Cristian Tudorel Badea


Professor in Radiology

  • Our lab's research focus lies primarily in developing novel quantitative imaging systems, reconstruction algorithms and analysis methods.  My major expertise is in preclinical CT.
  • Currently, we are particularly interested in developing novel strategies for spectral CT imaging using nanoparticle-based contrast agents for theranostics (i.e. therapy and diagnostics).
  • We are also engaged in developing new approaches for multidimensional CT image reconstruction suitable to address difficult undersampling cases in cardiac and spectral CT (dual energy and photon counting) using compressed sensing and/or deep learning.

Appointments and Affiliations

  • Professor in Radiology
  • Professor in the Department of Biomedical Engineering
  • Member of the Duke Cancer Institute

Contact Information


  • Ph.D. University of Patras (Greece), 2001

Research Interests

Spectral CT,  Cardiac CT, Image Reconstruction, Deep Learning, Nanoparticles, Theranostics,  Co-Clinical cancer trials, Small Animal Imaging

Courses Taught

  • MEDPHY 732: Advanced Topics of Ionizing-based Imaging Modalities

In the News

Representative Publications

  • Holbrook, MD; Clark, DP; Patel, R; Qi, Y; Bassil, AM; Mowery, YM; Badea, CT, Detection of Lung Nodules in Micro-CT Imaging Using Deep Learning., Tomography, vol 7 no. 3 (2021), pp. 358-372 [10.3390/tomography7030032] [abs].
  • Clark, DP; Badea, CT, Advances in micro-CT imaging of small animals., Phys Med, vol 88 (2021), pp. 175-192 [10.1016/j.ejmp.2021.07.005] [abs].
  • Shoghi, KI; Badea, CT; Blocker, SJ; Chenevert, TL; Laforest, R; Lewis, MT; Luker, GD; Manning, HC; Marcus, DS; Mowery, YM; Pickup, S; Richmond, A; Ross, BD; Vilgelm, AE; Yankeelov, TE; Zhou, R, Co-Clinical Imaging Resource Program (CIRP): Bridging the Translational Divide to Advance Precision Medicine., Tomography, vol 6 no. 3 (2020), pp. 273-287 [10.18383/j.tom.2020.00023] [abs].
  • Holbrook, MD; Blocker, SJ; Mowery, YM; Badea, A; Qi, Y; Xu, ES; Kirsch, DG; Johnson, GA; Badea, CT, MRI-Based Deep Learning Segmentation and Radiomics of Sarcoma in Mice., Tomography, vol 6 no. 1 (2020), pp. 23-33 [10.18383/j.tom.2019.00021] [abs].
  • Clark, DP; Lee, C-L; Kirsch, DG; Badea, CT, Spectrotemporal CT data acquisition and reconstruction at low dose., Med Phys, vol 42 no. 11 (2015), pp. 6317-6336 [10.1118/1.4931407] [abs].
  • Ashton, JR; West, JL; Badea, CT, In vivo small animal micro-CT using nanoparticle contrast agents., Frontiers in Pharmacology, vol 6 (2015) [10.3389/fphar.2015.00256] [abs].
  • Clark, DP; Badea, CT, Micro-CT of rodents: state-of-the-art and future perspectives., Phys Med, vol 30 no. 6 (2014), pp. 619-634 [10.1016/j.ejmp.2014.05.011] [abs].
  • Badea, CT; Panetta, D, High-Resolution CT for Small-Animal Imaging Research, vol 2. X-Ray and Ultrasound Imaging (2014), pp. 221-242 [10.1016/B978-0-444-53632-7.00210-0] [abs].
  • Lee, C-L; Min, H; Befera, N; Clark, D; Qi, Y; Das, S; Johnson, GA; Badea, CT; Kirsch, DG, Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation., Int J Radiat Oncol Biol Phys, vol 88 no. 3 (2014), pp. 686-693 [10.1016/j.ijrobp.2013.11.238] [abs].
  • Ashton, JR; Befera, N; Clark, D; Qi, Y; Mao, L; Rockman, HA; Johnson, GA; Badea, CT, Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent., Contrast Media Mol Imaging, vol 9 no. 2 (2014), pp. 161-168 [10.1002/cmmi.1557] [abs].
  • Ashton, JR; Clark, DP; Moding, EJ; Ghaghada, K; Kirsch, DG; West, JL; Badea, CT, Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study., Plos One, vol 9 no. 2 (2014) [10.1371/journal.pone.0088129] [abs].
