Nenad Bursac

Research Themes

Bioelectric Engineering, Tissue Engineering & Regenerative Medicine

Research Interests

Embryonic and adult stem cell therapies for heart and muscle disease; cardiac and skeletal muscle tissue engineering; cardiac electrophysiology and arrhythmias; genetic modifications of stem and somatic cells; micropatterning of proteins and hydrogels.

Bio

Bursac's research interests include: Stem cell, tissue engineering, and gene based therapies for heart and muscle regeneration; Cardiac electrophysiology and arrhythmias; Organ-on-chip and tissue engineering technologies for disease modeling and therapeutic screening; Small and large animal models of heart and muscle injury, disease, and regeneration.

The focus of my research is on application of pluripotent stem cells, tissue engineering, and gene therapy technologies for: 1) basic studies of striated muscle biology and disease in vitro and 2) regenerative therapies in small and large animal models in vivo. For in vitro studies, micropatterning of extracellular matrix proteins or protein hydrogels and 3D cell culture are used to engineer rodent and human striated muscle tissues that replicate the structure-function relationships present in healthy and diseased muscles. We use these models to separate and systematically study the roles of structural and genetic factors that contribute cardiac and skeletal muscle function and disease at multiple organizational levels, from single cells to tissues. Combining cardiac and skeletal muscle cells with primary or iPSC-derived non-muscle cells (endothelial cells, smooth muscle cells, immune system cells, neurons) allows us to generate more realistic models of healthy and diseased human tissues and utilize them to mechanistically study molecular and cellular processes of tissue injury, vascularization, innervation, electromechanical integration, fibrosis, and functional repair. Currently, in vitro models of Duchenne Muscular Dystrophy, Pompe disease, dyspherlinopathies, and various cardiomyopathies are studied in the lab. For in vivo studies, we employ rodent models of volumetric skeletal muscle loss, cardiotoxin and BaCl2 injury as well as myocardial infarction and transverse aortic constriction to study how cell, tissue engineering, and gene (viral) therapies can lead to safe and efficient tissue repair and regeneration. In large animal (porcine) models of myocardial injury and arrhythmias, we are exploring how human iPSC derived heart tissue patches and application of engineered ion channels can improve cardiac function and prevent heart failure or sudden cardiac death.

 

Education

• B.S.E. University of Belgrade (Serbia), 1994
• Ph.D. Boston University, 2000

Positions

• Professor of Biomedical Engineering
• Professor in Cell Biology
• Associate Professor in Medicine
• Co-Director of the Duke Regeneration Center
• Member of the Duke Cancer Institute

Courses Taught

• NEUROSCI 301L: Bioelectricity (AC or GE)
• EGR 393: Research Projects in Engineering
• CELLBIO 493: Research Independent Study
• BME 792: Continuation of Graduate Independent Study
• BME 791: Graduate Independent Study
• BME 578: Quantitative Cell and Tissue Engineering (GE, BB, MC)
• BME 507: Cardiovascular System Engineering, Disease and Therapy (GE, BB, EL)
• BME 494: Projects in Biomedical Engineering (GE)
• BME 493: Projects in Biomedical Engineering (GE)
• BME 394: Projects in Biomedical Engineering (GE)
• BME 301L: Bioelectricity (AC or GE)
• BIOLOGY 493: Research Independent Study

