George A. Truskey

R. Eugene and Susie E. Goodson Distinguished Professor of Biomedical Engineering

My research interests focus upon the effect of physical forces on the function of vascular cells and skeletal muscle, cell adhesion, and the design of engineered tissues.  Current research projects examine the  effect of endothelial cell senescence upon permeability to macromolecules and the response to fluid shear stress, the development of microphysiological blood vessels and muscles for evaluation of drug toxicity and the design of engineered endothelialized blood vessels and skeletal muscle bundles.

Appointments and Affiliations

  • R. Eugene and Susie E. Goodson Distinguished Professor of Biomedical Engineering
  • Professor of Biomedical Engineering
  • Affiliate of the Duke Regeneration Center
  • Affiliate of the Duke Initiative for Science & Society

Contact Information

  • Office Location: 1395 Fciemas, 101 Science Drive, Durham, NC 27708-0281
  • Office Phone: (919) 660-5147
  • Email Address: george.truskey@duke.edu
  • Websites:

Education

  • B.S.E. University of Pennsylvania, 1979
  • Ph.D. Massachusetts Institute of Technology, 1985

Research Interests

Cardiovascular tissue engineering, mechanisms of atherogenesis, cell adhesion, and cell biomechanics.

Courses Taught

  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493-1: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 566: Transport Phenomena in Cells and Organs (GE, MC)
  • BME 590: Special Topics in Biomedical Engineering
  • BME 791: Graduate Independent Study
  • BME 792: Continuation of Graduate Independent Study
  • EGR 393: Research Projects in Engineering

In the News

Representative Publications

  • Covert, Lauren T., Hailee Patel, Alaa Osman, Lavonia Duncan, Jeffrey Dvergsten, and George A. Truskey. “Effect of type I interferon on engineered pediatric skeletal muscle: a promising model for juvenile dermatomyositis.” Rheumatology (Oxford, England) 63, no. 1 (January 2024): 209–17. https://doi.org/10.1093/rheumatology/kead186.
  • Lee, Jounghyun H., Kevin L. Shores, Jason J. Breithaupt, Caleb S. Lee, Daniella M. Fodera, Jennifer B. Kwon, Adarsh R. Ettyreddy, et al. “PCSK9 activation promotes early atherosclerosis in a vascular microphysiological system.” APL Bioengineering 7, no. 4 (December 2023): 046103. https://doi.org/10.1063/5.0167440.
  • Truskey, George A. “The Potential of Deep Learning to Advance Clinical Applications of Computational Biomechanics.” Bioengineering (Basel, Switzerland) 10, no. 9 (September 2023): 1066. https://doi.org/10.3390/bioengineering10091066.
  • Zhang, Qiao, Ren-Zhi Zhan, Marisa Patsy, Binjie Li, Yifan Chen, Barbara D. Lipes, Nenad Bursac, and George A. Truskey. “Differential Response of Engineered Human Cardiac Tissues to Delta and Omicron COVID-19 Virus.” J Am Heart Assoc 12, no. 12 (June 20, 2023): e029390. https://doi.org/10.1161/JAHA.123.029390.
  • Abutaleb, Nadia O., Leigh Atchison, Leandro Choi, Akhil Bedapudi, Kevin Shores, Yantenew Gete, Kan Cao, and George A. Truskey. “Lonafarnib and everolimus reduce pathology in iPSC-derived tissue engineered blood vessel model of Hutchinson-Gilford Progeria Syndrome.” Scientific Reports 13, no. 1 (March 2023): 5032. https://doi.org/10.1038/s41598-023-32035-3.