Duke-Coulter Partnership Projects

A High-Throughput Screening Platform for Engineering Next-Generation Gene Therapy Vectors

BME Investigator:

• Charles Gersbach, Ph.D., Department of Biomedical Engineering

Clinical Investigators

• Edward Smith, M.D., Ph.D., Department of Pediatrics

Determining Fractional Flow Reserve from 2D Angiograms

BME Investigator:

• Amanda Randles, Ph.D., Department of Biomedical Engineering

Clinical Investigators:

• Manesh Patel, M.D., Department of Medicine
• Schuyler Jones, M.D., Department of Medicine
• Sreekanth Vemulapalli, M.D., Department of Medicine
• Jane Leopold, M.D., Department of Medicine, Harvard Medical School

Enhanced Lesion Evaluation Catheter for Improving Pulmonary Vein Isolation Therapy

BME Investigator:

• Patrick Wolf, Ph.D., Department of Biomedical Engineering

Clinical Investigator:

• Tristram Bahnson, M.D., Department of Medicine

Parallelized 3D Whole-Slide Microscopy for Thick Cytopathology Slides

BME Investigator:

• Roarke Horstmeyer, Ph.D., Department of Biomedical Engineering

Clinical Investigators:

• Sara Jiang, M.D., Department of Pathology

Recombinant Matrix to Improve Autologous Tissue Grafts

BME Investigators:

• Bruce Klitzman, Ph.D., Department of Surgery and Biomedical Engineering
• Stefan Roberts, Ph.D., Department of Biomedical Engineering

Clinical Investigator:

• Scott Hollenbeck, M.D., Department of Surgery

Determining Fractional Flow Reserve from 2D Angiograms

BME Investigator:

• Amanda Randles, Ph.D., Department of Biomedical Engineering

Clinical Investigators:

• Manesh Patel, M.D., Department of Medicine
• Schuyler Jones, M.D., Department of Medicine
• Sreekanth Vemulapalli, M.D., Department of Medicine
• Jane Leopold, M.D., Department of Medicine, Harvard Medical School

Enhanced Lesion Evaluation Catheter for Improving Pulmonary Vein Isolation Therapy

BME Investigator:

• Patrick Wolf, Ph.D., Department of Biomedical Engineering

Clinical Investigator:

• Tristram Bahnson, M.D., Department of Medicine

Integrated Radio-Frequency/Shim Head Coil Array for MRI with Inherent Localized B0 Shimming

BME Investigators:

• Allen Song, Ph.D., Departments of Biomedical Engineering, Radiology and Neurobiology
• Trong-Kha Truong, Ph.D., Department of Radiology, Brain Imaging and Analysis Center

Clinical Investigators:

• Jeffrey Petrella, M.D., Department of Radiology, Brain Imaging and Analysis Center

Rapid Credentialing of the Drug Responses and Expression Patterns in Single Cells

BME Investigator:

• Benjamin Yellen, Ph.D., Department of Mechanical Engineering and Materials Science

Clinical Investigators:

• Sandeep Dave, M.D., Department of Medicine
• Kris Wood, Ph.D., Department of Pharmacology and Cancer Biology

3D-Printed Implants with Reservoirs for Sustained Drug Delivery

BME Investigator:

• Kenneth Gall, Ph.D., Department of Mechanical Engineering and Materials Science

Clinical Investigator:

• Thorsten Seyler, M.D., Ph.D., Department of Orthopaedic Surgery

Integrated Radio-Frequency/Shim Head Coil Array for MRI with Inherent Localized B0 Shimming

BME Investigator:
Allen Song, Ph.D., Departments of Biomedical Engineering, Radiology and Neurobiology

Clinical Investigator:
Jeffrey Petrella, M.D., Department of Radiology

Intrapulse Spatial Compounding

BME Investigator:
Gregg Trahey, Ph.D., Department of Biomedical Engineering

Clinical Investigator:
Anna Lisa Crowley, M.D., Department of Medicine

Low-Cost Optical Coherence Tomography for Point of Care

BME Investigators:
Adam Wax, Ph.D., Department of Biomedical Engineering

Clinical Investigator:
J. Niklas Ulrich, M.D., Department of Opthalmology, University of North Carolina

Next-Generation Non-Immunogenic PEG-like Protein Conjugates

BME Investigator:
Angus Hucknall, Ph.D., Biomedical Engineering

Clinical Investigator:
Michael Hershfield, M.D., Department of Biochemistry

Rapid Credentialing of the Heterogeneity in Single Cell Drug Responses in B Cell Lymphomas