Publications

• Broer T, Tsintolas N, Purkey K, Hammond S, DeLuca S, Wu T, et al. Engineered Myovascular Tissues for Studies of Endothelial/Satellite Cell Interactions. Acta biomaterialia. 2024 Sep;S1742-7061(24)00536-1.
• Khodabukus A, Prabhu NK, Roberts T, Buldo M, Detwiler A, Fralish ZD, et al. Bioengineered Model of Human LGMD2B Skeletal Muscle Reveals Roles of Intracellular Calcium Overload in Contractile and Metabolic Dysfunction in Dysferlinopathy. Adv Sci (Weinh). 2024 Aug;11(31):e2400188.
• Strash N, DeLuca S, Janer Carattini GL, Chen Y, Wu T, Helfer A, et al. Time-dependent effects of BRAF-V600E on cell cycling, metabolism, and function in engineered myocardium. Science advances. 2024 Jan;10(4):eadh2598.
• Fuchs MA, Burke EJ, Latic N, Murray S, Li H, Sparks M, et al. Fibroblast Growth Factor (FGF) 23 and FGF Receptor 4 promote cardiac metabolic remodeling in chronic kidney disease. Res Sq. 2023 Dec 23;
• Nguyen HX, Wu T, Needs D, Zhang H, Perelli RM, DeLuca S, et al. Author Correction: Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy. Nat Commun. 2023 Nov 16;14(1):7411.
• Needs D, Wu T, Nguyen HX, Henriquez CS, Bursac N. Prokaryotic voltage-gated sodium channels are more effective than endogenous Na_v1.5 channels in rescuing cardiac action potential conduction: an in silico study. American journal of physiology Heart and circulatory physiology. 2023 Nov;325(5):H1178–92.
• Chakraborty A, Peterson NG, King JS, Gross RT, Pla MM, Thennavan A, et al. Conserved chamber-specific polyploidy maintains heart function in Drosophila. Development. 2023 Aug 15;150(16).
• Wu T, Li B, Koconis J, Bhattacharjee A, Ye L, Bursac N. Abstract P2164: Expression Of Engineered Bacterial Sodium Channel Improves Cardiomyocyte Contractility. In: Circulation Research. Ovid Technologies (Wolters Kluwer Health); 2023.
• Zhang Q, Zhan R-Z, Patsy M, Li B, Chen Y, Lipes BD, et al. Differential Response of Engineered Human Cardiac Tissues to Delta and Omicron COVID-19 Virus. J Am Heart Assoc. 2023 Jun 20;12(12):e029390.
• Sitton MJ, Khodabukus A, Bohning JD, Bursac N, Gersbach CA. Modeling Gene Editing Outcomes in Microphysiological Human Tissue System Models of Duchenne Muscular Dystrophy. In: MOLECULAR THERAPY. 2023. p. 65–65.
• Yan R, Cigliola V, Oonk KA, Petrover Z, DeLuca S, Wolfson DW, et al. An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair. Cell stem cell. 2023 Jan;30(1):96-111.e6.
• Lee DE, McKay LK, Bareja A, Li Y, Khodabukus A, Bursac N, et al. Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling. Nat Commun. 2022 Dec 9;13(1):7613.
• Scherba JC, Karra R, Turek JW, Bursac N. Toward improved understanding of cardiac development and congenital heart disease: The advent of cardiac organoids. J Thorac Cardiovasc Surg. 2022 Dec;164(6):2013–8.
• Khodabukus A, Guyer T, Moore AC, Stevens MM, Guldberg RE, Bursac N. Translating musculoskeletal bioengineering into tissue regeneration therapies. Science translational medicine. 2022 Oct;14(666):eabn9074.
• Scherba JC, Halushka MK, Andersen ND, Maleszewski JJ, Landstrom AP, Bursac N, et al. BRG1 is a biomarker of hypertrophic cardiomyopathy in human heart specimens. Sci Rep. 2022 May 17;12(1):7996.
• Wang J, Broer T, Chavez T, Zhou CJ, Tran S, Xiang Y, et al. Myoblast deactivation within engineered human skeletal muscle creates a transcriptionally heterogeneous population of quiescent satellite-like cells. Biomaterials. 2022 May;284:121508.
• Nguyen HX, Wu T, Needs D, Zhang H, Perelli RM, DeLuca S, et al. Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy. Nat Commun. 2022 Feb 2;13(1):620.
• Janbandhu V, Tallapragada V, Patrick R, Li Y, Abeygunawardena D, Humphreys DT, et al. Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction. Cell stem cell. 2022 Feb;29(2):281-297.e12.
• Vann CG, Zhang X, Khodabukus A, Orenduff MC, Chen Y-H, Corcoran DL, et al. Differential microRNA profiles of intramuscular and secreted extracellular vesicles in human tissue-engineered muscle. Front Physiol. 2022;13:937899.
• DeLuca S, Bursac N. CRISPR Library Screening in Cultured Cardiomyocytes. Methods in molecular biology (Clifton, NJ). 2022 Jan;2485:1–13.
• Strash N, DeLuca S, Janer Carattini G, Chen Y, Scherba J, Jain M, et al. BRAF-V600E-Mediated Erk Activation Promotes Sustained Cell Cycling and Broad Transcriptional Changes in Neonatal Cardiomyocytes. bioRxiv. 2022.
• Sitton MJ, Khodabukus A, McCullough KT, Bursac N, Gersbach CA. CRISPR Genome Editing in Microphysiological Human Tissue System Models of Duchenne Muscular Dystrophy. In: MOLECULAR THERAPY. 2022. p. 500–500.
• Dzirasa K, Ransey E, Chesnov K, Wisdom E, Bowman R, Rodriguez T, et al. Long-Term Precision Editing of Neural Circuits Using Engineered Gap Junction Hemichannels. In: BIOLOGICAL PSYCHIATRY. 2022. p. S14–5.
• Wu T, Loo S-J, Gao Y, Luo J-H, Su L, Tee NG-Z, et al. Engineered Bacterial Sodium Channel Gene Therapy Prevents Contractile Deficit and Reduces Ventricular Arrhythmias in a Non-Human Primate Model of Myocardial Infarction. In: CIRCULATION. 2022.
• Vekstein AM, Wendell DC, DeLuca S, Yan R, Chen Y, Bishawi M, et al. Targeted Delivery for Cardiac Regeneration: Comparison of Intra-coronary Infusion and Intra-myocardial Injection in Porcine Hearts. Front Cardiovasc Med. 2022;9:833335.
• Strash N, DeLuca S, Janer Carattini GL, Heo SC, Gorsuch R, Bursac N. Human Erbb2-induced Erk activity robustly stimulates cycling and functional remodeling of rat and human cardiomyocytes. eLife. 2021 Oct;10:e65512.
