Josh Huang

Duke School of Medicine Distinguished Professor in Neuroscience

We study the development and function of cortical circuits underlying motor control and cognitive processing. Our research program integrates multi-faceted approaches from genetic engineering to single-cell genomics, developmental neurobiology, imaging, electrophysiology, and behavioral analyses, and aims to link fundamental neuroscience to the understanding and treatment of neuropsychiatric disorders.    

Appointments and Affiliations

  • Duke School of Medicine Distinguished Professor in Neuroscience
  • Professor of Neurobiology
  • Professor of Biomedical Engineering
  • Professor of Cell Biology

Contact Information

  • Office Location: 311 Research Drive, Box 3209, Durham, NC 27710
  • Office Phone: (919) 613-1573
  • Email Address:
  • Websites:


  • Ph.D. Brandeis University, 1995

Courses Taught

  • BME 791: Graduate Independent Study
  • NEUROBIO 393: Research Independent Study
  • NEUROBIO 793: Research in Neurobiology

In the News

Representative Publications

  • Qian, Yongjun, Jiayun Li, Shengli Zhao, Elizabeth A. Matthews, Michael Adoff, Weixin Zhong, Xu An, et al. “Programmable RNA sensing for cell monitoring and manipulation.” Nature 610, no. 7933 (October 2022): 713–21.
  • Huilgol, Dhananjay, Jesse Levine, William Galbavy, Bor-Shuen Wang, Miao He, Shreyas Suryanarayana, and Josh Huang. “Direct and indirect neurogenesis generate a mosaic of distinct glutamatergic projection neuron types and cortical subnetworks.” BioRxiv, 2022.
  • Mohan, Hemanth, Xu An, Hideki Kondo, Shengli Zhao, Katherine Matho, Simon Musall, Partha Mitra, and Josh Huang. “Cortical glutamatergic projection neuron types contribute to distinct functional subnetworks.” Research Square, 2022.
  • Deng, Hanfei, Xiong Xiao, Tao Yang, Kimberly Ritola, Adam Hantman, Yulong Li, Z Josh Huang, and Bo Li. “A genetically defined insula-brainstem circuit selectively controls motivational vigor.” Cell 184, no. 26 (December 22, 2021): 6344-6360.e18.
  • Dudok, Barna, Miklos Szoboszlay, Anirban Paul, Peter M. Klein, Zhenrui Liao, Ernie Hwaun, Gergely G. Szabo, et al. “Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior.” Neuron 109, no. 23 (December 1, 2021): 3838-3850.e8.