Cristian Tudorel Badea

Cristian Tudorel Badea

Associate Professor in Radiology

Dr. Cristian T. Badea is an Associate Professor in the Department of Radiology and faculty in the Departments of Biomedical Engineering and Medical Physics. His research focuses on pre-clinical imaging. Dr. Badea has research interests in the physics and biomedical applications of computed tomography (CT), micro-CT, tomosynthesis, fluorecence tomography and image reconstruction algorithms.


Appointments and Affiliations

  • Associate Professor in Radiology
  • Member of the Duke Cancer Institute

Contact Information

  • Office Location: Bryan Research Building, Room 161F, Durham, NC 27710
  • Office Phone: (919) 684-7509
  • Email Address: cristian.badea@duke.edu
  • Websites:

Education

  • Ph.D. University of Patras (Greece), 2001

In the News

Representative Publications

  • Clark, DP; Lee, CL; Kirsch, DG; Badea, CT, Spectrotemporal CT data acquisition and reconstruction at low dose., Medical physics, vol 42 no. 11 (2015), pp. 6317-6336 [10.1118/1.4931407] [abs].
  • Ashton, JR; West, JL; Badea, CT, In vivo small animal micro-CT using nanoparticle contrast agents., Frontiers in Pharmacology, vol 6 (2015) [10.3389/fphar.2015.00256] [abs].
  • Clark, DP; Badea, CT, Micro-CT of rodents: state-of-the-art and future perspectives., Physica Medica, vol 30 no. 6 (2014), pp. 619-634 [10.1016/j.ejmp.2014.05.011] [abs].
  • Badea, CT; Panetta, D, High-Resolution CT for Small-Animal Imaging Research, vol 2. X-Ray and Ultrasound Imaging (2014), pp. 221-242 [10.1016/B978-0-444-53632-7.00210-0] [abs].
  • Lee, CL; Min, H; Befera, N; Clark, D; Qi, Y; Das, S; Johnson, GA; Badea, CT; Kirsch, DG, Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation., International Journal of Radiation Oncology, Biology, Physics, vol 88 no. 3 (2014), pp. 686-693 [10.1016/j.ijrobp.2013.11.238] [abs].
  • Ashton, JR; Befera, N; Clark, D; Qi, Y; Mao, L; Rockman, HA; Johnson, GA; Badea, CT, Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent., Contrast Media & Molecular Imaging, vol 9 no. 2 (2014), pp. 161-168 [10.1002/cmmi.1557] [abs].
  • Clark, DP; Badea, CT, Micro-CT of rodents: State-of-the-art and future perspectives, Physica Medica, vol 30 no. 6 (2014), pp. 619-634 [10.1016/j.ejmp.2014.05.011] [abs].
  • Ashton, JR; Clark, DP; Moding, EJ; Ghaghada, K; Kirsch, DG; West, JL; Badea, CT, Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study., PloS one, vol 9 no. 2 (2014) [10.1371/journal.pone.0088129] [abs].
  • Moding, EJ; Clark, DP; Qi, Y; Li, Y; Ma, Y; Ghaghada, K; Johnson, GA; Kirsch, DG; Badea, CT, Dual-energy micro-computed tomography imaging of radiation-induced vascular changes in primary mouse sarcomas., International Journal of Radiation: Oncology - Biology - Physics, vol 85 no. 5 (2013), pp. 1353-1359 [10.1016/j.ijrobp.2012.09.027] [abs].
  • Clark, DP; Ghaghada, K; Moding, EJ; Kirsch, DG; Badea, CT, In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT., Physics in Medicine and Biology, vol 58 no. 6 (2013), pp. 1683-1704 [10.1088/0031-9155/58/6/1683] [abs].
  • Bhavane, R; Badea, C; Ghaghada, KB; Clark, D; Vela, D; Moturu, A; Annapragada, A; Johnson, GA; Willerson, JT; Annapragada, A, Dual-energy computed tomography imaging of atherosclerotic plaques in a mouse model using a liposomal-iodine nanoparticle contrast agent, Circulation: Cardiovascular Imaging, vol 6 no. 2 (2013), pp. 285-294 [10.1161/CIRCIMAGING.112.000119] [abs].