• Ransey E, Chesnov K, Bursac N, Dzirasa K. FETCH: A platform for high-throughput quantification of gap junction hemichannel docking. Cold Spring Harbor Laboratory. 2021.
• Wang J, Zhou CJ, Khodabukus A, Tran S, Han S-O, Carlson AL, et al. Three-dimensional tissue-engineered human skeletal muscle model of Pompe disease. Commun Biol. 2021 May 5;4(1):524.
• Zhan R-Z, Rao L, Chen Z, Strash N, Bursac N. Loss of sarcomeric proteins via upregulation of JAK/STAT signaling underlies interferon-γ-induced contractile deficit in engineered human myocardium. Acta biomaterialia. 2021 May;126:144–53.
• Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, et al. The NIH Somatic Cell Genome Editing program. Nature. 2021 Apr;592(7853):195–204.
• Fralish Z, Lotz EM, Chavez T, Khodabukus A, Bursac N. Neuromuscular Development and Disease: Learning From in vitro and in vivo Models. Frontiers in cell and developmental biology. 2021 Jan;9:764732.
• Vekstein AM, Wendell DC, Bowles DE, DeLuca S, Yan R, Bishawi M, et al. Targeted Intra-Coronary Delivery versus Intra-Myocardial Injection of Therapeutics for Myocardial Recovery: A Nanoparticle Image Guided Porcine Study. In: CIRCULATION. 2021.
• Arnson B, Wang J, Courtney D, Han S-O, Li S, Cullen BR, et al. Single Vector AAV Approach to Genome Editing in Pompe Disease. In: MOLECULAR THERAPY. 2021. p. 291–291.
• Wu T, Nguyen HX, Bursac N. In vitro discovery of novel prokaryotic ion channel candidates for antiarrhythmic gene therapy. In 2021. p. 407–34.
• Helfer A, Bursac N. Frame-Hydrogel Methodology for Engineering Highly Functional Cardiac Tissue Constructs. Methods in molecular biology (Clifton, NJ). 2021 Jan;2158:171–86.
• Chen Z, Li B, Zhan R-Z, Rao L, Bursac N. Exercise mimetics and JAK inhibition attenuate IFN-γ-induced wasting in engineered human skeletal muscle. Science advances. 2021 Jan;7(4):eabd9502.
• Kondash ME, Ananthakumar A, Khodabukus A, Bursac N, Truskey GA. Glucose Uptake and Insulin Response in Tissue-engineered Human Skeletal Muscle. Tissue engineering and regenerative medicine. 2020 Dec;17(6):801–13.
• Khodabukus A, Kaza A, Wang J, Prabhu N, Goldstein R, Vaidya VS, et al. Tissue-Engineered Human Myobundle System as a Platform for Evaluation of Skeletal Muscle Injury Biomarkers. Toxicological sciences : an official journal of the Society of Toxicology. 2020 Jul;176(1):124–36.
• Broer T, Khodabukus A, Bursac N. Can we mimic skeletal muscles for novel drug discovery? Expert opinion on drug discovery. 2020 Jun;15(6):643–5.
• Li Y, Song D, Mao L, Abraham DM, Bursac N. Lack of Thy1 defines a pathogenic fraction of cardiac fibroblasts in heart failure. Biomaterials. 2020 Apr;236:119824.
• Strash N, DeLuca S, Janer Carattini G, Heo SC, Gorsuch R, Bursac N. Human Erbb2-induced Erk Activity Robustly Stimulates Cycling and Functional Remodeling of Rat and Human Cardiomyocytes. bioRxiv. 2020.
• Sklivas AB, Goss DII, Bursac N, Khodahukus A, Koves T, Muoio D, et al. Gene Expression Differences In Three-dimensional Myobundles Compared To Two-dimensional Myocultures. In: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020. p. 781–2.
• Pomeroy JE, Helfer A, Bursac N. Biomaterializing the promise of cardiac tissue engineering. Biotechnol Adv. 2020;42:107353.
• Yifa O, Weisinger K, Bassat E, Li H, Kain D, Barr H, et al. The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice. JCI insight. 2019 Nov;4(22):128025.
• Wang J, Khodabukus A, Rao L, Vandusen K, Abutaleb N, Bursac N. Engineered skeletal muscles for disease modeling and drug discovery. Biomaterials. 2019 Nov;221:119416.
• Sengupta S, Rothenberg KE, Li H, Hoffman BD, Bursac N. Altering integrin engagement regulates membrane localization of K_ir2.1 channels. Journal of cell science. 2019 Sep;132(17):jcs225383.
• Nguyen HX, Bursac N. Ion channel engineering for modulation and de novo generation of electrical excitability. Current opinion in biotechnology. 2019 Aug;58:100–7.
• Khodabukus A, Madden L, Prabhu NK, Koves TR, Jackman CP, Muoio DM, et al. Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle. Biomaterials. 2019 Apr;198:259–69.
• Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, et al. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circ Res. 2019 Jan 4;124(1):161–9.
• Juhas M, Abutaleb N, Wang JT, Ye J, Shaikh Z, Sriworarat C, et al. Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration. Nature biomedical engineering. 2018 Dec;2(12):942–54.
• Koeberl DD, Case LE, Smith EC, Walters C, Han S-O, Li Y, et al. Correction of Biochemical Abnormalities and Improved Muscle Function in a Phase I/II Clinical Trial of Clenbuterol in Pompe Disease. Mol Ther. 2018 Sep 5;26(9):2304–14.
• Jackman C, Li H, Bursac N. Long-term contractile activity and thyroid hormone supplementation produce engineered rat myocardium with adult-like structure and function. Acta biomaterialia. 2018 Sep;78:98–110.
• Khodabukus A, Prabhu N, Wang J, Bursac N. In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease. Advanced healthcare materials. 2018 Aug;7(15):e1701498.
• Gokhale TA, Asfour H, Verma S, Bursac N, Henriquez CS. Microheterogeneity-induced conduction slowing and wavefront collisions govern macroscopic conduction behavior: A computational and experimental study. PLoS computational biology. 2018 Jul;14(7):e1006276.
• Nguyen HX, Kirkton RD, Bursac N. Generation and customization of biosynthetic excitable tissues for electrophysiological studies and cell-based therapies. Nature protocols. 2018 May;13(5):927–45.