BME Investigator:
Benjamin Yellen, Ph.D., Department of Mechanical Engineering and Materials Science

Clinical Investigator:
Sandeep Dave, M.D., Department of Medicine

Surgical Image-Guided Robot Assist Device for Partial Thickness Corneal Transplantation

BME Investigator:
Joseph Izatt, Ph.D., Departments of Biomedical Engineering and Opthalmology

Clinical Investigator:
Anthony Kuo, M.D., Departments of Biomedical Engineering and Opthalmology

High-Throughput Screening of Gene Regulator Elements that Enhance T Cell Immunotherapy

BME Investigator:
Charles Gersbach, Ph.D., Assistant Professor, Biomedical Engineering

Clinical Investigator:
John Sampson, M.D., Ph.D., Department of Neurosurgery

Next-Generation Non-Immunogenic PEG-like Protein Conjugates

BME Investigator:
Angus Hucknall, Ph.D., Biomedical Engineering

Clinical Investigator:
Michael Hershfield, M.D., Department of Biochemistry

Novel Technique for Noninvasive Intracranial Pressure Measurement

BME Investigator:
Dale Bass, Ph.D., Associate Research Professor, Biomedical Engineering

Clinical Investigator:
Carrie Muh, M.D., Department of Surgery

Surgical Image-Guided Robot Assist Device for Partial Thickness Corneal Transplantation

BME Investigator:
Joseph Izatt, Ph.D., Department of BME and Opthalmology

Clinical Investigator:
Anthony Kuo, M.D., Department of Opthalmology

Ultrasonic Skin Elasticity Imaging

BME Investigators:
Peter Hollender, Ph.D., Department of Biomedical Engineering
Mark Palmeri, M.D., Ph.D., Department of Biomedical Engineering

Clinical Investigator:
Adela Rambi Cardones, M.D., Department of Dermatology

Targeted Gene Editing of Skeletal Muscle Progenitor Cells

BME Investigator:
Charles Gersbach, Ph.D., Assistant Professor, Biomedical Engineering

Clinical Investigator:
Edward Smith, M.D., Pediatrics

Novel Technique for Noninvasive Intracranial Pressure Measurement 

BME Investigator:
Dale Bass, Ph.D., Associate Research Professor, Biomedical Engineering

Clinical Investigator:
Carrie Muh, M.D., Assistant Professor, Surgery

Program Portable Ultrasound Device for Staging Liver Fibrosis 

BME Investigator:
Peter Hollender, Ph.D., Research Scientist, Biomedical Engineering

Clinical Investigator:
Mark Palmeri, M.D., Ph.D., Asst Res Professor, Biomedical Engineering

Real-Time, In Vivo, Radiation Dose Monitoring for External Beam Radiotherapy and Brachytherapy 

BME Investigator:
Michael Therien, Ph.D., Professor, Chemistry

Clinical Investigator:
Terry Yoshizumi Ph.D., Professor, Radiology

A Video Analysis Approach for Early Screening and Clinical Trial Monitoring in Child Mental Health

BME Investigator:
Guillermo Sapiro, Ph.D., Professor, Electrical and Computer Engineering

Clinical Investigator:
Geraldine Dawson, Ph.D.., Professor, Psychiatry

Novel and Predictive Spinal Cord Stimulation Algorithm for Chronic Pain

Primary Investigator:
Nandan Lad, M.D., Ph.D., Assistant Professor, Neurosurgery

BME Investigator:
Warren Grill, Ph.D., Professor, Biomedical Engineering

Genetic Correction of Duchenne Muscular Dystrophy with Engineered Nucleases

BME Investigator:
Charles Gersbach, PhD, Assistant Professor, Biomedical Engineering

Clinical Investigator:
Edward Smith, MD, Pediatrics

The Synergy of Nanoparticle Technology and Retroject Delivery for the Treatment of  Glaucoma

BME Investigator:
Jennifer West, PhD, Professor, Biomedical Engineering

Clinical Investigator:
Molly Walsh, MD, Assistant Professor, Ophthalmology

Prevention of Temporal Lobe Epilepsy

BME Investigator:
G Allan Johnson, PhD, Professor, Radiology, Biomedical Engineering

