Lingchong You

Professor of Biomedical Engineering

The You lab uses a combination of mathematical modeling, machine learning, and quantitative experiments to elucidate principles underlying the dynamics of microbial communities in time and space and to control these dynamics for applications in computation, engineering, and medicine.

Appointments and Affiliations

  • Professor of Biomedical Engineering
  • James L. Meriam Distinguished Professor of Biomedical Engineering
  • Associate Professor in Molecular Genetics and Microbiology
  • Professor in Molecular Genetics and Microbiology

Contact Information

Education

  • B.S.E. Chengdu University of Science and Technology (China), 1994
  • M.S. University of Science and Technology of China (China), 1997
  • Ph.D. University of Wisconsin - Madison, 2002

Research Interests

Quantitative biology, synthetic biology, machine learning, antibiotic resistance, microbiome

Courses Taught

  • BIOLOGY 293-1: Research Independent Study
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 574: Modeling and Engineering Gene Circuits (GE, MC)
  • BME 791: Graduate Independent Study
  • CBB 574: Modeling and Engineering Gene Circuits (GE, MC)
  • EGR 393: Research Projects in Engineering
  • MGM 293: Research Independent Study I
  • MGM 593: Research Independent Study
  • PHARM 394: Research Independent Study

In the News

Representative Publications

  • Silver, Anita, and Lingchong You. “A change of phase.” Nature Chemical Biology, December 2022. https://doi.org/10.1038/s41589-022-01209-x.
  • Bethke, Jonathan H., Helena R. Ma, Ryan Tsoi, Li Cheng, Minfeng Xiao, and Lingchong You. “Vertical and horizontal gene transfer tradeoffs direct plasmid fitness.” Molecular Systems Biology, December 2022, e11300. https://doi.org/10.15252/msb.202211300.
  • Wang, Teng, Andrea Weiss, Ammara Aqeel, Feilun Wu, Allison J. Lopatkin, Lawrence A. David, and Lingchong You. “Horizontal gene transfer enables programmable gene stability in synthetic microbiota.” Nat Chem Biol 18, no. 11 (November 2022): 1245–52. https://doi.org/10.1038/s41589-022-01114-3.
  • Şimşek, Emrah, Yi Yao, Dongheon Lee, and Lingchong You. “Toward predictive engineering of gene circuits.” Trends in Biotechnology, November 2022, S0167-7799(22)00298-0. https://doi.org/10.1016/j.tibtech.2022.11.001.
  • Lu, Jia, Ryan Tsoi, Nan Luo, Yuanchi Ha, Shangying Wang, Minjun Kwak, Yasa Baig, et al. “Distributed information encoding and decoding using self-organized spatial patterns.” Patterns (New York, N.Y.) 3, no. 10 (October 2022): 100590. https://doi.org/10.1016/j.patter.2022.100590.