Louis Edwin DeFrate

Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery

Appointments and Affiliations

  • Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery
  • Professor in Orthopaedic Surgery
  • Professor in the Department of Biomedical Engineering
  • Affiliate of the Duke Regeneration Center

Contact Information


  • Sc.D. Massachusetts Institute of Technology, 2005

Courses Taught

  • EGR 393: Research Projects in Engineering
  • BME 792: Continuation of Graduate Independent Study
  • BME 791: Graduate Independent Study
  • BME 493: Projects in Biomedical Engineering (GE)

In the News

Representative Publications

  • Zhao, Qi, Abigail Holt, Charles E. Spritzer, Louis E. DeFrate, Amy L. McNulty, and Nian Wang. “High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging.” Quant Imaging Med Surg 14, no. 4 (April 3, 2024): 2738–46. https://doi.org/10.21037/qims-23-1355.
  • Heckelman, Lauren N., Avery L. Kratzer, Charles E. Spritzer, Brian J. Soher, Brian D. Lewis, and Louis E. DeFrate. “Influence of running on femoroacetabular joint bone-to-bone distances.” J Orthop Res 42, no. 4 (April 2024): 837–42. https://doi.org/10.1002/jor.25735.
  • Coppock, James A., Amy L. McNulty, Kathryn N. Porter Starr, Abigail G. Holt, Michael S. Borack, Andrzej S. Kosinski, Amber T. Collins, Connie W. Bales, and Louis E. DeFrate. “The effects of a 6-month weight loss intervention on physical function and serum biomarkers in older adults with and without osteoarthritis.” Osteoarthr Cartil Open 5, no. 3 (September 2023): 100376. https://doi.org/10.1016/j.ocarto.2023.100376.
  • Coppock, James A., Nicole E. Zimmer, Charles E. Spritzer, Adam P. Goode, and Louis E. DeFrate. “Automated segmentation and prediction of intervertebral disc morphology and uniaxial deformations from MRI.” Osteoarthr Cartil Open 5, no. 3 (September 2023): 100378. https://doi.org/10.1016/j.ocarto.2023.100378.
  • Kim-Wang, Sophia Y., Charles E. Spritzer, Kwadwo Owusu-Akyaw, James A. Coppock, Adam P. Goode, Zoë A. Englander, Jocelyn R. Wittstein, and Louis E. DeFrate. “The Predicted Position of the Knee Near the Time of ACL Rupture Is Similar Between 2 Commonly Observed Patterns of Bone Bruising on MRI: Response.” Am J Sports Med 51, no. 8 (July 2023): NP22–24. https://doi.org/10.1177/03635465231172184.