• Chen Y-H, Chou C-H, Khodabukus A, Bursac N, Truskey G, Kraus W, et al. Effects of simulated muscle exercise on chondrocyte gene expression in a 3D-alginate bead model system. In: Osteoarthritis and Cartilage. Elsevier BV; 2018. p. S139–40.
• Jackman CP, Ganapathi AM, Asfour H, Qian Y, Allen BW, Li Y, et al. Engineered cardiac tissue patch maintains structural and electrical properties after epicardial implantation. Biomaterials. 2018 Mar;159:48–58.
• Koeberl D, Case L, Smith EC, Li Y, Walters C, Hornik C, et al. Correction of biochemical abnormalities and gene expression associated with improved muscle function in a phase I/II clinical trial of clenbuterol in Pompe disease patients stably treated with ERT. In: Molecular Genetics and Metabolism. Elsevier BV; 2018. p. S79–80.
• Rao L, Qian Y, Khodabukus A, Ribar T, Bursac N. Engineering human pluripotent stem cells into a functional skeletal muscle tissue. Nature communications. 2018 Jan;9(1):126.
• Pomeroy JE, Bursac N. Selective Gq Activation in Cardiac Fibroblasts Decreases Isometric Force Generation in 3D Engineered Cardiac Tissues. In: CIRCULATION. 2018.
• Jackman CP, Heo S, Bursac N. Tissue-engineered Cardiobundles for In Vitro Development of Heart Regeneration Therapies. In: TISSUE ENGINEERING PART A. MARY ANN LIEBERT, INC; 2017. p. S2–S2.
• Juhas M, Abutaleb NO, Wang JT, Bursac N. Skeletal Muscle-Macrophage Platform for Modeling Tissue Regeneration. In: TISSUE ENGINEERING PART A. MARY ANN LIEBERT, INC; 2017. p. S9–S9.
• Li Y, Asfour H, Mao L, Rockman HA, Bursac N. 3D Tissue-engineered Model of Pressure-overload Induced Cardiac Fibrosis. In: TISSUE ENGINEERING PART A. MARY ANN LIEBERT, INC; 2017. p. S64–S64.
• Rao L, Qian Y, Khodabukus A, Ribar T, Bursac N. Contractile hPSC derived Skeletal Muscle Tissues for Human Disease Modeling. In: TISSUE ENGINEERING PART A. MARY ANN LIEBERT, INC; 2017. p. S128–S128.
• Wang J, Khodabukus A, Juhas M, Abutaleb N, Bursac N. In Vitro Bioengineered Model for Studies of Human Muscle Regeneration. In: TISSUE ENGINEERING PART A. MARY ANN LIEBERT, INC; 2017. p. S71–S71.
• Khodabukus A, Prabhu N, Bursac N. Development of a Human Tissue-Engineered Model of Duchenne Muscular Dystrophy. In: TISSUE ENGINEERING PART A. MARY ANN LIEBERT, INC; 2017. p. S115–S115.
• Khodabukus A, Madden L, Jackman C, Prabhu N, Koves T, Bursac N. Combined Drug and Electrical Stimulation Synergistically Increase Function of Engineered Human Skeletal Muscle. In: TISSUE ENGINEERING PART A. MARY ANN LIEBERT, INC; 2017. p. S39–40.
• Shadrin IY, Allen BW, Qian Y, Jackman CP, Carlson AL, Juhas ME, et al. Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues. Nat Commun. 2017 Nov 28;8(1):1825.
• Polstein LR, Juhas M, Hanna G, Bursac N, Gersbach CA. An Engineered Optogenetic Switch for Spatiotemporal Control of Gene Expression, Cell Differentiation, and Tissue Morphogenesis. ACS synthetic biology. 2017 Nov;6(11):2003–13.
• Cao J, Wang J, Jackman CP, Cox AH, Trembley MA, Balowski JJ, et al. Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue. Dev Cell. 2017 Sep 25;42(6):600-615.e4.
• Yanamandala M, Zhu W, Garry DJ, Kamp TJ, Hare JM, Jun H-W, et al. Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering. Journal of the American College of Cardiology. 2017 Aug;70(6):766–75.
• Bassat E, Mutlak YE, Genzelinakh A, Shadrin IY, Baruch Umansky K, Yifa O, et al. The extracellular matrix protein agrin promotes heart regeneration in mice. Nature. 2017 Jul;547(7662):179–84.
• Li Y, Asfour H, Bursac N. Age-dependent functional crosstalk between cardiac fibroblasts and cardiomyocytes in a 3D engineered cardiac tissue. Acta biomaterialia. 2017 Jun;55:120–30.
• Liau B, Jackman CP, Li Y, Bursac N. Developmental stage-dependent effects of cardiac fibroblasts on function of stem cell-derived engineered cardiac tissues. Scientific reports. 2017 Feb;7:42290.
• Pomeroy JE, Nguyen HX, Hoffman BD, Bursac N. Genetically Encoded Photoactuators and Photosensors for Characterization and Manipulation of Pluripotent Stem Cells. Theranostics. 2017;7(14):3539–58.
• Gokhale TA, Kim JM, Kirkton RD, Bursac N, Henriquez CS. Modeling an Excitable Biosynthetic Tissue with Inherent Variability for Paired Computational-Experimental Studies. PLoS computational biology. 2017 Jan;13(1):e1005342.
• Li Y, Dal-Pra S, Mirotsou M, Jayawardena TM, Hodgkinson CP, Bursac N, et al. Tissue-engineered 3-dimensional (3D) microenvironment enhances the direct reprogramming of fibroblasts into cardiomyocytes by microRNAs. Sci Rep. 2016 Dec 12;6:38815.
• Jackman CP, Carlson AL, Bursac N. Dynamic culture yields engineered myocardium with near-adult functional output. Biomaterials. 2016 Dec;111:66–79.
• Shadrin IY, Khodabukus A, Bursac N. Striated muscle function, regeneration, and repair. Cellular and molecular life sciences : CMLS. 2016 Nov;73(22):4175–202.
• Nguyen HX, Kirkton RD, Bursac N. Engineering prokaryotic channels for control of mammalian tissue excitability. Nature communications. 2016 Oct;7:13132.
• Ogle BM, Bursac N, Domian I, Huang NF, Menasché P, Murry CE, et al. Distilling complexity to advance cardiac tissue engineering. Science translational medicine. 2016 Jun;8(342):342ps13.
• Bursac N. Cardiac tissue engineering: Matching native architecture and function to develop safe and efficient therapy. In: Tissue Engineering and Artificial Organs. 2016. p. 877–900.
• Cheng CS, Ran L, Bursac N, Kraus WE, Truskey GA. Cell Density and Joint microRNA-133a and microRNA-696 Inhibition Enhance Differentiation and Contractile Function of Engineered Human Skeletal Muscle Tissues. Tissue Eng Part A. 2016 Apr;22(7–8):573–83.
