Computational Modeling of Biological Systems

Researchers within the Duke BME community focus on the study and advancement of computational methods and data analysis techniques to understand biological phenomena.

This quantitative research uses modeling and simulation, high-performance computing, and large-scale data analysis to create testable hypotheses about mechanisms driving complex biological function.

At Duke, this research spans many application areas including electrophysiology, patient-specific hemodynamics, cellular mechanisms, gene circuits, and synthetic biology. Researchers in this area are broadly interactive with departments throughout the university, including clinical departments of the Duke University School of Medicine, the 'big data' Information Initiative at Duke (iiD), the Duke Cancer Institute, and the academic departments of Computer Science and Mechanical Engineering and Materials Science. 

Primary Faculty

Roger C. Barr

Roger C. Barr

Professor

Research Interests: Bioelectricity and biomedical computing.

Jessilyn Dunn

Jessilyn Dunn

Assistant Professor of Biomedical Engineering

Research Interests: Use of large-scale biomedical datasets to model and guide personalized therapies

Yiyang Gong

Yiyang Gong

Assistant Professor in the Department of Biomedical Engineering

Research Interests: Recording and understanding brain activity by developing novel combinations of optical microscopy and genetically encoded sensors. Using these technologies, we wish to dissect neural circuit function and investigate how neural activity drives complex behaviors.

Warren M. Grill

Warren M. Grill

Professor of Biomedical Engineering

Research Interests: Neural engineering and neural prostheses and include design and testing of electrodes and stimulation techniques, the electrical properties of tissues and cells, and computational neuroscience with applications in restoration of bladder function, treatment of movement disorders...

Craig S. Henriquez

Craig S. Henriquez

Professor of Biomedical Engineering

Research Interests: Large-scale computing, heart modeling, and brain modeling.

David F. Katz

David F. Katz

Nello L. Teer, Jr. Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering

Research Interests: Methods for prophylaxis against STD's, emphasizing topical microbicides and contraception; biofluid mechanics; rheology and transport phenomena; biophysical aspects of mammalian sperm motility, sperm transport, and fertilization; and biomechanical functioning of the vitreous of...

Michael D Lynch

Michael D Lynch

Assistant Professor in the Department of Biomedical Engineering

Research Interests: Focused on genetically engineering microbes to shut off their growth circuits and turn on new pathways to produce different compounds—improving production of biofuels, pharmacological molecules and industrial chemicals.

Wanda Krassowska Neu

Wanda Krassowska Neu

Professor of Biomedical Engineering

Research Interests: Electroporation-mediated drug delivery and gene therapy; Control of cardiac arrhythmias using nonlinear dynamics

Amanda Randles

Amanda Randles

Alfred Winborne and Victoria Stover Mordecai Assistant Professor of Biomedical Sciences

Research Interests: Biomedical simulation and high-performance computing

Xiling Shen

Xiling Shen

Hawkins Family Associate Professor

Research Interests: Metabolic and epigenetic reprogramming of cancer metastasis, stem cell and organoid technology, microbiome-host-disease interaction, humanized immune cancer models, intravital imaging, CRISPR/dCAS9 epigenetic screening, and peripheral neuromodulation.

George A. Truskey

George A. Truskey

R. Eugene and Susie E. Goodson Professor of Biomedical Engineering

Research Interests: Cardiovascular tissue engineering, mechanisms of atherogenesis, cell adhesion, and cell biomechanics.

Lingchong You

Lingchong You

Professor of Biomedical Engineering

Research Interests: Computational systems biology & synthetic biology, including mathematical modeling of cellular networks; mechanisms of information processing by gene networks; design, modeling and construction of robust gene networks for applications in engineering and medicine.

Secondary Faculty

Anita T. Layton

Anita T. Layton

Professor in the Department of Mathematics

Research Interests: The application of mathematics to biological systems, specifically, mathematical modeling of renal physiology.

Research Faculty

Cameron R. Bass

Cameron R. Bass

Associate Research Professor of Biomedical Engineering

Research Interests: Dr. Bass's research interests include the biomechanics of blast, blunt and ballistic trauma and pediatric trauma. His research focuses on injury risk from microscale to macroscale for the head, neck, thorax and extremities.