Dennis Alan Turner

Research Interests

Clinical trials in Parkinson disease, Alzheimer disease, translational research in Parkinson disease, tremor, stroke, and preclinical studies on Alzheimer's disease models, stroke, metabolism, and cerebral blood flow.

Bio

Current clinical research interests include clinical trials regarding adaptive or closed-loop deep brain stimulation with novel devices, cellular, and gene therapy in Parkinson disease. Additional trials have included gene therapy for Alzheimer's disease and sensory restoration for development of brain machine interfaces. Clinical treatments include deep brain stimulation, which is now a common procedure for treating Parkinson disease and tremor. Translational approaches include testing new devices and stimulation patterns in the operating room. Pre-clinical research interests focus on evaluation of cerebral perfusion and metabolism changes with stroke, aging and Alzheimer's disease, using both in vivo and in vitro approaches. These basic science interests include new approaches to cerebral blood flow enhancement with brain stimulation, optical imaging of the brain, cellular understanding of metabolism using direct substrate recordings (ie, oxygen, glucose, lactate, respirometry) and developing new methods to understand neurovascular coupling, analyzing complex interactions between neurons, astrocytes and blood vessels.  Further interests include changes in cerebral blood flow with stroke and enhanced recovery after stroke.

Education

• B.A. Indiana University at Bloomington, 1971
• M.A. Indiana University at Bloomington, 1973
• M.D. Indiana University, School of Medicine, 1975

Trainings & Certifications

• Intern (1975 - 1976) University of Minnesota, Medical School
• Resident, NEUROLOGICAL SURGERY (1976 - 1981) University of Washington
• Fellowship, FUNCTIONAL NEUROSURGERY (1981 - 1982) University of Oslo (Norway)

Positions

• Professor of Neurosurgery
• Professor of Biomedical Engineering
• Professor in Orthopaedic Surgery
• Professor of Neurobiology
• Faculty Network Member of the Duke Institute for Brain Sciences

Publications

• Moffatt ME, Ford R, Lujano BN, Reed S, Singh A, Stewart DA, et al. Competency based medical education - Where do I start? Curr Probl Pediatr Adolesc Health Care. 2024 Oct;54(10):101674.
• Hsu D, Rassbach C, Leaming-Van Zandt K, Morrow A, Rubenstein J, Tatem A, et al. Competency based medical education and trust in the learning environment. Curr Probl Pediatr Adolesc Health Care. 2024 Sep;54(9):101640.
• Turner DA, Poitevien P. Foreword: Preparing future pediatricians and pediatric subspecialists: Competency-Based Medical Education-Part 1. Curr Probl Pediatr Adolesc Health Care. 2024 Sep;54(9):101639.
• Schlesinger O, Kundu R, Isaev D, Choi JY, Goetz SM, Turner DA, et al. Scalp surface estimation and head registration using sparse sampling and 3D statistical models. Comput Biol Med. 2024 Aug;178:108689.
• Himebauch AS, Priest JR, Annich GM, McMullan DM, Turner DA, Muszynski JA, et al. The Influence of the Extracorporeal Membrane Oxygenation Circuit and Components on Anticoagulation Management: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatr Crit Care Med. 2024 Jul 1;25(7 Suppl 1):e1–6.
• Palopoli-Trojani K, Trumpis M, Chiang C-H, Wang C, Williams AJ, Evans CL, et al. High-density cortical µECoG arrays concurrently track spreading depolarizations and long-term evolution of stroke in awake rats. Commun Biol. 2024 Mar 4;7(1):263.
• Schmidt SL, Chowdhury AH, Mitchell KT, Peters JJ, Gao Q, Lee H-J, et al. At home adaptive dual target deep brain stimulation in Parkinson's disease with proportional control. Brain. 2024 Mar 1;147(3):911–22.
• Schumacher DJ, Martini A, Michelson C, Turner DA, Winn AS, Kinnear B. A realist evaluation of prospective entrustment decisions in paediatric residency clinical competency committees. Medical Education. 2024 Jan 1;
• Turner DA, Poitevien P. Foreword: Preparing future pediatricians and pediatric subspecialists: Competency-based medical education – Part 2. Current Problems in Pediatric and Adolescent Health Care. 2024 Jan 1;
• Zhang D, Wang W, Zhu X, Li R, Liu W, Chen M, et al. Epinephrine-induced Effects on Cerebral Microcirculation and Oxygenation Dynamics Using Multimodal Monitoring and Functional Photoacoustic Microscopy. Anesthesiology. 2023 Aug 1;139(2):173–85.
• Degan S, Feng Y, Hoffmann U, Turner DA. Placement of Extracranial Stimulating Electrodes and Measurement of Cerebral Blood Flow and Intracranial Electrical Fields in Anesthetized Mice. J Vis Exp. 2023 Jun 2;(196).
• Gao Q, Schimdt SL, Chowdhury A, Feng G, Peters JJ, Genty K, et al. Offline Learning of Closed-Loop Deep Brain Stimulation Controllers for Parkinson Disease Treatment. ArXiv. 2023 Mar 16;
• Wang Z, Li Q, Kolls BJ, Mace B, Yu S, Li X, et al. Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice. Commun Biol. 2023 Mar 9;6(1):252.
• Palopoli-Trojani K, Schmidt SL, Baringer KD, Slotkin TA, Peters JJ, Turner DA, et al. Temporally non-regular patterns of deep brain stimulation (DBS) enhance assessment of evoked potentials while maintaining motor symptom management in Parkinson's disease (PD). Brain Stimul. 2023;16(6):1630–42.
• Dahlben B, Bukhari-Parlakturk N, Turner DA, Harward S, Southwell D, Mitchell KT. Deep Brain Stimulation Outcomes in Underreported Dystonias: A Case Series. In: MOVEMENT DISORDERS. 2023. p. S732–S732.
