Aravind Asokan

Professor in Surgery

Synthetic Virology & Gene Therapy

Appointments and Affiliations

  • Professor in Surgery
  • Director of Gene Therapy
  • Professor of Biomedical Engineering
  • Professor of Molecular Genetics and Microbiology
  • Affiliate of the Duke Regeneration Center

Contact Information


  • Ph.D. University of North Carolina - Chapel Hill, 2004

Research Interests

RNA Biology
Viral Engineering
RNA Engineering
Gene Therapy
Gene Editing
Gene Regulation
Regenerative Medicine

Courses Taught

  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 791: Graduate Independent Study
  • MGM 293: Research Independent Study I
  • MGM 593: Research Independent Study

In the News

Representative Publications

  • Gonzalez, Trevor J., Aaron Mitchell-Dick, Leo O. Blondel, Marco M. Fanous, Joshua A. Hull, Daniel K. Oh, Sven Moller-Tank, Ruth M. Castellanos Rivera, Jorge A. Piedrahita, and Aravind Asokan. “Structure-guided AAV capsid evolution strategies for enhanced CNS gene delivery.” Nature Protocols, September 21, 2023.
  • Konkimalla, Arvind, Zachary Elmore, Satoshi Konishi, Lauren Macadlo, Hiroaki Katsura, Aleksandra Tata, Aravind Asokan, and Purushothama Rao Tata. “Efficient Adeno-associated Virus-mediated Transgenesis in Alveolar Stem Cells and Associated Niches.” Am J Respir Cell Mol Biol 69, no. 3 (September 2023): 255–65.
  • Cigliola, Valentina, Adam Shoffner, Nutishia Lee, Jianhong Ou, Trevor J. Gonzalez, Jiaul Hoque, Clayton J. Becker, et al. “Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer.” Nature Communications 14, no. 1 (August 2023): 4857.
  • Grigsby, Daniel, Mikael Klingeborn, Una Kelly, Lindsey A. Chew, Aravind Asokan, Garth Devlin, Sharon Smith, et al. “AAV Gene Augmentation of Truncated Complement Factor H Differentially Rescues Ocular Complement Dysregulation in a Mouse Model.” Invest Ophthalmol Vis Sci 64, no. 10 (July 3, 2023): 25.
  • Kesseli, S. J., M. K. Krischak, Q. Gao, T. Gonzalez, M. Zhang, S. E. Halpern, R. Kahan, et al. “Adeno-associated virus mediates gene transduction after static cold storage treatment in rodent lung transplantation.” In Journal of Thoracic and Cardiovascular Surgery, 166:e38–49, 2023.