• Juhas M, Ye J, Bursac N. Design, evaluation, and application of engineered skeletal muscle. Methods (San Diego, Calif). 2016 Apr;99:81–90.
• Albers A, Bursac N, Rapp S. PGE - Product generation engineering - Case study of the dual mass flywheel. In: Proceedings of International Design Conference, DESIGN. 2016. p. 791–800.
• Hung N, Bursac N. Engineering Prokaryotic Sodium Channels for Generation and Control of Mammalian Tissue Excitability. In: CIRCULATION. 2016.
• Zhang H, Sun AY, Kim JJ, Graham V, Finch EA, Nepliouev I, et al. STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node. In: Proc Natl Acad Sci U S A. 2015. p. E5618–27.
• Madden L, Jackman C, Wang J, Kraus W, Truskey G, Bursac N. Novel In Vitro Exercise Model of Engineered Human Skeletal Muscle. In: TISSUE ENGINEERING PART A. MARY ANN LIEBERT, INC; 2015. p. S46–S46.
• Juhas M, Wang J, Ye J, Shadrin I, Bursac N. Engineering Regenerative Skeletal Muscle Tissues. In: TISSUE ENGINEERING PART A. MARY ANN LIEBERT, INC; 2015. p. S310–S310.
• Shadrin IY, Yoon W, Li L, Shepherd N, Bursac N. Rapid fusion between mesenchymal stem cells and cardiomyocytes yields electrically active, non-contractile hybrid cells. Scientific reports. 2015 Jul;5:12043.
• Madden L, Koeberl D, Bursac N. BIOENGINEERED HUMAN MUSCLE FOR PHYSIOLOGICAL STUDIES AND DISEASE MODELING. In: MOLECULAR GENETICS AND METABOLISM. ACADEMIC PRESS INC ELSEVIER SCIENCE; 2015. p. 304–5.
• Jackman CP, Shadrin IY, Carlson AL, Bursac N. Human Cardiac Tissue Engineering: From Pluripotent Stem Cells to Heart Repair. Current opinion in chemical engineering. 2015 Feb;7:57–64.
• Madden L, Juhas M, Kraus WE, Truskey GA, Bursac N. Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs. Elife. 2015 Jan 9;4:e04885.
• Wang L, Liu Z, Yin C, Asfour H, Chen O, Li Y, et al. Stoichiometry of Gata4, Mef2c, and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming. Circulation research. 2015 Jan;116(2):237–44.
• Juhas M, Bursac N. Roles of adherent myogenic cells and dynamic culture in engineered muscle function and maintenance of satellite cells. Biomaterials. 2014 Nov;35(35):9438–46.
• Cheng CS, Davis BNJ, Madden L, Bursac N, Truskey GA. Physiology and metabolism of tissue-engineered skeletal muscle. Experimental biology and medicine (Maywood, NJ). 2014 Sep;239(9):1203–14.
• Hsiai T, Li S, Bursac N. Introduction to the special issue on tissue engineering and regenerative medicine. Annals of biomedical engineering. 2014 Jul;42(7):1355–6.
• Bursac N. Cardiac fibroblasts in pressure overload hypertrophy: the enemy within? The Journal of clinical investigation. 2014 Jul;124(7):2850–3.
• Rangarajan S, Madden L, Bursac N. Use of flow, electrical, and mechanical stimulation to promote engineering of striated muscles. Annals of biomedical engineering. 2014 Jul;42(7):1391–405.
• Bian W, Jackman CP, Bursac N. Controlling the structural and functional anisotropy of engineered cardiac tissues. Biofabrication. 2014 Jun;6(2):24109–24109.
• Madden LR, Koeberl DD, Bursac N. Tissue Engineered Human Skeletal Muscle as a Pre-Clinical Model for AAV Treatment of Pompe Disease. In: MOLECULAR THERAPY. NATURE PUBLISHING GROUP; 2014. p. S157–S157.
• Hung N, Bursac N. Gene Therapy for Heart Disease Using Electrically Active Fibroblasts. In: MOLECULAR THERAPY. NATURE PUBLISHING GROUP; 2014. p. S144–5.
• Juhas M, Engelmayr G, Bursac N. Bioengineered Skeletal Muscle With Functional Stem Cell Pool and Capacity for Vascular Integration and Maturation In Vivo. In: MOLECULAR THERAPY. NATURE PUBLISHING GROUP; 2014. p. S53–4.
• Farah BL, Madden L, Li S, Nance S, Bird A, Bursac N, et al. Adjunctive β2-agonist treatment reduces glycogen independently of receptor-mediated acid α-glucosidase uptake in the limb muscles of mice with Pompe disease. FASEB J. 2014 May;28(5):2272–80.
• Shadrin IY, Carlson AL, Bursac N. Human Pluripotent Stem Cell-Derived Cardiac Tissue Patch for Use in Cell-Based Cardiac Therapy. In: MOLECULAR THERAPY. NATURE PUBLISHING GROUP; 2014. p. S206–S206.
• Polstein LR, Gersbach CA. Spatiotemporal genetic control of cellular systems. In: Tissue and Organ Regeneration: Advances in Micro- and Nanotechnology. 2014. p. 156–97.
• Juhas M, Engelmayr GC, Fontanella AN, Palmer GM, Bursac N. Biomimetic engineered muscle with capacity for vascular integration and functional maturation in vivo. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5508–13.
• Bian W, Badie N, Himel HD, Bursac N. Robust T-tubulation and maturation of cardiomyocytes using tissue-engineered epicardial mimetics. Biomaterials. 2014 Apr;35(12):3819–28.
• Nguyen H, Badie N, McSpadden L, Pedrotty D, Bursac N. Quantifying electrical interactions between cardiomyocytes and other cells in micropatterned cell pairs. Methods in Molecular Biology. 2014;1181:249–62.
• Engelmayr GC, Zhang D, Bursac N. Maturation of functional cardiac tissue patches. 2014 Jan 1;248–82.
• Bursac N, Kim JJ. Cardiac Fibroblasts and Arrhythmogenesis. In: Cardiac Electrophysiology: From Cell to Bedside: Sixth Edition. 2014. p. 297–308.
• Nguyen H, Badie N, McSpadden L, Pedrotty D, Bursac N. Quantifying electrical interactions between cardiomyocytes and other cells in micropatterned cell pairs. Methods in molecular biology (Clifton, NJ). 2014 Jan;1181:249–62.
• Kirkton RD, Badie N, Bursac N. Spatial profiles of electrical mismatch determine vulnerability to conduction failure across a host-donor cell interface. Circulation Arrhythmia and electrophysiology. 2013 Dec;6(6):1200–7.
• Juhas M, Bursac N. Engineering skeletal muscle repair. Current opinion in biotechnology. 2013 Oct;24(5):880–6.
