Louis E. DeFrate


Frank H. Bassett III, M. D. Associate Professor

Appointments and Affiliations

  • Frank H. Bassett III, M. D. Associate Professor
  • Associate Professor in Orthopaedic Surgery
  • Associate Professor in the Department of Biomedical Engineering
  • Affiliate of the Regeneration Next Initiative

Contact Information


  • Sc.D. Massachusetts Institute of Technology, 2005

Awards, Honors, and Distinctions

  • Kappa Delta Young Investigator Award. American Academy of Orthopaedic Surgeons and the Orthopaedic Research Society. 2016

Courses Taught

  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 791: Graduate Independent Study
  • BME 792: Continuation of Graduate Independent Study

In the News

Representative Publications

  • DeFrate, LE; Kim-Wang, SY; Englander, ZA; McNulty, AL, Osteoarthritis year in review 2018: mechanics., Osteoarthritis Cartilage, vol 27 no. 3 (2019), pp. 392-400 [10.1016/j.joca.2018.12.011] [abs].
  • Paranjape, CS; Cutcliffe, HC; Grambow, SC; Utturkar, GM; Collins, AT; Garrett, WE; Spritzer, CE; DeFrate, LE, A New Stress Test for Knee Joint Cartilage., Scientific Reports, vol 9 no. 1 (2019) [10.1038/s41598-018-38104-2] [abs].
  • Taylor, KA; Collins, AT; Heckelman, LN; Kim, SY; Utturkar, GM; Spritzer, CE; Garrett, WE; DeFrate, LE, Activities of daily living influence tibial cartilage T1rho relaxation times., J Biomech, vol 82 (2019), pp. 228-233 [10.1016/j.jbiomech.2018.10.029] [abs].
  • Collins, AT; Hatcher, CC; Kim, SY; Ziemian, SN; Spritzer, CE; Guilak, F; DeFrate, LE; McNulty, AL, Selective Enzymatic Digestion of Proteoglycans and Collagens Alters Cartilage T1rho and T2 Relaxation Times., Ann Biomed Eng, vol 47 no. 1 (2019), pp. 190-201 [10.1007/s10439-018-02143-7] [abs].
  • Sutter, EG; Liu, B; Utturkar, GM; Widmyer, MR; Spritzer, CE; Cutcliffe, HC; Englander, ZA; Goode, AP; Garrett, WE; DeFrate, LE, Effects of Anterior Cruciate Ligament Deficiency on Tibiofemoral Cartilage Thickness and Strains in Response to Hopping., Am J Sports Med, vol 47 no. 1 (2019), pp. 96-103 [10.1177/0363546518802225] [abs].