Lingchong You

Lingchong You

Paul Ruffin Scarborough Associate Professor of Engineering

Dr. You's research interest focus on computational systems biology & synthetic biology, including mathematical modeling of cellular networks; mechanisms of information processing by gene networks; design, modeling and construction of robust gene networks for applications in engineering and medicine.

Appointments and Affiliations

  • Paul Ruffin Scarborough Associate Professor of Engineering
  • Associate Professor of Biomedical Engineering
  • Associate Professor in Molecular Genetics and Microbiology

Contact Information

  • Office Location: 2355 CIEMAS, 101 Science Drive, Durham, NC 27708
  • Office Phone: (919) 660-8408
  • Websites:

Education

  • Ph.D. University of Wisconsin at Madison, 2002
  • M.S. University of Science and Technology of China (China), 1997
  • B.S.E. Chengdu University of Science and Technology (China), 1994

Research Interests

Dr. You's research interest focus on computational systems biology & synthetic biology, including mathematical modeling of cellular networks; mechanisms of information processing by gene networks; design, modeling and construction of robust gene networks for applications in engineering and medicine.

Specialties

Genomics
Computational Biology
Nonlinear Dynamics

Awards, Honors, and Distinctions

  • Faculty Early Career Development (CAREER) Program. National Science Foundation. 2010
  • Fellowships for Science and Engineering. David and Lucile Packard Foundation. 2006

Courses Taught

  • BME 260L: Modeling Cellular and Molecular Systems
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 574: Modeling and Engineering Gene Circuits (GE, MC)
  • BME 590: Special Topics in Biomedical Engineering
  • BME 791: Graduate Independent Study
  • CBB 574: Modeling and Engineering Gene Circuits (GE, MC)
  • COMPSCI 391: Independent Study
  • COMPSCI 394: Research Independent Study
  • EGR 393: Research Projects in Engineering
  • ISS 391: Bass Connections in Information Science and Culture: Independent Study Project
  • MGM 293: Research Independent Study I
  • MGM 593: Research Independent Study
  • PHARM 394: Research Independent Study

In the News

Representative Publications

  • Lopatkin, AJ; Meredith, HR; Srimani, JK; Pfeiffer, C; Durrett, R; You, L, Persistence and reversal of plasmid-mediated antibiotic resistance., Nature Communications, vol 8 no. 1 (2017) [10.1038/s41467-017-01532-1] [abs].
  • Cao, Y; Feng, Y; Ryser, MD; Zhu, K; Herschlag, G; Cao, C; Marusak, K; Zauscher, S; You, L, Programmable assembly of pressure sensors using pattern-forming bacteria., Nature Biotechnology, vol 35 no. 11 (2017), pp. 1087-1093 [10.1038/nbt.3978] [abs].
  • Srimani, JK; Huang, S; Lopatkin, AJ; You, L, Drug detoxification dynamics explain the postantibiotic effect., Molecular systems biology, vol 13 no. 10 (2017) [10.15252/msb.20177723] [abs].
  • Wu, F; You, L, Hacking DNA copy number for circuit engineering., Nature Genetics, vol 49 no. 8 (2017), pp. 1164-1165 [10.1038/ng.3923] [abs].
  • Shats, I; Deng, M; Davidovich, A; Zhang, C; Kwon, JS; Manandhar, D; Gordân, R; Yao, G; You, L, Expression level is a key determinant of E2F1-mediated cell fate., Cell Death & Differentiation, vol 24 no. 4 (2017), pp. 626-637 [10.1038/cdd.2017.12] [abs].