  • Moding, EJ; Clark, DP; Qi, Y; Li, Y; Ma, Y; Ghaghada, K; Johnson, GA; Kirsch, DG; Badea, CT, Dual-energy micro-computed tomography imaging of radiation-induced vascular changes in primary mouse sarcomas., Int J Radiat Oncol Biol Phys, vol 85 no. 5 (2013), pp. 1353-1359 [10.1016/j.ijrobp.2012.09.027] [abs].
  • Clark, DP; Ghaghada, K; Moding, EJ; Kirsch, DG; Badea, CT, In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT., Phys Med Biol, vol 58 no. 6 (2013), pp. 1683-1704 [10.1088/0031-9155/58/6/1683] [abs].
  • Clark, D; Badea, A; Liu, Y; Johnson, GA; Badea, CT, Registration-based segmentation of murine 4D cardiac micro-CT data using symmetric normalization., Phys Med Biol, vol 57 no. 19 (2012), pp. 6125-6145 [10.1088/0031-9155/57/19/6125] [abs].
  • Johnston, SM; Johnson, GA; Badea, CT, Temporal and spectral imaging with micro-CT., Medical Physics, vol 39 no. 8 (2012), pp. 4943-4958 [10.1118/1.4736809] [abs].
  • Badea, CT; Guo, X; Clark, D; Johnston, SM; Marshall, CD; Piantadosi, CA, Dual-energy micro-CT of the rodent lung., Am J Physiol Lung Cell Mol Physiol, vol 302 no. 10 (2012), pp. L1088-L1097 [10.1152/ajplung.00359.2011] [abs].
  • Clark, D; Johnson, GA; Badea, CT, Denoising of 4D Cardiac Micro-CT Data Using Median-Centric Bilateral Filtration., Smart Structures and Materials 2005: Active Materials: Behavior and Mechanics, vol 8314 (2012) [10.1117/12.911478] [abs].
  • Guo, X; Johnston, SM; Qi, Y; Johnson, GA; Badea, CT, 4D micro-CT using fast prospective gating., Phys Med Biol, vol 57 no. 1 (2012), pp. 257-271 [10.1088/0031-9155/57/1/257] [abs].
  • Badea, CT; Athreya, KK; Espinosa, G; Clark, D; Ghafoori, AP; Li, Y; Kirsch, DG; Johnson, GA; Annapragada, A; Ghaghada, KB, Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent., Plos One, vol 7 no. 4 (2012) [10.1371/journal.pone.0034496] [abs].
  • Badea, CT; Stanton, IN; Johnston, SM; Johnson, GA; Therien, MJ, Investigations on X-ray luminescence CT for small animal imaging., Smart Structures and Materials 2005: Active Materials: Behavior and Mechanics, vol 8313 (2012) [10.1117/12.911465] [abs].
  • Zhang, X; Badea, C; Hood, G; Wetzel, A; Qi, Y; Stiles, J; Johnson, GA, High-resolution reconstruction of fluorescent inclusions in mouse thorax using anatomically guided sampling and parallel Monte Carlo computing., Biomedical Optics Express, vol 2 no. 9 (2011), pp. 2449-2460 [10.1364/BOE.2.002449] [abs].
  • Lin, M; Qi, Y; Chen, AF; Badea, CT; Johnson, GA, Phenylephrine-modulated cardiopulmonary blood flow measured with use of X-ray digital subtraction angiography., J Pharmacol Toxicol Methods, vol 64 no. 2 (2011), pp. 180-186 [10.1016/j.vascn.2011.08.001] [abs].
  • Badea, CT; Hedlund, LW; Qi, Y; Berridge, B; Johnson, GA, In vivo imaging of rat coronary arteries using bi-plane digital subtraction angiography., J Pharmacol Toxicol Methods, vol 64 no. 2 (2011), pp. 151-157 [10.1016/j.vascn.2011.05.008] [abs].
  • Badea, CT; Johnston, SM; Qi, Y; Johnson, GA, 4D micro-CT for cardiac and perfusion applications with view under sampling., Phys Med Biol, vol 56 no. 11 (2011), pp. 3351-3369 [10.1088/0031-9155/56/11/011] [abs].
  • Ghaghada, KB; Badea, CT; Karumbaiah, L; Fettig, N; Bellamkonda, RV; Johnson, GA; Annapragada, A, Evaluation of tumor microenvironment in an animal model using a nanoparticle contrast agent in computed tomography imaging., Acad Radiol, vol 18 no. 1 (2011), pp. 20-30 [10.1016/j.acra.2010.09.003] [abs].
  • Badea, CT; Hedlund, LW; Cook, J; Berridge, BR; Johnson, GA, Micro-CT imaging assessment of dobutamine-induced cardiac stress in rats., J Pharmacol Toxicol Methods, vol 63 no. 1 (2011), pp. 24-29 [10.1016/j.vascn.2010.04.002] [abs].
