Megan Madonna

Education

• Ph.D. Duke University, 2020

Positions

• Assistant Research Professor in the Department of Biomedical Engineering

Courses Taught

• ISS 796T: Bass Connections Information, Society & Culture Research Team
• ISS 795T: Bass Connections Information, Society & Culture Research Team
• ISS 396T: Bass Connections Information, Society & Culture Research Team
• ISS 395T: Bass Connections Information, Society & Culture Research Team
• EGR 393: Research Projects in Engineering
• BME 791: Graduate Independent Study
• BME 494: Projects in Biomedical Engineering (GE)
• BME 493: Projects in Biomedical Engineering (GE)
• BME 462L: Design for the Developing World (DR)

Publications

• Sunassee ED, Deutsch RJ, D’Agostino VW, Castellano-Escuder P, Siebeneck EA, Ilkayeva O, et al. Optical imaging reveals chemotherapy-induced metabolic reprogramming of residual disease and recurrence. Sci Adv. 2024 Apr 5;10(14):eadj7540.
• Sunassee ED, Jardim-Perassi BV, Madonna MC, Ordway B, Ramanujam N. Metabolic Imaging as a Tool to Characterize Chemoresistance and Guide Therapy in Triple-Negative Breast Cancer (TNBC). Molecular cancer research : MCR. 2023 Oct;21(10):995–1009.
• Madonna MC, Duer JE, McKinney BJ, Sunassee ED, Crouch BT, Ilkayeva O, et al. In vivo metabolic imaging identifies lipid vulnerability in a preclinical model of Her2+/Neu breast cancer residual disease and recurrence. NPJ Breast Cancer. 2022 Sep 26;8(1):111.
• Ramanujam N, Madonna M. Editorial overview: Biomedical engineering and women's health: Breaking new ground in gender- and sex-specific research. Current Opinion in Biomedical Engineering. 2022 Jun 1;22.
• Deutsch RJ, D’Agostino VW, Sunassee ED, Kwan M, Madonna MC, Palmer G, et al. A Spectroscopic Technique to Simultaneously Characterize Fatty Acid Uptake, Mitochondrial Activity, Vascularity, and Oxygen Saturation for Longitudinal Studies In Vivo. Metabolites. 2022 Apr 19;12(5).
• Solingapuram Sai KK, Chen X, Li Z, Zhu C, Shukla K, Forshaw TE, et al. [¹⁸F]Fluoro-DCP, a first generation PET radiotracer for monitoring protein sulfenylation in vivo. Redox biology. 2022 Feb;49:102218.
• Madonna MC, Duer JE, Lee JV, Williams J, Avsaroglu B, Zhu C, et al. In Vivo Optical Metabolic Imaging of Long-Chain Fatty Acid Uptake in Orthotopic Models of Triple-Negative Breast Cancer. Cancers (Basel). 2021 Jan 5;13(1).
• Madonna M, Duer J, Lee J, Williams J, Avsaroglu B, Zhu C, et al. In vivo optical metabolic imaging of long-chain fatty acid uptake in orthotopic models of triple negative breast cancer. 2020;
• Madonna MC, Duer J, Fox D, Alvarez J, Ramanujam N. In vivo metabolic imaging reveals mitochondrial membrane potential reprogramming following Her2-targeted therapy and dormant disease. In: Optics InfoBase Conference Papers. 2020.
• Madonna MC, Fox DB, Crouch BT, Lee J, Zhu C, Martinez AF, et al. Optical Imaging of Glucose Uptake and Mitochondrial Membrane Potential to Characterize Her2 Breast Tumor Metabolic Phenotypes. Mol Cancer Res. 2019 Jul;17(7):1545–55.
• Zhu C, Li M, Vincent T, Martin HL, Crouch BT, Martinez AF, et al. Simultaneous in vivo optical quantification of key metabolic and vascular endpoints reveals tumor metabolic diversity in murine breast tumor models. J Biophotonics. 2019 Apr;12(4):e201800372.
• Morhard R, Nief C, Barrero Castedo C, Hu F, Madonna M, Mueller JL, et al. Development of enhanced ethanol ablation as an alternative to surgery in treatment of superficial solid tumors. Sci Rep. 2017 Aug 18;7(1):8750.
• Zhu C, Martinez AF, Hu F, Li M, Madonna MC, Lee M, et al. Integrated dual-modal microscope for imaging of key metabolic and vascular endpoints in preclinical cancer models. In: Optics InfoBase Conference Papers. 2016.