Biomechanics

Biomechanics research in the department focuses upon mechanics at the cellular, tissue, and joint level with applications in orthopaedics and musculoskeletal and cardiovascular systems.

Injury and orthopaedic biomechanics investigations focus on the clinically relevant biomechanical research problems of injury. Experimental and computational methods are used to develop and validate models of soft and hard tissue behavior.

Tissue mechanics research focuses on material characterization of native and healing biological tissues as well as tissue engineered biomaterial constructs. Material testing methods and constitutive models are used to describe the mechanical behaviors of these tissues in compression, tension and shear.

Cell biomechanics research focuses upon chondrocytes, epithelium, mucosal extracellular matrix, and endothelium. This work is accomplished using micropipet aspiration, atomic force microscopy, flow chamber assays, rheometry, and computational methods. Experimental and computational hemodynamic simulations support research carried out under Pratt's Center for Biomolecular and Tissue Engineering.

Collaborations exist with faculty in the divisions of Cardiology, Hematology, Orthopaedic Surgery, Obstetrics and Gynecology, Ophthalmology, and Rheumatology at the Medical Center and with faculty in the departments of Civil and Environmental Engineering and Mechanical Engineering in the School of Engineering.

Biomechanics Faculty

Ken Gall

Ken Gall

Professor in the Department of Mechanical Engineering and Materials Science

Farshid Guilak

Farshid Guilak

Lazlo Ormandy Professor of Orthopaedic Surgery

Brenton D. Hoffman

Brenton D. Hoffman

Assistant Professor of Biomedical Engineering

Research Interests: Dr. Hoffman's research focuses on understanding, on a molecular level, how mechanical and chemical cues from the environment are detected, integrated, and manipulated by cells to dictate physiological and patho-physiological responses important in vascular biology.

Joseph A. Izatt

Joseph A. Izatt

Michael J. Fitzpatrick Professor of Engineering in the Edmund T. Pratt, Jr. School of Engineering

Research Interests: Professor Izatt's research interests are in the area of biophotonics and include coherence-based biomedical imaging and microscopy, novel technologies for ophthalmic imaging, and nanoscale studies of cellular morphology and dynamics.

David F. Katz

David F. Katz

Nello L. Teer, Jr. Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering

Research Interests: Dr. Katz's research interest include methods for prophylaxis against STD's, emphasizing topical microbicides and contraception; biofluid mechanics; rheology and transport phenomena; biophysical aspects of mammalian sperm motility, sperm transport, and fertilization; and biomechanical functioning of...

Piotr E. Marszalek

Piotr E. Marszalek

Professor of Mechanical Engineering and Materials Science

Research Interests: The invention of the atomic force microscope (AFM) in 1986 by Binnig, Quate and Gerber (Phys. Rev. Lett. 56, 930) started a revolution in many branches of science by realizing an unprecedented possibility to visualize and manipulate individual molecules under ambient conditions including water,...

Barry S. Myers

Barry S. Myers

Professor of Biomedical Engineering

Research Interests: Dr. Myers is an expert in head and neck impact injury biomechanics. He is also interested in translational research innovation overseeing programs to advance faculty research to market.

Lori A. Setton

Lori A. Setton

William Bevan Professor of Biomedical Engineering

Research Interests: Research in Setton's laboratory is focused on the role of mechanical factors in the degeneration and repair of soft tissues of the musculoskeletal system, including the intervertebral disc, articular cartilage and meniscus.

W Daniel Stamer

W Daniel Stamer

Joseph A.C. Wadsworth Professor of Ophthalmology

Research Interests: The Mechanobiology of Ocular Hypertension in Glaucoma: My laboratory studies the disease of glaucoma, the second leading cause of blindness in the United States, affecting nearly 3 million people (70 million Worldwide). The primary risk factor for developing glaucoma is ocular hypertension (high...

George A. Truskey

George A. Truskey

R. Eugene and Susie E. Goodson Professor of Biomedical Engineering

Research Interests: Dr. Truskey's research interests include cardiovascular tissue engineering, mechanisms of atherogenesis, cell adhesion, and cell biomechanics.

Fan Yuan

Fan Yuan

Professor of Biomedical Engineering

Research Interests: Dr. Yuan's research interests include drug and gene delivery, mechanisms of molecular transport in cells and tissues, and tumor pathophysiology.

Stefan Zauscher

Stefan Zauscher

Sternberg Family Professor of Mechanical Engineering & Materials Science

Research Interests: Nano-mechanical and nano-tribological characterization (elasticity, friction, adhesion) of materials including organic thin films; self-assembled monolayers, polymeric gels, and cellulosics; Fabrication of polymeric nanostructures by scanning probe lithography; Colloidal probe and atomic force...