Louis Edwin DeFrate

Professor in Orthopaedic Surgery

Appointments and Affiliations

  • Professor in Orthopaedic Surgery
  • Professor in the Department of Biomedical Engineering
  • Affiliate of the Duke Regeneration Center

Contact Information


  • Sc.D. Massachusetts Institute of Technology, 2005

Courses Taught

  • BME 791: Graduate Independent Study

In the News

Representative Publications

  • Kim-Wang, Sophia Y., Patrick X. Bradley, Hattie C. Cutcliffe, Amber T. Collins, Bryan S. Crook, Chinmay S. Paranjape, Charles E. Spritzer, and Louis E. DeFrate. “Auto-segmentation of the tibia and femur from knee MR images via deep learning and its application to cartilage strain and recovery.” J Biomech 149 (March 2023): 111473. https://doi.org/10.1016/j.jbiomech.2023.111473.
  • Bradley, Patrick X., Karl N. Thomas, Avery L. Kratzer, Allison C. Robinson, Jocelyn R. Wittstein, Louis E. DeFrate, and Amy L. McNulty. “The Interplay of Biomechanical and Biological Changes Following Meniscus Injury.” Curr Rheumatol Rep 25, no. 2 (February 2023): 35–46. https://doi.org/10.1007/s11926-022-01093-3.
  • Foody, Jacqueline N., Patrick X. Bradley, Charles E. Spritzer, Jocelyn R. Wittstein, Louis E. DeFrate, and Zoë A. Englander. “Elevated In Vivo ACL Strain Is Associated With a Straight Knee in Both the Sagittal and the Coronal Planes.” Am J Sports Med 51, no. 2 (February 2023): 422–28. https://doi.org/10.1177/03635465221141876.
  • Coppock, J. A., N. E. Zimmer, Z. A. Englander, S. T. Danyluk, A. S. Kosinski, C. E. Spritzer, A. P. Goode, and L. E. DeFrate. “In vivo intervertebral disc mechanical deformation following a treadmill walking "stress test" is inversely related to T1rho relaxation time.” Osteoarthritis Cartilage 31, no. 1 (January 2023): 126–33. https://doi.org/10.1016/j.joca.2022.09.008.
  • Kim-Wang, Sophia Y., Charles E. Spritzer, Kwadwo Owusu-Akyaw, James A. Coppock, Adam P. Goode, Zoë A. Englander, Jocelyn R. Wittstein, and Louis E. DeFrate. “The Predicted Position of the Knee Near the Time of ACL Rupture Is Similar Between 2 Commonly Observed Patterns of Bone Bruising on MRI.” Am J Sports Med 51, no. 1 (January 2023): 58–65. https://doi.org/10.1177/03635465221131551.