Duke-Coulter Partnership Projects
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2020-2021
An Injectable Therapeutic Formulation to Accelerate Bone Fracture Healing
BME Investigator:
Shyni Varghese, Ph.D., Department of Biomedical Engineering
Clinical Investigator:
Mark Gage, M.D., Department of Orthopaedic Surgery
Clinical Trial of a Device for Tracking Urine and Stool Output in a Hospital Setting
BME Investigator:
Lawrence David, Ph.D., Department of Biomedical Engineering
Clinical Investigator:
Anthony Sung, M.D., Department of Medicine
Digital Pathology with a Compact Intelligent Microscope
BME Investigator:
Roarke Horstmeyer, Ph.D., Department of Biomedical Engineering
Clinical Investigators:
- Carolyn Glass, M.D., Department of Pathology
- Jadee Neff, M.D., Department of Pathology
Multivalent T-Cell Engagers for Targeted Cancer Therapy
BME Investigator:
Joseph Bellucci, Ph.D., Department of Biomedical Engineering
Clinical Investigator:
Scott Antonia, M.D., Department of Medicine
Recombinant Matrix to Improve Autologous Tissue Grafts
BME Investigators:
- Bruce Klitzman, Ph.D., departments of Surgery and Biomedical Engineering
- Stefan Roberts, Ph.D., Department of Biomedical Engineering
Clinical Investigator:
Scott Hollenbeck, M.D., Department of Surgery
2019-2020
A High-Throughput Screening Platform for Engineering Next-Generation Gene Therapy Vectors
BME Investigator:
- Charles Gersbach, Ph.D., Department of Biomedical Engineering
Clinical Investigators
- Edward Smith, M.D., Ph.D., Department of Pediatrics
Determining Fractional Flow Reserve from 2D Angiograms
BME Investigator:
- Amanda Randles, Ph.D., Department of Biomedical Engineering
Clinical Investigators:
- Manesh Patel, M.D., Department of Medicine
- Schuyler Jones, M.D., Department of Medicine
- Sreekanth Vemulapalli, M.D., Department of Medicine
- Jane Leopold, M.D., Department of Medicine, Harvard Medical School
Enhanced Lesion Evaluation Catheter for Improving Pulmonary Vein Isolation Therapy
BME Investigator:
- Patrick Wolf, Ph.D., Department of Biomedical Engineering
Clinical Investigator:
- Tristram Bahnson, M.D., Department of Medicine
Parallelized 3D Whole-Slide Microscopy for Thick Cytopathology Slides
BME Investigator:
- Roarke Horstmeyer, Ph.D., Department of Biomedical Engineering
Clinical Investigators:
- Sara Jiang, M.D., Department of Pathology
Recombinant Matrix to Improve Autologous Tissue Grafts
BME Investigators:
- Bruce Klitzman, Ph.D., Department of Surgery and Biomedical Engineering
- Stefan Roberts, Ph.D., Department of Biomedical Engineering
Clinical Investigator:
- Scott Hollenbeck, M.D., Department of Surgery
2018-2019
Determining Fractional Flow Reserve from 2D Angiograms
BME Investigator:
- Amanda Randles, Ph.D., Department of Biomedical Engineering
Clinical Investigators:
- Manesh Patel, M.D., Department of Medicine
- Schuyler Jones, M.D., Department of Medicine
- Sreekanth Vemulapalli, M.D., Department of Medicine
- Jane Leopold, M.D., Department of Medicine, Harvard Medical School
Enhanced Lesion Evaluation Catheter for Improving Pulmonary Vein Isolation Therapy
BME Investigator:
- Patrick Wolf, Ph.D., Department of Biomedical Engineering
Clinical Investigator:
- Tristram Bahnson, M.D., Department of Medicine
