Biomedical Imaging

The Duke BME Biomedical Imaging program features considerable expertise in the construction and clinical evaluation of novel imaging methods. Imaging research at Duke focuses upon photonics, ultrasound, magnetic resonance imaging, x-ray, and nuclear medicine.

Biomedical photonics research is centered in the Fitzpatrick Institute for Photonics as a Duke-wide effort. Resesarch encompasses area such as detecting early stage cancer, helping clinicians determine if tumor excision margins are cancer free, or diagnosing vision-related problems.

The ultrasound research team, which includes four graduate faculty with primary appointments in BME, has a long history of developing clinically relevant, novel ultrasonic imaging methods. Research is divided into four groups: transducer design, design of advanced ultrasound systems and applications, real-time image processing and acoustic radiation-force based imaging. The team has extensive facilities for system and transducer construction, allowing basic imaging algorithm development, and real-time implementation of new algorithms. The team collaborates with the Medical Center's Departments of Medicine and Radiology to perform clinical trials.

Research in MRI focuses upon diffusion tensor imaging and in vivo MRI microscopy. New optical imaging methods focus upon epithelium and synthetic coatings. Other biomedical optics applications address identification and ablation of atherosclerotic plaque. For the most part, these techniques focus upon large organ and animal level analysis.

There are extensive collaborations between BME and Medical Center faculty. In a collaboration with the Department of Cardiovascular Medicine, the relationship between coronary artery motion and geometry, and the predispositional to arterial disease, is being examined by applying unique image processing tools to biplane cineangiograms and intravascular ultrasound records obtained in the clinic.The biomedical imaging faculty is strengthened by nine secondary appointments to PhD researchers with a primary appointment in the Department of Radiology. These faculty supervise BME graduate students. Their research focuses on CT scanners, mammography, PET, SPECT, and computer-aided diagnosis.

Biomedical Imaging Faculty

Mark Wesley Dewhirst

Mark Wesley Dewhirst

Gustavo S. Montana Professor of Radiation Oncology, in the School of Medicine

Research Interests: Dr. Dewhirst's research interests focus on the tumor microenvironment and how it influences treatment responses. Areas of particular focus are hypoxia, acidosis, angiogenesis and oxidative stress.

James T. Dobbins

James T. Dobbins

Professor in Radiology

Bastiaan Driehuys

Bastiaan Driehuys

Professor of Radiology

Research Interests: Driehuys' laboratory focuses on the development and application of hyperpolarized gas MRI for non-invasive imaging of pulmonary function and spectroscopic evaluation of pathology. We seek to improve the care of patients with pulmonary disease by developing non-invasive, 3D imaging of pulmonary...

Sina Farsiu

Sina Farsiu

Associate Professor in the Department of Biomedical Engineering

Research Interests: Farsiu's research focuses on medical imaging and image processing to improve the overall health and vision outcome of patients with ocular and neurological diseases (e.g., age-related macular degeneration, diabetic retinopathy, Alzheimer, and ALS) through earlier and personalized therapy.

Yiyang Gong

Yiyang Gong

Assistant Professor in the Department of Biomedical Engineering

Research Interests: We're interested in recording and understanding brain activity by developing novel combinations of optical microscopy and genetically encoded sensors. Using these technologies, we wish to dissect neural circuit function and investigate how neural activity drives complex behaviors....

Joseph A. Izatt

Joseph A. Izatt

Michael J. Fitzpatrick Professor of Engineering in the Edmund T. Pratt, Jr. School of Engineering

Research Interests: Professor Izatt's research interests are in the area of biophotonics and include coherence-based biomedical imaging and microscopy, novel technologies for ophthalmic imaging, and nanoscale studies of cellular morphology and dynamics.

G. Allan Johnson

G. Allan Johnson

Charles E. Putman University Professor of Radiology

Research Interests: Dr. Johnson's research involves magnetic resonance histology (MRH), the application of MR microscopy to study tissue architecture. Using MRH for morphologic phenotyping in the mouse was first suggested by Dr. Johnson and his colleagues in this article (Radiology 2002;222:789-793 2002). A...

David F. Katz

David F. Katz

Nello L. Teer, Jr. Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering

Research Interests: Dr. Katz's research interest include methods for prophylaxis against STD's, emphasizing topical microbicides and contraception; biofluid mechanics; rheology and transport phenomena; biophysical aspects of mammalian sperm motility, sperm transport, and fertilization; and biomechanical functioning of...

Joseph Yuan-Chieh Lo

Joseph Yuan-Chieh Lo

Professor of Radiology

Research Interests: My lab investigates three areas in the advanced imaging of breast cancer: (1) digital mammography and breast tomosynthesis, (2) radiogenomics for improved management of breast cancer using computer vision and machine learning models, and (3) computational and physical breast phantoms to facilitate...

Paolo F Maccarini

Paolo F Maccarini

Assistant Research Professor of the Department of Biomedical Engineering

Research Interests: By merging advanced circuit/antenna design with multiphysics modeling, Dr. Maccarini pioneered low-cost passive sensors to noninvasively measure deep temperature for various diagnostic applications. By combining novel engineering solutions with immunotherapy/thermo-drugs, his collaborative efforts...

