Warren M. Grill

Image of Warren M. Grill

Bass Fellow

Our research is in the area of neural engineering: using engineering approaches to understand and control neural function. We work on fundamental questions and applied development in electrical stimulation of the nervous system to restore function to individuals with neurological impairment or injury.

Current projects include:
• understanding the mechanisms of and developing advanced approaches to deep brain stimulation to treat movement disorders,
• developing novel approaches to peripheral nerve electrical stimulation for restoration of bladder function, 
• understanding the mechanisms of and developing advanced approaches to spinal cord stimulation to treat chronic pain,
• understanding and controlling the cellular effects of transcranial magnetic stimulation, and
• design of novel electrodes and waveforms for selective stimulation of the nervous system.

Appointments and Affiliations
  • Bass Fellow
  • Professor of Biomedical Engineering
  • Professor in the Department of Electrical and Computer Engineering
  • Professor in Neurobiology
  • Faculty Network Member of the Duke Institute for Brain Sciences
  • Affiliate of the Duke Initiative for Science & Society
Contact Information:

  • Ph.D. Case Western Reserve University, 1995
  • M.S. Case Western Reserve University, 1992
  • B.S. Boston University, 1989

Research Interests:

Dr. Grill’s research interests and in neural engineering and neural prostheses and include design and testing of electrodes and stimulation techniques, the electrical properties of tissues and cells, and computational neuroscience with applications in restoration of bladder function, treatment of movement disorders with deep brain stimulation, and treatment of chronic pain.


Neural Prosthesis

Awards, Honors, and Distinctions:

  • Fellows. American Institute for Medical and Biological Engineering. 2007

Courses Taught:
  • BME 301L: Bioelectricity (AC or GE)
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 504: Fundamentals of Electrical Stimulation of the Nervous System (GE, EL)
  • BME 515: Neural Prosthetic Systems (GE,EL,IM)
  • BME 791: Graduate Independent Study
  • BME 899: Special Readings in Biomedical Engineering
  • NEUROSCI 301L: Bioelectricity (AC or GE)
  • NEUROSCI 504: Fundamentals of Electrical Stimulation of the Nervous System (GE, EL)
  • NEUROSCI 515: Neural Prosthetic Systems (GE,EL,IM)

Representative Publications: (More Publications)
    • Danziger, ZC; Grill, WM, Dynamics of the sensory response to urethral flow over multiple time scales in rat., The Journal of Physiology, vol 593 no. 15 (2015), pp. 3351-3371 [10.1113/jp270911] [abs].
    • Howell, B; Huynh, B; Grill, WM, Design and in vivo evaluation of more efficient and selective deep brain stimulation electrodes., Journal of Neural Engineering, vol 12 no. 4 (2015) [10.1088/1741-2560/12/4/046030] [abs].
    • Lee, H-M; Kwon, KY; Li, W; Howell, B; Grill, WM; Ghovanloo, M, Corrections to “A Power-Efficient Switched-Capacitor Stimulating System for Electrical/Optical Deep-Brain Stimulation” [Jan 15 360-374], IEEE Journal of Solid-State Circuits, vol 50 no. 7 (2015), pp. 1736-1736 [10.1109/JSSC.2015.2443431] [abs].
    • McGee, MJ; Grill, WM, Temporal pattern of stimulation modulates reflex bladder activation by pudendal nerve stimulation., Neurourology and Urodynamics (2015) [10.1002/nau.22822] [abs].
    • Zhang, TC; Janik, JJ; Peters, RV; Chen, G; Ji, RR; Grill, WM, Spinal sensory projection neuron responses to spinal cord stimulation are mediated by circuits beyond gate control., Journal of neurophysiology, vol 114 no. 1 (2015), pp. 284-300 [10.1152/jn.00147.2015] [abs].
Selected Activities:
  • Consultant, Neurological Devices Panel of the Medical Devices Advisory Committee,Center for Devices and Radiological Health,
  • Editorial Board, Journal of Neural Engineering,
  • Editorial Board, Brain Stimulation,