Timothy E Reddy

Reddy

Associate Professor of Biostatistics & Bioinformatics

Appointments and Affiliations

  • Associate Professor of Biostatistics & Bioinformatics
  • Associate Professor in Molecular Genetics and Microbiology

Contact Information

  • Office Location: 101 Science Drive, 2347 Ciemas, Duke Box 3382, Durham, NC 27708
  • Office Phone: (919) 564-9536
  • Email Address: tim.reddy@duke.edu
  • Websites:

Education

  • Ph.D. Boston University, 2007

Research Interests

Understanding how genetic variation that alters gene regulation contributes to human traits, including risk for common diseases such as diabetes. The Reddy Lab uses an interdisciplinary combination of high-throughput genomics, computational biology, and traditional molecular biology and genetics experiments. We hope that, through our research, we can better understand the gene-regulatory bases for human evolution and human disease. Those findings will likely reveal new pathways of disease that can ultimately be targeted for novel diagnostics and treatment.

Courses Taught

  • BIOLOGY 728E: University Program in Genetics and Genomics Biological Solutions Module V
  • BIOLOGY 728F: University Program in Genetics and Genomics Biological Solutions Module VI
  • CBB 511: Journal Club
  • CBB 591: Independent Study
  • CBB 700: Internship
  • CMB 778E: University Program in Genetics and Genomics Biological Solutions Module V
  • CMB 778F: University Program in Genetics and Genomics Biological Solutions Module VI
  • MGM 778E: University Program in Genetics and Genomics Biological Solutions Module V
  • MGM 778F: University Program in Genetics and Genomics Biological Solutions Module VI
  • UPGEN 778E: University Program in Genetics and Genomics Biological Solutions Module V
  • UPGEN 778F: University Program in Genetics and Genomics Biological Solutions Module VI

In the News

Representative Publications

  • Lea, AJ; Vockley, CM; Johnston, RA; Del Carpio, CA; Barreiro, LB; Reddy, TE; Tung, J, Genome-wide quantification of the effects of DNA methylation on human gene regulation., Elife, vol 7 (2018) [10.7554/eLife.37513] [abs].
  • Johnson, GD; Barrera, A; McDowell, IC; D'Ippolito, AM; Majoros, WH; Vockley, CM; Wang, X; Allen, AS; Reddy, TE, Human genome-wide measurement of drug-responsive regulatory activity., Nature Communications, vol 9 no. 1 (2018) [10.1038/s41467-018-07607-x] [abs].
  • McDowell, IC; Barrera, A; D'Ippolito, AM; Vockley, CM; Hong, LK; Leichter, SM; Bartelt, LC; Majoros, WH; Song, L; Safi, A; Ko├žak, DD; Gersbach, CA; Hartemink, AJ; Crawford, GE; Engelhardt, BE; Reddy, TE, Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding., Genome Res, vol 28 no. 9 (2018), pp. 1272-1284 [10.1101/gr.233346.117] [abs].
  • Bryois, J; Garrett, ME; Song, L; Safi, A; Giusti-Rodriguez, P; Johnson, GD; Shieh, AW; Buil, A; Fullard, JF; Roussos, P; Sklar, P; Akbarian, S; Haroutunian, V; Stockmeier, CA; Wray, GA; White, KP; Liu, C; Reddy, TE; Ashley-Koch, A; Sullivan, PF; Crawford, GE, Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia., Nature Communications, vol 9 no. 1 (2018) [10.1038/s41467-018-05379-y] [abs].
  • D'Ippolito, AM; McDowell, IC; Barrera, A; Hong, LK; Leichter, SM; Bartelt, LC; Vockley, CM; Majoros, WH; Safi, A; Song, L; Gersbach, CA; Crawford, GE; Reddy, TE, Pre-established Chromatin Interactions Mediate the Genomic Response to Glucocorticoids., Cell Systems, vol 7 no. 2 (2018), pp. 146-160.e7 [10.1016/j.cels.2018.06.007] [abs].