Shruti Agashe

Research Interests

Neuromodulation in epilepsy
Deep brain stimulation in epilepsy
Responsive Neuromodulation
Machine learning/AI in epilepsy
StereoEEG
Drug and device trials for epilepsy
Presurgical epilepsy
Biomarkers in epilepsy

Bio

My patients have motivated me to be involved in clinical research. My interests spans areas such as identification of biomarkers in epilepsy, pre-surgical evaluation in epilepsy including stereoEEG and drugs/ device trials in epilepsy. Given my background in biomedical engineering, I have a special interest in Neuromodulation including deep brain stimulation, responsive neurostimulation, use of Artificial intelligence/machine learning on EEGs as well as developing novel device therapies for use in epilepsy care.

Education

• M.D. University of Texas, Medical Branch at Galveston, 2017

Trainings & Certifications

• Neurology Residency, Houston Methodist Hospital, STANLEY APPEL DEPARTMENT OF NEUROLOGY 2017 - 2021 (2017 - 2021) Houston Methodist Hospital
• Mayo Clinic Rochester, Mayo Clinic, EPILEPSY AND CLINICAL NEUROPHYSIOLOGY FELLOWSHIP 2021 - 2023 (2021 - 2023) Mayo Clinic

Positions

• Assistant Professor of Neurology
• Assistant Professor of Biomedical Engineering
• Assistant Professor of Neurosurgery

Awards, Honors, and Distinctions

• Young Investigator Award. American Clinical Neurophysiology Society. 2023
• Young Investigator Travel Award. American Clinical Neurophysiology Society. 2022
• David Chiu Excellence in Stroke Research. Houston Methodist Hospital. 2021
• Medical Student Excellence in Neurology Award. University of Texas Medical Branch. 2017

Courses Taught

• BME 792: Continuation of Graduate Independent Study
• BME 791: Graduate Independent Study