Clinical Investigator:
James McNamara, MD, Professor, Department of Neurobiology

Real-Time, In Vivo, Radiation Dose Monitoring Device for External Beam Radiation Therapy and Brachytherapy

BME Investigator:
Michael Therien, PhD, Professor, Chemistry

Clinical Investigator:
Terry Yoshizumi PhD, Professor, Radiology

Anti-infection Urinary Catheter

BME Investigator:
Gabriel Lopez, PhD, Professor, Biomedical Engineering

Clinical Investigator:
Howard Levinson, MD, Department of Surgery

Image Vaults in the Cloud

BME Investigator
G Allan Johnson, Ph.D., Professor, Radiology, Biomedical Engineering

Clinical Investigator
James Provenzale, M.D., Professor, Medical Physics

Retroject Device and Nanoparticle Technology: A Novel Approach to Glaucoma Drug Delivery 

BME Investigator
Jennifer West, Ph.D., Professor, Biomedical Engineering

Clinical Investigator
Molly Walsh, M.D., Assistant Professor, Ophthalmology 

Registration of Multi-parametric MR and Quantitative Shear Wave Elasticity Images for Focal Prostate Cancer Procedures

BME Investigator
Mark Palmeri, M.D., Ph.D., Assistant Research Professor, Biomedical Engineering

Clinical Investigator
Rajan Gupta, M.D., Assistant Professor, Radiology

Prevention of Temporal Lobe Epilepsy 

BME Investigator
G Allan Johnson, Ph.D., Professor, Radiology, Biomedical Engineering

Clinical Investigator
James McNamara, M.D., Professor, Department of Neurobiology

A Real-Time, Pin-Point, in vivo Dosimetry Monitoring Device for Brachytherapy Radiation Treatment 

BME Investigator
Michael Therien, Ph.D., Professor, Chemistry

Clinical Investigator
Terry Yoshizumi Ph.D., Professor, Radiology

Developing Nucleic Acid Binding Polymers as Molecular Scavengers to Control Aseptic Inflammation

BME Investigator
Kam Leong, Ph.D., Associate Research Professor, Biomedical Engineering

Clinical Investigator
Bruce Sullenger, Professor, Department of Surgery

Image Vaults in the Cloud

BME Investigator
G Allan Johnson, Ph.D., Professor, Radiology, Biomedical Engineering

Clinical Investigator
James Provenzale, M.D., Professor, Medical Physics

A Prototype Real-Time SLSC Imaging System for Fetal Diagnostic Imaging

BME Investigators
Gregg Trahey, Ph.D., Professor, Biomedical Engineering
Jeremy Dahl, Ph.D., Assistant Research Professor, Biomedical Engineering

Clinical Investigator
Sarah Ellestad, M.D., Assistant Professor, Maternal-Fetal Medicine

FEM based Acoustic Radiation Force Impulse and Magnetic Resonance Image

BME Investigator
Mark Palmeri, MD, Ph.D., Assistant Research Professor, Biomedical Engineering

Clinical Investigator
Rajan Gupta, M.D., Assistant Professor, Radiology

Detecting Dysplasia in Inflammatory Bowel Disease

BME Investigator
Adam Wax Ph.D., Associate Professor, Biomedical Engineering

Clinical Investigator
Jane Onken, M.D., Associate Professor, Department of Medicine

Diagnostic and Therapeutic Use of a Novel Gonioscopic OCT Imaging Device

BME Investigator
Joseph A Izatt, Ph.D., Professor, Biomedical Engineering and Ophthalmology

Clinical Investigator
Anthony Kuo, M.D., Assistant Professor, Ophthalmology

Linearized apoE Peptides are Neuroprotective in Acute Brain Injury

BME Investigator
Cameron R. 'Dale' Bass, Ph.D., Associate Research Professor, Biomedical Engineering

Clinical Investigator
Daniel Laskowitz, M.D., Associate Professor, Medicine

Enhancing Neuromodulation with Transcranial Magnetic Stimulation (TMS)

BME Investigator
Warren M Grill Ph.D., Professor, Biomedical Engineering

Clinical Investigators
Sarah Lisanby, M.D., Professor Biological Psychiatry
Angel Peterchev, Ph.D., Assistant Professor, Biological Psychiatry
Bruce Luber, Ph.D., Associate Professor, Psychiatry and Behavioral Sciences

Evaluation of Regional Ventilation in Normal Subjects and Subjects with Airway and Lung Disorders

BME Investigators
James R MacFall, Ph.D., Associate Professor, Radiology
Cecil Charles, Ph.D., Associate Professor, Radiology

Clinical Investigators
Neil MacIntyre, M.D., Professor, Pulmonary Medicine
Richard Moon, M.D., Professor, Anesthesiology
H. Page McAdams, M.D., Professor, Radiology
Bastiaan Driehuys, Ph.D., Associate Professor, Radiology
Brian Soher, Ph.D., Assistant Professor, Radiology
William Michael Foster, Ph.D.

