Biomedical Imaging

The Duke BME Biomedical Imaging program features considerable expertise in the construction and clinical evaluation of novel imaging methods. Imaging research at Duke focuses upon photonics, ultrasound, magnetic resonance imaging, x-ray, and nuclear medicine.

Biomedical photonics research is centered in the Fitzpatrick Institute for Photonics as a Duke-wide effort. Resesarch encompasses area such as detecting early stage cancer, helping clinicians determine if tumor excision margins are cancer free, or diagnosing vision-related problems.

The ultrasound research team, which includes four graduate faculty with primary appointments in BME, has a long history of developing clinically relevant, novel ultrasonic imaging methods. Research is divided into four groups: transducer design, design of advanced ultrasound systems and applications, real-time image processing and acoustic radiation-force based imaging. The team has extensive facilities for system and transducer construction, allowing basic imaging algorithm development, and real-time implementation of new algorithms. The team collaborates with the Medical Center's Departments of Medicine and Radiology to perform clinical trials.

Research in MRI focuses upon diffusion tensor imaging and in vivo MRI microscopy. New optical imaging methods focus upon epithelium and synthetic coatings. Other biomedical optics applications address identification and ablation of atherosclerotic plaque. For the most part, these techniques focus upon large organ and animal level analysis.

There are extensive collaborations between BME and Medical Center faculty. In a collaboration with the Department of Cardiovascular Medicine, the relationship between coronary artery motion and geometry, and the predispositional to arterial disease, is being examined by applying unique image processing tools to biplane cineangiograms and intravascular ultrasound records obtained in the clinic.The biomedical imaging faculty is strengthened by nine secondary appointments to PhD researchers with a primary appointment in the Department of Radiology. These faculty supervise BME graduate students. Their research focuses on CT scanners, mammography, PET, SPECT, and computer-aided diagnosis.

