James L. Meriam Distinguished Professor of Biomedical Engineering
The You lab uses a combination of mathematical modeling, machine learning, and quantitative experiments to elucidate principles underlying the dynamics of microbial communities in time and space and to control these dynamics for applications in computation, engineering, and medicine.
Appointments and Affiliations
- Professor of Biomedical Engineering
- James L. Meriam Distinguished Professor of Biomedical Engineering
- Associate Professor in Molecular Genetics and Microbiology
- Professor in Molecular Genetics and Microbiology
Contact Information
- Office Location: 1381 CIEMAS, 101 Science Drive, Durham, NC 27708
- Office Phone: (919) 660-8408
- Websites:
Education
- B.S.E. Chengdu University of Science and Technology (China), 1994
- M.S. University of Science and Technology of China (China), 1997
- Ph.D. University of Wisconsin - Madison, 2002
Research Interests
Quantitative biology, synthetic biology, machine learning, antibiotic resistance, microbiomeCourses Taught
- BIOLOGY 293-1: Research Independent Study
- BME 394: Projects in Biomedical Engineering (GE)
- BME 493: Projects in Biomedical Engineering (GE)
- BME 494: Projects in Biomedical Engineering (GE)
- BME 574: Modeling and Engineering Gene Circuits (GE, MC)
- BME 791: Graduate Independent Study
- BME 792: Continuation of Graduate Independent Study
- CBB 574: Modeling and Engineering Gene Circuits (GE, MC)
- EGR 393: Research Projects in Engineering
- MGM 293: Research Independent Study I
- MGM 593: Research Independent Study
- PHARM 394: Research Independent Study
In the News
- Synthetic Compartments Stop Pathogens from Sharing Antibiotic Resistance Genes …
- A Bacterial Message: ‘Be Sure to Drink Your Ovaltine’ (Sep 28, 2022 | Pratt Sch…
- University Awards 24 New Distinguished Professorships (May 18, 2022)
- Tiny Jumping Genes Fingered as Culprit in Rise of Antibiotic Resistance (Apr 6,…
- The Surprising Structural Reason Your Kitchen Sponge is Disgusting (Feb 17, 202…
- Study Shows Some Bacteria Are Better Able to Share Resistance With Peers Than W…
- Machine Learning Is Providing New Insights When the Biology Is Too Complex for …
- Distinguishing Resistance from Resilience to Prolong Antibiotic Potency (Dec 5,…
- Where Are All the Germs? Students Explore Duke's Microbiome (Dec 7, 2017 | Cent…
- Lingchong You: Tales of the genetically altered, superhero bacteria swarmbot (M…
- Biologists turn bacteria into 'swarmbots' (Mar 2, 2016 | Gizmodo)
- Engineered Swarmbots Rely on Peers for Survival (Feb 29, 2016 | Pratt School of…
- How Dividing Cells End Up the Same Size (Jun 4, 2015 | Pratt School of Engineer…
- Lingchong You comments: Paper test can detect Ebola strains (Oct 27, 2014 | BBC…
- Chinese-Americans protest Kimmel skit in front of ABC station in downtown Ralei…
- Growing Bacteria Keep Time, Know Their Place (Oct 8, 2013)
Representative Publications
- Şimşek, Emrah, Yi Yao, Dongheon Lee, and Lingchong You. “Toward predictive engineering of gene circuits.” Trends in Biotechnology 41, no. 6 (June 2023): 760–68. https://doi.org/10.1016/j.tibtech.2022.11.001.
- Silver, Anita, and Lingchong You. “A change of phase.” Nature Chemical Biology 19, no. 4 (April 2023): 397–98. https://doi.org/10.1038/s41589-022-01209-x.
- Dai, Yifan, Mina Farag, Dongheon Lee, Xiangze Zeng, Kyeri Kim, Hye-In Son, Xiao Guo, et al. “Programmable synthetic biomolecular condensates for cellular control.” Nature Chemical Biology 19, no. 4 (April 2023): 518–28. https://doi.org/10.1038/s41589-022-01252-8.
- Bethke, Jonathan H., Helena R. Ma, Ryan Tsoi, Li Cheng, Minfeng Xiao, and Lingchong You. “Vertical and horizontal gene transfer tradeoffs direct plasmid fitness.” Molecular Systems Biology 19, no. 2 (February 2023): e11300. https://doi.org/10.15252/msb.202211300.
- Kim, K., T. Wang, H. R. Ma, E. Şimşek, B. Li, V. Andreani, and L. You. “Mapping single-cell responses to population-level dynamics during antibiotic treatment.” Molecular Systems Biology, January 1, 2023. https://doi.org/10.15252/msb.202211475.