• Rojas E, Schmidt SL, Chowdhury A, Pajic M, Turner DA, Won DS. A comparison of an implanted accelerometer with a wearable accelerometer for closed-loop DBS. Annu Int Conf IEEE Eng Med Biol Soc. 2022 Jul;2022:3439–42.
• Mitchell KT, Schmidt SL, Cooney JW, Grill WM, Peters J, Rahimpour S, et al. Initial Clinical Outcome With Bilateral, Dual-Target Deep Brain Stimulation Trial in Parkinson Disease Using Summit RC + S. Neurosurgery. 2022 Jul 1;91(1):132–8.
• Rahimpour S, Zhang S-C, Vitek JL, Mitchell KT, Turner DA. Comparative efficacy of surgical approaches to disease modification in Parkinson disease. NPJ Parkinsons Dis. 2022 Mar 25;8(1):33.
• Gao Q, Schmidt SL, Kamaravelu K, Turner DA, Grill WM, Pajic M. Offline Policy Evaluation for Learning-based Deep Brain Stimulation Controllers. In: Proceedings - 13th ACM/IEEE International Conference on Cyber-Physical Systems, ICCPS 2022. 2022. p. 80–91.
• Dale J, Schmidt SL, Mitchell K, Turner DA, Grill WM. Evoked potentials generated by deep brain stimulation for Parkinson's disease. Brain Stimul. 2022;15(5):1040–7.
• Turner DA, Degan S, Hoffmann U, Galeffi F, Colton CA. CVN-AD Alzheimer's mice show premature reduction in neurovascular coupling in response to spreading depression and anoxia compared to aged controls. Alzheimers Dement. 2021 Jul;17(7):1109–20.
• Turner DA. Contrasting Metabolic Insufficiency in Aging and Dementia. Aging and disease. 2021 Jul;12(4):1081–96.
• Turner DA, Yang W. Phase-specific manipulation of neuronal activity: a promising stroke therapy approach. Neural Regen Res. 2021 Jul;16(7):1425–6.
• Rahimpour S, Gaztanaga W, Yadav AP, Chang SJ, Krucoff MO, Cajigas I, et al. Freezing of Gait in Parkinson's Disease: Invasive and Noninvasive Neuromodulation. Neuromodulation. 2021 Jul;24(5):829–42.
• Creed J, Cantillana-Riquelme V, Yan BH, Ma S, Chu D, Wang H, et al. Argon Inhalation for 24 h After Closed-Head Injury Does not Improve Recovery, Neuroinflammation, or Neurologic Outcome in Mice. Neurocrit Care. 2021 Jun;34(3):833–43.
• Rahimpour S, Kiyani M, Hodges SE, Turner DA. Deep brain stimulation and electromagnetic interference. Clin Neurol Neurosurg. 2021 Apr;203:106577.
• Rahimpour S, Calakos N, Turner DA, Mitchell KT. Treatment of diaphragmatic dystonia with pallidal deep brain stimulation. BMJ Case Rep. 2021 Mar 25;14(3).
• Turner DA, Degan S, Galeffi F, Schmidt S, Peterchev AV. Rapid, Dose-Dependent Enhancement of Cerebral Blood Flow by transcranial AC Stimulation in Mouse. Brain Stimul. 2021;14(1):80–7.
• Yang W, Li R, Li X, Turner DA. Linking proteostasis, aging, and brain ischemia. In: Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet. 2021. p. 313–24.
• Yu S, Galeffi F, Rodriguiz RM, Wang Z, Shen Y, Lyu J, et al. Small ubiquitin-like modifier 2 (SUMO2) is critical for memory processes in mice. FASEB J. 2020 Nov;34(11):14750–67.
• Wang Y-C, Galeffi F, Wang W, Li X, Lu L, Sheng H, et al. Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome. Exp Neurol. 2020 Apr;326:113206.
• Swan BD, Brocker DT, Gross RE, Turner DA, Grill WM. Effects of ramped-frequency thalamic deep brain stimulation on tremor and activity of modeled neurons. Clin Neurophysiol. 2020 Mar;131(3):625–34.
• Schmidt SL, Brocker DT, Swan BD, Turner DA, Grill WM. Evoked potentials reveal neural circuits engaged by human deep brain stimulation. Brain Stimul. 2020;13(6):1706–18.
• Schmidt SL, Peters JJ, Turner DA, Grill WM. Continuous deep brain stimulation of the subthalamic nucleus may not modulate beta bursts in patients with Parkinson's disease. Brain Stimul. 2020;13(2):433–43.
• Hoang KB, Turner DA. The Emerging Role of Biomarkers in Adaptive Modulation of Clinical Brain Stimulation. Neurosurgery. 2019 Sep 1;85(3):E430–9.
• Ma S, Chu D, Li L, Creed JA, Ryang Y-M, Sheng H, et al. Argon Inhalation for 24 Hours After Onset of Permanent Focal Cerebral Ischemia in Rats Provides Neuroprotection and Improves Neurologic Outcome. Crit Care Med. 2019 Aug;47(8):e693–9.
• Krucoff MO, Miller JP, Saxena T, Bellamkonda R, Rahimpour S, Harward SC, et al. Toward Functional Restoration of the Central Nervous System: A Review of Translational Neuroscience Principles. Neurosurgery. 2019 Jan 1;84(1):30–40.
• Swan BD, Gasperson LB, Krucoff MO, Grill WM, Turner DA. Sensory percepts induced by microwire array and DBS microstimulation in human sensory thalamus. Brain Stimul. 2018;11(2):416–22.
• Krucoff MO, Zhuang K, MacLeod D, Yin A, Byun YW, Manson RJ, et al. A novel paraplegia model in awake behaving macaques. J Neurophysiol. 2017 Sep 1;118(3):1800–8.