Integrated Radio-Frequency/Shim Head Coil Array for MRI with Inherent Localized B0 Shimming
BME Investigators:
- Allen Song, Ph.D., Departments of Biomedical Engineering, Radiology and Neurobiology
- Trong-Kha Truong, Ph.D., Department of Radiology, Brain Imaging and Analysis Center
Clinical Investigators:
- Jeffrey Petrella, M.D., Department of Radiology, Brain Imaging and Analysis Center
Rapid Credentialing of the Drug Responses and Expression Patterns in Single Cells
BME Investigator:
- Benjamin Yellen, Ph.D., Department of Mechanical Engineering and Materials Science
Clinical Investigators:
- Sandeep Dave, M.D., Department of Medicine
- Kris Wood, Ph.D., Department of Pharmacology and Cancer Biology
3D-Printed Implants with Reservoirs for Sustained Drug Delivery
BME Investigator:
- Kenneth Gall, Ph.D., Department of Mechanical Engineering and Materials Science
Clinical Investigator:
- Thorsten Seyler, M.D., Ph.D., Department of Orthopaedic Surgery
2017-2018
Integrated Radio-Frequency/Shim Head Coil Array for MRI with Inherent Localized B0 Shimming
BME Investigator:
Allen Song, Ph.D., Departments of Biomedical Engineering, Radiology and Neurobiology
Clinical Investigator:
Jeffrey Petrella, M.D., Department of Radiology
Intrapulse Spatial Compounding
BME Investigator:
Gregg Trahey, Ph.D., Department of Biomedical Engineering
Clinical Investigator:
Anna Lisa Crowley, M.D., Department of Medicine
Low-Cost Optical Coherence Tomography for Point of Care
BME Investigators:
Adam Wax, Ph.D., Department of Biomedical Engineering
Clinical Investigator:
J. Niklas Ulrich, M.D., Department of Opthalmology, University of North Carolina
Next-Generation Non-Immunogenic PEG-like Protein Conjugates
BME Investigator:
Angus Hucknall, Ph.D., Biomedical Engineering
Clinical Investigator:
Michael Hershfield, M.D., Department of Biochemistry
Rapid Credentialing of the Heterogeneity in Single Cell Drug Responses in B Cell Lymphomas
BME Investigator:
Benjamin Yellen, Ph.D., Department of Mechanical Engineering and Materials Science
Clinical Investigator:
Sandeep Dave, M.D., Department of Medicine
Surgical Image-Guided Robot Assist Device for Partial Thickness Corneal Transplantation
BME Investigator:
Joseph Izatt, Ph.D., Departments of Biomedical Engineering and Opthalmology
Clinical Investigator:
Anthony Kuo, M.D., Departments of Biomedical Engineering and Opthalmology
2016-2017
High-Throughput Screening of Gene Regulator Elements that Enhance T Cell Immunotherapy
BME Investigator:
Charles Gersbach, Ph.D., Assistant Professor, Biomedical Engineering
Clinical Investigator:
John Sampson, M.D., Ph.D., Department of Neurosurgery
Next-Generation Non-Immunogenic PEG-like Protein Conjugates
BME Investigator:
Angus Hucknall, Ph.D., Biomedical Engineering
Clinical Investigator:
Michael Hershfield, M.D., Department of Biochemistry
Novel Technique for Noninvasive Intracranial Pressure Measurement
BME Investigator:
Dale Bass, Ph.D., Associate Research Professor, Biomedical Engineering
Clinical Investigator:
Carrie Muh, M.D., Department of Surgery
Surgical Image-Guided Robot Assist Device for Partial Thickness Corneal Transplantation
BME Investigator:
Joseph Izatt, Ph.D., Department of BME and Opthalmology
