Lingchong You
Professor of Biomedical Engineering
Dr. You's research interest focus on computational systems biology & synthetic biology, including mathematical modeling of cellular networks; mechanisms of information processing by gene networks; design, modeling and construction of robust gene networks for applications in engineering and medicine.
Appointments and Affiliations
- Professor of Biomedical Engineering
- Associate Professor in Molecular Genetics and Microbiology
Contact Information
- Office Location: 2355 CIEMAS, 101 Science Drive, Durham, NC 27708
- Office Phone: (919) 660-8408
- Websites:
Education
- Ph.D. University of Wisconsin at Madison, 2002
- M.S. University of Science and Technology of China (China), 1997
- B.S.E. Chengdu University of Science and Technology (China), 1994
Research Interests
Computational systems biology & synthetic biology, including mathematical modeling of cellular networks; mechanisms of information processing by gene networks; design, modeling and construction of robust gene networks for applications in engineering and medicine.
Awards, Honors, and Distinctions
- Faculty Early Career Development (CAREER) Program. National Science Foundation. 2010
- Fellowships for Science and Engineering. David and Lucile Packard Foundation. 2006
Courses Taught
- BME 260L: Modeling Cellular and Molecular Systems
- BME 394: Projects in Biomedical Engineering (GE)
- BME 493: Projects in Biomedical Engineering (GE)
- BME 494: Projects in Biomedical Engineering (GE)
- BME 574: Modeling and Engineering Gene Circuits (GE, MC)
- BME 590: Special Topics in Biomedical Engineering
- BME 791: Graduate Independent Study
- BME 792: Continuation of Graduate Independent Study
- COMPSCI 391: Independent Study
- COMPSCI 394: Research Independent Study
- EGR 393: Research Projects in Engineering
- ISS 391: Bass Connections in Information Science and Culture: Independent Study Project
- MGM 293: Research Independent Study I
- MGM 593: Research Independent Study
- PHARM 394: Research Independent Study
- PHARM 493: Research Independent Study
In the News
- Machine Learning Is Providing New Insights When the Biology Is Too Complex for Traditional Research (Oct 3, 2019 | Pratt School of Engineering)
- Distinguishing Resistance from Resilience to Prolong Antibiotic Potency (Dec 5, 2018 | Pratt School of Engineering)
- New Tool Tells Bioengineers When to Build Microbial Teams (Feb 21, 2018 | Pratt School of Engineering)
- Where Are All the Germs? Students Explore Duke's Microbiome (Dec 7, 2017 | Center for Genomic and Computational Biology)
- Lingchong You: Tales of the genetically altered, superhero bacteria swarmbot (May 2, 2016 | WFDD-Winston-Salem’s “SciWorks Radio”)
- Time Cues Help Keep Humans Looking Human (Apr 25, 2016)
- Antibiotics Don't Promote Swapping of Resistance Genes (Apr 11, 2016)
- Biologists turn bacteria into 'swarmbots' (Mar 2, 2016 | Gizmodo)
- Bioengineers Design 'Swarmbot' Cells That Die If They Leave the Confines of Their Capsule (Feb 29, 2016)
- Why Do Dividing Cells End Up the Same Size? (Jun 4, 2015)
- Lingchong You comments: Paper test can detect Ebola strains (Oct 27, 2014 | BBC News)
- Dispersal Patterns Key to Invasive Species' Success (Jan 21, 2014)
- Chinese-Americans protest Kimmel skit in front of ABC station in downtown Raleigh (Nov 11, 2013 | The News & Observer)
- Growing Bacteria Keep Time, Know Their Place (Oct 8, 2013)
Representative Publications
- Dai, Z; Lee, AJ; Roberts, S; Sysoeva, TA; Huang, S; Dzuricky, M; Yang, X; Zhang, X; Liu, Z; Chilkoti, A; You, L, Versatile biomanufacturing through stimulus-responsive cell-material feedback., Nature Chemical Biology, vol 15 no. 10 (2019), pp. 1017-1024 [10.1038/s41589-019-0357-8] [abs].
- Wang, S; Fan, K; Luo, N; Cao, Y; Wu, F; Zhang, C; Heller, KA; You, L, Massive computational acceleration by using neural networks to emulate mechanism-based biological models., Nature Communications, vol 10 no. 1 (2019) [10.1038/s41467-019-12342-y] [abs].
- Ma, HR; You, L, Polar-opposite fates., Nature Chemical Biology, vol 15 no. 9 (2019), pp. 850-852 [10.1038/s41589-019-0337-z] [abs].
- Meredith, HR; Andreani, V; Ma, HR; Lopatkin, AJ; Lee, AJ; Anderson, DJ; Batt, G; You, L, Applying ecological resistance and resilience to dissect bacterial antibiotic responses., Science Advances, vol 4 no. 12 (2018) [10.1126/sciadv.aau1873] [abs].
- Dong, P; Maddali, MV; Srimani, JK; Thélot, F; Nevins, JR; Mathey-Prevot, B; You, L, Author Correction: Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control., Nature Communications, vol 9 no. 1 (2018) [10.1038/s41467-018-07169-y] [abs].