Charles A Gersbach

Charles Gersbach

Rooney Family Associate Professor of Biomedical Engineering

Appointments and Affiliations

  • Rooney Family Associate Professor of Biomedical Engineering
  • Associate Professor of Biomedical Engineering
  • Associate Professor of Orthopaedic Surgery
  • Affiliate of the Duke Initiative for Science & Society
  • Member of the Duke Cancer Institute

Contact Information

Education

  • Ph.D. Georgia Institute of Technology, 2006
  • B.S. Georgia Institute of Technology, 2001

Research Interests

Dr. Gersbach's research interests are in gene therapy, biomolecular and cellular engineering, regenerative medicine, and synthetic biology.

Specialties

Drug Delivery
Genomics
Tissue Repair, Tissue Engineering
Polymer and Protein Engineering
Biological Materials

Courses Taught

  • BME 260L: Modeling Cellular and Molecular Systems
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 562: Biology by Design (GE, MC)
  • BME 711S: Biological Engineering Seminar Series (CBIMMS and CBTE)
  • BME 712S: Biological Engineering Seminar Series (CBIMMS and CBTE)
  • BME 791: Graduate Independent Study
  • EGR 391: Projects in Engineering
  • EGR 393: Research Projects in Engineering
  • GENOME 293: Research Independent Study Genome Sciences
  • GENOME 294: Research Independent Study Genome Sciences
  • ME 717S: Biological Engineering Seminar Series (CBIMMS and CBTE)
  • ME 718S: Biological Engineering Seminar Series (CBIMMS and CBTE)

In the News

Representative Publications

  • Nelson, CE; Gersbach, CA, Engineering Delivery Vehicles for Genome Editing, Annual Review of Chemical and Biomolecular Engineering, vol 7 no. 1 (2016), pp. 637-662 [10.1146/annurev-chembioeng-080615-034711] [abs].
  • Landau, DJ; Brooks, ED; Perez-Pinera, P; Amarasekara, H; Mefferd, A; Li, S; Bird, A; Gersbach, CA; Koeberl, DD, In Vivo Zinc Finger Nuclease-mediated Targeted Integration of a Glucose-6-phosphatase Transgene Promotes Survival in Mice With Glycogen Storage Disease Type IA., Molecular Therapy, vol 24 no. 4 (2016), pp. 697-706 [abs].
  • Nelson, CE; Gersbach, CA, Cas9 loosens its grip on off-target sites, Nature Biotechnology, vol 34 no. 3 (2016), pp. 298-299 [10.1038/nbt.3501] [abs].
  • Josephs, EA; Kocak, DD; Fitzgibbon, CJ; McMenemy, J; Gersbach, CA; Marszalek, PE, Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage., Nucleic Acids Research, vol 44 no. 5 (2016) [abs].
  • Thakore, PI; Black, JB; Hilton, IB; Gersbach, CA, Editing the epigenome: technologies for programmable transcription and epigenetic modulation, Nature Methods, vol 13 no. 2 (2016), pp. 127-137 [10.1038/nmeth.3733] [abs].