Developing Nucleic Acid Binding Polymers as Molecular Scavengers to Control Aseptic Inflammation

BME Investigator
Kam W Leong, Ph.D., Professor, Biomedical Engineering

Clinical Investigators
David Pisetsky, M.D. Professor, Department of Medicine
Bruce Sullenger, Ph.D., Professor, Department of Surgery
Jaewoo Lee, Ph.D., Assistant Professor, Department of Surgery

Clinical Development of Porphyrin Therapeutics

BME Investigator
Mark W Dewhirst, D.V.M., Ph.D., Professor, Radiation Oncology

Clinical Investigators
David Warner, M.D., Professor, Anesthesiology
David Brizel, M.D., Professor, Radiation Oncology
Christopher Lascola, M.D., Assistant Professor, Neuroradiology
Ines Batinic-Haberle, Ph.D., Associate Professor, Radiation Oncology
Ivan Spasojevic, Ph.D., Postdoc Associate, Oncology
Greg Palmer, Ph.D., Assistant Professor, Radiation Oncology

Gonioscopic OCT: A Novel In Vivo Glaucoma Imaging Device

BME Investigator
Joseph A Izatt, Ph.D., Professor, Biomedical Engineering and Ophthalmology

Clinical Investigator
Anthony Kuo, M.D., Assistant Professor, Ophthalmology

Linearized apoE for Treatment of Acute Brain Injury

BME Investigator
Cameron R. 'Dale' Bass, Ph.D., Associate Research Professor, Biomedical Engineering

Clinical Investigator
Daniel Laskowitz, M.D., Associate Professor, Medicine

Evaluation of Regional Ventilation in Normal Subjects and Subjects with Airway and Lung Disorders

BME Investigator:
James MacFall, Ph.D., Associate Professor, Radiology

Clinical Investigators:
Cecil Charles, Ph.D., Associate Professor, Radiology
Neil MacIntyre, M.D., Professor, Pulmonary Medicine
Richard Moon, M.D., Professor, Anesthesiology
H. Page McAdams., Professor, Radiology

Real-time Visualization of Injected Regional Anesthetics Using Ultrasonic Decorrelation

BME Investigators:
Mark Palmeri, M.D., Ph.D., Assistant Research Professor of Biomedical Engineering
Kathy Nightingale, Ph.D., Assistant Professor of Biomedical Engineering

Clinical Investigator:
David Macleod, M.B., Assistant Professor, Anesthesiology
Stuart Grant, M.B., CH.B., Professor, Anesthesiology

MicroRNAs for the Diagnosis of Lymphomas

BME Investigator:
Ashutosh Chilkoti, Ph.D., Professor of Biomedical Engineering 

Clinical Investigator:
Sandeep Dave, M.D., Assistant Professor, Oncology

Detection of Disease-Specific Whole Blood mRNA Expression Signature using Molecular Sentinel Nanoprobe Technology

BME Investigator:
Tuan Vo-Dinh, Ph.D., Professor of Biomedical Engineering

Clinical Investigators:
Aimee Zaas, M.D., Assistant Professor, Department of Medicine
Geoffrey Ginsburg, M.D., Ph.D., Professor, Department of Medicine
Chris Woods, M.D., Associate Professor, Department of Medicine

SDOCT Keratometer for Improving Cataract Surgery Outcome in Post-Laser Refractive Surgery

BME Investigator
Joseph Izatt, Ph.D., Professor, Biomedical Engineering

Clinical Investigator:
Anthony Kuo, M.D., Assistant Professor, Ophthalmology

Detection of Disease-Specific Whole Blood mRNA Expression Signature using Molecular Sentinel Nanoprobe Technology

BME Investigator:
Tuan Vo-Dinh, Ph.D., Professor of Biomedical Engineering

Clinical Investigator:
Aimee Zaas, M.D., Assistant Professor, Department of Medicine
Geoffrey Ginsburg, M.D., Ph.D., Professor, Department of Medicine
Chris Woods, M.D., Associate Professor, Department of Medicine

