Samira Musah

Assistant Professor in the Department of Biomedical Engineering

The Musah Lab is interested in understanding how molecular signals and biophysical forces can function either synergistically or independently to guide organ development and physiology, and how these processes can be therapeutically harnessed to treat human disease. Given the escalating medical crisis in nephrology as growing number of patients suffer from kidney disease that can lead to organ failure, the Musah Lab focuses on engineering stem cell fate for applications in human kidney disease, extra-renal complications, and therapeutic development. Dr. Musah’s research interests include stem cell biology and regenerative medicine, molecular and cellular basis of human organ development and disease progression, organ engineering, patient-specific disease models, biomarker identification, therapeutic discovery, tissue and organ transplantation, microphysiological systems including Organ Chips (organs-on-chips) and organoids, matrix biology, mechanotransduction and disease biophysics.

Appointments and Affiliations

  • Assistant Professor in the Department of Biomedical Engineering
  • Assistant Professor in Medicine
  • Assistant Professor in Cell Biology
  • Member of the Duke Cancer Institute
  • Affiliate of the Duke Regeneration Center

Contact Information

Education

  • Ph.D. University of Wisconsin - Madison, 2013

Research Interests

Induced pluripotent stem cells (iPS cells), disease mechanisms, regenerative medicine, molecular and cellular basis of human kidney development and disease, organ engineering, patient-specific disease models, biomarkers, therapeutic discovery, tissue and organ transplantation, microphysiological systems including organs-on-chips and organoids, matrix biology, mechanotransduction, mechanobiology, and disease biophysics.

Courses Taught

  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 790: Advanced Topics for Graduate Students in Biomedical Engineering
  • BME 791: Graduate Independent Study
  • BME 792: Continuation of Graduate Independent Study
  • EGR 393: Research Projects in Engineering

In the News

Representative Publications

  • Roye, Yasmin, and Samira Musah. “Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells.” Journal of Visualized Experiments : Jove, no. 189 (November 2022). https://doi.org/10.3791/63821.
  • Musah, Samira. “Uncovering SARS-CoV-2 kidney tropism.” Nature Reviews. Molecular Cell Biology 22, no. 8 (August 2021): 509. https://doi.org/10.1038/s41580-021-00370-w.
  • “Introductions to the Community: Early-Career Researchers in the Time of COVID-19.” Cell Stem Cell 27, no. 2 (August 2020): 200–201. https://doi.org/10.1016/j.stem.2020.07.016.
  • Burt, Morgan, Rohan Bhattachaya, Arinze E. Okafor, and Samira Musah. “Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions.” Journal of Visualized Experiments : Jove, no. 161 (July 2020). https://doi.org/10.3791/61299.
  • Musah, Samira, Nikolaos Dimitrakakis, Diogo M. Camacho, George M. Church, and Donald E. Ingber. “Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip.” Nature Protocols 13, no. 7 (July 2018): 1662–85. https://doi.org/10.1038/s41596-018-0007-8.