• Brocker DT, Swan BD, So RQ, Turner DA, Gross RE, Grill WM. Optimized temporal pattern of brain stimulation designed by computational evolution. Sci Transl Med. 2017 Jan 4;9(371).
• Hoang KB, Cassar IR, Grill WM, Turner DA. Biomarkers and Stimulation Algorithms for Adaptive Brain Stimulation. Front Neurosci. 2017;11:564.
• Pearson JM, Hickey PT, Lad SP, Platt ML, Turner DA. Local Fields in Human Subthalamic Nucleus Track the Lead-up to Impulsive Choices. Front Neurosci. 2017;11:646.
• Cobb MI-PH, Taekman JM, Zomorodi AR, Gonzalez LF, Turner DA. Simulation in Neurosurgery-A Brief Review and Commentary. World Neurosurg. 2016 May;89:583–6.
• Turner DA. Enhanced functional outcome from traumatic brain injury with brain-machine interface neuromodulation neuroprosthetic scaling in relation to injury severity. In: Translational Research in Traumatic Brain Injury. 2016. p. 365–78.
• Galeffi F, Degan S, Britz G, Turner DA. Dysregulation of oxygen hemodynamic responses to synaptic train stimulation in a rat hippocampal model of subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2016 Apr;36(4):696–701.
• Swan BD, Brocker DT, Hilliard JD, Tatter SB, Gross RE, Turner DA, et al. Short pauses in thalamic deep brain stimulation promote tremor and neuronal bursting. Clin Neurophysiol. 2016 Feb;127(2):1551–9.
• Petraglia FW, Farber SH, Han JL, Verla T, Gallis J, Lokhnygina Y, et al. Comparison of Bilateral vs. Staged Unilateral Deep Brain Stimulation (DBS) in Parkinson's Disease in Patients Under 70 Years of Age. Neuromodulation. 2016 Jan;19(1):31–7.
• Krucoff MO, Rahimpour S, Slutzky MW, Edgerton VR, Turner DA. Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation. Front Neurosci. 2016;10:584.
• Warren Olanow C, Bartus RT, Baumann TL, Factor S, Boulis N, Stacy M, et al. Gene delivery of neurturin to putamen and substantia nigra in Parkinson disease: A double-blind, randomized, controlled trial. Ann Neurol. 2015 Aug;78(2):248–57.
• Verla T, Marky A, Farber H, Petraglia FW, Gallis J, Lokhnygina Y, et al. Impact of advancing age on post-operative complications of deep brain stimulation surgery for essential tremor. J Clin Neurosci. 2015 May;22(5):872–6.
• Ivanov AI, Bernard C, Turner DA. Metabolic responses differentiate between interictal, ictal and persistent epileptiform activity in intact, immature hippocampus in vitro. Neurobiol Dis. 2015 Mar;75:1–14.
• Rahimpour S, Turner DA, Lad SP. Deep brain stimulation for Parkinson disease in elderly individuals—reply. JAMA Neurol. 2015 Mar;72(3):368.
• Galeffi F, Shetty PK, Sadgrove MP, Turner DA. Age-related metabolic fatigue during low glucose conditions in rat hippocampus. Neurobiol Aging. 2015 Feb;36(2):982–92.
• Kent AR, Swan BD, Brocker DT, Turner DA, Gross RE, Grill WM. Measurement of evoked potentials during thalamic deep brain stimulation. Brain Stimul. 2015;8(1):42–56.
• Rahimpour S, Turner DA, Lad SP. In reply. JAMA Neurology. 2015 Jan 1;72(3):368.
• Turner DA. Neurovascular regulation is critical for metabolic recovery from spreading depression. Brain. 2014 Nov;137(Pt 11):2877–8.
• DeLong MR, Huang KT, Gallis J, Lokhnygina Y, Parente B, Hickey P, et al. Effect of advancing age on outcomes of deep brain stimulation for Parkinson disease. JAMA Neurol. 2014 Oct;71(10):1290–5.
• Swan BD, Grill WM, Turner DA. Investigation of deep brain stimulation mechanisms during implantable pulse generator replacement surgery. Neuromodulation. 2014 Jul;17(5):419–24.
• Shetty PK, Galeffi F, Turner DA. Nicotinamide pre-treatment ameliorates NAD(H) hyperoxidation and improves neuronal function after severe hypoxia. Neurobiol Dis. 2014 Feb;62:469–78.
• Turner DA. Re-engineering the subthalamus. World Neurosurg. 2013 Nov;80(5):476–8.
• Bartus RT, Baumann TL, Siffert J, Herzog CD, Alterman R, Boulis N, et al. Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients. Neurology. 2013 Apr 30;80(18):1698–701.
• Brocker DT, Swan BD, Turner DA, Gross RE, Tatter SB, Koop MM, et al. Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease. Exp Neurol. 2013 Jan;239:60–7.
• Galeffi F, Turner DA. Exploiting metabolic differences in glioma therapy. Curr Drug Discov Technol. 2012 Dec;9(4):280–93.
• Hanson TL, Fuller AM, Lebedev MA, Turner DA, Nicolelis MAL. Subcortical neuronal ensembles: an analysis of motor task association, tremor, oscillations, and synchrony in human patients. J Neurosci. 2012 Jun 20;32(25):8620–32.
• Quilichini PP, Le Van Quyen M, Ivanov A, Turner DA, Carabalona A, Gozlan H, et al. Hub GABA neurons mediate gamma-frequency oscillations at ictal-like event onset in the immature hippocampus. Neuron. 2012 Apr 12;74(1):57–64.
• Shetty PK, Galeffi F, Turner DA. Cellular Links between Neuronal Activity and Energy Homeostasis. Front Pharmacol. 2012;3:43.
• Shetty PK, Sadgrove MP, Galeffi F, Turner DA. Pyruvate incubation enhances glycogen stores and sustains neuronal function during subsequent glucose deprivation. Neurobiol Dis. 2012 Jan;45(1):177–87.
