Nimmi Ramanujam

Ramanujam

Robert W. Carr, Jr., Distinguished Professor of Biomedical Engineering

Dr. Ramanujam is the Robert W. Carr Professor of Engineering and Professor of Cancer Pharmacology and Global Health at Duke University and co-program leader of the Radiation Oncology and Imaging Program (ROIP) at the Duke Cancer Institute. She founded the Center for Global Women’s Health Technologies (GWHT) in 2013 where she empowers trainees to create impactful solutions to improve the lives of women and girls globally. This center, since inception, has catalyzed new research activities and the development and commercialization of several technologies that advance prevention and treatment of cervical and breast cancer. 

Dr. Ramanujam’s work has led to low-cost and efficient health care and home-based technology innovations that provide surveillance of cancer and its recurrence. To complement her translational efforts, Dr. Ramanujam’s work exploits the dynamic changes in tumor metabolism that allow cancers to go under the radar and recur in a stealth mode when conditions are favorable. She is also creating a liquid-based ablative therapy with dual roles - (1) to address the pressing issue of cancer control in environments where access to surgery is scarce, and (2) enhance tumor kill through a combination of necrosis and T cell infiltration occurring as a result of tumor antigen presentation following ablation.

Dr. Ramanujam has built several global initiatives. The most notable is a consortium to impact cervical cancer prevention in low resource settings. Her MacArthur Foundation 100&Change proposal, Women-Inspired Strategies for Health:  A Revolution against Cervical Cancer (WISH) was recognized as one of the Top 100 of the 755 proposals submitted to this $100M grant competition (Macarthur 100&Change). In addition to her cervical cancer prevention initiative, she has also created a global women’s education program that intersects design-thinking, STEM concepts, and the U.N. Sustainable Development Goals to promote social justice awareness (IGNITE). She has launched an arts and storytelling initiative to raise awareness of sexual and reproductive health inequities (The (In) Visible Organ).

She has created two companies Zenalux and Calla Health to commercialize her technologies.

 

Calla Health, a GWHT venture, is centered on sustainably improving women's access to cancer prevention and creating innovations that increase wide scale surveillance of cervical pre-cancers and cancers. Zenalux Biomedical, in collaboration with Duke University, is developing a suite of optical microscopy and spectroscopy tools for preclinical and clinical applications in cancer research. Zenalux’ newest product offering is the Zenascope™ ZF1, a combined portable platform for optical imaging and spectroscopy to characterize the major axes of metabolism along with key vascular features.

Dr. Ramanujam has more than 20 patents to-date and more than 150 publications for screening, diagnostic, and surgical applications. She has received funding from a agencies including NIH R01s and R21s, NIH Bioengineering Partnerships, NCI Academic Industry Partnerships, NIH Small Business grants, DOD, Burroughs Wellcome Fund, DIHI: Innovation Jam, Prevent Cancer and USAID funding. As the director of the Center for Global Women’s Health Technologies, she has developed a network of 50+ partners including international academic institutions and hospitals, non-governmental organizations, ministries of health, and commercial partners; this consortium works to ensure the technologies developed at the center are adopted by cancer control programs in geographically and economically diverse healthcare settings. 

Dr. Ramanujam has received a number of awards including the MIT TR100 Young Innovator award (MIT), the Global Indus Technovator award (MIT), the Stansell Family award (Duke), multiple Era of Hope Scholar awards (DoD), the Emerging Leader in Global Health Award (CUGH), the Social Impact Abie Award (AnitaB.org), the Biophotonics Technology Innovator Award (SPIE), the Women in Molecular Imaging Leadership Award (WMIC), the Michael S. Feld Biophotonics Award (OSA) and the Wom C Global Impact Award (Duke). She is a fellow of several optical and biomedical engineering societies including OSA, SPIE, and AIMBE. She is a Fulbright scholar and the 2020 IEEE Distinguished Lecturer. She is an elected member of the National Academy of Inventors. She has demonstrated her work’s global impact through presentations at the United Nations and TEDx events, and a number of national and international plenary talks. Her work has been featured in a number of venues including Medical Daily, Wired Magazine, NPR and several podcasts.

Appointments and Affiliations

  • Robert W. Carr, Jr., Distinguished Professor of Biomedical Engineering
  • Professor of Biomedical Engineering
  • Research Professor of Global Health
  • Professor of Pharmacology and Cancer Biology
  • Affiliate of the Duke Initiative for Science & Society
  • Core Faculty Member, Duke-Margolis Center for Health Policy
  • Member of the Duke Cancer Institute

Contact Information

Education

  • Ph.D. University of Texas, Austin, 1995
  • M.S. University of Texas, Austin, 1992
  • B.S. University of Texas, Austin, 1989

Research Interests

Innovating on optical strategies to peer into the biological landscape of thick tissues. Technologies being developed in her lab leverage principles of optical spectroscopy, optical sectioning microscopy, and molecular imaging. Her research group is developing and applying these optically based tools for three problems in cancer: cancer screening in resource-limited settings, intra-operative margin assessment to detect residual disease during cancer surgery, and visualizing tumor hypoxia and metabolism in the context of cancer therapy and drug discovery. Prof. Ramanujam is leading a multi-disciplinary effort to translate these technologies to clinical applications in the breast, and cervix.

