Our biomechanics and mechanobiology research focuses upon mechanics at and across the molecular, cellular, tissue, and organ levels.
While biomechanics research largely involves determining, manipulating, and testing the forces and deformations experienced by biological tissues, tissue replacements, or their constitutive elements, mechanobiology studies how physical cues, such as applied forces or the stiffness of the environment around the cell, affect cell behavior.
Research efforts range from applications in orthopaedics, injury mechanics, biomaterial and tissue engineering design to those aimed at affecting disease states where mechanical perturbations in tissues are known to augment pathogenesis, such as cancer and atherosclerosis.
Collaborations in this area at Duke involve faculty from the Duke University Medical Center divisions of Cardiology, Hematology, Orthopaedic Surgery, Obstetrics and Gynecology, Ophthalmology, and Rheumatology, as well as faculty in the departments of Civil and Environmental Engineering and of Mechanical Engineering in the Pratt School of Engineering and the departments of Biology and Cell Biology in the Trinity College of Arts and Sciences.
Assistant Professor of Biomedical Engineering
Research Interests: Dr. Hoffman's research focuses on understanding, on a molecular level, how mechanical and chemical cues from the environment are detected, integrated, and manipulated by cells to dictate physiological and patho-physiological responses important in vascular biology.
Nello L. Teer, Jr. Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering
Research Interests: Dr. Katz's research interest include methods for prophylaxis against STD's, emphasizing topical microbicides and contraception; biofluid mechanics; rheology and transport phenomena; biophysical aspects of mammalian sperm motility, sperm transport, and fertilization; and...
Professor of Biomedical Engineering
Research Interests: Dr. Myers is an expert in head and neck impact injury biomechanics. He is also interested in translational research innovation overseeing programs to advance faculty research to market.
Professor in the Department of Biomedical Engineering
Research Interests: Ultrasonic and elasticity imaging, specifically nonlinear propagation, acoustic streaming and radiation force; the intentional generation of these phenomena for the purpose of tissue characterization; finite element modeling of normal and diseased tissue when exposed to...
Alfred Winborne and Victoria Stover Mordecai Assistant Professor of Biomedical Sciences
Research Interests: Randle's research in biomedical simulation and high performance computing focuses on the development of new computational tools that she uses to provide insight into the localization and development of human diseases ranging from atherosclerosis to cancer.
R. Eugene and Susie E. Goodson Professor of Biomedical Engineering
Research Interests: Dr. Truskey's research interests include cardiovascular tissue engineering, mechanisms of atherogenesis, cell adhesion, and cell biomechanics.
Professor of Biomedical Engineering
Research Interests: Dr. Yuan's research interests include drug and gene delivery, mechanisms of molecular transport in cells and tissues, and tumor pathophysiology.
Frank H. Bassett III, M. D. Associate Professor
Professor in the Department of Mechanical Engineering and Materials Science
Research Interests: Materials Science, Mechanical Properties, Metals and Polymers. Specialities: Shape Memory Materials, Biomaterials, 3D Printing.
Professor of Mechanical Engineering and Materials Science
Research Interests: The invention of the atomic force microscope (AFM) in 1986 by Binnig, Quate and Gerber (Phys. Rev. Lett. 56, 930) started a revolution in many branches of science by realizing an unprecedented possibility to visualize and manipulate individual molecules under ambient conditions...
Joseph A.C. Wadsworth Professor of Ophthalmology
Research Interests: The Mechanobiology of Ocular Hypertension in Glaucoma: My laboratory studies the disease of glaucoma, the second leading cause of blindness in the United States, affecting nearly 3 million people (70 million Worldwide). The primary risk factor for developing glaucoma is ocular...
Sternberg Family Professor of Mechanical Engineering & Materials Science
Research Interests: Nano-mechanical and nano-tribological characterization (elasticity, friction, adhesion) of materials including organic thin films; self-assembled monolayers, polymeric gels, and cellulosics; Fabrication of polymeric nanostructures by scanning probe lithography; Colloidal probe...
Professor in the Department of Mechanical Enginnering and Materials Science
Research Interests: Ultrasound-targeted gene delivery and activation; synergistic combination of high-intensity focused ultrasound (HIFU) and immunotherapy for cancer treatment; innovations in shock wave lithotripsy (SWL) technology; and mechanics and bioeffects of acoustic cavitation.
Associate Research Professor of Biomedical Engineering
Research Interests: Dr. Bass's research interests include the biomechanics of blast, blunt and ballistic trauma and pediatric trauma. His research focuses on injury risk from microscale to macroscale for the head, neck, thorax and extremities.
Adjunct Associate Professor of Biomedical Engineering
Research Interests: Dr. Nightingale's current research interests include: crash test dummies, pediatric head and neck injury, the biomechanics of trauma, modeling of the human head and cervical spine, and the mechanical characterization of head and neck tissues.