Timothy E Reddy

Reddy

Associate Professor of Biostatistics & Bioinformatics

Appointments and Affiliations

  • Associate Professor of Biostatistics & Bioinformatics
  • Associate Professor in Molecular Genetics and Microbiology

Contact Information

  • Office Location: 101 Science Drive, 2347 Ciemas, Duke Box 3382, Durham, NC 27708
  • Office Phone: (919) 564-9536
  • Email Address: tim.reddy@duke.edu
  • Websites:

Education

  • Ph.D. Boston University, 2007

Research Interests

Understanding how genetic variation that alters gene regulation contributes to human traits, including risk for common diseases such as diabetes. The Reddy Lab uses an interdisciplinary combination of high-throughput genomics, computational biology, and traditional molecular biology and genetics experiments. We hope that, through our research, we can better understand the gene-regulatory bases for human evolution and human disease. Those findings will likely reveal new pathways of disease that can ultimately be targeted for novel diagnostics and treatment.

Courses Taught

  • CBB 510S: Computational Biology Seminar
  • CBB 511: Journal Club
  • CBB 591: Independent Study
  • CBB 700: Internship

In the News

Representative Publications

  • Kadur Lakshminarasimha Murthy, P; Xi, R; Arguijo, D; Everitt, JI; Kocak, DD; Kobayashi, Y; Bozec, A; Vicent, S; Ding, S; Crawford, GE; Hsu, D; Tata, PR; Reddy, T; Shen, X, Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity., Dev Cell, vol 57 no. 3 (2022), pp. 310-328.e9 [10.1016/j.devcel.2022.01.006] [abs].
  • Kabadi, AM; Machlin, L; Dalal, N; Lee, RE; McDowell, I; Shah, NN; Drowley, L; Randell, SH; Reddy, TE, Epigenome editing of the CFTR-locus for treatment of cystic fibrosis., J Cyst Fibros, vol 21 no. 1 (2022), pp. 164-171 [10.1016/j.jcf.2021.04.008] [abs].
  • Miller, DE; Sulovari, A; Wang, T; Loucks, H; Hoekzema, K; Munson, KM; Lewis, AP; Fuerte, EPA; Paschal, CR; Walsh, T; Thies, J; Bennett, JT; Glass, I; Dipple, KM; Patterson, K; Bonkowski, ES; Nelson, Z; Squire, A; Sikes, M; Beckman, E; Bennett, RL; Earl, D; Lee, W; Allikmets, R; Perlman, SJ; Chow, P; Hing, AV; Wenger, TL; Adam, MP; Sun, A; Lam, C; Chang, I; Zou, X; Austin, SL; Huggins, E; Safi, A; Iyengar, AK; Reddy, TE; Majoros, WH; Allen, AS; Crawford, GE; Kishnani, PS; University of Washington Center for Mendelian Genomics, ; King, M-C; Cherry, T; Chong, JX; Bamshad, MJ; Nickerson, DA; Mefford, HC; Doherty, D; Eichler, EE, Targeted long-read sequencing identifies missing disease-causing variation., Am J Hum Genet, vol 108 no. 8 (2021), pp. 1436-1449 [10.1016/j.ajhg.2021.06.006] [abs].
  • Gemberling, MP; Siklenka, K; Rodriguez, E; Tonn-Eisinger, KR; Barrera, A; Liu, F; Kantor, A; Li, L; Cigliola, V; Hazlett, MF; Williams, CA; Bartelt, LC; Madigan, VJ; Bodle, JC; Daniels, H; Rouse, DC; Hilton, IB; Asokan, A; Ciofani, M; Poss, KD; Reddy, TE; West, AE; Gersbach, CA, Transgenic mice for in vivo epigenome editing with CRISPR-based systems., Nat Methods, vol 18 no. 8 (2021), pp. 965-974 [10.1038/s41592-021-01207-2] [abs].
  • Prekovic, S; Schuurman, K; Mayayo-Peralta, I; Manjón, AG; Buijs, M; Yavuz, S; Wellenstein, MD; Barrera, A; Monkhorst, K; Huber, A; Morris, B; Lieftink, C; Chalkiadakis, T; Alkan, F; Silva, J; Győrffy, B; Hoekman, L; van den Broek, B; Teunissen, H; Debets, DO; Severson, T; Jonkers, J; Reddy, T; de Visser, KE; Faller, W; Beijersbergen, R; Altelaar, M; de Wit, E; Medema, R; Zwart, W, Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer., Nature Communications, vol 12 no. 1 (2021) [10.1038/s41467-021-24537-3] [abs].