• Birdno MJ, Kuncel AM, Dorval AD, Turner DA, Gross RE, Grill WM. Stimulus features underlying reduced tremor suppression with temporally patterned deep brain stimulation. J Neurophysiol. 2012 Jan;107(1):364–83.
• Turner DA. Deep brain stimulation shape and surface characteristics: electrical and mechanical design goals. World Neurosurg. 2012;77(3–4):468–9.
• Shetty PK, Galeffi F, Turner DA. Age-Induced Alterations in Hippocampal Function and Metabolism. Aging Dis. 2011 Jun;2(3):196–218.
• Dombrowski KE, Mehta AI, Turner DA, McDonagh DL. Life-saving hemicraniectomy for fulminant acute disseminated encephalomyelitis. Br J Neurosurg. 2011 Apr;25(2):249–52.
• Turner DA, Adamson DC. Neuronal-astrocyte metabolic interactions: understanding the transition into abnormal astrocytoma metabolism. J Neuropathol Exp Neurol. 2011 Mar;70(3):167–76.
• Galeffi F, Somjen GG, Foster KA, Turner DA. Simultaneous monitoring of tissue PO2 and NADH fluorescence during synaptic stimulation and spreading depression reveals a transient dissociation between oxygen utilization and mitochondrial redox state in rat hippocampal slices. J Cereb Blood Flow Metab. 2011 Feb;31(2):626–39.
• Waldau B, Clayton DA, Gasperson LB, Turner DA. Analysis of the time course of the effect of subthalamic nucleus stimulation upon hand function in Parkinson's patients. Stereotact Funct Neurosurg. 2011;89(1):48–55.
• Marks WJ, Bartus RT, Siffert J, Davis CS, Lozano A, Boulis N, et al. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurol. 2010 Dec;9(12):1164–72.
• Gollub RL, Turner DA. Neuroinformatics in clinical and translational medicine--novel approaches. Neuroinformatics. 2010 Dec;8(4):207–12.
• Dorval AD, Kuncel AM, Birdno MJ, Turner DA, Grill WM. Deep brain stimulation alleviates parkinsonian bradykinesia by regularizing pallidal activity. J Neurophysiol. 2010 Aug;104(2):911–21.
• Hickey JV, Olson DM, Turner DA. Intracranial pressure waveform analysis during rest and suctioning. Biol Res Nurs. 2009 Oct;11(2):174–86.
• Rizk M, Bossetti CA, Jochum TA, Callender SH, Nicolelis MAL, Turner DA, et al. A fully implantable 96-channel neural data acquisition system. J Neural Eng. 2009 Apr;6(2):026002.
• Kuncel AM, Turner DA, Ozelius LJ, Greene PE, Grill WM, Stacy MA. Myoclonus and tremor response to thalamic deep brain stimulation parameters in a patient with inherited myoclonus-dystonia syndrome. Clin Neurol Neurosurg. 2009 Apr;111(3):303–6.
• Calhoun AW, Guyatt GH, Cabana MD, Lu D, Turner DA, Valentine S, et al. Addressing the unit of analysis in medical care studies: a systematic review. Med Care. 2008 Jun;46(6):635–43.
• Foster KA, Margraf RR, Turner DA. NADH hyperoxidation correlates with enhanced susceptibility of aged rats to hypoxia. Neurobiol Aging. 2008 Apr;29(4):598–613.
• Birdno MJ, Kuncel AM, Dorval AD, Turner DA, Grill WM. Tremor varies as a function of the temporal regularity of deep brain stimulation. Neuroreport. 2008 Mar 26;19(5):599–602.
• Patil PG, Turner DA. The development of brain-machine interface neuroprosthetic devices. Neurotherapeutics. 2008 Jan;5(1):137–46.
• Galeffi F, Foster KA, Sadgrove MP, Beaver CJ, Turner DA. Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices. J Neurochem. 2007 Dec;103(6):2449–61.
• Sadgrove MP, Beaver CJ, Turner DA. Effects of relative hypoglycemia on LTP and NADH imaging in rat hippocampal slices. Brain Res. 2007 Aug 24;1165:30–9.
• Turner DA, Foster KA, Galeffi F, Somjen GG. Differences in O2 availability resolve the apparent discrepancies in metabolic intrinsic optical signals in vivo and in vitro. Trends Neurosci. 2007 Aug;30(8):390–8.
• Clayton DA, Hanson T, Nicolelis MAL, Turner DA. Subcortical Ensemble Recordings for the Control of a Brain-Machine Interface. In: Neurosurgery. Ovid Technologies (Wolters Kluwer Health); 2007. p. 212–212.
• Grill WM, Dostrovsky JO, Turner DA. Guest editorial: Special theme on deep brain stimulation. IEEE Transactions on Neural Systems and Rehabilitation Engineering. 2007 Mar 1;15(1):153–4.
• Turner DA, Patil PG, Nicolelis MAL. Conceptual and technical approaches to human neural ensemble recordings. In: Methods for Neural Ensemble Recordings, Second Edition. 2007. p. 241–58.
• Olson DM, Thoyre SM, Turner DA, Bennett S, Graffagnino C. Changes in intracranial pressure associated with chest physiotherapy. Neurocrit Care. 2007;6(2):100–3.
• Cook CE, Richardson JK, Pietrobon R, Braga L, Silva HM, Turner D. Validation of the NHANES ADL scale in a sample of patients with report of cervical pain: factor analysis, item response theory analysis, and line item validity. Disabil Rehabil. 2006 Aug 15;28(15):929–35.
• Foster KA, Galeffi F, Gerich FJ, Turner DA, Müller M. Optical and pharmacological tools to investigate the role of mitochondria during oxidative stress and neurodegeneration. Prog Neurobiol. 2006 Jun;79(3):136–71.