Publications

• Haskell-Mendoza AP, Ramani P, Dhoot R, Parikh P, Frauscher B, Sinha SR, et al. Responsive neurostimulation detections: "Recognizing the unseen". Epileptic Disord. 2025 Oct;27(5):997u20131003.
• Wadi L, Pati S, Agashe S. Individualizing Programming of Responsive Neurostimulation and Deep Brain Stimulation Therapies in Epilepsy. J Clin Neurophysiol. 2025 Jul 25;42(6):513u201320.
• Mehta K, Damiani A, Pirondini E, Agashe S, McIntyre CC, Gonzalez-Martinez JA. Leveraging Functional and Structural Connectomics to Guide Neuromodulation in Epilepsy. J Clin Neurophysiol. 2025 Jul 25;42(6):521u20136.
• Agashe S, Worrell G. Editorial: Personalizing Intracranial Neuromodulation in Epilepsy. J Clin Neurophysiol. 2025 Jul 16;42(6):479u201380.
• Chang V, Reeders PC, Blackwood ER, Palmi E, Lundstrom BN, Pati S, et al. A Scoping Review of Responsive Neurostimulation in Focal Cortical Dysplasia-Related Epilepsy. Epilepsy Behav. 2025 May;166:110362.
• Agashe S, Cascino GD, Devinsky O, Barnard S, Gidal B, Abou-Khalil B, et al. Focal to bilateral tonic-clonic seizures in newly diagnosed focal epilepsy. Epilepsia. 2025 Apr;66(4):e54u20139.
• Agashe S, Alcala-Zermeno JL, Osman GM, Starnes K, Sheffield WD, Leyde K, et al. Thalamocortical network neuromodulation for epilepsy. Brain Commun. 2025;7(5):fcaf270.
• Succop BS, Seas A, Woo J, Bode Padron KJ, Bartlett AM, Shah B, et al. Focused Ultrasound in the Treatment of Epilepsy: Current Applications and Future Directions. Stereotact Funct Neurosurg. 2025;103(3):166u201388.
• Agashe S. MORE Than Meets the Eye: The Evolving Landscape of DBS in Epilepsy. Epilepsy Curr. 2025;25(2):113u20135.
• Wadi L, Khweileh M, Agashe S, Southwell D, Parikh P, Frauscher B. Sleep-related hypermotor seizures originating from the occipital lobe. Epileptic Disord. 2024 Dec;26(6):868u201374.
• Park S, Permezel F, Agashe S, Osman G, Simpson HD, Miller KJ, et al. Centromedian thalamic deep brain stimulation for idiopathic generalized epilepsy: Connectivity and target optimization. Epilepsia. 2024 Nov;65(11):e197u2013203.
• Cox BC, Agashe SH, Smith KM, Kanth KM, Van Gompel JJ, Krecke KN, et al. EEG Source Localization in Temporal Encephaloceles: Concordance With Surgical Resection and Clinical Outcomes. J Clin Neurophysiol. 2024 Sep 1;41(6):515u201321.
• Pati S, Agashe S, Kheder A, Riley K, Gavvala J, McGovern R, et al. Stereoelectroencephalography of the Deep Brain: Basal Ganglia and Thalami. J Clin Neurophysiol. 2024 Jul 1;41(5):423u20139.
• Agashe S. Stereo-EEG Planning: Hitting the Target but Missing the Point? Epilepsy Curr. 2024;24(4):254u20135.
• Agashe S. Osteoporosis: The Brittle Reality of an Epilepsy Diagnosis. Epilepsy Curr. 2024;24(3):168u201370.
• Fox J, Barnard S, Agashe SH, Holmes MG, Gidal B, Klein P, et al. Patterns of antiseizure medication utilization in the Human Epilepsy Project. Epilepsia. 2023 Dec;64(12):3196u2013204.
• Agashe S, Brinkmann BH, Cox BC, Wong-Kisiel L, Van Gompel JJ, Marsh RW, et al. Implications of intracranial hemorrhage associated with stereo-EEG. Clin Neurophysiol. 2023 Nov;155:86u201393.
• Agashe S, Worrell G, Britton J, Noe K, Ritaccio A, Wirrell EC, et al. Cenobamate in Generalized Epilepsy and Combined Generalized and Focal Epilepsy. Neurol Clin Pract. 2023 Apr;13(2):e200133.
• Agashe S, Lundstrom BN, Brinkmann BH, So E, Cascino GD, Gregg N, et al. Temporal encephalocele: An epileptogenic focus confirmed by direct intracranial electroencephalography. Epilepsy Behav Rep. 2023;22:100601.
• Agashe S, Burkholder D, Starnes K, Van Gompel JJ, Lundstrom BN, Worrell GA, et al. Centromedian Nucleus of the Thalamus Deep Brain Stimulation for Genetic Generalized Epilepsy: A Case Report and Review of Literature. Front Hum Neurosci. 2022;16:858413.
• Agashe S, Hooper D, Nisar T, McCane D, Lee J, Chyuan Ling K, et al. Incidence, predictors, and outcomes of post-thrombectomy seizures in the extended time window. Epilepsy Behav Rep. 2021;15:100426.
• Agashe S, Petak S. Cardiac Autonomic Neuropathy in Diabetes Mellitus. Methodist Debakey Cardiovasc J. 2018;14(4):251u20136.
• Pages DS, Ross DA, Puu00f1al VM, Agashe S, Dweck I, Mueller J, et al. Effects of Electrical Stimulation in the Inferior Colliculus on Frequency Discrimination by Rhesus Monkeys and Implications for the Auditory Midbrain Implant. J Neurosci. 2016 May 4;36(18):5071u201383.
• Eyerly SA, Hsu SJ, Agashe SH, Trahey GE, Li Y, Wolf PD. An in vitro assessment of acoustic radiation force impulse imaging for visualizing cardiac radiofrequency ablation lesions. J Cardiovasc Electrophysiol. 2010 May;21(5):557u201363.