Clinical Investigator:
Anthony Kuo, M.D., Department of Opthalmology
Ultrasonic Skin Elasticity Imaging
BME Investigators:
Peter Hollender, Ph.D., Department of Biomedical Engineering
Mark Palmeri, M.D., Ph.D., Department of Biomedical Engineering
Clinical Investigator:
Adela Rambi Cardones, M.D., Department of Dermatology
2015-2016
Targeted Gene Editing of Skeletal Muscle Progenitor Cells
BME Investigator:
Charles Gersbach, Ph.D., Assistant Professor, Biomedical Engineering
Clinical Investigator:
Edward Smith, M.D., Pediatrics
Novel Technique for Noninvasive Intracranial Pressure Measurement
BME Investigator:
Dale Bass, Ph.D., Associate Research Professor, Biomedical Engineering
Clinical Investigator:
Carrie Muh, M.D., Assistant Professor, Surgery
Program Portable Ultrasound Device for Staging Liver Fibrosis
BME Investigator:
Peter Hollender, Ph.D., Research Scientist, Biomedical Engineering
Clinical Investigator:
Mark Palmeri, M.D., Ph.D., Asst Res Professor, Biomedical Engineering
Real-Time, In Vivo, Radiation Dose Monitoring for External Beam Radiotherapy and Brachytherapy
BME Investigator:
Michael Therien, Ph.D., Professor, Chemistry
Clinical Investigator:
Terry Yoshizumi Ph.D., Professor, Radiology
A Video Analysis Approach for Early Screening and Clinical Trial Monitoring in Child Mental Health
BME Investigator:
Guillermo Sapiro, Ph.D., Professor, Electrical and Computer Engineering
Clinical Investigator:
Geraldine Dawson, Ph.D.., Professor, Psychiatry
Novel and Predictive Spinal Cord Stimulation Algorithm for Chronic Pain
Primary Investigator:
Nandan Lad, M.D., Ph.D., Assistant Professor, Neurosurgery
BME Investigator:
Warren Grill, Ph.D., Professor, Biomedical Engineering
2014-2015
Genetic Correction of Duchenne Muscular Dystrophy with Engineered Nucleases
BME Investigator:
Charles Gersbach, PhD, Assistant Professor, Biomedical Engineering
Clinical Investigator:
Edward Smith, MD, Pediatrics
The Synergy of Nanoparticle Technology and Retroject Delivery for the Treatment of Glaucoma
BME Investigator:
Jennifer West, PhD, Professor, Biomedical Engineering
Clinical Investigator:
Molly Walsh, MD, Assistant Professor, Ophthalmology
Prevention of Temporal Lobe Epilepsy
BME Investigator:
G Allan Johnson, PhD, Professor, Radiology, Biomedical Engineering
Clinical Investigator:
James McNamara, MD, Professor, Department of Neurobiology
Real-Time, In Vivo, Radiation Dose Monitoring Device for External Beam Radiation Therapy and Brachytherapy
BME Investigator:
Michael Therien, PhD, Professor, Chemistry
Clinical Investigator:
Terry Yoshizumi PhD, Professor, Radiology
Anti-infection Urinary Catheter
BME Investigator:
Gabriel Lopez, PhD, Professor, Biomedical Engineering
Clinical Investigator:
Howard Levinson, MD, Department of Surgery
2013-2014
Image Vaults in the Cloud
BME Investigator
G Allan Johnson, Ph.D., Professor, Radiology, Biomedical Engineering
Clinical Investigator
James Provenzale, M.D., Professor, Medical Physics
Retroject Device and Nanoparticle Technology: A Novel Approach to Glaucoma Drug Delivery
BME Investigator
Jennifer West, Ph.D., Professor, Biomedical Engineering
Clinical Investigator
Molly Walsh, M.D., Assistant Professor, Ophthalmology
