Bastiaan Driehuys

Bastiaan Driehuys

Professor of Radiology

My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.

Appointments and Affiliations

  • Professor of Radiology
  • Professor of Physics

Contact Information

  • Office Location: 161-B Bryan Research, 311 Research Drive, Durham, NC 27710
  • Office Phone: (919) 684-7786
  • Email Address: bastiaan.driehuys@duke.edu
  • Websites:

Education

  • Ph.D. Princeton University, 1995

Research Interests

Driehuys' laboratory focuses on the development and application of hyperpolarized gas MRI for non-invasive imaging of pulmonary function and spectroscopic evaluation of pathology. We seek to improve the care of patients with pulmonary disease by developing non-invasive, 3D imaging of pulmonary function.

Courses Taught

  • BME 791: Graduate Independent Study
  • PHYSICS 491: Independent Study: Advanced Topics
  • PHYSICS 493: Research Independent Study
  • PHYSICS 495: Thesis Independent Study

Representative Publications

  • Kaushik, SS; Freeman, MS; Cleveland, ZI; Davies, J; Stiles, J; Virgincar, RS; Robertson, SH; He, M; Kelly, KT; Foster, WM; McAdams, HP; Driehuys, B, Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging., Journal of applied physiology (Bethesda, Md. : 1985), vol 115 no. 6 (2013), pp. 850-860 [10.1152/japplphysiol.00092.2013] [abs].
  • Driehuys, B; Martinez-Jimenez, S; Cleveland, ZI; Metz, GM; Beaver, DM; Nouls, JC; Kaushik, SS; Firszt, R; Willis, C; Kelly, KT; Wolber, J; Kraft, M; McAdams, HP, Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients., Radiology, vol 262 no. 1 (2012), pp. 279-289 [10.1148/radiol.11102172] [abs].
  • Cleveland, ZI; Möller, HE; Hedlund, LW; Nouls, JC; Freeman, MS; Qi, Y; Driehuys, B, In vivo MR imaging of pulmonary perfusion and gas exchange in rats via continuous extracorporeal infusion of hyperpolarized 129Xe., PloS one, vol 7 no. 2 (2012) [10.1371/journal.pone.0031306] [abs].
  • Driehuys, B; Nouls, J; Badea, A; Bucholz, E; Ghaghada, K; Petiet, A; Hedlund, LW, Small animal imaging with magnetic resonance microscopy, ILAR Journal, vol 53 no. 1 (2012), pp. 35-53 [abs].
  • Thomas, AC; Nouls, JC; Driehuys, B; Voltz, JW; Fubara, B; Foley, J; Bradbury, JA; Zeldin, DC, Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury., American journal of respiratory cell and molecular biology, vol 44 no. 5 (2011), pp. 648-654 [10.1165/rcmb.2009-0287OC] [abs].
  • Kaushik, SS; Cleveland, ZI; Cofer, GP; Metz, G; Beaver, D; Nouls, J; Kraft, M; Auffermann, W; Wolber, J; McAdams, HP; Driehuys, B, Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease., Magnetic Resonance in Medicine, vol 65 no. 4 (2011), pp. 1154-1165 [10.1002/mrm.22697] [abs].
  • Kaushik, SS; Cleveland, ZI; Cofer, GP; Metz, G; Beaver, D; Nouls, J; Kraft, M; Auffermann, W; Wolber, J; McAdams, HP; Driehuys, B, Diffusion-weighted hyperpolarized (129)Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease., Magnetic Resonance in Medicine (2010) [10.1002/mrm.22697] [abs].
  • Cleveland, ZI; Cofer, GP; Metz, G; Beaver, D; Nouls, J; Kaushik, SS; Kraft, M; Wolber, J; Kelly, KT; McAdams, HP; Driehuys, B, Hyperpolarized Xe MR imaging of alveolar gas uptake in humans., PloS one, vol 5 no. 8 (2010) [10.1371/journal.pone.0012192] [abs].
  • Branca, RT; Cleveland, ZI; Fubara, B; Kumar, CS; Maronpot, RR; Leuschner, C; Warren, WS; Driehuys, B, Molecular MRI for sensitive and specific detection of lung metastases., Proceedings of the National Academy of Sciences of USA, vol 107 no. 8 (2010), pp. 3693-3697 [10.1073/pnas.1000386107] [abs].
  • Cleveland, ZI; Möller, HE; Hedlund, LW; Driehuys, B, Continuously infusing hyperpolarized 129Xe into flowing aqueous solutions using hydrophobic gas exchange membranes., The Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces and Biophysical, vol 113 no. 37 (2009), pp. 12489-12499 [10.1021/jp9049582] [abs].
  • Driehuys, B; Möller, HE; Cleveland, ZI; Pollaro, J; Hedlund, LW, Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe., Radiology, vol 252 no. 2 (2009), pp. 386-393 [10.1148/radiol.2513081550] [abs].
  • Thomas, AC; Potts, EN; Chen, BT; Slipetz, DM; Foster, WM; Driehuys, B, A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI., Nmr in Biomedicine, vol 22 no. 5 (2009), pp. 502-515 [10.1002/nbm.1362] [abs].
  • Driehuys, B; Pollaro, J; Cofer, GP, In vivo MRI using real-time production of hyperpolarized 129Xe., Magnetic Resonance in Medicine, vol 60 no. 1 (2008), pp. 14-20 [10.1002/mrm.21651] [abs].
