Chen Family Associate Professor of Pediatrics
Our group is interested in diseases of the liver, ranging from viral hepatitis to metabolic liver disorders and liver cancer. The lab specializes in human liver chimeric mice and created the first xenograft model for metabolic liver disease as well as a novel patient derived cancer model. We use these next generation humanized mouse models to develop new therapeutic approaches, such as metabolic pathway reprogramming - a CRISPR based gene therapy approach.
Appointments and Affiliations
- Chen Family Associate Professor of Pediatrics
- Associate Professor in Pediatrics
- Associate Professor of Biomedical Engineering
- Associate Professor in Pharmacology and Cancer Biology
- Affiliate of the Duke Regeneration Center
- Member of the Duke Cancer Institute
Contact Information
- Email Address: karldimiter.bissig@duke.edu
Education
- MD./PhD. Universitat Bern (Switzerland), 2000
- Inselspital (Switzerland), 2005
- Salk Institute for Biological Studies, 2011
Research Interests
Our group is interested in diseases of the liver, ranging from viral hepatitis to metabolic liver disorders and liver cancer. The lab specializes in human liver chimeric mice and created the first xenograft model for metabolic liver disease as well as a novel patient derived cancer model. We use these next generation humanized mouse models to develop new therapeutic approaches, such as metabolic pathway reprogramming - a CRISPR based gene therapy approach.Courses Taught
- PHARM 494: Research Independent Study
- PHARM 493: Research Independent Study
- PHARM 394: Research Independent Study
- BME 791: Graduate Independent Study