Charles Gersbach

Image of Charles Gersbach

Associate Professor of Biomedical Engineering

Appointments and Affiliations
  • Associate Professor of Biomedical Engineering
  • Assistant Professor of Orthopaedic Surgery
  • Member of Duke Cancer Institute
Contact Information:
Education:

  • Ph.D. Georgia Institute of Technology, 2006
  • B.S. Georgia Institute of Technology, 2001

Research Interests:

Dr. Gersbach’s research interests are in gene therapy, biomolecular and cellular engineering, regenerative medicine, and synthetic biology.

Specialties:

Drug Delivery
Genomics
Tissue Repair, Tissue Engineering
Polymer and Protein Engineering
Biological Materials

Awards, Honors, and Distinctions:

    Courses Taught:
    • BME 260L: Modeling Cellular and Molecular Systems
    • BME 394: Projects in Biomedical Engineering (GE)
    • BME 493: Projects in Biomedical Engineering (GE)
    • BME 494: Projects in Biomedical Engineering (GE)
    • BME 562: Biology by Design (GE, MC)
    • BME 711S: Biological Engineering Seminar Series (CBIMMS and CBTE)
    • BME 712S: Biological Engineering Seminar Series (CBIMMS and CBTE)
    • BME 899: Special Readings in Biomedical Engineering
    • EGR 391: Projects in Engineering
    • GENOME 293: Research Independent Study Genome Sciences
    • GENOME 294: Research Independent Study Genome Sciences
    • ME 717S: Biological Engineering Seminar Series (CBIMMS and CBTE)
    • ME 718S: Biological Engineering Seminar Series (CBIMMS and CBTE)

    Representative Publications: (More Publications)
      • Gibson, TM; Gersbach, CA, Single-molecule analysis of myocyte differentiation reveals bimodal lineage commitment., Integrative Biology, vol 7 no. 6 (2015), pp. 663-671 [10.1039/c5ib00057b] [abs].
      • Kabadi, AM; Thakore, PI; Vockley, CM; Ousterout, DG; Gibson, TM; Guilak, F; Reddy, TE; Gersbach, CA, Enhanced MyoD-Induced Transdifferentiation to a Myogenic Lineage by Fusion to a Potent Transactivation Domain., ACS Synthetic Biology, vol 4 no. 6 (2015), pp. 689-699 [10.1021/sb500322u] [abs].
      • Frank, CL; Liu, F; Wijayatunge, R; Song, L; Biegler, MT; Yang, MG; Vockley, CM; Safi, A; Gersbach, CA; Crawford, GE; West, AE, Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum., Nature Neuroscience, vol 18 no. 5 (2015), pp. 647-656 [10.1038/nn.3995] [abs].
      • Hilton, IB; D'Ippolito, AM; Vockley, CM; Thakore, PI; Crawford, GE; Reddy, TE; Gersbach, CA, Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers., Nature Biotechnology, vol 33 no. 5 (2015), pp. 510-517 [10.1038/nbt.3199] [abs].
      • Diekman, BO; Thakore, PI; O'Connor, SK; Willard, VP; Brunger, JM; Christoforou, N; Leong, KW; Gersbach, CA; Guilak, F, Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells., Tissue Engineering, Part A, vol 21 no. 7-8 (2015), pp. 1261-1274 [10.1089/ten.tea.2014.0240] [abs].