Shyni Varghese

Shyni Varghese

Professor of Biomedical Engineering, Mechanical Engineering & Materials Science and Orthopaedics

Shyni Varghese has a triple appointment in the Duke departments of Biomedical Engineering, Mechanical Engineering and Materials Science, and Orthopaedic Surgery. She is the first MEDx Investigator.

A leader in the field of biomaterials and stem cells, Varghese will develop her research at Duke in three major areas:

  • Musculoskeletal tissue repair
  • Disease biophysics, and
  • Organ-on-a-chip technology

A new initiative of the Pratt School of Engineering and Duke School of Medicine, Duke MEDx seeks to enhance and form new collaborations between doctors and engineers.

Appointments and Affiliations

  • Professor of Orthopaedic Surgery
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Professor in the Department of Biomedical Engineering
  • Affiliate of the Regeneration Next Initiative

Contact Information


  • Ph.D. National Chemical Laboratory (India), 2002

Research Interests

Musculoskeletal tissue repair, disease biophysics and organ-on-a-chip technology

Courses Taught

  • BME 791: Graduate Independent Study
  • BME 792: Continuation of Graduate Independent Study

In the News

Representative Publications

  • Seale, N; Ramaswamy, S; Shih, Y-R; Verma, I; Varghese, S, Macroporous Dual-compartment Hydrogels for Minimally Invasive Transplantation of Primary Human Hepatocytes., Transplantation, vol 102 no. 9 (2018), pp. e373-e381 [10.1097/tp.0000000000002330] [abs].
  • Liu, M; Nakasaki, M; Shih, Y-RV; Varghese, S, Effect of age on biomaterial-mediated in situ bone tissue regeneration., Acta Biomaterialia, vol 78 (2018), pp. 329-340 [10.1016/j.actbio.2018.06.035] [abs].
  • Kang, H; Zeng, Y; Varghese, S, Functionally graded multilayer scaffolds for in vivo osteochondral tissue engineering., Acta Biomaterialia, vol 78 (2018), pp. 365-377 [10.1016/j.actbio.2018.07.039] [abs].
  • González Díaz, EC; Shih, Y-RV; Nakasaki, M; Liu, M; Varghese, S, Mineralized Biomaterials Mediated Repair of Bone Defects Through Endogenous Cells., Tissue Engineering. Part A, vol 24 no. 13-14 (2018), pp. 1148-1156 [10.1089/ten.tea.2017.0297] [abs].
  • Moreno, AM; Fu, X; Zhu, J; Katrekar, D; Shih, Y-RV; Marlett, J; Cabotaje, J; Tat, J; Naughton, J; Lisowski, L; Varghese, S; Zhang, K; Mali, P, In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation., Molecular Therapy, vol 26 no. 7 (2018), pp. 1818-1827 [10.1016/j.ymthe.2018.04.017] [abs].