Lingchong You

James L. Meriam Distinguished Professor of Biomedical Engineering

The You lab uses a combination of mathematical modeling, machine learning, and quantitative experiments to elucidate principles underlying the dynamics of microbial communities in time and space and to control these dynamics for applications in computation, engineering, and medicine.

Appointments and Affiliations

  • Professor of Biomedical Engineering
  • James L. Meriam Distinguished Professor of Biomedical Engineering
  • Professor in Molecular Genetics and Microbiology

Contact Information

Education

  • B.S.E. Chengdu University of Science and Technology (China), 1994
  • M.S. University of Science and Technology of China (China), 1997
  • Ph.D. University of Wisconsin - Madison, 2002

Research Interests

Quantitative biology, synthetic biology, machine learning, antibiotic resistance, microbiome

Courses Taught

  • BIOLOGY 293-1: Research Independent Study
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 574: Modeling and Engineering Gene Circuits (GE, MC)
  • BME 590: Special Topics in Biomedical Engineering
  • BME 713S: QBio Seminar Series
  • BME 791: Graduate Independent Study
  • BME 792: Continuation of Graduate Independent Study
  • CBB 574: Modeling and Engineering Gene Circuits (GE, MC)
  • EGR 393: Research Projects in Engineering
  • MGM 593: Research Independent Study
  • PHARM 394: Research Independent Study

In the News

Representative Publications

  • Luo, Nan, Jia Lu, Emrah Şimşek, Anita Silver, Yi Yao, Xiaoyi Ouyang, Stuart A. West, and Lingchong You. “The collapse of cooperation during range expansion of Pseudomonas aeruginosa.” Nature Microbiology, March 2024. https://doi.org/10.1038/s41564-024-01627-8.
  • Maddamsetti, Rohan, Yi Yao, Teng Wang, Junheng Gao, Vincent T. Huang, Grayson S. Hamrick, Hye-In Son, and Lingchong You. “Duplicated antibiotic resistance genes reveal ongoing selection and horizontal gene transfer in bacteria.” Nature Communications 15, no. 1 (February 2024): 1449. https://doi.org/10.1038/s41467-024-45638-9.
  • Baig, Yasa, Helena R. Ma, Helen Xu, and Lingchong You. “Autoencoder neural networks enable low dimensional structure analyses of microbial growth dynamics.” Nature Communications 14, no. 1 (December 2023): 7937. https://doi.org/10.1038/s41467-023-43455-0.
  • Weiss, Andrea, Teng Wang, and Lingchong You. “Promotion of plasmid maintenance by heterogeneous partitioning of microbial communities.” Cell Systems 14, no. 10 (October 2023): 895-905.e5. https://doi.org/10.1016/j.cels.2023.09.002.
  • Kim, K., T. Wang, H. R. Ma, E. Şimşek, B. Li, V. Andreani, and L. You. “Mapping single-cell responses to population-level dynamics during antibiotic treatment.” Molecular Systems Biology 19, no. 7 (July 11, 2023). https://doi.org/10.15252/msb.202211475.