• Lang AE, Langston JW, Stoessl AJ, Brodsky M, Brooks DJ, Dhawan V, et al. GDNF in treatment of Parkinson's disease: response to editorial. Lancet Neurol. 2006 Mar;5(3):200–2.
• Lang AE, Gill S, Patel NK, Lozano A, Nutt JG, Penn R, et al. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Ann Neurol. 2006 Mar;59(3):459–66.
• Galeffi F, Foster KA, Turner DA. Effect of monocarboxylate transporter inhibition on NADH biphasic response and oxygen utilization after neuronal stimulation. In: JOURNAL OF NEUROCHEMISTRY. BLACKWELL PUBLISHING; 2006. p. 60–60.
• Patil PG, Turner DA, Pietrobon R. National trends in surgical procedures for degenerative cervical spine disease: 1990-2000. Neurosurgery. 2005 Oct;57(4):753–8.
• Patil PG, West M, Wheal HV, Turner DA. Physiological and statistical approaches to modeling of synaptic responses. In: Modeling in the Neurosciences: From Biological Systems to Neuromimetic Robotics. 2005. p. 61–88.
• Foster KA, Beaver CJ, Turner DA. Interaction between tissue oxygen tension and NADH imaging during synaptic stimulation and hypoxia in rat hippocampal slices. Neuroscience. 2005;132(3):645–57.
• Patil PG, Carmena JM, Nicolelis MAL, Turner DA. Ensemble recordings of human subcortical neurons as a source of motor control signals for a brain-machine interface. Neurosurgery. 2004 Jul;55(1):27–35.
• Langmoen IA, Svensson M, Berg-Johnsen J, Turner DA, Liu CY, Bakay RAE. Hippocampal neurotransplantation evaluated in the rat kainic acid epilepsy model: Comments. Neurosurgery. 2004 Jul 1;55(1):198–200.
• Smith-Hammond CA, New KC, Pietrobon R, Curtis DJ, Scharver CH, Turner DA. Prospective analysis of incidence and risk factors of dysphagia in spine surgery patients: comparison of anterior cervical, posterior cervical, and lumbar procedures. Spine (Phila Pa 1976). 2004 Jul 1;29(13):1441–6.
• Li Q, Guo-Ross S, Lewis DV, Turner D, White AM, Wilson WA, et al. Dietary prenatal choline supplementation alters postnatal hippocampal structure and function. J Neurophysiol. 2004 Apr;91(4):1545–55.
• Patil PG, Nicolelis MAL, Turner DA. Brain-machine interface: Ensembles of human subcortical neurons and signals for neuroprosthetic control. In: JOURNAL OF NEUROSURGERY. AMER ASSOC NEUROLOGICAL SURGEONS; 2004. p. 796–796.
• Turner DA, Nicolelis MAL, van Landingham K. Pre-ictal seizure detection and demand treatment strategies for epilepsy. In: Modern Neurosurgery: Clinical Translation of Neuroscience Advances. 2004. p. 105–18.
• Pradhan AA, Turner DA. Neuroscience ICU therapeutics. In: Modern Neurosurgery: Clinical Translation of Neuroscience Advances. 2004. p. 233–46.
• Pradhan AA, Shetty AK, Turner DA. Clinical prospects for neural grafting therapy for cortical lesions. In: Modern Neurosurgery: Clinical Translation of Neuroscience Advances. 2004. p. 17–35.
• Patil PG, Turner DA. Surgical treatment of movement disorders: DBS, gene therapy, and beyond. In: Modern Neurosurgery: Clinical Translation of Neuroscience Advances. 2004. p. 141–58.
• Turner DA, Archibald SJ. Neuroscience hypotheses and translation into neurosurgery practice. In: Modern Neurosurgery: Clinical Translation of Neuroscience Advances. 2004. p. 1–16.
• New KC, Smith C, Niklason L, Turner DA. Delayed cerebral vasospasm: Current hypotheses and future treatments. In: Modern Neurosurgery: Clinical Translation of Neuroscience Advances. 2004. p. 201–12.
• Henn JS, Turner DA. Neurosurgery teaching techniques and neurosurgical simulation. In: Modern Neurosurgery: Clinical Translation of Neuroscience Advances. 2004. p. 291–301.
• Turner DA. Modern neurosurgery: Clinical translation of neuroscience advances. 2004.
• Foster KA, Beaver CJ, Goldstein LB, Turner DA. Cellular brain ischemia and stroke: Neuroprotection, metabolism, and new strategies for brain recovery. In: Modern Neurosurgery: Clinical Translation of Neuroscience Advances. 2004. p. 59–83.
• Turner DA, Richardson WJ. New directions and therapeutics in surgical spine treatment. In: Modern Neurosurgery: Clinical Translation of Neuroscience Advances. 2004. p. 247–70.
• Pietrobon R, Turner DA. Clinical research in surgery. In: Modern Neurosurgery: Clinical Translation of Neuroscience Advances. 2004. p. 271–90.
• Turner DA, Dimitrov DF, Nicolelis MAL. Neuroprosthetics and clinical realization of brain-machine interfaces. In: Modern Neurosurgery: Clinical Translation of Neuroscience Advances. 2004. p. 119–39.
• Turner DA, Shetty AK. Clinical prospects for neural grafting therapy for hippocampal lesions and epilepsy. Neurosurgery. 2003 Mar;52(3):632–44.
• Speciale AC, Pietrobon R, Urban CW, Richardson WJ, Helms CA, Major N, et al. Observer variability in assessing lumbar spinal stenosis severity on magnetic resonance imaging and its relation to cross-sectional spinal canal area. Spine (Phila Pa 1976). 2002 May 15;27(10):1082–6.
