Biomechanics

Biomechanics research in the department focuses upon mechanics at the cellular, tissue, and joint level with applications in orthopaedics and musculoskeletal and cardiovascular systems.

Injury and orthopaedic biomechanics investigations focus on the clinically relevant biomechanical research problems of injury. Experimental and computational methods are used to develop and validate models of soft and hard tissue behavior.

Tissue mechanics research focuses on material characterization of native and healing biological tissues as well as tissue engineered biomaterial constructs. Material testing methods and constitutive models are used to describe the mechanical behaviors of these tissues in compression, tension and shear.

Cell biomechanics research focuses upon chondrocytes, epithelium, mucosal extracellular matrix, and endothelium. This work is accomplished using micropipet aspiration, atomic force microscopy, flow chamber assays, rheometry, and computational methods. Experimental and computational hemodynamic simulations support research carried out under the Duke Center for Biomolecular and Tissue Engineering.

Collaborations exist with faculty in the divisions of Cardiology, Hematology, Orthopaedic Surgery, Obstetrics and Gynecology, Ophthalmology, and Rheumatology at the Medical Center and with faculty in the departments of Civil and Environmental Engineering and Mechanical Engineering in the School of Engineering.

Biomechanics Faculty

Lazlo Ormandy Professor of Orthopaedic Surgery
Assistant Professor of Biomedical Engineering
Dr. Hoffman’s research focuses on understanding, on a molecular level, how mechanical and chemical cues from the environment are detected, integrated, and manipulated by cells to dictate physiological and patho-physiological responses important in vascular biology.
Michael J. Fitzpatrick Professor of Engineering in the Edmund T. Pratt, Jr. School of Engineering
Professor Izatt's research interests are in the area of biophotonics and include coherence-based biomedical imaging and microscopy, novel technologies for ophthalmic imaging, and nanoscale studies of cellular morphology and dynamics.
Nello L. Teer, Jr. Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering
Dr. Katz's research interest include methods for prophylaxis against STD's, emphasizing topical microbicides and contraception; biofluid mechanics; rheology and transport phenomena; biophysical aspects of mammalian sperm motility, sperm transport, and fertilization; and biomechanical functioning of...
Professor of Mechanical Engineering and Materials Science
The invention of the atomic force microscope (AFM) in 1986 by Binnig, Quate and Gerber (Phys. Rev. Lett. 56, 930) started a revolution in many branches of science by realizing an unprecedented possibility to visualize and manipulate individual molecules under ambient conditions including water,...
Professor of Biomedical Engineering
Dr. Myers is an expert in head and neck impact injury biomechanics. He is also interested in translational research innovation overseeing programs to advance faculty research to market.
William Bevan Professor of Biomedical Engineering
Research in Setton's laboratory is focused on the role of mechanical factors in the degeneration and repair of soft tissues of the musculoskeletal system, including the intervertebral disc, articular cartilage and meniscus.
Joseph A.C. Wadsworth Professor of Ophthalmology
The Mechanobiology of Ocular Hypertension in Glaucoma: My laboratory studies the disease of glaucoma, the second leading cause of blindness in the United States, affecting nearly 3 million people (70 million Worldwide). The primary risk factor for developing glaucoma is ocular hypertension (high...
R. Eugene and Susie E. Goodson Professor of Biomedical Engineering
Dr. Truskey's research interests include cardiovascular tissue engineering, mechanisms of atherogenesis, cell adhesion, and cell biomechanics.
Professor of Biomedical Engineering
Dr. Yuan's research interests include drug and gene delivery, mechanisms of molecular transport in cells and tissues, and tumor pathophysiology.
Sternberg Family Professor of Mechanical Engineering & Materials Science
Nano-mechanical and nano-tribological characterization (elasticity, friction, adhesion) of materials including organic thin films; self-assembled monolayers, polymeric gels, and cellulosics; Fabrication of polymeric nanostructures by scanning probe lithography; Colloidal probe and atomic force...