  • Clark, D; Badea, A; Liu, Y; Johnson, GA; Badea, CT, Registration-based segmentation of murine 4D cardiac micro-CT data using symmetric normalization., Physics in Medicine and Biology, vol 57 no. 19 (2012), pp. 6125-6145 [10.1088/0031-9155/57/19/6125] [abs].
  • Johnston, SM; Johnson, GA; Badea, CT, Temporal and spectral imaging with micro-CT., Medical physics, vol 39 no. 8 (2012), pp. 4943-4958 [10.1118/1.4736809] [abs].
  • Badea, CT; Guo, X; Clark, D; Johnston, SM; Marshall, CD; Piantadosi, CA, Dual-energy micro-CT of the rodent lung., American journal of physiology. Lung cellular and molecular physiology, vol 302 no. 10 (2012), pp. L1088-L1097 [10.1152/ajplung.00359.2011] [abs].
  • Guo, X; Johnston, SM; Qi, Y; Johnson, GA; Badea, CT, 4D micro-CT using fast prospective gating., Physics in Medicine and Biology, vol 57 no. 1 (2012), pp. 257-271 [10.1088/0031-9155/57/1/257] [abs].
  • Badea, CT; Athreya, KK; Espinosa, G; Clark, D; Ghafoori, AP; Li, Y; Kirsch, DG; Johnson, GA; Annapragada, A; Ghaghada, KB, Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent., PloS one, vol 7 no. 4 (2012) [10.1371/journal.pone.0034496] [abs].
  • Clark, D; Johnson, GA; Badea, CT, Denoising of 4D cardiac micro-CT data using median-centric bilateral filtration, Proceedings of SPIE, vol 8314 (2012) [10.1117/12.911478] [abs].
  • Badea, CT; Stanton, IN; Johnston, SM; Johnson, GA; Therien, MJ, Investigations on X-ray luminescence CT for small animal imaging., Proceedings of SPIE - The International Society for Optical Engineering, vol 8313 (2012) [abs].
  • Zhang, X; Badea, C; Hood, G; Wetzel, A; Qi, Y; Stiles, J; Johnson, GA, High-resolution reconstruction of fluorescent inclusions in mouse thorax using anatomically guided sampling and parallel Monte Carlo computing., Biomedical Optics Express, vol 2 no. 9 (2011), pp. 2449-2460 [10.1364/BOE.2.002449] [abs].
  • Lin, M; Qi, Y; Chen, AF; Badea, CT; Johnson, GA, Phenylephrine-modulated cardiopulmonary blood flow measured with use of X-ray digital subtraction angiography., Journal of Pharmacological and Toxicological Methods, vol 64 no. 2 (2011), pp. 180-186 [10.1016/j.vascn.2011.08.001] [abs].
  • Badea, CT; Hedlund, LW; Qi, Y; Berridge, B; Johnson, GA, In vivo imaging of rat coronary arteries using bi-plane digital subtraction angiography., Journal of Pharmacological and Toxicological Methods, vol 64 no. 2 (2011), pp. 151-157 [10.1016/j.vascn.2011.05.008] [abs].
  • Badea, CT; Johnston, SM; Qi, Y; Johnson, GA, 4D micro-CT for cardiac and perfusion applications with view under sampling., Physics in Medicine and Biology, vol 56 no. 11 (2011), pp. 3351-3369 [10.1088/0031-9155/56/11/011] [abs].
  • Ghaghada, KB; Badea, CT; Karumbaiah, L; Fettig, N; Bellamkonda, RV; Johnson, GA; Annapragada, A, Evaluation of tumor microenvironment in an animal model using a nanoparticle contrast agent in computed tomography imaging., Academic Radiology, vol 18 no. 1 (2011), pp. 20-30 [10.1016/j.acra.2010.09.003] [abs].
  • Badea, CT; Hedlund, LW; Cook, J; Berridge, BR; Johnson, GA, Micro-CT imaging assessment of dobutamine-induced cardiac stress in rats., Journal of Pharmacological and Toxicological Methods, vol 63 no. 1 (2011), pp. 24-29 [10.1016/j.vascn.2010.04.002] [abs].
