Bioelectric Engineering

Research in Bioelectric Engineering at Duke spans a range of length scales from the ion-channel to the organ level. One of the main areas of focus is the development of realistic mathematical and computer models of cardiac muscle.

One of the strengths of Bioelectric Engineering research at Duke is the close relationship between modelers and experimentalists. In vitro experimental work uses micropatterning of cardiac cells and optical mapping of membrane potentials to study the normal and abnormal electrical function of synthetic heart tissues.

Animal experimental work uses high-density electrical mapping to examine the effect of interventional therapies (e.g., catheter ablation and automatic implantable cardioverter/defibrillator implantation) upon electrical activity of the heart. Experimental and simulation studies are being conducted to elucidate the electrophysiological processes underlying arrhythmias and arrhythmia control.

Duke BME researchers also collaborate with faculty from Duke's Math and Physics Departments in using methods of nonlinear dynamics to characterize and control electrical activity of the heart.

Primary Faculty

Roger C. Barr

Roger C. Barr

Professor

Research Interests: Dr. Barr's research interests include bioelectricity and biomedical computing.

Nenad Bursac

Nenad Bursac

Professor of Biomedical Engineering

Research Interests: Bursac's research interests include embryonic and adult stem cell therapies for heart and muscle disease. Cardiac and skeletal muscle tissue engineering. Cardiac electrophysiology and arrhythmias. Genetic modifications of stem and somatic cells. Micropatterning of proteins and hydrogels.

Yiyang Gong

Yiyang Gong

Assistant Professor in the Department of Biomedical Engineering

Research Interests: We're interested in recording and understanding brain activity by developing novel combinations of optical microscopy and genetically encoded sensors. Using these technologies, we wish to dissect neural circuit function and investigate how neural activity drives complex behaviors. Specialties:...

Warren M. Grill

Warren M. Grill

Professor of Biomedical Engineering

Research Interests: Dr. Grill's research interests and in neural engineering and neural prostheses and include design and testing of electrodes and stimulation techniques, the electrical properties of tissues and cells, and computational neuroscience with applications in restoration of bladder function, treatment of...

Craig S. Henriquez

Craig S. Henriquez

Professor of Biomedical Engineering

Research Interests: Henriquez's research interests include large scale computing, heart modeling, and brain modeling.

Wanda Krassowska Neu

Wanda Krassowska Neu

Professor of Biomedical Engineering

Research Interests: Electroporation-mediated drug delivery and gene therapy; Control of cardiac arrhythmias using nonlinear dynamics

Xiling Shen

Xiling Shen

Associate Professor in the Department of Biomedical Engineering

Research Interests: Dr. Shen's research integrates systems biology and implantable devices to study non-coding RNA, colon cancer, stem cells, and the enteric nervous system. His multidisciplinary approach provides a new window for developing novel therapeutics against heterogeneous diseases such as cancer.

Marc A. Sommer

Marc A. Sommer

W. H. Gardner, Jr. Associate Professor

Research Interests: Dr. Marc Sommer studies neuronal circuits of the brain. Research in his laboratory involves recording from single neurons and studying the effects of inactivating or stimulating well-defined brain areas. His goals are to understand how individual areas process signals and how multiple areas...

Michael Raphael Tadross

Michael Raphael Tadross

Assistant Professor of Biomedical Engineering

Research Interests: Our goal is to bridge the gap between the study of brain as a computational device and the search for novel neuropathological treatments. We develop technologies to manipulate molecules, cells, and synapses in the brain, and deploy these reagents in mouse models of disease.

Jonathan Viventi

Jonathan Viventi

Assistant Professor in the Department of Biomedical Engineering

Research Interests: Dr. Viventi's research uses flexible electronics to create new technology for interfacing with the brain at high resolution over large areas. These new tools can help diagnose and treat neurological disorders such as epilepsy, and help improve the performance of brain machine interfaces.

Patrick D. Wolf

Patrick D. Wolf

Associate Professor of Biomedical Engineering

Research Interests: Wolf's research is primarily in the area of advanced instrumentation for diagnosis and treatment of electrophysiological problems. This research covers two primary organ systems: the heart and the brain. In the heart, Dr. Wolf is developing an image guided ablation system for treatment of...

Secondary Faculty

Miguel Angelo L. Nicolelis

Miguel Angelo L. Nicolelis

Duke School of Medicine Professor in Neuroscience

Research Interests: Dr. Nicolelis investigates how the brains of freely behaving animals encode sensory and motor information. He was first to propose and demonstrate that animals and human subjects can utilize their electrical brain activity to directly control neuroprosthetic devices via brain-machine interfaces (...

Angel Vladimirov Peterchev

Angel Vladimirov Peterchev

Associate Professor in Psychiatry and Behavioral Sciences

Research Interests: I direct the Brain Stimulation Engineering Lab (BSEL) which focuses on the development and modeling of devices and application paradigms for transcranial brain stimulation. Transcranial brain stimulation involves non-invasive delivery of fields (e.g., electric and magnetic) to the brain that...