Mikhail A. Nikiforov

Research Themes

Synthetic & Systems Biology

Education

• B.S. Lomonosov Moscow State University (Russia), 1992
• M.S. Lomonosov Moscow State University (Russia), 1992
• Ph.D. University of Illinois, 1997

Positions

• Professor of Pathology
• Professor in the Department of Biomedical Engineering
• Member of the Duke Cancer Institute

Courses Taught

• PATHOL 793: Research Independent Study
• BME 792: Continuation of Graduate Independent Study
• BME 791: Graduate Independent Study
• BME 644: Physiology for Engineers
• BME 590: Special Topics in Biomedical Engineering
• BME 570L: Introduction to Biomolecular Engineering (GE, BB, MC)
• BME 494: Projects in Biomedical Engineering (GE)
• BME 493: Projects in Biomedical Engineering (GE)

Publications

• Bouch RJ, Zhang J, Miller BC, Robbins CJ, Mosher TH, Li W, et al. Distinct inflammatory Th17 subsets emerge in autoimmunity and infection. J Exp Med. 2023 Oct 2;220(10).
• Wolff DW, Bianchi-Smiraglia A, Nikiforov MA. Compartmentalization and regulation of GTP in control of cellular phenotypes. Trends Mol Med. 2022 Sep;28(9):758–69.
• Wolff DW, Deng Z, Bianchi-Smiraglia A, Foley CE, Han Z, Wang X, et al. Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4. Cell Chem Biol. 2022 Jun 16;29(6):970-984.e6.
• Bianchi-Smiraglia A, Wolff DW, Marston DJ, Deng Z, Han Z, Moparthy S, et al. Regulation of local GTP availability controls RAC1 activity and cell invasion. Nat Commun. 2021 Oct 19;12(1):6091.
• Lipchick BC, Utley A, Han Z, Moparthy S, Yun DH, Bianchi-Smiraglia A, et al. The fatty acid elongase ELOVL6 regulates bortezomib resistance in multiple myeloma. Blood Advances. 2021 Apr 13;5(7):1933–46.
• Fink EE, Moparthy S, Bagati A, Bianchi-Smiraglia A, Lipchick BC, Wolff DW, et al. XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response. Cell Reports. 2018 Oct;25(1):212-223.e4.
• Bianchi-Smiraglia A, Bagati A, Fink EE, Affronti HC, Lipchick BC, Moparthy S, et al. Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma. Journal of Clinical Investigation. 2018 Sep 10;128(10):4682–96.
• Bianchi-Smiraglia A, Rana MS, Foley CE, Paul LM, Lipchick BC, Moparthy S, et al. Internally ratiometric fluorescent sensors for evaluation of intracellular GTP levels and distribution. Nature Methods. 2017 Oct;14(10):1003–9.
• Bagati A, Bianchi-Smiraglia A, Moparthy S, Kolesnikova K, Fink EE, Lipchick BC, et al. Melanoma Suppressor Functions of the Carcinoma Oncogene FOXQ1. Cell Reports. 2017 Sep;20(12):2820–32.