• Fayuk D, Aitken PG, Somjen GG, Turner DA. Two different mechanisms underlie reversible, intrinsic optical signals in rat hippocampal slices. J Neurophysiol. 2002 Apr;87(4):1924–37.
• Eastwood JD, Turner DA, McLendon RE, Provenzale JM. Diffusion-weighted MR imaging in a patient with spinal meningioma. AJR Am J Roentgenol. 2001 Dec;177(6):1479–81.
• Villavicencio AT, Dimitrov DF, McGirt MJ, Turner DA. Management of acute cervical spinal cord injury. Neurologist. 2001 Sep;7(5):287–94.
• Shetty AK, Turner DA. Glutamic acid decarboxylase-67-positive hippocampal interneurons undergo a permanent reduction in number following kainic acid-induced degeneration of ca3 pyramidal neurons. Exp Neurol. 2001 Jun;169(2):276–97.
• Zaman V, Turner DA, Shetty AK. Prolonged postlesion transplantation delay adversely influences survival of both homotopic and heterotopic fetal hippocampal cell grafts in Kainate-lesioned CA3 region of adult hippocampus. Cell Transplant. 2001;10(1):41–52.
• Villavicencio AT, Bulsara KR, Little K, Turner DA. Multiple intracranial epidural hematomas after lumbar puncture: Case report and review of the literature. Neurologist. 2001 Jan 1;7(2):122–6.
• Shetty AK, Turner DA. Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy. J Neurosci. 2000 Dec 1;20(23):8788–801.
• Bahar S, Fayuk D, Somjen GG, Aitken PG, Turner DA. Mitochondrial and intrinsic optical signals imaged during hypoxia and spreading depression in rat hippocampal slices. J Neurophysiol. 2000 Jul;84(1):311–24.
• Zaman V, Turner DA, Shetty AK. Survival of grafted fetal neural cells in kainic acid lesioned CA3 region of adult hippocampus depends upon cell specificity. Exp Neurol. 2000 Feb;161(2):535–61.
• Smith DW, Turner DA, Henson MM. Psychophysical correlates of contralateral efferent suppression. I. The role of the medial olivocochlear system in "central masking" in nonhuman primates. J Acoust Soc Am. 2000 Feb;107(2):933–41.
• Danisa OA, Turner D, Richardson WJ. Surgical correction of lumbar kyphotic deformity: posterior reduction "eggshell" osteotomy. J Neurosurg. 2000 Jan;92(1 Suppl):50–6.
• Shetty AK, Zaman V, Turner DA. Pattern of long-distance projections from fetal hippocampal field CA3 and CA1 cell grafts in lesioned CA3 of adult hippocampus follows intrinsic character of respective donor cells. Neuroscience. 2000;99(2):243–55.
• Shetty AK, Turner DA. Aging impairs axonal sprouting response of dentate granule cells following target loss and partial deafferentation. J Comp Neurol. 1999 Nov 15;414(2):238–54.
• Cannon RC, Wheal HV, Turner DA. Dendrites of classes of hippocampal neurons differ in structural complexity and branching patterns. J Comp Neurol. 1999 Nov 1;413(4):619–33.
• Pyapali GK, Turner DA, Wilson WA, Swartzwelder HS. Age and dose-dependent effects of ethanol on the induction of hippocampal long-term potentiation. Alcohol. 1999 Oct;19(2):107–11.
• Mott DD, Li Q, Okazaki MM, Turner DA, Lewis DV. GABAB-Receptor-mediated currents in interneurons of the dentate-hilus border. J Neurophysiol. 1999 Sep;82(3):1438–50.
• Shetty AK, Turner DA. Vulnerability of the dentate gyrus to aging and intracerebroventricular administration of kainic acid. Exp Neurol. 1999 Aug;158(2):491–503.
• Aitken PG, Fayuk D, Somjen GG, Turner DA. Use of intrinsic optical signals to monitor physiological changes in brain tissue slices. Methods. 1999 Jun;18(2):91–103.
• Shetty AK, Turner DA. Neurite outgrowth from progeny of epidermal growth factor-responsive hippocampal stem cells is significantly less robust than from fetal hippocampal cells following grafting onto organotypic hippocampal slice cultures: effect of brain-derived neurotrophic factor. J Neurobiol. 1999 Feb 15;38(3):391–413.
• Cannon RC, Turner DA, Pyapali GK, Wheal HV. An on-line archive of reconstructed hippocampal neurons. J Neurosci Methods. 1998 Oct 1;84(1–2):49–54.
• Wheal HV, Cannon RC, Turner DA. An on-line archive of hippocampal neuronal morphology. JOURNAL OF PHYSIOLOGY-LONDON. 1998 Sep 1;511P:18P-19P.
• Aitken PG, Tombaugh GC, Turner DA, Somjen GG. Similar propagation of SD and hypoxic SD-like depolarization in rat hippocampus recorded optically and electrically. J Neurophysiol. 1998 Sep;80(3):1514–21.
• Bulinski JC, Ohm T, Roder H, Spruston N, Turner DA, Wheal HV. Changes in dendritic structure and function following hippocampal lesions: correlations with developmental events? Prog Neurobiol. 1998 Aug;55(6):641–50.
• Turner DA, Buhl EH, Hailer NP, Nitsch R. Morphological features of the entorhinal-hippocampal connection. Prog Neurobiol. 1998 Aug;55(6):537–62.
• Shetty AK, Turner DA. In vitro survival and differentiation of neurons derived from epidermal growth factor-responsive postnatal hippocampal stem cells: inducing effects of brain-derived neurotrophic factor. J Neurobiol. 1998 Jun 15;35(4):395–425.
• Shetty AK, Turner DA. Hippocampal interneurons expressing glutamic acid decarboxylase and calcium-binding proteins decrease with aging in Fischer 344 rats. J Comp Neurol. 1998 May 4;394(2):252–69.
