Al-Hafeez Z Dhalla

Research Themes

Biomedical Imaging & Biophotonics

Research Interests

Biomedical optics, especially optical coherence tomography, scanning laser ophthalmoscopy and LiDAR, applied to the diagnostic imaging, image guided surgery and robotic microsurgery.

Bio

My research focuses on the application of optical technologies for non-invasive, high-resolution imaging of biological tissues.  In particular, our laboratory develops optical coherence tomography (OCT), scanning laser ophthalmoscopy (SLO), light detection and ranging (LiDAR) and other optical imaging technologies for applications in the diagnosis and treatment of disease, particularly diseases of the eye. My work focuses not only on the engineering and technical development of novel imaging technologies, but also the preparation of these technologies for commercialization through clinical validation and regulatory approval.

Education

• Ph.D. Duke University, 2012

Positions

• Assistant Research Professor in the Department of Biomedical Engineering
• Faculty Network Member of the Duke Institute for Brain Sciences

Courses Taught

• ME 494: Engineering Undergraduate Fellows Projects
• ME 493: Engineering Undergraduate Fellows Projects
• BME 791: Graduate Independent Study
• BME 590: Special Topics in Biomedical Engineering
• BME 494: Projects in Biomedical Engineering (GE)
• BME 493: Projects in Biomedical Engineering (GE)
• BME 436L: Biophotonic Instrumentation (DR)
• BME 394: Projects in Biomedical Engineering (GE)

