Pranam D. Chatterjee

Assistant Professor of Biomedical Engineering

Appointments and Affiliations

  • Assistant Professor of Biomedical Engineering
  • Assistant Professor in Biostatistics & Bioinformatics
  • Assistant Professor of Computer Science

Contact Information

  • Office Location: 101 Science Drive, CIEMAS 2353A, Durham, NC 27705
  • Email Address: pranam.chatterjee@duke.edu
  • Websites:

Education

  • Ph.D. Massachusetts Institute of Technology, 2020

Research Interests

Integration of computational and experimental methodologies to design novel proteins for applications in genome editing, targeted protein modulation, and reproductive bioengineering

Courses Taught

  • BME 390L: Special Topics with a Lab
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 590: Special Topics in Biomedical Engineering
  • BME 791: Graduate Independent Study
  • COMPSCI 394: Research Independent Study
  • COMPSCI 590: Advanced Topics in Computer Science
  • EGR 393: Research Projects in Engineering

In the News

Representative Publications

  • Chen, T., L. Hong, V. Yudistyra, S. Vincoff, and P. Chatterjee. “Generative design of therapeutics that bind and modulate protein states.” Current Opinion in Biomedical Engineering 28 (December 1, 2023). https://doi.org/10.1016/j.cobme.2023.100496.
  • Zhao, Lin, Sabrina R. T. Koseki, Rachel A. Silverstein, Nadia Amrani, Christina Peng, Christian Kramme, Natasha Savic, et al. “PAM-flexible genome editing with an engineered chimeric Cas9.” Nature Communications 14, no. 1 (October 2023): 6175. https://doi.org/10.1038/s41467-023-41829-y.
  • Brixi, Garyk, Tianzheng Ye, Lauren Hong, Tian Wang, Connor Monticello, Natalia Lopez-Barbosa, Sophia Vincoff, et al. “SaLT&PepPr is an interface-predicting language model for designing peptide-guided protein degraders.” Communications Biology 6, no. 1 (October 2023): 1081. https://doi.org/10.1038/s42003-023-05464-z.
  • Bhat, Suhaas, Kalyan Palepu, Vivian Yudistyra, Lauren Hong, Venkata Srikar Kavirayuni, Tianlai Chen, Lin Zhao, Tian Wang, Sophia Vincoff, and Pranam Chatterjee. “De NovoGeneration and Prioritization of Target-Binding Peptide Motifs from Sequence Alone.” Cold Spring Harbor Laboratory, June 28, 2023. https://doi.org/10.1101/2023.06.26.546591.
  • Liang, Shun-Qing, Pengpeng Liu, Karthikeyan Ponnienselvan, Sneha Suresh, Zexiang Chen, Christian Kramme, Pranam Chatterjee, et al. “Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag.” Nature Methods 20, no. 6 (June 2023): 898–907. https://doi.org/10.1038/s41592-023-01859-2.