• Pyapali GK, Turner DA, Williams CL, Meck WH, Swartzwelder HS. Prenatal dietary choline supplementation decreases the threshold for induction of long-term potentiation in young adult rats. J Neurophysiol. 1998 Apr;79(4):1790–6.
• Pyapali GK, Sik A, Penttonen M, Buzsaki G, Turner DA. Dendritic properties of hippocampal CA1 pyramidal neurons in the rat: intracellular staining in vivo and in vitro. J Comp Neurol. 1998 Feb 16;391(3):335–52.
• Mott DD, Turner DA, Okazaki MM, Lewis DV. Interneurons of the dentate-hilus border of the rat dentate gyrus: morphological and electrophysiological heterogeneity. J Neurosci. 1997 Jun 1;17(11):3990–4005.
• Turner DA, Chen Y, Isaac JT, West M, Wheal HV. Excitatory synaptic site heterogeneity during paired pulse plasticity in CA1 pyramidal cells in rat hippocampus in vitro. J Physiol. 1997 Apr 15;500 ( Pt 2)(Pt 2):441–61.
• Shetty AK, Turner DA. Development of long-distance efferent projections from fetal hippocampal grafts depends upon pathway specificity and graft location in kainate-lesioned adult hippocampus. Neuroscience. 1997 Feb;76(4):1205–19.
• Shetty AK, Turner DA. Fetal hippocampal cells grafted to kainate-lesioned CA3 region of adult hippocampus suppress aberrant supragranular sprouting of host mossy fibers. Exp Neurol. 1997 Feb;143(2):231–45.
• Shetty AK, Turner DA. Development of fetal hippocampal grafts in intact and lesioned hippocampus. Prog Neurobiol. 1996 Dec;50(5–6):597–653.
• Pyapali GK, Turner DA. Increased dendritic extent in hippocampal CA1 neurons from aged F344 rats. Neurobiol Aging. 1996;17(4):601–11.
• Turner DA, Scott BL, Johnson PB, Gorecki J. Resurgence of stereotaxic procedures for relief of parkinsonism. Role of image-directed targeting and current status. N C Med J. 1996;57(5):320–4.
• Shetty AK, Turner DA. Intracerebroventricular kainic acid administration in adult rat alters hippocampal calbindin and non-phosphorylated neurofilament expression. J Comp Neurol. 1995 Dec 25;363(4):581–99.
• Marks LB, Sherouse GW, Das S, Bentel GC, Spencer DP, Turner D. Conformal radiation therapy with fixed shaped coplanar or noncoplanar radiation beam bouquets: a possible alternative to radiosurgery. Int J Radiat Oncol Biol Phys. 1995 Dec 1;33(5):1209–19.
• Shetty AK, Rapoza D, Madison RD, Turner DA. Selective laser-activated lesioning of prelabeled fetal hippocampal grafts by intracellular photolytic chromophore. Neuroscience. 1995 Nov;69(2):407–16.
• Gabriel EM, Sampson JH, Dodd LG, Turner DA. Glomus jugulare tumor metastatic to the sacrum after high-dose radiation therapy: case report. Neurosurgery. 1995 Nov;37(5):1001–5.
• Turner DA, Aitken PG, Somjen GG. Optical mapping of translucence changes in rat hippocampal slices during hypoxia. Neurosci Lett. 1995 Aug 11;195(3):209–13.
• Shetty AK, Turner DA. Enhanced cell survival in fetal hippocampal suspension transplants grafted to adult rat hippocampus following kainate lesions: a three-dimensional graft reconstruction study. Neuroscience. 1995 Aug;67(3):561–82.
• Turner DA, Li XG, Pyapali GK, Ylinen A, Buzsaki G. Morphometric and electrical properties of reconstructed hippocampal CA3 neurons recorded in vivo. J Comp Neurol. 1995 Jun 12;356(4):580–94.
• Shetty AK, Turner DA. Non-phosphorylated neurofilament protein immunoreactivity in adult and developing rat hippocampus: specificity and application in grafting studies. Brain Res. 1995 Apr 10;676(2):293–306.
• Migliore M, Cook EP, Jaffe DB, Turner DA, Johnston D. Computer simulations of morphologically reconstructed CA3 hippocampal neurons. J Neurophysiol. 1995 Mar;73(3):1157–68.
• Clarke SR, Shetty AK, Bradley JL, Turner DA. Reactive astrocytes express the embryonic intermediate neurofilament nestin. Neuroreport. 1994 Oct 3;5(15):1885–8.
• Swett JW, Paramore CG, Turner DA. Quantitative estimation of cryopreservation viability in rat fetal hippocampal cells. Exp Neurol. 1994 Oct;129(2):330–4.
• Pyapali GK, Turner DA. Denervation-induced dendritic alterations in CA1 pyramidal cells following kainic acid hippocampal lesions in rats. Brain Res. 1994 Aug 1;652(2):279–90.
• Shetty AK, Madison RD, Bradley J, Turner DA. Quantitative graft integration of fetal hippocampal transplants labeled with 5' bromodeoxyuridine into normal adult hippocampus. Exp Neurol. 1994 Apr;126(2):205–24.
• West M, Turner DA. Deconvolution of Mixtures in Analysis of Neural Synaptic Transmission. The Statistician. 1994;43(1):31–31.
• Paramore CG, Turner DA. Relative risks of ventriculostomy infection and morbidity. Acta Neurochir (Wien). 1994;127(1–2):79–84.
• Pyapali GK, Turner DA, Madison RD. Fetal transplants in rat hippocampus following kainic acid lesions: influence of post-lesion delay on graft survival and integration. Restor Neurol Neurosci. 1994 Jan 1;6(2):113–26.
• Pyapali GK, Dong WQ, Deupree DL, Bradley J, Turner DA. Influence of fetal hippocampal grafts on lesions induced by intraventricular infusion of N-methyl-D-aspartate (NMDA) into rats. Restor Neurol Neurosci. 1994 Jan 1;6(3):251–6.