Registration of Multi-parametric MR and Quantitative Shear Wave Elasticity Images for Focal Prostate Cancer Procedures
BME Investigator
Mark Palmeri, M.D., Ph.D., Assistant Research Professor, Biomedical Engineering
Clinical Investigator
Rajan Gupta, M.D., Assistant Professor, Radiology
Prevention of Temporal Lobe Epilepsy
BME Investigator
G Allan Johnson, Ph.D., Professor, Radiology, Biomedical Engineering
Clinical Investigator
James McNamara, M.D., Professor, Department of Neurobiology
A Real-Time, Pin-Point, in vivo Dosimetry Monitoring Device for Brachytherapy Radiation Treatment
BME Investigator
Michael Therien, Ph.D., Professor, Chemistry
Clinical Investigator
Terry Yoshizumi Ph.D., Professor, Radiology
Developing Nucleic Acid Binding Polymers as Molecular Scavengers to Control Aseptic Inflammation
BME Investigator
Kam Leong, Ph.D., Associate Research Professor, Biomedical Engineering
Clinical Investigator
Bruce Sullenger, Professor, Department of Surgery
2012-2013
Image Vaults in the Cloud
BME Investigator
G Allan Johnson, Ph.D., Professor, Radiology, Biomedical Engineering
Clinical Investigator
James Provenzale, M.D., Professor, Medical Physics
A Prototype Real-Time SLSC Imaging System for Fetal Diagnostic Imaging
BME Investigators
Gregg Trahey, Ph.D., Professor, Biomedical Engineering
Jeremy Dahl, Ph.D., Assistant Research Professor, Biomedical Engineering
Clinical Investigator
Sarah Ellestad, M.D., Assistant Professor, Maternal-Fetal Medicine
FEM based Acoustic Radiation Force Impulse and Magnetic Resonance Image
BME Investigator
Mark Palmeri, MD, Ph.D., Assistant Research Professor, Biomedical Engineering
Clinical Investigator
Rajan Gupta, M.D., Assistant Professor, Radiology
Detecting Dysplasia in Inflammatory Bowel Disease
BME Investigator
Adam Wax Ph.D., Associate Professor, Biomedical Engineering
Clinical Investigator
Jane Onken, M.D., Associate Professor, Department of Medicine
Diagnostic and Therapeutic Use of a Novel Gonioscopic OCT Imaging Device
BME Investigator
Joseph A Izatt, Ph.D., Professor, Biomedical Engineering and Ophthalmology
Clinical Investigator
Anthony Kuo, M.D., Assistant Professor, Ophthalmology
Linearized apoE Peptides are Neuroprotective in Acute Brain Injury
BME Investigator
Cameron R. 'Dale' Bass, Ph.D., Associate Research Professor, Biomedical Engineering
Clinical Investigator
Daniel Laskowitz, M.D., Associate Professor, Medicine
2011-2012
Enhancing Neuromodulation with Transcranial Magnetic Stimulation (TMS)
BME Investigator
Warren M Grill Ph.D., Professor, Biomedical Engineering
Clinical Investigators
Sarah Lisanby, M.D., Professor Biological Psychiatry
Angel Peterchev, Ph.D., Assistant Professor, Biological Psychiatry
Bruce Luber, Ph.D., Associate Professor, Psychiatry and Behavioral Sciences
Evaluation of Regional Ventilation in Normal Subjects and Subjects with Airway and Lung Disorders
BME Investigators
James R MacFall, Ph.D., Associate Professor, Radiology
Cecil Charles, Ph.D., Associate Professor, Radiology
Clinical Investigators
Neil MacIntyre, M.D., Professor, Pulmonary Medicine
Richard Moon, M.D., Professor, Anesthesiology
H. Page McAdams, M.D., Professor, Radiology
Bastiaan Driehuys, Ph.D., Associate Professor, Radiology
Brian Soher, Ph.D., Assistant Professor, Radiology
William Michael Foster, Ph.D.