• Zhang D, Shadrin IY, Lam J, Xian H-Q, Snodgrass HR, Bursac N. Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes. Biomaterials. 2013 Jul;34(23):5813–20.
• Christoforou N, Liau B, Chakraborty S, Chellapan M, Bursac N, Leong KW. Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues. PloS one. 2013 Jan;8(6):e65963.
• Christoforou N, Chellappan M, Adler AF, Kirkton RD, Wu T, Addis RC, et al. Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. PloS one. 2013 Jan;8(5):e63577.
• Jiang W, Zhang D, Bursac N, Zhang Y. WNT3 is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCs. Stem cell reports. 2013 Jan;1(1):46–52.
• Truskey GA, Achneck HE, Bursac N, Chan H, Cheng CS, Fernandez C, et al. Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing. Stem Cell Res Ther. 2013;4 Suppl 1(Suppl 1):S10.
• Zhang D, Lam J, Liau B, Snodgrass R, Bursac N. Human Embryonic Stem Cell-Derived Cardiac Tissue Patch with Advanced Structure and Function. CIRCULATION. 2012 Nov 20;126(21).
• Kirkton RD, Bursac N. Genetic engineering of somatic cells to study and improve cardiac function. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2012 Nov;14 Suppl 5:v40–9.
• McSpadden LC, Nguyen H, Bursac N. Size and ionic currents of unexcitable cells coupled to cardiomyocytes distinctly modulate cardiac action potential shape and pacemaking activity in micropatterned cell pairs. Circulation Arrhythmia and electrophysiology. 2012 Aug;5(4):821–30.
• Piacentino V, Milano CA, Bolanos M, Schroder J, Messina E, Cockrell AS, et al. X-linked inhibitor of apoptosis protein-mediated attenuation of apoptosis, using a novel cardiac-enhanced adeno-associated viral vector. Hum Gene Ther. 2012 Jun;23(6):635–46.
• Christoforou N, Liau B, Bursac N, Leong KW. Engineering an electromechanically functional 3d biosynthetic tissue using embryonic or induced pluripotent stem cells. In: CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS; 2012. p. E735–E735.
• Scull JA, McSpadden LC, Himel HD, Badie N, Bursac N. Single-detector simultaneous optical mapping of V(m) and [Ca(2+)](i) in cardiac monolayers. Annals of biomedical engineering. 2012 May;40(5):1006–17.
• Bian W, Juhas M, Pfeiler TW, Bursac N. Local tissue geometry determines contractile force generation of engineered muscle networks. Tissue engineering Part A. 2012 May;18(9–10):957–67.
• Bursac N. Colonizing the heart from the epicardial side. Stem cell research & therapy. 2012 Apr;3(2):15.
• Liau B, Zhang D, Bursac N. Functional cardiac tissue engineering. Regenerative medicine. 2012 Mar;7(2):187–206.
• Bian W, Bursac N. Soluble miniagrin enhances contractile function of engineered skeletal muscle. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 Feb;26(2):955–65.
• Badie N, Scull JA, Klinger RY, Krol A, Bursac N. Conduction block in micropatterned cardiomyocyte cultures replicating the structure of ventricular cross-sections. Cardiovasc Res. 2012 Feb 1;93(2):263–71.
• Muller-Borer B, Esch G, Aldina R, Woon W, Fox R, Bursac N, et al. Calcium dependent CAMTA1 in adult stem cell commitment to a myocardial lineage. PloS one. 2012 Jan;7(6):e38454.
• Liau B, Christoforou N, Leong KW, Bursac N. Pluripotent stem cell-derived cardiac tissue patch with advanced structure and function. Biomaterials. 2011 Dec;32(35):9180–7.
• McSpadden LC, Bursac N. Size and Ionic Currents of Unexcitable Cells Coupled to Cardiomyocytes Distinctly Modulate Cardiac Action Potential Shape and Pacemaking Activity. CIRCULATION. 2011 Nov 22;124(21).
• Wang C, Hennessey JA, Kirkton RD, Graham V, Puranam RS, Rosenberg PB, et al. Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts. Circ Res. 2011 Sep 16;109(7):775–82.
• Lin N, Badie N, Yu L, Abraham D, Cheng H, Bursac N, et al. A method to measure myocardial calcium handling in adult Drosophila. Circ Res. 2011 May 27;108(11):1306–15.
• Hinds S, Bian W, Dennis RG, Bursac N. The role of extracellular matrix composition in structure and function of bioengineered skeletal muscle. Biomaterials. 2011 May;32(14):3575–83.
• Shaked NT, Satterwhite LL, Bursac N, Wax A. Whole cell imaging based on wide-field interferometric phase microscopy and its application to cardiomyocytes. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2011 Apr 29;7904.
• Wang C, Hennessey JA, Kirkton RD, Bryson V, Rosenberg PB, Bursac N, et al. FGF13 is a Regulator of the Cardiac Voltage-Gated Sodium Channel Nav1.5. In: BIOPHYSICAL JOURNAL. 2011. p. 420–1.
• Kirkton RD, Bursac N. Engineering biosynthetic excitable tissues from unexcitable cells for electrophysiological and cell therapy studies. Nature communications. 2011 Jan;2:300.
• Piacentino V, Bolanos M, Schroder J, Messina E, Jones E, Krol A, et al. X-Linked Inhibitor of Apoptosis Protein (XIAP)-Mediated Attenuation of Apoptosis Using a Novel Cardiac Enhanced Adeno-Associated Viral Vector. CIRCULATION. 2010 Nov 23;122(21).
• Kirkton RD, Bursac N. Engineered Somatic Cells for Cardiac Repair. CIRCULATION. 2010 Nov 23;122(21).
• Bian W, Liau B, Badie N, Bursac N. Engineering of Functional Cardiac Tissue Patch with Realistic Myofiber Orientations. CIRCULATION. 2010 Nov 23;122(21).
• Shaked NT, Satterwhite LL, Bursac N, Wax A. Whole-cell-analysis of live cardiomyocytes using wide-field interferometric phase microscopy. Biomedical optics express. 2010 Aug;1(2):706–19.
• Christoforou N, Oskouei BN, Esteso P, Hill CM, Zimmet JM, Bian W, et al. Implantation of mouse embryonic stem cell-derived cardiac progenitor cells preserves function of infarcted murine hearts. PloS one. 2010 Jul;5(7):e11536.
