Louis E. DeFrate


Professor in Orthopaedic Surgery

Appointments and Affiliations

  • Professor in Orthopaedic Surgery
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Frank H. Bassett III, M. D. Associate Professor
  • Affiliate of the Regeneration Next Initiative

Contact Information


  • Sc.D. Massachusetts Institute of Technology, 2005

Awards, Honors, and Distinctions

  • Kappa Delta Young Investigator Award. American Academy of Orthopaedic Surgeons and the Orthopaedic Research Society. 2016

Courses Taught

  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)

In the News

Representative Publications

  • Kim-Wang, SY; Scribani, MB; Whiteside, MB; DeFrate, LE; Lassiter, TE; Wittstein, JR, Distribution of Bone Contusion Patterns in Acute Noncontact Anterior Cruciate Ligament-Torn Knees., Am J Sports Med (2021) [10.1177/0363546520981569] [abs].
  • Cutcliffe, HC; DeFrate, LE, Four-Point Bending Testing for Mechanical Assessment of Mouse Bone Structural Properties., Methods Mol Biol, vol 2230 (2021), pp. 199-215 [10.1007/978-1-0716-1028-2_12] [abs].
  • Andress, B; Kim, JH; Cutcliffe, HC; Amendola, A; Goode, AP; Varghese, S; DeFrate, LE; McNulty, AL, Meniscus cell regional phenotypes: Dedifferentiation and reversal by biomaterial embedding., J Orthop Res (2020) [10.1002/jor.24954] [abs].
  • Cutcliffe, HC; Davis, KM; Spritzer, CE; DeFrate, L, The Characteristic Recovery Time as a Novel, Noninvasive Metric for Assessing In Vivo Cartilage Mechanical Function., Ann Biomed Eng, vol 48 no. 12 (2020), pp. 2901-2910 [10.1007/s10439-020-02558-1] [abs].
  • Collins, AT; Kulvaranon, M; Spritzer, CE; McNulty, AL; DeFrate, LE, The Influence of Obesity and Meniscal Coverage on In Vivo Tibial Cartilage Thickness and Strain., Orthopaedic Journal of Sports Medicine, vol 8 no. 12 (2020) [10.1177/2325967120964468] [abs].