  • Johnston, SM; Perez, BA; Kirsch, DG; Badea, CT, Phase-selective image reconstruction of the lungs in small animals using Micro-CT., Smart Structures and Materials 2005: Active Materials: Behavior and Mechanics, vol 7622 (2010), pp. 76223G.1-76223G.9 [10.1117/12.844359] [abs].
  • Badea, CT; Johnston, SM; Subashi, E; Qi, Y; Hedlund, LW; Johnson, GA, Lung perfusion imaging in small animals using 4D micro-CT at heartbeat temporal resolution., Medical Physics, vol 37 no. 1 (2010), pp. 54-62 [10.1118/1.3264619] [abs].
  • Zhang, X; Badea, CT; Hood, G; Wetzel, AW; Stiles, JR; Johnson, GA, Free-space fluorescence tomography with adaptive sampling based on anatomical information from microCT., Smart Structures and Materials 2005: Active Materials: Behavior and Mechanics, vol 7757 no. 775706 (2010) [10.1117/12.841891] [abs].
  • Lin, M; Marshall, CT; Qi, Y; Johnston, SM; Badea, CT; Piantadosi, CA; Johnson, GA, Quantitative blood flow measurements in the small animal cardiopulmonary system using digital subtraction angiography., Medical Physics, vol 36 no. 11 (2009), pp. 5347-5358 [10.1118/1.3231823] [abs].
  • Zhang, X; Badea, C, Effects of sampling strategy on image quality in noncontact panoramic fluorescence diffuse optical tomography for small animal imaging., Optics Express, vol 17 no. 7 (2009), pp. 5125-5138 [10.1364/oe.17.005125] [abs].
  • Zhang, X; Badea, C; Jacob, M; Johnson, GA, Development of a noncontact 3-D fluorescence tomography system for small animal in vivo imaging., Smart Structures and Materials 2005: Active Materials: Behavior and Mechanics, vol 7191 (2009) [10.1117/12.808199] [abs].
  • Samei, E; Saunders, RS; Badea, CT; Ghaghada, KB; Hedlund, LW; Qi, Y; Yuan, H; Bentley, RC; Mukundan, S, Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent., Int J Nanomedicine, vol 4 (2009), pp. 277-282 [abs].
  • Badea, CT; Johnston, S; Johnson, B; Lin, M; Hedlund, LW; Johnson, GA, A dual micro-CT system for small animal imaging., Smart Structures and Materials 2005: Active Materials: Behavior and Mechanics, vol 6913 (2008) [10.1117/12.772303] [abs].
  • de Lin, M; Ning, L; Badea, CT; Mistry, NN; Qi, Y; Johnson, GA, A high-precision contrast injector for small animal x-ray digital subtraction angiography., Ieee Transactions on Bio Medical Engineering, vol 55 no. 3 (2008), pp. 1082-1091 [10.1109/TBME.2007.909541] [abs].
  • Song, J; Liu, QH; Johnson, GA; Badea, CT, Sparseness prior based iterative image reconstruction for retrospectively gated cardiac micro-CT., Medical Physics, vol 34 no. 11 (2007), pp. 4476-4483 [10.1118/1.2795830] [abs].
  • Nahrendorf, M; Badea, C; Hedlund, LW; Figueiredo, J-L; Sosnovik, DE; Johnson, GA; Weissleder, R, High-resolution imaging of murine myocardial infarction with delayed-enhancement cine micro-CT., American Journal of Physiology Heart and Circulatory Physiology, vol 292 no. 6 (2007), pp. H3172-H3178 [10.1152/ajpheart.01307.2006] [abs].
  • Badea, CT; Hedlund, LW; De Lin, M; Mackel, JSB; Samei, E; Johnson, GA, Tomographic digital subtraction angiography for lung perfusion estimation in rodents., Medical Physics, vol 34 no. 5 (2007), pp. 1546-1555 [10.1118/1.2717384] [abs].
  • De Lin, M; Samei, E; Badea, CT; Yoshizumi, TT; Allan Johnson, G, Optimized radiographic spectra for small animal digital subtraction angiography., Med Phys, vol 33 no. 11 (2006), pp. 4249-4257 [10.1118/1.2356646] [abs].
  • Oldham, M; Sakhalkar, H; Oliver, T; Wang, YM; Kirpatrick, J; Cao, Y; Badea, C; Johnson, GA; Dewhirst, M, Three-dimensional imaging of xenograft tumors using optical computed and emission tomography., Medical Physics, vol 33 no. 9 (2006), pp. 3193-3202 [10.1118/1.2217109] [abs].
