Charles A Gersbach

Charles Gersbach

Rooney Family Associate Professor of Biomedical Engineering

Appointments and Affiliations

  • Rooney Family Associate Professor of Biomedical Engineering
  • Associate Professor of Biomedical Engineering
  • Associate Professor of Orthopaedic Surgery
  • Affiliate of the Duke Initiative for Science & Society
  • Member of the Duke Cancer Institute

Contact Information

Education

  • Ph.D. Georgia Institute of Technology, 2006
  • B.S. Georgia Institute of Technology, 2001

Research Interests

Dr. Gersbach's research interests are in gene therapy, biomolecular and cellular engineering, regenerative medicine, and synthetic biology.

Specialties

Drug Delivery
Genomics
Tissue Repair, Tissue Engineering
Polymer and Protein Engineering
Biological Materials

Courses Taught

  • BME 260L: Modeling Cellular and Molecular Systems
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 562: Biology by Design (GE, MC)
  • BME 711S: Biological Engineering Seminar Series (CBIMMS and CBTE)
  • BME 712S: Biological Engineering Seminar Series (CBIMMS and CBTE)
  • BME 791: Graduate Independent Study
  • EGR 391: Projects in Engineering
  • EGR 393: Research Projects in Engineering
  • GENOME 293: Research Independent Study Genome Sciences
  • GENOME 294: Research Independent Study Genome Sciences
  • ME 717S: Biological Engineering Seminar Series (CBIMMS and CBTE)
  • ME 718S: Biological Engineering Seminar Series (CBIMMS and CBTE)

In the News

Representative Publications

  • Hilton, IB; Gersbach, CA, Genetic engineering: Chemical control for CRISPR editing, Nature Chemical Biology (2016) [10.1038/nchembio.2243] [abs].
  • Brunger, JM; Zutshi, A; Willard, VP; Gersbach, CA; Guilak, F, CRISPR/Cas9 editing of induced pluripotent stem cells for engineering inflammation-resistant tissues., Arthritis and Rheumatology (2016) [10.1002/art.39982] [abs].
  • Housden, BE; Muhar, M; Gemberling, M; Gersbach, CA; Stainier, DYR; Seydoux, G; Mohr, SE; Zuber, J; Perrimon, N, Loss-of-function genetic tools for animal models: cross-species and cross-platform differences, Nature Reviews Genetics (2016) [10.1038/nrg.2016.118] [abs].
  • Black, JB; Adler, AF; Wang, HG; D'Ippolito, AM; Hutchinson, HA; Reddy, TE; Pitt, GS; Leong, KW; Gersbach, CA, Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells., Cell Stem Cell, vol 19 no. 3 (2016), pp. 406-414 [10.1016/j.stem.2016.07.001] [abs].
  • Lee, J; Xu, L; Gibson, TM; Gersbach, CA; Sullenger, BA, Differential effects of toll-like receptor stimulation on mRNA-driven myogenic conversion of human and mouse fibroblasts., Biochemical and Biophysical Research Communications, vol 478 no. 3 (2016), pp. 1484-1490 [10.1016/j.bbrc.2016.08.159] [abs].