  • Driehuys, B; Nouls, J; Badea, A; Bucholz, E; Ghaghada, K; Petiet, A; Hedlund, LW, Small animal imaging with magnetic resonance microscopy., ILAR Journal, vol 49 no. 1 (2008), pp. 35-53 [abs].
  • Driehuys, B; Walker, J; Pollaro, J; Cofer, GP; Mistry, N; Schwartz, D; Johnson, GA, 3He MRI in mouse models of asthma., Magnetic Resonance in Medicine, vol 58 no. 5 (2007), pp. 893-900 [10.1002/mrm.21306] [abs].
  • Driehuys, B; Cofer, GP; Pollaro, J; Mackel, JB; Hedlund, LW; Johnson, GA, Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI., Proceedings of the National Academy of Sciences of USA, vol 103 no. 48 (2006), pp. 18278-18283 [10.1073/pnas.0608458103] [abs].
  • Månsson, S; Wolber, J; Driehuys, B; Wollmer, P; Golman, K, Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe., Magnetic Resonance in Medicine, vol 50 no. 6 (2003), pp. 1170-1179 [10.1002/mrm.10649] [abs].
  • Babcock, E; Nelson, I; Kadlecek, S; Driehuys, B; Anderson, LW; Hersman, FW; Walker, TG, Hybrid spin-exchange optical pumping of 3He., Physical Review Letters, vol 91 no. 12 (2003) [10.1103/PhysRevLett.91.123003] [abs].
  • Ruppert, K; Brookeman, JR; Hagspiel, KD; Driehuys, B; Mugler, JP, NMR of hyperpolarized (129)Xe in the canine chest: spectral dynamics during a breath-hold., Nmr in Biomedicine, vol 13 no. 4 (2000), pp. 220-228 [abs].
  • Chen, XJ; Möller, HE; Chawla, MS; Cofer, GP; Driehuys, B; Hedlund, LW; MacFall, JR; Johnson, GA, Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T *(2)., Magnetic Resonance in Medicine, vol 42 no. 4 (1999), pp. 729-737 [abs].
  • Chen, XJ; Möller, HE; Chawla, MS; Cofer, GP; Driehuys, B; Hedlund, LW; Johnson, GA, Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient., Magnetic Resonance in Medicine, vol 42 no. 4 (1999), pp. 721-728 [abs].
  • Möller, HE; Chen, XJ; Chawla, MS; Cofer, GP; Driehuys, B; Hedlund, LW; Suddarth, SA; Johnson, GA, Sensitivity and resolution in 3D NMR microscopy of the lung with hyperpolarized noble gases., Magnetic Resonance in Medicine, vol 41 no. 4 (1999), pp. 800-808 [abs].
  • Möller, HE; Chen, XJ; Chawla, MS; Driehuys, B; Hedlund, LW; Johnson, GA, Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases., Journal of Magnetic Resonance, vol 135 no. 1 (1998), pp. 133-143 [10.1006/jmre.1998.1563] [abs].
  • Johnson, GA; Cates, G; Chen, XJ; Cofer, GP; Driehuys, B; Happer, W; Hedlund, LW; Saam, B; Shattuck, MD; Swartz, J, Dynamics of magnetization in hyperpolarized gas MRI of the lung., Magnetic Resonance in Medicine, vol 38 no. 1 (1997), pp. 66-71 [abs].
  • Mugler, JP; Driehuys, B; Brookeman, JR; Cates, GD; Berr, SS; Bryant, RG; Daniel, TM; de Lange, EE; Downs, JH; Erickson, CJ; Happer, W; Hinton, DP; Kassel, NF; Maier, T; Phillips, CD; Saam, BT; Sauer, KL; Wagshul, ME, MR imaging and spectroscopy using hyperpolarized 129Xe gas: preliminary human results., Magnetic Resonance in Medicine, vol 37 no. 6 (1997), pp. 809-815 [abs].
  • MacFall, JR; Charles, HC; Black, RD; Middleton, H; Swartz, JC; Saam, B; Driehuys, B; Erickson, C; Happer, W; Cates, GD; Johnson, GA; Ravin, CE, Human lung air spaces: potential for MR imaging with hyperpolarized He-3., Radiology, vol 200 no. 2 (1996), pp. 553-558 [10.1148/radiology.200.2.8685356] [abs].
  • Black, RD; Middleton, HL; Cates, GD; Cofer, GP; Driehuys, B; Happer, W; Hedlund, LW; Johnson, GA; Shattuck, MD; Swartz, JC, In vivo He-3 MR images of guinea pig lungs., Radiology, vol 199 no. 3 (1996), pp. 867-870 [10.1148/radiology.199.3.8638019] [abs].
  • Driehuys, B; Cates, GD; Miron, E; Sauer, K; Walter, DK; Happer, W, High-volume production of laser-polarized 129Xe, Applied Physics Letters, vol 69 no. 12 (1996), pp. 1668-1670 [abs].
  • Driehuys, B; Cates, GD; Happer, W, Surface relaxation mechanisms of laser-polarized 129Xe., Physical Review Letters, vol 74 no. 24 (1995), pp. 4943-4946 [10.1103/PhysRevLett.74.4943] [abs].
  • Albert, MS; Cates, GD; Driehuys, B; Happer, W; Saam, B; Springer, CS; Wishnia, A, Biological magnetic resonance imaging using laser-polarized 129Xe., Nature, vol 370 no. 6486 (1994), pp. 199-201 [10.1038/370199a0] [abs].
  • Gatzke, M; Cates, GD; Driehuys, B; Fox, D; Happer, W; Saam, B, Extraordinarily slow nuclear spin relaxation in frozen laser-polarized 129Xe., Physical Review Letters, vol 70 no. 5 (1993), pp. 690-693 [10.1103/PhysRevLett.70.690] [abs].