  • Badea, CT; Hedlund, LW; De Lin, M; Boslego Mackel, JF; Johnson, GA, Tumor imaging in small animals with a combined micro-CT/micro-DSA system using iodinated conventional and blood pool contrast agents., Contrast Media Mol Imaging, vol 1 no. 4 (2006), pp. 153-164 [10.1002/cmmi.103] [abs].
  • Mukundan, S; Ghaghada, KB; Badea, CT; Kao, C-Y; Hedlund, LW; Provenzale, JM; Johnson, GA; Chen, E; Bellamkonda, RV; Annapragada, A, A liposomal nanoscale contrast agent for preclinical CT in mice., Ajr. American Journal of Roentgenology, vol 186 no. 2 (2006), pp. 300-307 [10.2214/AJR.05.0523] [abs].
  • Badea, CT; Bucholz, E; Hedlund, LW; Rockman, HA; Johnson, GA, Imaging methods for morphological and functional phenotyping of the rodent heart., Toxicologic Pathology, vol 34 no. 1 (2006), pp. 111-117 [10.1080/01926230500404126] [abs].
  • Badea, CT; Fubara, B; Hedlund, LW; Johnson, GA, 4-D micro-CT of the mouse heart., Molecular Imaging, vol 4 no. 2 (2005), pp. 110-116 [abs].
  • Maï, W; Badea, CT; Wheeler, CT; Hedlund, LW; Johnson, GA, Effects of breathing and cardiac motion on spatial resolution in the microscopic imaging of rodents., Magnetic Resonance in Medicine, vol 53 no. 4 (2005), pp. 858-865 [10.1002/mrm.20400] [abs].
  • Badea, C; Hedlund, LW; Johnson, GA, Micro-CT with respiratory and cardiac gating., Medical Physics, vol 31 no. 12 (2004), pp. 3324-3329 [10.1118/1.1812604] [abs].
  • Badea, C; Gordon, R, Experiments with the nonlinear and chaotic behaviour of the multiplicative algebraic reconstruction technique (MART) algorithm for computed tomography., Physics in Medicine and Biology, vol 49 no. 8 (2004), pp. 1455-1474 [10.1088/0031-9155/49/8/006] [abs].
  • Buliev, IG; Badea, CT; Kolitsi, Z; Pallikarakis, N, Estimation of the heart respiratory motion with applications for cone beam computed tomography imaging: a simulation study., Ieee Transactions on Information Technology in Biomedicine : a Publication of the Ieee Engineering in Medicine and Biology Society, vol 7 no. 4 (2003), pp. 404-411 [10.1109/titb.2003.821336] [abs].
  • Soimu, D; Badea, C; Pallikarakis, N, A novel approach for distortion correction for X-ray image intensifiers., Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society, vol 27 no. 1 (2003), pp. 79-85 [10.1016/s0895-6111(02)00055-1] [abs].
  • Buliev, I; Badea, C; Pallikarakis, N, Logarithmic amplifier for computed tomography tasks using fluoroscopic projections., Journal of Medical Engineering & Technology, vol 26 no. 6 (2002), pp. 247-252 [10.1080/03091900210156832] [abs].
  • Badea, C; Kolitsi, Z; Pallikarakis, N, Image quality in extended arc filtered digital tomosynthesis., Acta Radiologica (Stockholm, Sweden : 1987), vol 42 no. 2 (2001), pp. 244-248 [abs].
  • Messaris, G; Kolitsi, Z; Badea, C; Pallikarakis, N, Three-dimensional localisation based on projectional and tomographic image correlation: an application for digital tomosynthesis., Medical Engineering & Physics, vol 21 no. 2 (1999), pp. 101-109 [10.1016/s1350-4533(99)00015-6] [abs].
  • Badea, C; Kolitsi, Z; Pallikarakis, N, A wavelet-based method for removal of out-of-plane structures in digital tomosynthesis., Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society, vol 22 no. 4 (1998), pp. 309-315 [10.1016/s0895-6111(98)00037-8] [abs].
  • Badea, C; Kolitsi, Z; Pallikarakis, N; Papapanagiotou, A, Medical device surveillance world-wide., Studies in Health Technology and Informatics, vol 28 (1996), pp. 157-174 [abs].