Aravind Asokan

Professor in Surgery

Synthetic Virology & Gene Therapy

Appointments and Affiliations

  • Professor in Surgery
  • Director of Gene Therapy
  • Professor of Biomedical Engineering
  • Professor of Molecular Genetics and Microbiology
  • Affiliate of the Duke Regeneration Center

Contact Information

Education

  • Ph.D. University of North Carolina, Chapel Hill, 2004

Research Interests

Virology
RNA Biology
Viral Engineering
RNA Engineering
Gene Therapy
Gene Editing
Gene Regulation
Regenerative Medicine

Courses Taught

  • MGM 593: Research Independent Study
  • BME 791: Graduate Independent Study
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)

In the News

Representative Publications

  • Zhu, Xiaoyi, Qiang Huang, Laiming Jiang, Van-Tu Nguyen, Tri Vu, Garth Devlin, Jabbar Shaima, et al. “Longitudinal intravital imaging of mouse placenta.” Sci Adv 10, no. 12 (March 22, 2024): eadk1278. https://doi.org/10.1126/sciadv.adk1278.
  • Fiflis, David N., Nicolas A. Rey, Harshitha Venugopal-Lavanya, Beatrice Sewell, Aaron Mitchell-Dick, Katie N. Clements, Sydney Milo, et al. “Repurposing CRISPR-Cas13 systems for robust mRNA trans-splicing.” Nat Commun 15, no. 1 (March 14, 2024): 2325. https://doi.org/10.1038/s41467-024-46172-4.
  • Kurt, Evan, Garth Devlin, Aravind Asokan, and Tatiana Segura. “Gene Delivery From Granular Scaffolds for Tunable Biologics Manufacturing.” Small, March 11, 2024, e2309911. https://doi.org/10.1002/smll.202309911.
  • Barzi, Mercedes, Tong Chen, Trevor J. Gonzalez, Francis P. Pankowicz, Seh Hoon Oh, Helen L. Streff, Alan Rosales, et al. “A humanized mouse model for adeno-associated viral gene therapy.” Nat Commun 15, no. 1 (March 4, 2024): 1955. https://doi.org/10.1038/s41467-024-46017-0.
  • Loeb, Ezra J., Patrick L. Havlik, Zachary C. Elmore, Alan Rosales, Sophia M. Fergione, Trevor J. Gonzalez, Timothy J. Smith, Abigail R. Benkert, David N. Fiflis, and Aravind Asokan. “Capsid-mediated control of adeno-associated viral transcription determines host range.” Cell Rep 43, no. 3 (March 2, 2024): 113902. https://doi.org/10.1016/j.celrep.2024.113902.