Bastiaan Driehuys
Radiology
Professor of Radiology
Research Themes
Biomedical Imaging & Biophotonics
Bio
Our research focuses on magnetic resonance imaging (MRI) research with hyperpolarized 129Xe gas. We are at at the forefront of developing this novel technology for imaging the lungs of patients with pulmonary disease. We currently have multiple, ongoing NIH and industry-sponsored studies invovling this technique. Hyperpolarization is a laser-based process that enhances the MRI signal of xenon gas by a factor of 100,000 to allow for high-resolution, non-invasive MRI of pulmonary function. In addition to our research program, this technology was recently FDA approved and efforts are underway to implement it clinically.
Current studies are applying 129Xe MRI for early diagnosis and monitoring of interstitial and pulmonary vascular diseases. Our group, which is comprised of MRI scientists and radiologists, works closely with colleagues in pulmonary medicine. Our laboratory provides research opportunities to Ph.D., Masters, and medical students as well as select undergraduate students.
Education
- Ph.D. Princeton University, 1995
Positions
- Professor of Radiology
- Professor of Biomedical Engineering
Courses Taught
- PHYSICS 495: Thesis Independent Study
- PHYSICS 493: Research Independent Study
- EGR 393: Research Projects in Engineering
- BME 791: Graduate Independent Study
Publications
- Wulfeck MK, Mummy DG, Zhang S, Kadi D, Goins S, Swaminathan A, et al. Hyperpolarized 129Xe MRI and spectroscopy of gas exchange abnormalities in chronic hypersensitivity pneumonitis. Respir Med. 2024 Oct 5;234:107827.
- Rankine LJ, Lu J, Wang Z, Kelsey CR, Marks LB, Das SK, et al. Quantifying Regional Radiation-Induced Lung Injury in Patients Using Hyperpolarized 129Xe Gas Exchange Magnetic Resonance Imaging. Int J Radiat Oncol Biol Phys. 2024 Sep 1;120(1):216–28.
- Lu J, Alenezi F, Bier E, Leewiwatwong S, Mummy D, Kabir S, et al. Optimized quantitative mapping of cardiopulmonary oscillations using hyperpolarized 129 Xe gas exchange MRI: Digital phantoms and clinical evaluation in CTEPH. Magn Reson Med. 2024 Apr;91(4):1541–55.
- Eddy RL, Mummy D, Zhang S, Dai H, Bechtel A, Schmidt A, et al. Cluster Analysis to Identify Long COVID Phenotypes Using 129Xe Magnetic Resonance Imaging: A Multi-centre Evaluation. Eur Respir J. 2024 Feb 8;63(3).
- Mummy D, Zhang S, Bechtel A, Lu J, Mammarappallil J, Leewiwatwong S, et al. Functional gas exchange measures on 129Xe MRI and spectroscopy are associated with age, sex, and BMI in healthy subjects. Front Med (Lausanne). 2024;11:1342499.
- Leewiwatwong S, Lu J, Dummer I, Yarnall K, Mummy D, Wang Z, et al. Combining neural networks and image synthesis to enable automatic thoracic cavity segmentation of hyperpolarized 129Xe MRI without proton scans. Magn Reson Imaging. 2023 Nov;103:145–55.
- Bechtel A, Lu J, Mummy D, Bier E, Leewiwatwong S, Mugler J, et al. Establishing a hemoglobin adjustment for 129 Xe gas exchange MRI and MRS. Magn Reson Med. 2023 Oct;90(4):1555–68.
- Bell LC, Fernandez Coimbra A, Zou Y, Dimond C, Mata J, Muglar J, et al. Multisite implementation of 129Xe-MRI assessment of COPD disease progression: XeCITE early results. In: Imaging. European Respiratory Society; 2023. p. PA2283–PA2283.
- Erratum: Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report. Annals of the American Thoracic Society. 2023 Apr;20(4):620–620.
- Hsia CCW, Bates JHT, Driehuys B, Fain SB, Goldin JG, Hoffman EA, et al. Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report. Ann Am Thorac Soc. 2023 Feb;20(2):161–95.
- El Haddad L, Khan M, Soufny R, Mummy D, Driehuys B, Mansour W, et al. Monitoring and Management of Respiratory Function in Pompe Disease: Current Perspectives. Ther Clin Risk Manag. 2023;19:713–29.