Biomedical Imaging Faculty

John Cocke Professor of Electrical and Computer Engineering in the Edmund T. Pratt , Jr. School of Engineering
Assistant Research Professor
Gustavo S. Montana Professor of Radiation Oncology, in the School of Medicine
Dr. Dewhirst’s research interests focus on the tumor microenvironment and how it influences treatment responses. Areas of particular focus are hypoxia, acidosis, angiogenesis and oxidative stress.
Professor in Radiology
There are several research projects underway in my laboratory, focusing on the improvement of diagnostic accuracy in digital chest radiography and digital mammography. The first project uses a dual-energy digital radiography technique that forms images which have either the bones or soft-tissues...
Associate Professor in the Department of Radiology
Driehuys' laboratory focuses on the development and application of hyperpolarized gas MRI for non-invasive imaging of pulmonary function and spectroscopic evaluation of pathology. We seek to improve the care of patients with pulmonary disease by developing non-invasive, 3D imaging of pulmonary...
Assistant Professor in the Department of Biomedical Engineering
Farsiu's research focuses on medical imaging and image processing to improve the overall health and vision outcome of patients with ocular and neurological diseases (e.g., age-related macular degeneration, diabetic retinopathy, Alzheimer, and ALS) through earlier and personalized therapy.
Assistant Professor (effective November 1)
We're interested in recording and understanding brain activity by developing novel combinations of optical microscopy and genetically encoded sensors. Using these technologies, we wish to dissect neural circuit function and investigate how neural activity drives complex behaviors....
Michael J. Fitzpatrick Professor of Engineering in the Edmund T. Pratt, Jr. School of Engineering
Professor Izatt's research interests are in the area of biophotonics and include coherence-based biomedical imaging and microscopy, novel technologies for ophthalmic imaging, and nanoscale studies of cellular morphology and dynamics.
Charles E. Putman University Professor of Radiology
Dr. Johnson's research involves magnetic resonance histology (MRH), the application of MR microscopy to study tissue architecture. Using MRH for morphologic phenotyping in the mouse was first suggested by Dr. Johnson and his colleagues in this article (Radiology 2002;222:789 –793 2002). A...
Nello L. Teer, Jr. Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering
Dr. Katz's research interest include methods for prophylaxis against STD's, emphasizing topical microbicides and contraception; biofluid mechanics; rheology and transport phenomena; biophysical aspects of mammalian sperm motility, sperm transport, and fertilization; and biomechanical functioning of...
Professor of Radiology
The lab focuses on the diagnosis and treatment of cancer using advanced imaging techniques. There are 3 main projects: breast tomosynthesis, computer aided diagnosis, and improved treatment planning for radiation therapy. First, Dr. Lo leads a team from the Ravin Advanced Imaging Laboratories (see...
Assistant Research Professor of the Department of Biomedical Engineering
By merging advanced circuit/antenna design with multiphysics modeling, Dr. Maccarini pioneered low-cost passive sensors to noninvasively measure deep temperature for various diagnostic applications. By combining novel engineering solutions with immunotherapy/thermo-drugs, his collaborative efforts...
Professor of Radiology
MacFall's research centers on application and/or development of image processing and magnetic resonance imaging (MRI) techniques for a variety of biomedical focus areas in psychiatry, oncology, lung disorders and pediatric neurological disorders.
James L. and Elizabeth M. Vincent Associate Professor of Biomedical Engineering
Nightingale's research interests include: ultrasonic and elasticity imaging, specifically nonlinear propagation, acoustic streaming and radiation force; the intentional generation of these phenomena for the purpose of tissue characterization; finite element modeling of normal and diseased tissue...
Robert W. Carr, Jr., Professor of Biomedical Engineering
Innovating on optical strategies to peer into the biological landscape of thick tissues. Technologies being developed in her lab leverage principles of optical spectroscopy, optical sectioning microscopy, and molecular imaging. Her research group is developing and applying these optically based...
Professor of Radiology
Edmund T. Pratt, Jr. School Professor of Electrical and Computer Engineering
Image and video processing, computer vision, computer graphics, computational vision, biomedical imaging, brain imaging, cryo-tomography of viruses, computational tools in cryo-tomography, computational tools in early diagnosis of psychiatric disorders, differential geometry and differential...
Professor of Biomedical Engineering
Current research interests are the development and evaluation of improved medical ultrasound image quality for applications in cardiology, radiology and obstetrics. Advances in image quality result from improvements in the spatial resolution and signal-to-noise ratio of diagnostic ultrasound...
Professor in Radiology
Song's research program is centered on high-resolution MRI methodological development to best depict and detect human brain structure and function.
Associate Professor of Radiology
Professor of Ophthalmology
Professor of Biomedical Engineering
Trahey's research interests include medical ultrasound, image guided surgery, adaptive imaging, imaging of tissue's mechanical properties, and radiation force imaging.
R. Eugene and Susie E. Goodson Professor of Biomedical Engineering in the Edmund T. Pratt, Jr. School of Engineering
Vo-Dinh’s research activities and interests involve biophotonics, laser-excited luminescence spectroscopy, room temperature phosphorimetry, synchronous luminescence spectroscopy, surface-enhanced Raman spectroscopy, field environmental instrumentation, fiberoptics sensors, nanosensors, biosensors...
Thomas Lord Professor of Engineering, in the School of Engineering
Dr. von Ramm's research interests include diagnostic ultrasound imaging systems, IR imaging, medical instrumentation and their new applications.
James B. Duke Professor of Chemistry
Our work focuses on the design and application of what might best be called novel pulsed techniques, using controlled radiation fields to alter dynamics. The heart of the work is chemical physics, and most of what we do is ultrafast laser spectroscopy or nuclear magnetic resonance. It generally...
Theodore Kennedy Professor of Biomedical Engineering
Dr. Wax's research interests include optical spectroscopy for early cancer detection, novel microscopy and interferometry techniques.
Associate Professor of Biomedical Engineering
Wolf's research is primarily in the area of advanced instrumentation for diagnosis and treatment of electrophysiological problems. This research covers two primary organ systems: the heart and the brain. In the heart, Dr. Wolf is developing an image guided ablation system for treatment of...
Assistant Research Professor
Dr. Yu's research interests include optical spectroscopy for cancer diagnostics, diffuse reflectance imaging for tumor margin detection, near-infrared spectroscopy for study of tumor hypoxia and angiogenesis, and specialized fiber optic sensors and photonics devices for medical applications.
Jonathan Spicehandler, M.D. Professor of Neuro Oncology, in the School of Medicine