Developing Nucleic Acid Binding Polymers as Molecular Scavengers to Control Aseptic Inflammation
BME Investigator
Kam W Leong, Ph.D., Professor, Biomedical Engineering
Clinical Investigators
David Pisetsky, M.D. Professor, Department of Medicine
Bruce Sullenger, Ph.D., Professor, Department of Surgery
Jaewoo Lee, Ph.D., Assistant Professor, Department of Surgery
Clinical Development of Porphyrin Therapeutics
BME Investigator
Mark W Dewhirst, D.V.M., Ph.D., Professor, Radiation Oncology
Clinical Investigators
David Warner, M.D., Professor, Anesthesiology
David Brizel, M.D., Professor, Radiation Oncology
Christopher Lascola, M.D., Assistant Professor, Neuroradiology
Ines Batinic-Haberle, Ph.D., Associate Professor, Radiation Oncology
Ivan Spasojevic, Ph.D., Postdoc Associate, Oncology
Greg Palmer, Ph.D., Assistant Professor, Radiation Oncology
Gonioscopic OCT: A Novel In Vivo Glaucoma Imaging Device
BME Investigator
Joseph A Izatt, Ph.D., Professor, Biomedical Engineering and Ophthalmology
Clinical Investigator
Anthony Kuo, M.D., Assistant Professor, Ophthalmology
Linearized apoE for Treatment of Acute Brain Injury
BME Investigator
Cameron R. 'Dale' Bass, Ph.D., Associate Research Professor, Biomedical Engineering
Clinical Investigator
Daniel Laskowitz, M.D., Associate Professor, Medicine
2010-2011
Evaluation of Regional Ventilation in Normal Subjects and Subjects with Airway and Lung Disorders
BME Investigator:
James MacFall, Ph.D., Associate Professor, Radiology
Clinical Investigators:
Cecil Charles, Ph.D., Associate Professor, Radiology
Neil MacIntyre, M.D., Professor, Pulmonary Medicine
Richard Moon, M.D., Professor, Anesthesiology
H. Page McAdams., Professor, Radiology
Real-time Visualization of Injected Regional Anesthetics Using Ultrasonic Decorrelation
BME Investigators:
Mark Palmeri, M.D., Ph.D., Assistant Research Professor of Biomedical Engineering
Kathy Nightingale, Ph.D., Assistant Professor of Biomedical Engineering
Clinical Investigator:
David Macleod, M.B., Assistant Professor, Anesthesiology
Stuart Grant, M.B., CH.B., Professor, Anesthesiology
MicroRNAs for the Diagnosis of Lymphomas
BME Investigator:
Ashutosh Chilkoti, Ph.D., Professor of Biomedical Engineering
Clinical Investigator:
Sandeep Dave, M.D., Assistant Professor, Oncology
Detection of Disease-Specific Whole Blood mRNA Expression Signature using Molecular Sentinel Nanoprobe Technology
BME Investigator:
Tuan Vo-Dinh, Ph.D., Professor of Biomedical Engineering
Clinical Investigators:
Aimee Zaas, M.D., Assistant Professor, Department of Medicine
Geoffrey Ginsburg, M.D., Ph.D., Professor, Department of Medicine
Chris Woods, M.D., Associate Professor, Department of Medicine
2009-2010
SDOCT Keratometer for Improving Cataract Surgery Outcome in Post-Laser Refractive Surgery
BME Investigator
Joseph Izatt, Ph.D., Professor, Biomedical Engineering
Clinical Investigator:
Anthony Kuo, M.D., Assistant Professor, Ophthalmology
Detection of Disease-Specific Whole Blood mRNA Expression Signature using Molecular Sentinel Nanoprobe Technology
BME Investigator:
Tuan Vo-Dinh, Ph.D., Professor of Biomedical Engineering
Clinical Investigator:
Aimee Zaas, M.D., Assistant Professor, Department of Medicine
Geoffrey Ginsburg, M.D., Ph.D., Professor, Department of Medicine
Chris Woods, M.D., Associate Professor, Department of Medicine
Development of a Transfusion Catheter to Restore the Oxygen Delivery Capabilities of Banked Blood
BME Investigators:
James Reynolds, Ph.D., Anesthesiology
