Karl-Dimiter Bissig
Pediatrics, Medical Genetics
Chen Family Associate Professor of Pediatrics
Research Interests
Our group is interested in diseases of the liver, ranging from viral hepatitis to metabolic liver disorders and liver cancer. The lab specializes in human liver chimeric mice and created the first xenograft model for metabolic liver disease as well as a novel patient derived cancer model. We use these next generation humanized mouse models to develop new therapeutic approaches, such as metabolic pathway reprogramming - a CRISPR based gene therapy approach.
Bio
Our group is interested in diseases of the liver, ranging from viral hepatitis to metabolic liver disorders and liver cancer. The lab specializes in human liver chimeric mice and created the first xenograft model for metabolic liver disease as well as a novel patient derived cancer model. We use these next generation humanized mouse models to develop new therapeutic approaches, such as metabolic pathway reprogramming - a CRISPR based gene therapy approach.
Education
- MD./PhD. Universitat Bern (Switzerland), 2000
Trainings & Certifications
- Residency, INTERNAL MEDICINE (2001 - 2005) Inselspital (Switzerland)
- Postdoctoral Fellow (2005 - 2011) Salk Institute for Biological Studies
Positions
- Chen Family Associate Professor of Pediatrics
- Associate Professor in Pediatrics
- Associate Professor of Biomedical Engineering
- Associate Professor in Pharmacology and Cancer Biology
- Affiliate of the Duke Regeneration Center
- Member of the Duke Cancer Institute
Courses Taught
- PHARM 494: Research Independent Study
- PHARM 493: Research Independent Study
- PHARM 394: Research Independent Study
- BME 791: Graduate Independent Study
- BME 493: Projects in Biomedical Engineering (GE)
In The News
- New Cause Identified for Metabolic Disease That Strikes Native Americans (Apr 20, 2023 | Duke Health News)