  • Johnston, SM; Perez, BA; Kirsch, DG; Badea, CT, Phase-selective image reconstruction of the lungs in small animals using Micro-CT., Proceedings of SPIE - The International Society for Optical Engineering, vol 7622 (2010), pp. 76223G.1-76223G.9 [10.1117/12.844359] [abs].
  • Badea, CT; Johnston, SM; Subashi, E; Qi, Y; Hedlund, LW; Johnson, GA, Lung perfusion imaging in small animals using 4D micro-CT at heartbeat temporal resolution., Medical physics, vol 37 no. 1 (2010), pp. 54-62 [10.1118/1.3264619] [abs].
  • Zhang, X; Badea, CT; Hood, G; Wetzel, AW; Stiles, JR; Johnson, GA, Free-space fluorescence tomography with adaptive sampling based on anatomical information from microCT., Proceedings of SPIE - The International Society for Optical Engineering, vol 7757 no. 775706 (2010) [10.1117/12.841891] [abs].
  • Lin, M; Marshall, CT; Qi, Y; Johnston, SM; Badea, CT; Piantadosi, CA; Johnson, GA, Quantitative blood flow measurements in the small animal cardiopulmonary system using digital subtraction angiography., Medical physics, vol 36 no. 11 (2009), pp. 5347-5358 [10.1118/1.3231823] [abs].
  • Zhang, X; Badea, C, Effects of sampling strategy on image quality in noncontact panoramic fluorescence diffuse optical tomography for small animal imaging., Optics express, vol 17 no. 7 (2009), pp. 5125-5138 [abs].
  • Zhang, X; Badea, C; Jacob, M; Johnson, GA, Development of a noncontact 3-D fluorescence tomography system for small animal in vivo imaging., Proceedings of SPIE - The International Society for Optical Engineering, vol 7191 (2009) [10.1117/12.808199] [abs].
  • Samei, E; Saunders, RS; Badea, CT; Ghaghada, KB; Hedlund, LW; Qi, Y; Yuan, H; Bentley, RC; Mukundan, S, Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent., International journal of nanomedicine, vol 4 (2009), pp. 277-282 [abs].
  • Badea, CT; Johnston, S; Johnson, B; Lin, M; Hedlund, LW; Johnson, GA, A dual micro-CT system for small animal imaging., Proceedings of SPIE - The International Society for Optical Engineering, vol 6913 (2008) [10.1117/12.772303] [abs].
  • de Lin, M; Ning, L; Badea, CT; Mistry, NN; Qi, Y; Johnson, GA, A high-precision contrast injector for small animal x-ray digital subtraction angiography., IEEE Transactions on Biomedical Engineering, vol 55 no. 3 (2008), pp. 1082-1091 [10.1109/TBME.2007.909541] [abs].
  • Song, J; Liu, QH; Johnson, GA; Badea, CT, Sparseness prior based iterative image reconstruction for retrospectively gated cardiac micro-CT., Medical physics, vol 34 no. 11 (2007), pp. 4476-4483 [10.1118/1.2795830] [abs].
  • Nahrendorf, M; Badea, C; Hedlund, LW; Figueiredo, JL; Sosnovik, DE; Johnson, GA; Weissleder, R, High-resolution imaging of murine myocardial infarction with delayed-enhancement cine micro-CT., American journal of physiology. Heart and circulatory physiology, vol 292 no. 6 (2007), pp. H3172-H3178 [10.1152/ajpheart.01307.2006] [abs].
  • Badea, CT; Hedlund, LW; De Lin, M; Mackel, JS; Samei, E; Johnson, GA, Tomographic digital subtraction angiography for lung perfusion estimation in rodents., Medical physics, vol 34 no. 5 (2007), pp. 1546-1555 [10.1118/1.2717384] [abs].
  • Lin, MD; Samei, E; Badea, CT; Yoshizumi, TT; Johnson, GA, Optimized radiographic spectra for small animal digital subtraction angiography., Medical physics, vol 33 no. 11 (2006), pp. 4249-4257 [10.1118/1.2356646] [abs].
  • Oldham, M; Sakhalkar, H; Oliver, T; Wang, YM; Kirpatrick, J; Cao, Y; Badea, C; Johnson, GA; Dewhirst, M, Three-dimensional imaging of xenograft tumors using optical computed and emission tomography., Medical physics, vol 33 no. 9 (2006), pp. 3193-3202 [10.1118/1.2217109] [abs].
