Brian T Crouch

Assistant Research Professor in the Department of Biomedical Engineering

Dr. Crouch is an Assistant Research Professor in the Department of Biomedical Engineering and the Assistant Director of Research for the Center for Global Women's Health Technologies (GWHT). Dr. Crouch’s research interests intersect oncology, translational research, and global health, with a particular focus on diagnostics and therapeutics in low-resource settings. He is an expert in translating diagnostic technologies from the bench to bedside using in vitro cell culture and cell-based assays, small animal models, fluorescence microscopy, image processing, machine learning, and clinical trial design.

Appointments and Affiliations

  • Assistant Research Professor in the Department of Biomedical Engineering

Contact Information

  • Office Location: 140 Science Drive, 373 Gross Hall, Durham, NC 27708
  • Office Phone: +1 919 660 5249
  • Email Address: brian.crouch@duke.edu

Education

  • Ph.D. Duke University, 2018

Research Interests

Developing novel, low cost technologies for cancer diagnostics and therapeutics with applications in resource limited settings. Particular focus on innovative strategies to induce a robust anti-tumor immune response following ablative therapy.

Courses Taught

  • GLHLTH 796T: Bass Connections Global Health Research Team
  • GLHLTH 795T: Bass Connections Global Health Research Team
  • GLHLTH 396T: Bass Connections Global Health Research Team
  • GLHLTH 395T: Bass Connections Global Health Research Team
  • EGR 491: Projects in Engineering
  • EGR 393: Research Projects in Engineering
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)

Representative Publications

  • Adhikari, Gatha, Venkata Polavarapu Sarojasamhita, Vene Richardson Powell, Asma Farooqui, Maya Budzinski, David T. Garvey, Jeffrey Yang, et al. “Impact of Injection-Based Delivery Parameters on Local Distribution Volume of Ethyl-Cellulose Ethanol Gel in Tissue and Tissue Mimicking Phantoms.” IEEE Transactions on Bio-Medical Engineering 71, no. 5 (May 2024): 1488–98. https://doi.org/10.1109/tbme.2023.3340613.
  • Sunassee, Enakshi D., Riley J. Deutsch, Victoria W. D’Agostino, Pol Castellano-Escuder, Elizabeth A. Siebeneck, Olga Ilkayeva, Brian T. Crouch, et al. “Optical imaging reveals chemotherapy-induced metabolic reprogramming of residual disease and recurrence.” Sci Adv 10, no. 14 (April 5, 2024): eadj7540. https://doi.org/10.1126/sciadv.adj7540.
  • Chelales, Erika, Katriana von Windheim, Arshbir Singh Banipal, Elizabeth Siebeneck, Claire Benham, Corrine A. Nief, Brian Crouch, et al. “Determining the Relationship between Delivery Parameters and Ablation Distribution for Novel Gel Ethanol Percutaneous Therapy in Ex Vivo Swine Liver.” Polymers (Basel) 16, no. 7 (April 5, 2024). https://doi.org/10.3390/polym16070997.
  • Quang, Tri T., Jeffrey Yang, Michele L. Kaluzienski, Anna Parrish, Asma Farooqui, David Katz, Brian Crouch, Nimmi Ramanujam, and Jenna L. Mueller. “In Vivo Evaluation of Safety and Efficacy of Ethyl Cellulose-Ethanol Tissue Ablation in a Swine Cervix Model.” Bioengineering (Basel, Switzerland) 10, no. 11 (October 2023): 1246. https://doi.org/10.3390/bioengineering10111246.
  • Madonna, Megan C., Douglas B. Fox, Brian T. Crouch, Jihong Lee, Caigang Zhu, Amy F. Martinez, James V. Alvarez, and Nirmala Ramanujam. “Data from Optical Imaging of Glucose Uptake and Mitochondrial Membrane Potential to Characterize Her2 Breast Tumor Metabolic Phenotypes,” April 3, 2023. https://doi.org/10.1158/1541-7786.c.6541071.v1.