Development of a Transfusion Catheter to Restore the Oxygen Delivery Capabilities of Banked Blood

BME Investigators:
James Reynolds, Ph.D., Anesthesiology
Fan Yuan, Ph.D., Professor, Biomedical Engineering

Clinical Investigator:
Jonathan Stamler, M.D., Department of Medicine

Clinical Validation of a/LCI for Detecting Pre-Cancerous Lesions in the Esophagus

BME Investigator:
Adam Wax, Ph.D., Professor, Biomedical Engineering

Clinical Investigator:
Nicholas Shaheen, M.D., Department of Medicine and Epidemiology, University of North Carolina School of Medicine

Oral Drug Delivery Design for Mn Porphyrins as Anticancer Therapeutics and Radioprotectors

BME Investigators:
Mark Dewhirst, Ph.D., DVM, Department of Radiation Oncology
Ines Batinic-Haberle, Ph.D., Department of Radiation Oncology
Kam Leong, Ph.D., Adjunct Professor, Biomedical Engineering

Clinical Investigator:
Zeljko Vujaskovic, M.D., Radiation Oncology

Knowledge-Based Optimization of Radiation Treatment Planning for Prostate Cancer

BME Investigators:
Joseph Lo, Ph.D., Professor, Radiology
Shiva Das, Ph.D., Adjunct Professor, Radiation Oncology

Clinical Investigator:
Robert Lee, M.D., Professor, Radiation Oncology

A Bladder Amplifier to Treat Urinary Retention

Primary Investigator:
Warren Grill, Ph.D., Associate Professor of Biomedical Engineering, Associate Professor in Surgery

Clinician(s):
Cindy L. Amundsen, M.D., Associate Professor of Obstetrics and Gynecology

A Novel Technology Platform for Efficient Vaccine Development

Primary Invesigator:
Jingdong Tian, Ph.D., Assistant Professor, Department of Biomedical Engineering

Clinicians:
Larry Liao, MD., Ph.D.; Associate Professor of Medicine, Associate Director of Duke Human Vaccine Institute
Jae-Sung Yu, Ph.D.; Assistant Professor of Medicine, Duke Human Vaccine Institute, Duke Medical Center

Ultra-Sensitive Microarray Platform for the Detection of Serum Markers of Prostate Cancer

Primary Investigator:

Ashutosh Chilkoti, Ph.D., Professor, Department of Biomedical Engineering, and Associate Director of the Center for Biologically Inspired Materials and Materials Systems (CBIMMS)

Clinician(s):
Philip Febbo, MD, Ph.D.; Department of Medicine and Institute for Genome Sciences & Policy

Oral Delivery of Factor VIII Gene for Hemophilia A Therapy

Primary Invesigator:
Kam Leong, Ph.D., James B. Duke Professor of Biomedical Engineering, Director of the Bioengineering Initiative

Clinicians:
Thomas L. Ortel, M.D., Ph.D., Associate Professor of Medicine

Intra-Articular Drug Delivery Based on Thermally-Responsive Biopolymers

BME Investigators:
Lori Setton, Ph.D., Associate Professor, Biomedical Engineering
Ashutosh Chilkoti, Ph.D., Associate Professor, Biomedical Engineering

Clinical Investigator:
Virginia Kraus, M.D., Ph.D., Professor, Rheumatology and Medicine

An Optical Assay System for Intra Operative Assessment of Tumor Margins in Patients with Breast Cancer

BME Investigator:
Nimmi Ramanujam, Ph.D., Professor, Biomedical Engineering 

Clinical Investigator:
Lee Wilke, M.D., Associate Professor, Surgery
Joseph Geradts, M.D., Adjunct Professor, Pathology

ELP for Targeted Delivery of Cancer Therapeutics

BME Investigators:
Ashutosh Chilkoti, Ph.D., Professor of Biomedical Engineering
Mark Dewhirst, Ph.D., DVM, Department of Radiation Oncology 

Clinical Investigator:
Michael Colvin, M.D., Professor, Hemotology/Oncology

Tissue Engineered Cartilage for Joint Resurfacing

BME Investigators:
Farshid Guilak, Ph.D., Professor, Surgery and Biomedical Engineering
Kam Leong, Ph.D., Professor, Surgery and Biomedical Engineering

Clinical Investigator:
T. Parker Vail, M.D., Professor, Surgery