  • Badea, CT; Hedlund, LW; De Lin, M; Boslego Mackel, JF; Johnson, GA, Tumor imaging in small animals with a combined micro-CT/micro-DSA system using iodinated conventional and blood pool contrast agents., Contrast Media & Molecular Imaging, vol 1 no. 4 (2006), pp. 153-164 [10.1002/cmmi.103] [abs].
  • Mukundan, S; Ghaghada, KB; Badea, CT; Kao, CY; Hedlund, LW; Provenzale, JM; Johnson, GA; Chen, E; Bellamkonda, RV; Annapragada, A, A liposomal nanoscale contrast agent for preclinical CT in mice., AJR. American journal of roentgenology, vol 186 no. 2 (2006), pp. 300-307 [10.2214/AJR.05.0523] [abs].
  • Badea, CT; Bucholz, E; Hedlund, LW; Rockman, HA; Johnson, GA, Imaging methods for morphological and functional phenotyping of the rodent heart., Toxicologic Pathology (Sage), vol 34 no. 1 (2006), pp. 111-117 [10.1080/01926230500404126] [abs].
  • Badea, CT; Fubara, B; Hedlund, LW; Johnson, GA, 4-D micro-CT of the mouse heart., Molecular imaging : official journal of the Society for Molecular Imaging, vol 4 no. 2 (2005), pp. 110-116 [abs].
  • Ma├», W; Badea, CT; Wheeler, CT; Hedlund, LW; Johnson, GA, Effects of breathing and cardiac motion on spatial resolution in the microscopic imaging of rodents., Magnetic Resonance in Medicine, vol 53 no. 4 (2005), pp. 858-865 [10.1002/mrm.20400] [abs].
  • Badea, C; Hedlund, LW; Johnson, GA, Micro-CT with respiratory and cardiac gating., Medical physics, vol 31 no. 12 (2004), pp. 3324-3329 [10.1118/1.1812604] [abs].
  • Badea, C; Gordon, R, Experiments with the nonlinear and chaotic behaviour of the multiplicative algebraic reconstruction technique (MART) algorithm for computed tomography., Physics in Medicine and Biology, vol 49 no. 8 (2004), pp. 1455-1474 [abs].
  • Buliev, IG; Badea, CT; Kolitsi, Z; Pallikarakis, N, Estimation of the heart respiratory motion with applications for cone beam computed tomography imaging: a simulation study., IEEE Transactions on Information Technology in Biomedicine, vol 7 no. 4 (2003), pp. 404-411 [abs].
  • Soimu, D; Badea, C; Pallikarakis, N, A novel approach for distortion correction for X-ray image intensifiers., Computerized Medical Imaging and Graphics, vol 27 no. 1 (2003), pp. 79-85 [abs].
  • Buliev, I; Badea, C; Pallikarakis, N, Logarithmic amplifier for computed tomography tasks using fluoroscopic projections., Journal of Medical Engineering & Technology, vol 26 no. 6 (2002), pp. 247-252 [10.1080/03091900210156832] [abs].
  • Badea, C; Kolitsi, Z; Pallikarakis, N, Image quality in extended arc filtered digital tomosynthesis., Acta Radiologica (Informa), vol 42 no. 2 (2001), pp. 244-248 [abs].
  • Messaris, G; Kolitsi, Z; Badea, C; Pallikarakis, N, Three-dimensional localisation based on projectional and tomographic image correlation: an application for digital tomosynthesis., Medical Engineering & Physics, vol 21 no. 2 (1999), pp. 101-109 [abs].
  • Badea, C; Kolitsi, Z; Pallikarakis, N, A wavelet-based method for removal of out-of-plane structures in digital tomosynthesis., Computerized Medical Imaging and Graphics, vol 22 no. 4 (1998), pp. 309-315 [abs].
  • Badea, C; Kolitsi, Z; Pallikarakis, N; Papapanagiotou, A, Medical device surveillance world-wide., Studies in health technology and informatics, vol 28 (1996), pp. 157-174 [abs].