Louis E. DeFrate

Frank H. Bassett III, M. D. Associate Professor

Appointments and Affiliations

• Frank H. Bassett III, M. D. Associate Professor
• Associate Professor in Orthopaedic Surgery
• Associate Professor in the Department of Mechanical Engineering and Material Science
• Associate Professor in the Department of Biomedical Engineering
• Affiliate of the Regeneration Next Initiative

Contact Information

• Office Location: Room 379, Medical Sciences Research Building, Box 3093 Med. Ctr., Durham, NC 27710
• Office Phone: (919) 681-9959
• Email Address: lou.defrate@duke.edu
• Websites:
  • Google Scholar
  • Musculoskeletal Bioengineering Laboratory

Education

• Sc.D. Massachusetts Institute of Technology, 2005

Awards, Honors, and Distinctions

• Kappa Delta Young Investigator Award. American Academy of Orthopaedic Surgeons and the Orthopaedic Research Society. 2016

Courses Taught

• BME 394: Projects in Biomedical Engineering (GE)
• BME 493: Projects in Biomedical Engineering (GE)
• BME 494: Projects in Biomedical Engineering (GE)
• BME 791: Graduate Independent Study
• BME 792: Graduate Independent Study
• BME 899: Special Readings in Biomedical Engineering
• ME 492: Special Projects in Mechanical Engineering

In the News

• Clinical Sciences Day: Collaboration, Mentorship Lead to Science Successes (Oct 22, 2013 | Duke Research Blog )

Representative Publications

• DeFrate, LE, Effects of ACL graft placement on in vivo knee function and cartilage thickness distributions., Journal of Orthopaedic Research, vol 35 no. 6 (2017), pp. 1160-1170 [10.1002/jor.23541] [abs].
• Liu, B; Lad, NK; Collins, AT; Ganapathy, PK; Utturkar, GM; McNulty, AL; Spritzer, CE; Moorman, CT; Sutter, EG; Garrett, WE; DeFrate, LE, In Vivo Tibial Cartilage Strains in Regions of Cartilage-to-Cartilage Contact and Cartilage-to-Meniscus Contact in Response to Walking., American Journal of Sports Medicine (2017) [10.1177/0363546517712506] [abs].
• Liu, B; Goode, AP; Carter, TE; Utturkar, GM; Huebner, JL; Taylor, DC; Moorman, CT; Garrett, WE; Kraus, VB; Guilak, F; DeFrate, LE; McNulty, AL, Matrix metalloproteinase activity and prostaglandin E2 are elevated in the synovial fluid of meniscus tear patients., Connective Tissue Research (Informa), vol 58 no. 3-4 (2017), pp. 305-316 [10.1080/03008207.2016.1256391] [abs].
• Hatcher, CC; Collins, AT; Kim, SY; Michel, LC; Mostertz, WC; Ziemian, SN; Spritzer, CE; Guilak, F; DeFrate, LE; McNulty, AL, Relationship between T1rho magnetic resonance imaging, synovial fluid biomarkers, and the biochemical and biomechanical properties of cartilage., Journal of Biomechanics, vol 55 (2017), pp. 18-26 [10.1016/j.jbiomech.2017.02.001] [abs].
• Collins, AT; Kulvaranon, ML; Utturkar, GM; Spritzer, CE; Guilak, F; Defrate, LE, In vivo biochemical and biomechanical properties of cartilage are affected by obesity., Osteoarthritis and Cartilage, vol 25 (2017), pp. S112-S113 [10.1016/j.joca.2017.02.181] [abs].