Louis E. DeFrate

Frank H. Bassett III, M. D. Associate Professor

Appointments and Affiliations

• Frank H. Bassett III, M. D. Associate Professor
• Associate Professor in Orthopaedic Surgery
• Associate Professor in the Department of Biomedical Engineering
• Affiliate of the Regeneration Next Initiative

Contact Information

• Office Location: Room 379, Medical Sciences Research Building, Box 3093 Med. Ctr., Durham, NC 27710
• Office Phone: (919) 681-9959
• Email Address: lou.defrate@duke.edu
• Websites:
  • Google Scholar
  • Musculoskeletal Bioengineering Laboratory

Education

• Sc.D. Massachusetts Institute of Technology, 2005

Awards, Honors, and Distinctions

• Kappa Delta Young Investigator Award. American Academy of Orthopaedic Surgeons and the Orthopaedic Research Society. 2016

Courses Taught

• BME 394: Projects in Biomedical Engineering (GE)
• BME 493: Projects in Biomedical Engineering (GE)
• BME 494: Projects in Biomedical Engineering (GE)
• BME 791: Graduate Independent Study
• BME 792: Continuation of Graduate Independent Study

In the News

• His and Her Knee Injuries Occur the Same Way (Apr 18, 2018 | US News and World Report )
• Study Shows Men and Women Tear ACL the Same Way In Non-Contact Injury (Apr 18, 2018 | Duke Health News )
• How to prevent knee injuries (Dec 1, 2017 | KSAT News )
• Knee arthritis in Americans has doubled since 1940 (Aug 17, 2017 | Science Magazine )
• Athletes: Try this to prevent ACL tears and knee injuries (Aug 10, 2017 | WRAL News )
• Clinical Sciences Day: Collaboration, Mentorship Lead to Science Successes (Oct 22, 2013 | Duke Research Blog )

Representative Publications

• Collins, AT; Hatcher, CC; Kim, SY; Ziemian, SN; Spritzer, CE; Guilak, F; DeFrate, LE; McNulty, AL, Selective Enzymatic Digestion of Proteoglycans and Collagens Alters Cartilage T1rho and T2 Relaxation Times., Annals of Biomedical Engineering (2018) [10.1007/s10439-018-02143-7] [abs].
• Englander, ZA; Martin, JT; Ganapathy, PK; Garrett, WE; DeFrate, LE, Automatic registration of MRI-based joint models to high-speed biplanar radiographs for precise quantification of in vivo anterior cruciate ligament deformation during gait., Journal of Biomechanics (2018) [10.1016/j.jbiomech.2018.09.010] [abs].
• Owusu-Akyaw, KA; Kim, SY; Spritzer, CE; Collins, AT; Englander, ZA; Utturkar, GM; Garrett, WE; DeFrate, LE, Determination of the Position of the Knee at the Time of an Anterior Cruciate Ligament Rupture for Male Versus Female Patients by an Analysis of Bone Bruises: Response., The American Journal of Sports Medicine, vol 46 no. 11 (2018), pp. NP48-NP51 [10.1177/0363546518788316] [abs].
• Zhang, H; Heckelman, LN; Spritzer, CE; Owusu-Akyaw, KA; Martin, JT; Taylor, DC; Moorman, CT; Garrigues, GE; DeFrate, LE, In Vivo Assessment of Exercise-Induced Glenohumeral Cartilage Strain., Orthopaedic Journal of Sports Medicine, vol 6 no. 7 (2018) [10.1177/2325967118784518] [abs].
• Owusu-Akyaw, KA; Kim, SY; Spritzer, CE; Collins, AT; Englander, ZA; Utturkar, GM; Garrett, WE; DeFrate, LE, Determination of the Position of the Knee at the Time of an Anterior Cruciate Ligament Rupture for Male Versus Female Patients by an Analysis of Bone Bruises., The American Journal of Sports Medicine, vol 46 no. 7 (2018), pp. 1559-1565 [10.1177/0363546518764681] [abs].