• Shaked NT, Zhu Y, Badie N, Bursac N, Wax A. Reflective interferometric chamber for quantitative phase imaging of biological sample dynamics. Journal of biomedical optics. 2010 May;15(3):030503.
• Kim JM, Bursac N, Henriquez CS. A computer model of engineered cardiac monolayers. Biophysical journal. 2010 May;98(9):1762–71.
• Tranquillo JV, Badie N, Henriquez CS, Bursac N. Collision-based spiral acceleration in cardiac media: roles of wavefront curvature and excitable gap. Biophysical journal. 2010 Apr;98(7):1119–28.
• Bursac N, Kirkton RD, McSpadden LC, Liau B. Characterizing functional stem cell-cardiomyocyte interactions. Regenerative medicine. 2010 Jan;5(1):87–105.
• Badie N, Satterwhite L, Bursac N. A method to replicate the microstructure of heart tissue in vitro using DTMRI-based cell micropatterning. Annals of biomedical engineering. 2009 Dec;37(12):2510–21.
• Bian W, Bursac N. Large 3-Dimensional Tissue Engineered Cardiac Patch With Controlled Electrical Anisotropy. In: CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS; 2009. p. S821–S821.
• Liau B, Christoforou N, Bursac N. Electromechanically Functional Cardiac Tissue Constructs Engineered From Embryonic Stem Cells. In: CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS; 2009. p. S810–1.
• McSpadden LC, Kirkton RD, Bursac N. Cell Therapies for Arrhythmias: Genetically Engineered Coupling Determines the Effect on Anisotropic Cardiac Conduction. In: CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS; 2009. p. S765–6.
• Bursac N. Cardiac Fibroblasts Strongly Affect Cardiac Action Potential Propagation by Paracrine Rather Than Coupling Mechanisms. In: CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS; 2009. p. S635–S635.
• Pedrotty DM, Klinger RY, Kirkton RD, Bursac N. Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes. Cardiovasc Res. 2009 Sep 1;83(4):688–97.
• McSpadden LC, Kirkton RD, Bursac N. Electrotonic loading of anisotropic cardiac monolayers by unexcitable cells depends on connexin type and expression level. American journal of physiology Cell physiology. 2009 Aug;297(2):C339–51.
• Badie N, Bursac N. Novel micropatterned cardiac cell cultures with realistic ventricular microstructure. Biophysical journal. 2009 May;96(9):3873–85.
• Bursac N. Cardiac tissue engineering using stem cells. IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society. 2009 Mar;28(2):80–9.
• Bian W, Bursac N. Engineered skeletal muscle tissue networks with controllable architecture. Biomaterials. 2009 Mar;30(7):1401–12.
• Bian W, Liau B, Badie N, Bursac N. Mesoscopic hydrogel molding to control the 3D geometry of bioartificial muscle tissues. Nature protocols. 2009 Jan;4(10):1522–34.
• Klinger R, Bursac N. In Vitro Cellular Implantation Assay To Quantitatively Compare The Ability Of Different Donor Cells To Electrically Conduct Within Cardiac Tissue. CIRCULATION. 2008 Oct 28;118(18):S395–S395.
• Badle N, Bursac N. Micropatterned Ventricular Slice: Role of Realistic Tissue Microstructure In Impulse Conduction. CIRCULATION. 2008 Oct 28;118(18):S493–S493.
• Bian W, Bursac N. Tissue engineering of functional skeletal muscle: challenges and recent advances. IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society. 2008 Sep;27(5):109–13.
• Liao I-C, Liu JB, Bursac N, Leong KW. Effect of Electromechanical Stimulation on the Maturation of Myotubes on Aligned Electrospun Fibers. Cellular and molecular bioengineering. 2008 Sep;1(2–3):133–45.
• Pedrotty DM, Klinger RY, Badie N, Hinds S, Kardashian A, Bursac N. Structural coupling of cardiomyocytes and noncardiomyocytes: quantitative comparisons using a novel micropatterned cell pair assay. Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H390–400.
• Kirkton RD, Bursac N. Genetic engineering and stem cells: combinatorial approaches for cardiac cell therapy. IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society. 2008 May;27(3):85–8.
• Klinger R, Bursac N. Cardiac cell therapy in vitro: reproducible assays for comparing the efficacy of different donor cells. IEEE Eng Med Biol Mag. 2008;27(1):72–80.
• Pedrotty D, Klinger R, Bursac N. Paracrine factors from cardiac fibroblasts slow conduction velocity and prolong the action potential duration of cardiomyocytes. CIRCULATION. 2007 Oct 16;116(16):87–87.
• Bian W, Bursac N. Micromolded cardiac network patches for treatment of infarcted heart. CIRCULATION. 2007 Oct 16;116(16):68–9.
• Bursac N, Loo Y, Leong K, Tung L. Novel anisotropic engineered cardiac tissues: studies of electrical propagation. Biochemical and biophysical research communications. 2007 Oct;361(4):847–53.
• Bursac N. Stem cell therapies for heart disease: why do we need bioengineers? IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society. 2007 Jul;26(4):76–9.
• Zhang Z-S, Tranquillo J, Neplioueva V, Bursac N, Grant AO. Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease. Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H399–407.
• Bursac N. Cardiac tissue engineering: Matching native architecture and function to develop safe and efficient therapy. In: Tissue Engineering. 2007. p. 437–60.
• Tranquillo JV, Bursac N. The role restitution in pacing induced spiral wave acceleration. Conference proceedings : . Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference. 2006 Dec 1;3919–22.
• Badie N, Bursac N. Micropatterned heart slice cultures for studies of intramural cardiac electrophysiology. CIRCULATION. 2006 Oct 31;114(18):331–331.