James R. MacFall

James R. MacFall

Adjunct Professor in the Department of Radiology

Research Interests: MacFall's research centers on application and/or development of image processing and magnetic resonance imaging (MRI) techniques for a variety of biomedical focus areas in psychiatry, oncology, lung disorders and pediatric neurological disorders.

Kathryn Radabaugh Nightingale

Kathryn Radabaugh Nightingale

James L. and Elizabeth M. Vincent Associate Professor of Biomedical Engineering

Research Interests: Ultrasonic and elasticity imaging, specifically nonlinear propagation, acoustic streaming and radiation force; the intentional generation of these phenomena for the purpose of tissue characterization; finite element modeling of normal and diseased tissue when exposed to ultrasound, and performing...

Mark L. Palmeri

Mark L. Palmeri

Associate Professor of the Practice in the Department of Biomedical Engineering

Research Interests: Dr. Palmeri's research interests include ultrasonic imaging, specifically using acoustic radiation force to characterize the mechanical properties of tissue, and finite element analysis of soft tissue response to impulsive radiation force excitation. Other research interests include ultrasonic...

Nimmi Ramanujam

Nimmi Ramanujam

Robert W. Carr, Jr., Professor of Biomedical Engineering

Research Interests: Innovating on optical strategies to peer into the biological landscape of thick tissues. Technologies being developed in her lab leverage principles of optical spectroscopy, optical sectioning microscopy, and molecular imaging. Her research group is developing and applying these optically based...

Ehsan Samei

Ehsan Samei

Professor of Radiology

Guillermo Sapiro

Guillermo Sapiro

Edmund T. Pratt, Jr. School Professor of Electrical and Computer Engineering

Research Interests: Image and video processing, computer vision, computer graphics, computational vision, biomedical imaging, brain imaging, cryo-tomography of viruses, computational tools in cryo-tomography, computational tools in early diagnosis of psychiatric disorders, differential geometry and differential...

Stephen William Smith

Stephen William Smith

Professor of Biomedical Engineering

Research Interests: Current research interests are the development and evaluation of improved medical ultrasound image quality for applications in cardiology, radiology and obstetrics. Advances in image quality result from improvements in the spatial resolution and signal-to-noise ratio of diagnostic ultrasound...

Allen Wuming Song

Allen Wuming Song

Professor in Radiology

Research Interests: Song's research program is centered on high-resolution MRI methodological development to best depict and detect human brain structure and function.

Martin Paul Tornai

Martin Paul Tornai

Associate Professor of Radiology

Cynthia Ann Toth

Cynthia Ann Toth

Joseph A.C. Wadsworth Professor of Ophthalmology

Gregg E. Trahey

Gregg E. Trahey

Robert Plonsey Professor of Biomedical Engineering

Research Interests: Trahey's research interests include medical ultrasound, image guided surgery, adaptive imaging, imaging of tissue's mechanical properties, and radiation force imaging.

Tuan Vo-Dinh

Tuan Vo-Dinh

R. Eugene and Susie E. Goodson Professor of Biomedical Engineering

Research Interests: Vo-Dinh's research activities and interests involve biophotonics, laser-excited luminescence spectroscopy, room temperature phosphorimetry, synchronous luminescence spectroscopy, surface-enhanced Raman spectroscopy, field environmental instrumentation, fiberoptics sensors, nanosensors, biosensors...

Olaf T. Von Ramm

Olaf T. Von Ramm

Thomas Lord Professor of Engineering in the Edmund T. Pratt, Jr. School of Engineering

Research Interests: Dr. von Ramm's research interests include diagnostic ultrasound imaging systems, IR imaging, medical instrumentation and their new applications.

Warren S. Warren

Warren S. Warren

James B. Duke Professor of Chemistry

Research Interests: Our work focuses on the design and application of what might best be called novel pulsed techniques, using controlled radiation fields to alter dynamics. The heart of the work is chemical physics, and most of what we do is ultrafast laser spectroscopy or nuclear magnetic resonance. It generally...

Adam P. Wax

Adam P. Wax

Professor of Biomedical Engineering

Research Interests: Dr. Wax's research interests include optical spectroscopy for early cancer detection, novel microscopy and interferometry techniques.

Patrick D. Wolf

Patrick D. Wolf

Associate Professor of Biomedical Engineering

Research Interests: Wolf's research is primarily in the area of advanced instrumentation for diagnosis and treatment of electrophysiological problems. This research covers two primary organ systems: the heart and the brain. In the heart, Dr. Wolf is developing an image guided ablation system for treatment of...

Junjie Yao

Junjie Yao

Assistant Professor of Biomedical Engineering (Fall 2016)

Research Interests: Photoacoustic and optical imaging technologies in the life sciences, especially in functional brain imaging and early cancer theranostics.

Michael Rod Zalutsky

Michael Rod Zalutsky

Jonathan Spicehandler, M.D. Professor of Neuro Oncology, in the School of Medicine