Awards, Honors, and Distinctions

  • Women In Molecular Imaging Network (WIMIN) Leadership Committee. WIMIN. 2020
  • Associate Editor. Inaugural Editorial Board of IEEE OJEMB. 2020
  • Michael S. Feld Biophotonics . OSA. 2020
  • The WomC Global Impact Award. Duke University Women’s Center. 2020
  • Associate Editor. Scientific Reports. 2019
  • Biophotonics Technology Innovator Award. International Society for Optics and Photonics. 2019
  • Program co-leader for Radiation Oncology and Imaging Program. Duke Cancer Institute. 2019
  • Social Impact Abie Award. AnitaB.org . 2019
  • Women in Molecular Imaging Network Outstanding Leadership in Molecular Imaging Award. World Molecular Imaging Society. 2019
  • CUGH Emerging Leader in Global Health Innovation Faculty Award. Consortium of Universities for Global Health. 2018
  • Fellow. National Academy of Inventors . 2017
  • Fellow. International Society for Optics and Photonics. 2013
  • Fellow. American Institute for Medical and Biological Engineering. 2012
  • Fellow. Optical Society of America. 2010

Courses Taught

  • BME 230L: Global Women's Health Technologies
  • BME 290: Intermediate Topics (GE)
  • BME 290L: Intermediate Topics with Lab (GE)
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • EGR 393: Research Projects in Engineering
  • EHD 395: Bass Connections: Interdisciplinary Team Projects
  • EHD 396: Bass Connections: Interdisciplinary Team Projects
  • EHD 795: Bass Connections: Interdisciplinary Team Projects
  • EHD 796: Bass Connections: Interdisciplinary Team Projects
  • GLHLTH 230L: Global Women's Health Technologies
  • GLHLTH 391: Independent Study in Global Health
  • GLHLTH 393: Research Independent Study in Global Health
  • GLHLTH 396: Connections in Global Health: Interdisciplinary Team Projects
  • GLHLTH 796: Connections in Global Health: Interdisciplinary Team Projects
  • ISS 397: Bass Connections Information, Society & Culture Research Team
  • ISS 795: Bass Connections Information, Society & Culture Research Team
  • PHARM 493: Research Independent Study
  • PHARM 494: Research Independent Study
  • PHARM 495: Research Independent Study
  • SOCIOL 393: Research Independent Study

In the News

Representative Publications

  • Mueller, JL; Morhard, R; DeSoto, M; Chelales, E; Yang, J; Nief, C; Crouch, B; Everitt, J; Previs, R; Katz, D; Ramanujam, N, Optimizing ethyl cellulose-ethanol delivery towards enabling ablation of cervical dysplasia., Scientific Reports, vol 11 no. 1 (2021) [10.1038/s41598-021-96223-9] [abs].
  • Gupta, A; Brown, E; Davis, JT; Sekabira, J; Ramanujam, N; Mueller, J; Fitzgerald, TN, KeyLoop: Mechanical Retraction of the Abdominal Wall for Gasless Laparoscopy., Surgical Innovation (2021) [10.1177/15533506211031084] [abs].
  • Mueller, JL; Rozman, N; Sunassee, ED; Gupta, A; Schuval, C; Biswas, A; Knight, B; Kulkarni, S; Brown, M; Ramanujam, N; Fitzgerald, TN, An Accessible Laparoscope for Surgery in Low- and Middle- Income Countries., Ann Biomed Eng, vol 49 no. 7 (2021), pp. 1657-1669 [10.1007/s10439-020-02707-6] [abs].
  • Rossman, AH; Reid, HW; Pieters, MM; Mizelle, C; von Isenburg, M; Ramanujam, N; Huchko, MJ; Vasudevan, L, Digital Health Strategies for Cervical Cancer Control in Low- and Middle-Income Countries: Systematic Review of Current Implementations and Gaps in Research., Journal of Medical Internet Research, vol 23 no. 5 (2021) [10.2196/23350] [abs].
  • Morhard, R; Mueller, JL; Tang, Q; Nief, C; Chelales, E; Lam, CT; Alvarez, DA; Rubinstein, M; Katz, DF; Ramanujam, N, Understanding Factors Governing Distribution Volume of Ethyl Cellulose-Ethanol to Optimize Ablative Therapy in the Liver., Ieee Transactions on Bio Medical Engineering, vol 67 no. 8 (2020), pp. 2337-2348 [10.1109/tbme.2019.2960049] [abs].