• Sathaye A, Bursac N, Sheehy S, Tung L. Electrical pacing counteracts intrinsic shortening of action potential duration of neonatal rat ventricular cells in culture. Journal of molecular and cellular cardiology. 2006 Oct;41(4):633–41.
• Bursac N, Tung L. Acceleration of functional reentry by rapid pacing in anisotropic cardiac monolayers: formation of multi-wave functional reentries. Cardiovascular research. 2006 Feb;69(2):381–90.
• Tranquillo JV, Bursac N. The role restitution in pacing induced spiral wave acceleration. In: 2006 28TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-15. IEEE; 2006. p. 2420-+.
• Tranquillo JV, Bursac N. The role restitution in pacing induced spiral wave acceleration. Conference proceedings : . Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual Conference. 2006 Jan;2006:3919–22.
• Tranquillo JV, Bursac N. The role restitution in pacing induced spiral wave acceleration. Conference proceedings : . Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference. 2006;3919–22.
• Pedrotty D, McSpadden L, Bursac N. Paracrine factors from stem cells improve electrical conduction in cardiac tissue. In: CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS; 2005. p. U145–6.
• Kong C-R, Bursac N, Tung L. Mechanoelectrical excitation by fluid jets in monolayers of cultured cardiac myocytes. Journal of applied physiology (Bethesda, Md : 1985). 2005 Jun;98(6):2328–2320.
• Pedrotty DM, Bursac N. Cardiomyoplasty: the prospect of human stem cells. IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society. 2005 May;24(3):125–7.
• Bursac N, Aguel F, Tung L. Multiarm spirals in a two-dimensional cardiac substrate. Proceedings of the National Academy of Sciences of the United States of America. 2004 Oct;101(43):15530–4.
• Tung L, Bursac N, Aguel F. Rotors and spiral waves in two dimensions. In: Cardiac Electrophysiology: From Cell to Bedside. 2004. p. 336–44.
• Bursac N, Papadaki M, White JA, Eisenberg SR, Vunjak-Novakovic G, Freed LE. Cultivation in rotating bioreactors promotes maintenance of cardiac myocyte electrophysiology and molecular properties. Tissue engineering. 2003 Dec;9(6):1243–53.
• Iravanian S, Nabutovsky Y, Kong C-R, Saha S, Bursac N, Tung L. Functional reentry in cultured monolayers of neonatal rat cardiac cells. American journal of physiology Heart and circulatory physiology. 2003 Jul;285(1):H449–56.
• Bursac N, Parker KK, Iravanian S, Tung L. Cardiomyocyte cultures with controlled macroscopic anisotropy: a model for functional electrophysiological studies of cardiac muscle. Circulation research. 2002 Dec;91(12):e45–54.
• Molmenti EP, Roodhouse TW, Molmenti H, Jaiswal K, Jung G, Marubashi S, et al. Thrombendvenectomy for organized portal vein thrombosis at the time of liver transplantation. Annals of surgery. 2002 Feb;235(2):292–6.
• Bursac N, Tung L. Novel stable functional Reentrant patterns induced by rapid pacing in uniformly anisotorpic cardiomyocyte cultures. In: CIRCULATION. 2002. p. 304–304.
• Aljuri AN, Bursac N, Marini R, Cohen RJ. System identification of dynamic closed-loop control of total peripheral resistance by arterial and cardiopulmonary baroreceptors. Acta astronautica. 2001 Aug;49(3–10):167–70.
• Iravanlan S, Nabutovsky Y, Saha S, Bursac N, Tung L. Optical maps of reentrant activity in cultured monolayers of neonatal rat cardiac myocytes. CIRCULATION. 2001;104(17):108–108.
• Papadaki M, Bursac N, Langer R, Merok J, Vunjak-Novakovic G, Freed LE. Tissue engineering of functional cardiac muscle: molecular, structural, and electrophysiological studies. American journal of physiology Heart and circulatory physiology. 2001 Jan;280(1):H168–78.
• Bursac N, Papadaki M, White J, Eisenberg S, Freed L. Three-dimensional cultures of cardiomyocytes for electrophysiological studies of cardiac muscle. Annals of Biomedical Engineering. 2000 Dec 1;28(SUPPL. 1).
• Bursac N, Papadaki M, White J, Eisenberg S, Freed L. Three-dimensional cultures of cardiomyocytes for electrophysiological studies of cardiac muscle. Annals of Biomedical Engineering. 2000;28(SUPPL 1):54.
• Bursac N, Papadaki M, Langer R, Eisenberg SR, Vunjak-Novakovic G, Freed LE. Three-dimensional environment promotes in vitro differentiation of cardiac myocytes. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 1999 Dec 1;1:128.
• Papadaki M, Bursac N, Gupta P, Langer R, Vunjak-Novakovic G, Freed LE. Towards a functional tissue engineered cardiac muscle. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 1999 Dec 1;1:125.
• Carrier RL, Papadaki M, Rupnick M, Schoen FJ, Bursac N, Langer R, et al. Cardiac tissue engineering: cell seeding, cultivation parameters, and tissue construct characterization. Biotechnology and bioengineering. 1999 Sep;64(5):580–9.
• Bursac N, Papadaki M, Cohen RJ, Schoen FJ, Eisenberg SR, Carrier R, et al. Cardiac muscle tissue engineering: toward an in vitro model for electrophysiological studies. The American journal of physiology. 1999 Aug;277(2):H433–44.
• Van Toi V, Abraham H, Bursac N. Post-LSD hallucinosis is associated with decrease in flicker-fusion sensitivities. Investigative Ophthalmology and Visual Science. 1996 Feb 15;37(3).
• VanToi V, Abraham H, Bursac N. Post-LSD hallucinosis is associated with decrease in flicker-fusion sensitivities. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 1996;37(3):3307–3307.
• Bursac N, Juhas M, Rando Thomas. Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease. Annual Review of Biomedical Engineering. 17:217–42.

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