- Subashi E, Feng L, Liu Y, Robertson S, Segars P, Driehuys B, et al. View-sharing for 4D magnetic resonance imaging with randomized projection-encoding enables improvements of respiratory motion imaging for treatment planning in abdominothoracic radiotherapy. Phys Imaging Radiat Oncol. 2023 Jan;25:100409.
- Kocher M, Mummy D, Tighe RM, Driehuys B, Mammarappallil J. Functional Imaging Signatures of Chronic Hypersensitivity Pneumonitis Utilizing Hyperpolarized 129Xe MRI and Spectroscopy. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2023.
- Swaminathan AC, Mummy D, Zhang S, Lu J, Morrison LD, Mammarappallil J, et al. Dynamic Changes in Hyperpolarized 129Xe MRI Measures After Initiation of Therapy in Patients With Idiopathic Pulmonary Fibrosis Associate With Lung Function. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2023.
- Eddy RL, Mummy D, Dai H, Bechtel A, Schmidt A, Frizzell B, et al. 129Xe Magnetic Resonance Imaging-based Phenotypes of Long COVID: A Multi-center Evaluation. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2023.
- O’Sullivan-Murphy B, Driehuys B, Mammarappallil J. MR Imaging for the Evaluation of Diffuse Lung Disease: Where Are We? Radiol Clin North Am. 2022 Nov;60(6):1021–32.
- Matheson AM, McIntosh MJ, Kooner HK, Lee J, Desaigoudar V, Bier E, et al. Persistent 129Xe MRI Pulmonary and CT Vascular Abnormalities in Symptomatic Individuals with Post-acute COVID-19 Syndrome. Radiology. 2022 Nov;305(2):466–76.
- Willmering MM, Walkup LL, Niedbalski PJ, Wang H, Wang Z, Hysinger EB, et al. Pediatric 129 Xe Gas-Transfer MRI-Feasibility and Applicability. J Magn Reson Imaging. 2022 Oct;56(4):1207–19.
- Lu J, Wang Z, Bier E, Leewiwatwong S, Mummy D, Driehuys B. Bias field correction in hyperpolarized 129 Xe ventilation MRI using templates derived by RF-depolarization mapping. Magn Reson Med. 2022 Aug;88(2):802–16.
- Bier EA, Alenezi F, Lu J, Wang Z, Mammarappallil JG, O’Sullivan-Murphy B, et al. Noninvasive diagnosis of pulmonary hypertension with hyperpolarised 129Xe magnetic resonance imaging and spectroscopy. In: ERJ Open Res. 2022.
- Niedbalski PJ, Lu J, Hall CS, Castro M, Mugler JP, Shim YM, et al. Utilizing flip angle/TR equivalence to reduce breath hold duration in hyperpolarized 129 Xe 1-point Dixon gas exchange imaging. Magn Reson Med. 2022 Mar;87(3):1490–9.
- Kooner HK, McIntosh MJ, Desaigoudar V, Rayment JH, Eddy RL, Driehuys B, et al. Pulmonary functional MRI: Detecting the structure-function pathologies that drive asthma symptoms and quality of life. Respirology. 2022 Feb;27(2):114–33.
- Mummy D, Swaminathan A, Yarnall K, Bier E, Lu J, Leewiwatwong S, et al. Hyperpolarized 129Xe MRI in Healthy Control Subjects Reveals Age-Related Changes in Measurements of Ventilation and Red Blood Cell Transfer but Not Interstitial Tissue Barrier. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022.
- Mummy D, Bier E, Lu J, Leewiwatwong S, Bechtel A, Dummer I, et al. Hyperpolarized 129Xe MRI Is Sensitive to Variations in Gas Exchange Impairment in Patients with Long Haul COVID-19 and Normal Cardiac Structure and Function. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022.
- Rankine LJ, Lu J, Wang Z, Kelsey CR, Marks LB, Das SK, et al. Radiation-Induced Lung Injury Quantified by Hyperpolarized 129Xe MRI: Dose-Dependence and Association with Changes in Global Lung Function. In: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2022. p. E556–E556.
