Josh Huang

Duke School of Medicine Distinguished Professor in Neuroscience

We study the development and function of cortical circuits underlying motor control and cognitive processing. Our research program integrates multi-faceted approaches from genetic engineering to single-cell genomics, developmental neurobiology, imaging, electrophysiology, and behavioral analyses, and aims to link fundamental neuroscience to the understanding and treatment of neuropsychiatric disorders.    

Appointments and Affiliations

  • Duke School of Medicine Distinguished Professor in Neuroscience
  • Professor of Neurobiology
  • Professor of Biomedical Engineering
  • Professor of Cell Biology

Contact Information

  • Office Location: 311 Research Drive, Box 3209, Durham, NC 27710
  • Office Phone: (919) 613-1573
  • Email Address:
  • Websites:


  • Ph.D. Brandeis University, 1995

Courses Taught

  • BME 791: Graduate Independent Study
  • CMB 710E: Cell & Molecular Biology Module V
  • CMB 710F: Cell & Molecular Biology Module VI
  • NEUROBIO 393: Research Independent Study
  • NEUROBIO 793: Research in Neurobiology

In the News

Representative Publications

  • Huilgol, Dhananjay, Jesse M. Levine, William Galbavy, Bor-Shuen Wang, Miao He, Shreyas M. Suryanarayana, and Z Josh Huang. “Direct and indirect neurogenesis generate a mosaic of distinct glutamatergic projection neuron types in cerebral cortex.” Neuron 111, no. 16 (August 16, 2023): 2557-2569.e4.
  • Huilgol, Dhananjay, Jeffrey B. Russ, Sweta Srivas, and Z Josh Huang. “The progenitor basis of cortical projection neuron diversity.” Curr Opin Neurobiol 81 (August 2023): 102726.
  • Yao, Mei, Ayizuohere Tudi, Tao Jiang, Xu An, Qingtao Sun, Anan Li, Z Josh Huang, Hui Gong, and Xiangning Li. “Long-range connectome of pyramidal neurons in the sensorimotor cortex.” Iscience 26, no. 4 (April 21, 2023): 106316.
  • Liu, Hao, René N. Caballero-Florán, Ty Hergenreder, Tao Yang, Jacob M. Hull, Geng Pan, Ruonan Li, et al. “DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models.” Plos Biol 21, no. 4 (April 2023): e3002078.
  • Mohan, Hemanth, Xu An, X Hermione Xu, Hideki Kondo, Shengli Zhao, Katherine S. Matho, Bor-Shuen Wang, Simon Musall, Partha Mitra, and Z Josh Huang. “Cortical glutamatergic projection neuron types contribute to distinct functional subnetworks.” Nat Neurosci 26, no. 3 (March 2023): 481–94.