. “Public health. Genomics and medicine at a crossroads in Chernobyl.” Science 314, no. 5796 (October 6, 2006): 62–63. https://doi.org/10.1126/science.1130274.
  • Stallings, Sarah C., Dan Huse, Stan N. Finkelstein, William H. Crown, Whitney P. Witt, Jon Maguire, Arthur J. Hiller, Anthony J. Sinskey, and Geoffrey S. Ginsburg. “A framework to evaluate the economic impact of pharmacogenomics.” Pharmacogenomics 7, no. 6 (September 2006): 853–62. https://doi.org/10.2217/14622416.7.6.853.
  • Potti, Anil, Sayan Mukherjee, Rebecca Petersen, Holly K. Dressman, Andrea Bild, Jason Koontz, Robert Kratzke, et al. “A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer.” N Engl J Med 355, no. 6 (August 10, 2006): 570–80. https://doi.org/10.1056/NEJMoa060467.
  • Seo, David, Geoffrey S. Ginsburg, and Pascal J. Goldschmidt-Clermont. “Gene expression analysis of cardiovascular diseases: novel insights into biology and clinical applications.” J Am Coll Cardiol 48, no. 2 (July 18, 2006): 227–35. https://doi.org/10.1016/j.jacc.2006.02.070.
  • Haga, Susanne B., and Geoffrey S. Ginsburg. “Prescribing BiDil: is it black and white?” J Am Coll Cardiol 48, no. 1 (July 4, 2006): 12–14. https://doi.org/10.1016/j.jacc.2006.04.017.
  • Cotten, C Michael, Geoffrey S. Ginsburg, Ronald N. Goldberg, and Marcy C. Speer. “Genomic analyses: a neonatology perspective.” J Pediatr 148, no. 6 (June 2006): 720–26. https://doi.org/10.1016/j.jpeds.2006.01.006.
  • West, Mike, Geoffrey S. Ginsburg, Andrew T. Huang, and Joseph R. Nevins. “Embracing the complexity of genomic data for personalized medicine.” Genome Res 16, no. 5 (May 2006): 559–66. https://doi.org/10.1101/gr.3851306.
  • Ginsburg, Geoffrey S., and Susanne B. Haga. “Translating genomic biomarkers into clinically useful diagnostics.” Expert Rev Mol Diagn 6, no. 2 (March 2006): 179–91. https://doi.org/10.1586/14737159.6.2.179.
  • Ginsburg, Geoffrey S., Richard P. Konstance, Jennifer S. Allsbrook, and Kevin A. Schulman. “Implications of pharmacogenomics for drug development and clinical practice.” Arch Intern Med 165, no. 20 (November 14, 2005): 2331–36. https://doi.org/10.1001/archinte.165.20.2331.
  • Ginsburg, Geoffrey S., Mark P. Donahue, and L Kristin Newby. “Prospects for personalized cardiovascular medicine: the impact of genomics.” J Am Coll Cardiol 46, no. 9 (November 1, 2005): 1615–27. https://doi.org/10.1016/j.jacc.2005.06.075.
  • Willard, Huntington F., Misha Angrist, and Geoffrey S. Ginsburg. “Genomic medicine: genetic variation and its impact on the future of health care.” Philos Trans R Soc Lond B Biol Sci 360, no. 1460 (August 29, 2005): 1543–50. https://doi.org/10.1098/rstb.2005.1683.
  • Seo, David, and Geoffrey S. Ginsburg. “Genomic medicine: bringing biomarkers to clinical medicine.” Curr Opin Chem Biol 9, no. 4 (August 2005): 381–86. https://doi.org/10.1016/j.cbpa.2005.06.009.
  • Abrahams, Edward, Geoffrey S. Ginsburg, and Mike Silver. “The Personalized Medicine Coalition: goals and strategies.” Am J Pharmacogenomics 5, no. 6 (2005): 345–55. https://doi.org/10.2165/00129785-200505060-00002.
  • Ross, Jeffrey S., David P. Schenkein, Robert Pietrusko, Mark Rolfe, Gerald P. Linette, James Stec, Nancy E. Stagliano, et al. “Targeted therapies for cancer 2004.” Am J Clin Pathol 122, no. 4 (October 2004): 598–609. https://doi.org/10.1309/5CWP-U41A-FR1V-YM3F.
  • Ross, Jeffrey S., and Geoffrey S. Ginsburg. “Integration of molecular diagnostics with therapeutics: implications for drug discovery and patient care.” Expert Rev Mol Diagn 2, no. 6 (November 2002): 531–41. https://doi.org/10.1586/14737159.2.6.531.
  • Meyer, Joanne M., and Geoffrey S. Ginsburg. “The path to personalized medicine.” Curr Opin Chem Biol 6, no. 4 (August 2002): 434–38. https://doi.org/10.1016/s1367-5931(02)00340-x.
  • Ginsburg, G. S., and J. J. McCarthy. “Personalized medicine: revolutionizing drug discovery and patient care.” Trends Biotechnol 19, no. 12 (December 2001): 491–96. https://doi.org/10.1016/s0167-7799(01)01814-5.