Louis Edwin DeFrate

Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery

Appointments and Affiliations

  • Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery
  • Professor in Orthopaedic Surgery
  • Professor in the Department of Biomedical Engineering
  • Affiliate of the Duke Regeneration Center

Contact Information


  • Sc.D. Massachusetts Institute of Technology, 2005

Courses Taught

  • BME 791: Graduate Independent Study
  • BME 792: Continuation of Graduate Independent Study

In the News

Representative Publications

  • Coppock, James A., Amy L. McNulty, Kathryn N. Porter Starr, Abigail G. Holt, Michael S. Borack, Andrzej S. Kosinski, Amber T. Collins, Connie W. Bales, and Louis E. DeFrate. “The effects of a 6-month weight loss intervention on physical function and serum biomarkers in older adults with and without osteoarthritis.” Osteoarthr Cartil Open 5, no. 3 (September 2023): 100376. https://doi.org/10.1016/j.ocarto.2023.100376.
  • Coppock, James A., Nicole E. Zimmer, Charles E. Spritzer, Adam P. Goode, and Louis E. DeFrate. “Automated segmentation and prediction of intervertebral disc morphology and uniaxial deformations from MRI.” Osteoarthr Cartil Open 5, no. 3 (September 2023): 100378. https://doi.org/10.1016/j.ocarto.2023.100378.
  • Kim-Wang, Sophia Y., Charles E. Spritzer, Kwadwo Owusu-Akyaw, James A. Coppock, Adam P. Goode, Zoë A. Englander, Jocelyn R. Wittstein, and Louis E. DeFrate. “The Predicted Position of the Knee Near the Time of ACL Rupture Is Similar Between 2 Commonly Observed Patterns of Bone Bruising on MRI: Response.” Am J Sports Med 51, no. 8 (July 2023): NP22–24. https://doi.org/10.1177/03635465231172184.
  • Kim-Wang, Sophia Y., Patrick X. Bradley, Hattie C. Cutcliffe, Amber T. Collins, Bryan S. Crook, Chinmay S. Paranjape, Charles E. Spritzer, and Louis E. DeFrate. “Auto-segmentation of the tibia and femur from knee MR images via deep learning and its application to cartilage strain and recovery.” J Biomech 149 (March 2023): 111473. https://doi.org/10.1016/j.jbiomech.2023.111473.
  • Bradley, Patrick X., Karl N. Thomas, Avery L. Kratzer, Allison C. Robinson, Jocelyn R. Wittstein, Louis E. DeFrate, and Amy L. McNulty. “The Interplay of Biomechanical and Biological Changes Following Meniscus Injury.” Curr Rheumatol Rep 25, no. 2 (February 2023): 35–46. https://doi.org/10.1007/s11926-022-01093-3.