Lingchong You

James L. Meriam Distinguished Professor of Biomedical Engineering

The You lab uses a combination of mathematical modeling, machine learning, and quantitative experiments to elucidate principles underlying the dynamics of microbial communities in time and space and to control these dynamics for applications in computation, engineering, and medicine.

Appointments and Affiliations

  • Professor of Biomedical Engineering
  • James L. Meriam Distinguished Professor of Biomedical Engineering
  • Associate Professor in Molecular Genetics and Microbiology
  • Professor in Molecular Genetics and Microbiology

Contact Information

Education

  • B.S.E. Chengdu University of Science and Technology (China), 1994
  • M.S. University of Science and Technology of China (China), 1997
  • Ph.D. University of Wisconsin - Madison, 2002

Research Interests

Quantitative biology, synthetic biology, machine learning, antibiotic resistance, microbiome

Courses Taught

  • BIOLOGY 293-1: Research Independent Study
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 574: Modeling and Engineering Gene Circuits (GE, MC)
  • BME 791: Graduate Independent Study
  • BME 792: Continuation of Graduate Independent Study
  • CBB 574: Modeling and Engineering Gene Circuits (GE, MC)
  • EGR 393: Research Projects in Engineering
  • MGM 293: Research Independent Study I
  • MGM 593: Research Independent Study
  • PHARM 394: Research Independent Study

In the News

Representative Publications

  • Şimşek, Emrah, Yi Yao, Dongheon Lee, and Lingchong You. “Toward predictive engineering of gene circuits.” Trends in Biotechnology 41, no. 6 (June 2023): 760–68. https://doi.org/10.1016/j.tibtech.2022.11.001.
  • Silver, Anita, and Lingchong You. “A change of phase.” Nature Chemical Biology 19, no. 4 (April 2023): 397–98. https://doi.org/10.1038/s41589-022-01209-x.
  • Dai, Yifan, Mina Farag, Dongheon Lee, Xiangze Zeng, Kyeri Kim, Hye-In Son, Xiao Guo, et al. “Programmable synthetic biomolecular condensates for cellular control.” Nature Chemical Biology 19, no. 4 (April 2023): 518–28. https://doi.org/10.1038/s41589-022-01252-8.
  • Bethke, Jonathan H., Helena R. Ma, Ryan Tsoi, Li Cheng, Minfeng Xiao, and Lingchong You. “Vertical and horizontal gene transfer tradeoffs direct plasmid fitness.” Molecular Systems Biology 19, no. 2 (February 2023): e11300. https://doi.org/10.15252/msb.202211300.
  • Kim, K., T. Wang, H. R. Ma, E. Şimşek, B. Li, V. Andreani, and L. You. “Mapping single-cell responses to population-level dynamics during antibiotic treatment.” Molecular Systems Biology, January 1, 2023. https://doi.org/10.15252/msb.202211475.