• Turner DA, Kearney W. Scientific and ethical concerns in neural fetal tissue transplantation. Neurosurgery. 1993 Dec;33(6):1031–7.
• Paramore CG, Turner DA, Madison RD. Induction of neuronal morphology in adrenal chromaffin cells cocultured with denervated Schwann cells. Exp Neurol. 1993 Jun;121(2):288–94.
• Weeks KJ, Marks L, Ray SK, Spencer DP, Turner DA, Friedman AH. 3-dimensional optimization of multiple arcs for stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 1993 Apr 30;26(1):147–54.
• Turner DA, West M. Bayesian analysis of mixtures applied to post-synaptic potential fluctuations. J Neurosci Methods. 1993 Apr;47(1–2):1–21.
• Deupree DL, Bradley J, Turner DA. Age-related alterations in potentiation in the CA1 region in F344 rats. Neurobiol Aging. 1993;14(3):249–58.
• Turner DA. Fontal lobe function and dysfunction. Neurosurgery. 1993 Jan 1;32(2):326.
• Paramore CG, Turner DA, Madison RD. Fluorescent labeling of dissociated fetal cells for tissue culture. J Neurosci Methods. 1992 Aug;44(1):7–17.
• Pyapali GK, Turner DA, Madison RD. Anatomical and physiological localization of prelabeled grafts in rat hippocampus. Exp Neurol. 1992 May;116(2):133–44.
• Camarata PJ, Suryanarayanan R, Turner DA, Parker RG, Ebner TJ. Sustained release of nerve growth factor from biodegradable polymer microspheres. Neurosurgery. 1992 Mar;30(3):313–9.
• Camarata PJ, Parker RG, Park SK, Haines SJ, Turner DA, Chae H, et al. Effects of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-induced hemiparkinsonism on the kinematics of a two-dimensional,multijoint arm movement in the rhesus monkey. Neuroscience. 1992;48(3):607–19.
• Turner DA, Wheal HV. Excitatory synaptic potentials in kainic acid-denervated rat CA1 pyramidal neurons. J Neurosci. 1991 Sep;11(9):2786–94.
• North American Symptomatic Carotid Endarterectomy Trial Collaborators, Barnett HJM, Taylor DW, Haynes RB, Sackett DL, Peerless SJ, et al. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med. 1991 Aug 15;325(7):445–53.
• Deupree DL, Turner DA, Watters CL. Spatial performance correlates with in vitro potentiation in young and aged Fischer 344 rats. Brain Res. 1991 Jul 19;554(1–2):1–9.
• Turner DA, Deupree DL. Functional elongation of CA1 hippocampal neurons with aging in Fischer 344 rats. Neurobiol Aging. 1991;12(3):201–10.
• Friehs GM, Parker RG, He LS, Haines SJ, Turner DA, Ebner TJ. Lesioning of the striatum reverses motor asymmetry in the 6-hydroxydopamine rodent model of parkinsonism. J Neural Transplant Plast. 1991;2(2):141–56.
• Turner DA, Schlieckert M. Data acquisition and analysis system for intracellular neuronal signals. J Neurosci Methods. 1990 Dec;35(3):241–51.
• Turner DA, Tracy J, Haines SJ. Risk of late stroke and survival following carotid endarterectomy procedures for symptomatic patients. J Neurosurg. 1990 Aug;73(2):193–200.
• Turner DA. Feed-forward inhibitory potentials and excitatory interactions in guinea-pig hippocampal pyramidal cells. J Physiol. 1990 Mar;422:333–50.
• Turner DA. Comparison of passive cable model predictions and physiologic measurements of CA1 hippocampal neurons. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 1989 Dec 1;11 pt 4:1283.
• Turner DA, McGeachie RE. Normal pressure hydrocephalus and dementia--evaluation and treatment. Clin Geriatr Med. 1988 Nov;4(4):815–30.
• Turner DA. Waveform and amplitude characteristics of evoked responses to dendritic stimulation of CA1 guinea-pig pyramidal cells. J Physiol. 1988 Jan;395:419–39.
• Stavas J, McGeachie RE, Turner DA, Nelson MJ. Symptomatic intracranial pneumatocele from mastoid sinus of spontaneous origin. Case report. J Neurosurg. 1987 Nov;67(5):773–5.
• Turner DA. Pathophysiology of neuronal signaling in the cerebral cortex. Minn Med. 1985 Jul;68(7):550–2.
• Turner DA. Segmental cable evaluation of somatic transients in hippocampal neurons (CA1, CA3, and dentate). Biophys J. 1984 Jul;46(1):73–84.
• Turner DA, Schwartzkroin PA. Electrical characteristics of dendrites and dendritic spines in intracellularly stained CA3 and dentate hippocampal neurons. J Neurosci. 1983 Nov;3(11):2381–94.
• Schwartzkroin PA, Turner DA, Knowles WD, Wyler AR. Studies of human and monkey "epileptic" neocortex in the in vitro slice preparation. Ann Neurol. 1983 Mar;13(3):249–57.
• Turner DA, Howe JF. Cerebellar hemorrhage as evaluated by computerized tomography. West J Med. 1982 Mar;136(3):198–202.
• Turner DA, Wyler AR. Temporal lobectomy for epilepsy: mesial temporal herniation as an operative and prognostic finding. Epilepsia. 1981 Dec;22(6):623–9.
• Turner DA, Calvin WH. Dendritic analysis of lobster stretch receptor neurons: electrotonic properties with single and distributed inputs. Cell Mol Neurobiol. 1981 Jun;1(2):189–207.
• Turner DA, Schwartzkroin PA. Steady-state electrotonic analysis of intracellularly stained hippocampal neurons. J Neurophysiol. 1980 Jul;44(1):184–99.

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