Fan Yuan, Ph.D., Professor, Biomedical Engineering
Clinical Investigator:
Jonathan Stamler, M.D., Department of Medicine
2008-2009
Clinical Validation of a/LCI for Detecting Pre-Cancerous Lesions in the Esophagus
BME Investigator:
Adam Wax, Ph.D., Professor, Biomedical Engineering
Clinical Investigator:
Nicholas Shaheen, M.D., Department of Medicine and Epidemiology, University of North Carolina School of Medicine
Oral Drug Delivery Design for Mn Porphyrins as Anticancer Therapeutics and Radioprotectors
BME Investigators:
Mark Dewhirst, Ph.D., DVM, Department of Radiation Oncology
Ines Batinic-Haberle, Ph.D., Department of Radiation Oncology
Kam Leong, Ph.D., Adjunct Professor, Biomedical Engineering
Clinical Investigator:
Zeljko Vujaskovic, M.D., Radiation Oncology
Knowledge-Based Optimization of Radiation Treatment Planning for Prostate Cancer
BME Investigators:
Joseph Lo, Ph.D., Professor, Radiology
Shiva Das, Ph.D., Adjunct Professor, Radiation Oncology
Clinical Investigator:
Robert Lee, M.D., Professor, Radiation Oncology
2007-2008
A Bladder Amplifier to Treat Urinary Retention
Primary Investigator:
Warren Grill, Ph.D., Associate Professor of Biomedical Engineering, Associate Professor in Surgery
Clinician(s):
Cindy L. Amundsen, M.D., Associate Professor of Obstetrics and Gynecology
A Novel Technology Platform for Efficient Vaccine Development
Primary Invesigator:
Jingdong Tian, Ph.D., Assistant Professor, Department of Biomedical Engineering
Clinicians:
Larry Liao, MD., Ph.D.; Associate Professor of Medicine, Associate Director of Duke Human Vaccine Institute
Jae-Sung Yu, Ph.D.; Assistant Professor of Medicine, Duke Human Vaccine Institute, Duke Medical Center
Ultra-Sensitive Microarray Platform for the Detection of Serum Markers of Prostate Cancer
Primary Investigator:
Ashutosh Chilkoti, Ph.D., Professor, Department of Biomedical Engineering, and Associate Director of the Center for Biologically Inspired Materials and Materials Systems (CBIMMS)
Clinician(s):
Philip Febbo, MD, Ph.D.; Department of Medicine and Institute for Genome Sciences & Policy
Oral Delivery of Factor VIII Gene for Hemophilia A Therapy
Primary Invesigator:
Kam Leong, Ph.D., James B. Duke Professor of Biomedical Engineering, Director of the Bioengineering Initiative
Clinicians:
Thomas L. Ortel, M.D., Ph.D., Associate Professor of Medicine
2006-2007
Intra-Articular Drug Delivery Based on Thermally-Responsive Biopolymers
BME Investigators:
Lori Setton, Ph.D., Associate Professor, Biomedical Engineering
Ashutosh Chilkoti, Ph.D., Associate Professor, Biomedical Engineering
Clinical Investigator:
Virginia Kraus, M.D., Ph.D., Professor, Rheumatology and Medicine
An Optical Assay System for Intra Operative Assessment of Tumor Margins in Patients with Breast Cancer
BME Investigator:
Nimmi Ramanujam, Ph.D., Professor, Biomedical Engineering
Clinical Investigator:
Lee Wilke, M.D., Associate Professor, Surgery
Joseph Geradts, M.D., Adjunct Professor, Pathology
ELP for Targeted Delivery of Cancer Therapeutics
BME Investigators:
Ashutosh Chilkoti, Ph.D., Professor of Biomedical Engineering
Mark Dewhirst, Ph.D., DVM, Department of Radiation Oncology
Clinical Investigator:
Michael Colvin, M.D., Professor, Hemotology/Oncology
Tissue Engineered Cartilage for Joint Resurfacing
BME Investigators:
Farshid Guilak, Ph.D., Professor, Surgery and Biomedical Engineering
Kam Leong, Ph.D., Professor, Surgery and Biomedical Engineering
Clinical Investigator:
T. Parker Vail, M.D., Professor, Surgery