Publications

• Zhang J, Trout R, Li JD, Foust JS, Zhou KC, Dhalla A-H, et al. Line-scan phase-resolved synthetic wavelength LiDAR using an off-axis holographic approach. Optics letters. 2024 Oct;49(20):5755–8.
• Wei F, Li CY, Hagan K, Stinnett SS, Kuo AN, Izatt JA, et al. Spiral scanning improves subject fixation in widefield retinal imaging. Opt Lett. 2024 May 1;49(9):2489–92.
• Hagan K, Zhou KC, Dhalla A-H, Izatt JA. Shot-noise limited optical hybrid based on fused fiber couplers. Optics letters. 2024 Jan;49(2):347–50.
• Wei F, Hagan K, Viehland C, Tao YK, Kuo AN, Izatt JA, et al. Hybrid spiral scanning in a double-clad fiber-based handheld confocal scanning light ophthalmoscope. Biomed Opt Express. 2023 Oct 1;14(10):5162–81.
• Trout RM, Viehland C, Li JD, Raynor W, Dhalla A-H, Vajzovic L, et al. Methods for real-time feature-guided image fusion of intrasurgical volumetric optical coherence tomography with digital microscopy. Biomed Opt Express. 2023 Jul 1;14(7):3308–26.
• Li JD, Viehland C, Dhalla A-H, Trout R, Raynor W, Kuo AN, et al. Visualization of surgical maneuvers using intraoperative real-time volumetric optical coherence tomography. Biomed Opt Express. 2023 Jul 1;14(7):3798–811.
• Hagan K, Park J, DuBose TB, Soltanian-Zadeh S, Dhalla AH, Kuo AN, et al. Dual modality handheld adaptive optics optical coherence tomography probe for in vivo 3-D photoreceptor imaging. In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2023.
• Li JD, Raynor W, Dhalla A-H, Viehland C, Trout R, Toth CA, et al. Quantitative measurements of intraocular structures and microinjection bleb volumes using intraoperative optical coherence tomography. Biomedical optics express. 2023 Jan;14(1):352–66.
• Zhang J, Qian R, Zhou KC, Viehland C, Draelos M, Dhalla AH, et al. Real-time wide-field spectral-scanning FMCW coherent 3D imaging and velocimetry. Optics Letters. 2022 Aug 15;47(16):4064–7.
• Zhou KC, McNabb RP, Qian R, Degan S, Dhalla A-H, Farsiu S, et al. Computational 3D microscopy with optical coherence refraction tomography. Optica. 2022 Jun 20;9(6):593–601.
• Qian R, Zhou KC, Zhang J, Viehland C, Dhalla A-H, Izatt JA. Video-rate high-precision time-frequency multiplexed 3D coherent ranging. Nature communications. 2022 Mar;13(1):1476.
• Zhang J, Qian R, Zhou KC, Viehland C, Draelos M, Dhalla AH, et al. Real-time wide-FOV spectral-scanning FMCW 3D imaging and velocimetry. In: Optics InfoBase Conference Papers. 2022.
• Zhou KC, Dhalla AH, McNabb RP, Qian R, Farsiu S, Izatt JA. High-speed multiview imaging approaching 4pi steradians using conic section mirrors: Theoretical and practical considerations. Journal of the Optical Society of America A: Optics and Image Science, and Vision. 2021 Dec 1;38(12):1810–22.
• Patel DD, Dhalla A-H, Viehland C, Connor TB, Lipinski DM. Development of a Preclinical Laser Speckle Contrast Imaging Instrument for Assessing Systemic and Retinal Vascular Function in Small Rodents. Translational vision science & technology. 2021 Aug;10(9):19.
• Zhou KC, Qian R, Dhalla AH, Farsiu S, Izatt JA. Unified k-space theory of optical coherence tomography. Advances in Optics and Photonics. 2021 Jan 1;13(2):462–514.
• Zhou KC, Qian R, Dhalla AH, Farsiu S, Izatt JA. Incoherent 3D k-space synthesis with volumetric optical coherence refraction tomography. In: Optics InfoBase Conference Papers. 2021.
• Izatt JA, Choma MA, Dhalla AH. Theory of optical coherence tomography. In: Optical Coherence Tomography: Technology and Applications, Second Edition. 2015. p. 65–94.
• Nankivil D, Dhalla A-H, Gahm N, Shia K, Farsiu S, Izatt JA. Coherence revival multiplexed, buffered swept source optical coherence tomography: 400 kHz imaging with a 100 kHz source. Optics letters. 2014 Jul;39(13):3740–3.
• Liu JJ, Witkin AJ, Adhi M, Grulkowski I, Kraus MF, Dhalla A-H, et al. Enhanced vitreous imaging in healthy eyes using swept source optical coherence tomography. PloS one. 2014 Jan;9(7):e102950.
• LaRocca F, Dhalla A-H, Kelly MP, Farsiu S, Izatt JA. Optimization of confocal scanning laser ophthalmoscope design. Journal of biomedical optics. 2013 Jul;18(7):076015.
• Tokayer J, Jia Y, Dhalla AH, Huang D. Blood flow velocity quantification using splitspectrum amplitude-decorrelation angiography with optical coherence tomography. Biomedical Optics Express. 2013 Jan 1;4(10):1909–24.
• Dhalla AH, Nankivil D, Bustamante T, Kuo A, Izatt JA. Simultaneous swept source optical coherence tomography of the anterior segment and retina. Biomedical Optics, BIOMED 2012. 2012 Dec 1;
• Dhalla A-H, Shia K, Izatt JA. Efficient sweep buffering in swept source optical coherence tomography using a fast optical switch. Biomedical optics express. 2012 Dec;3(12):3054–66.
• Dhalla A-H, Nankivil D, Bustamante T, Kuo A, Izatt JA. Simultaneous swept source optical coherence tomography of the anterior segment and retina using coherence revival. Opt Lett. 2012 Jun 1;37(11):1883–5.
• Dhalla A-H, Nankivil D, Izatt JA. Complex conjugate resolved heterodyne swept source optical coherence tomography using coherence revival. Biomedical optics express. 2012 Mar;3(3):633–49.
• Chowdhury S, Dhalla A-H, Izatt J. Coherent Super-Resolution Structured Illumination Microscopy of Non-Fluorescent Samples. Biomedical Optics. 2012;BSu4B-8.
• Chowdhury S, Dhalla A-H, Izatt J. Structured oblique illumination microscopy for enhanced resolution imaging of non-fluorescent, coherently scattering samples. Biomedical optics express. 2012;3:1841–54.
• Hendargo HC, McNabb RP, Dhalla A-H, Shepherd N, Izatt JA. Doppler velocity detection limitations in spectrometer-based versus swept-source optical coherence tomography. Biomed Opt Express. 2011 Aug 1;2(8):2175–88.
• Hendargo HC, McNabb RP, Dhalla AH, Shepherd N, Izatt JA. Doppler velocity detection limitations in spectrometer and swept-source Fourier-domain optical coherence tomography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2011 Apr 12;7889.
• Dhalla A-H, Izatt JA. Complete complex conjugate resolved heterodyne swept-source optical coherence tomography using a dispersive optical delay line. Biomedical optics express. 2011 Apr;2(5):1218–32.
• Dhalla A-H, Migacz JV, Izatt JA. Crosstalk rejection in parallel optical coherence tomography using spatially incoherent illumination with partially coherent sources. Optics letters. 2010 Jul;35(13):2305–7.
• Dhalla AH, Migacz J, Izatt JA. Crosstalk rejection in full-field optical coherence tomography using spatially incoherent illumination with a partially coherent source. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2010 May 3;7554.
• Yu B, Burnside ES, Sisney GA, Harter JM, Zhu C, Dhalla A-H, et al. Feasibility of near-infrared diffuse optical spectroscopy on patients undergoing imageguided core-needle biopsy. Optics express. 2007 Jun;15(12):7335–50.