- Barton AS, Newbury NR, Cates GD, Driehuys B, Middleton H, Saam B. Erratum: Self-calibrating measurement of polarization-dependent frequency shifts from Rb-
collisions [Phys. Rev. A 49 , 2766 (1994)]. Physical Review A. 2021 Dec 17;104(6).He 3 - Niedbalski PJ, Hall CS, Castro M, Eddy RL, Rayment JH, Svenningsen S, et al. Protocols for multi-site trials using hyperpolarized 129 Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129 Xe MRI clinical trials consortium. Magn Reson Med. 2021 Dec;86(6):2966–86.
- Rankine LJ, Wang Z, Kelsey CR, Bier E, Driehuys B, Marks LB, et al. Hyperpolarized 129Xe Magnetic Resonance Imaging for Functional Avoidance Treatment Planning in Thoracic Radiation Therapy: A Comparison of Ventilation- and Gas Exchange-Guided Treatment Plans. Int J Radiat Oncol Biol Phys. 2021 Nov 15;111(4):1044–57.
- Mummy DG, Bier EA, Wang Z, Korzekwinski J, Morrison L, Barkauskas C, et al. Hyperpolarized 129Xe MRI and Spectroscopy of Gas-Exchange Abnormalities in Nonspecific Interstitial Pneumonia. Radiology. 2021 Oct;301(1):211–20.
- Mummy DG, Coleman EM, Wang Z, Bier EA, Lu J, Driehuys B, et al. Regional Gas Exchange Measured by 129 Xe Magnetic Resonance Imaging Before and After Combination Bronchodilators Treatment in Chronic Obstructive Pulmonary Disease. J Magn Reson Imaging. 2021 Sep;54(3):964–74.
- Wang Z, Rankine L, Bier EA, Mummy D, Lu J, Church A, et al. Using hyperpolarized 129Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity. J Appl Physiol (1985). 2021 May 1;130(5):1398–409.
- Bier E, Lu J, Mummy D, Mammarappallil J, Palmer S, Driehuys B, et al. Hyperpolarized 129Xe MRI in the Imaging of Chronic Lung Allograft Dysfunction. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021.
- Bier E, Alenezi F, Lu J, Mammarappallil J, Driehuys B, Rajagopal S. Hyperpolarized 129Xe Magnetic Resonance Oscillation Imaging in Pulmonary Hypertension. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021.
- Bier E, Mummy D, Lu J, Driehuys B. Within-Session Repeatability of Pulmonary 129Xe Static and Dynamic Spectroscopy. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021.
- Mummy D, Coleman EM, Wang Z, Bier E, Lu J, Driehuys B, et al. Regional Changes in Ventilation Following Bronchodilation in COPD Are Not Associated with Improved Gas Exchange on Xenon-129 MRI. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021.
- Mummy D, Swaminathan A, Yarnall K, Mammarappallil J, Driehuys B, Tighe RM. Hyperpolarized 129Xe MRI Features Identify Functional Differences That Do Not Correlate with Chest CT in Patients with Idiopathic Pulmonary Fibrosis. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021.
- Rankine L, Wang Z, Bier E, Kelsey C, Das S, Marks L, et al. Quantifying Radiation-Induced Lung Injury as a Function of Regional Radiation Therapy Dose Using Hyperpolarized-129Xe MRI. In: MEDICAL PHYSICS. 2021.
- Huang Y-CT, Wencker M, Driehuys B. Imaging in alpha-1 antitrypsin deficiency: a window into the disease. Ther Adv Chronic Dis. 2021;12_suppl:20406223211024524.
- Driehuys B, Mata J, Hartwig M, Aragaki-Nakahodo A, West K, Emami K, et al. Randomized Phase III Trial Assessing Regional Lung Function for Lung Transplant by Hyperpolarized 129Xenon Gas MRI. In: Imaging. European Respiratory Society; 2020. p. 2084–2084.
- Shim Y, Mata J, Hartwig M, Aragaki-Nakahodo A, West K, Emami K, et al. Randomized Phase III Trial Assessing Regional Lung Function for Thoracic Resection by Hyperpolarized 129Xenon Gas MRI. In: Imaging. European Respiratory Society; 2020. p. 2080–2080.
- Niedbalski PJ, Bier EA, Wang Z, Willmering MM, Driehuys B, Cleveland ZI. Mapping cardiopulmonary dynamics within the microvasculature of the lungs using dissolved 129Xe MRI. J Appl Physiol (1985). 2020 Aug 1;129(2):218–29.
- He M, Wang Z, Rankine L, Luo S, Nouls J, Virgincar R, et al. Generalized Linear Binning to Compare Hyperpolarized 129Xe Ventilation Maps Derived from 3D Radial Gas Exchange Versus Dedicated Multislice Gradient Echo MRI. Acad Radiol. 2020 Aug;27(8):e193–203.
- Mummy D, Driehuys B. Illuminating Lung Inflammation at the Alveolar Capillary Interface. J Magn Reson Imaging. 2020 Jun;51(6):1677–8.
- Virgincar RS, Nouls JC, Wang Z, Degan S, Qi Y, Xiong X, et al. Quantitative 129Xe MRI detects early impairment of gas-exchange in a rat model of pulmonary hypertension. Sci Rep. 2020 Apr 30;10(1):7385.
- Rajagopal S, Bier E, Wang Z, Parikh K, Almeida-Peters S, Womack S, et al. Monitoring Response to Inhaled Prostacyclin Therapy with 129Xenon MR Imaging and Spectroscopy in Patients with Pulmonary Hypertension. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2020.
- Niedbalski PJ, Rankine LJ, Bier EA, Wang Z, Driehuys B, Tighe RM, et al. Hyperpolarized 129Xe MRI of Regional Capillary-Level Cardio-Pulmonary Dynamics Predict Outcomes in IPF Patients. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2020.
- Rankine L, Wang Z, Bier E, Kelsey C, Marks L, Driehuys B, et al. Using Hyperpolarized Xe-129 Gas-Exchange MRI to Guide Functional Avoidance Planning in Thoracic Radiation Therapy. In: MEDICAL PHYSICS. 2020. p. E370–E370.
- Wang Z, Swaminathan A, Bier E, Tighe RM, Huang YT, Rajagopal S, et al. Using 129Xenon MR Gas Exchange MRI to Measure the Membrane and Capillary Components of DLCO and KCO. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2020.
- Mummy D, Rankine L, Wang Z, Bier E, Rackley C, Morrison LD, et al. Hyperpolarized 129Xe Magnetic Resonance Imaging Is Sensitive to Therapy Response in Idiopathic Pulmonary Fibrosis. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2020.
- Rankine LJ, Wang Z, Bier E, Kelsey CR, Marks LB, Driehuys B, et al. Pulmonary Gas Exchange-guided Functional Avoidance Treatment Planning for Thoracic Radiation Therapy Using Hyperpolarized 129Xe Magnetic Resonance Imaging. In: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2020. p. S102–3.
- Shim YM, Mata J, Hartwig M, Nakahodo AA, West K, Emami K, et al. Positive Results from Two Randomized Phase III Trials Assessing Hyperpolarized 129Xenon Gas MRI as a Measure of Regional Lung Function as Compared to Imaging with 133Xenon Scintigraphy. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2020.
- Wang Z, Rankine L, Thorpe M, Mammarappallil J, Rajagopal S, Driehuys B. Spatial Correlation of 129Xenon Gas Exchange MRI with 99mTc Perfusion Scintigraphy. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2020.
- Mummy D, Wang Z, Bier E, Tighe RM, Driehuys B, Mammarappallil J. Hyperpolarized 129Xe Magnetic Resonance Imaging Measures of Gas Exchange in Non-Specific Interstitial Pneumonia. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2020.
- Coleman EM, Mummy D, Wang Z, Bier E, Womack S, Korzekwinski J, et al. Hyperpolarized 129Xe MRI Identifies Ventilation Responders to Glycopyrrolate/Formoterol Fumarate in Chronic Obstructive Pulmonary Disease. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2020.
- Rankine LJ, Wang Z, Wang JM, He M, McAdams HP, Mammarappallil J, et al. 129Xenon Gas Exchange Magnetic Resonance Imaging as a Potential Prognostic Marker for Progression of Idiopathic Pulmonary Fibrosis. Ann Am Thorac Soc. 2020 Jan;17(1):121–5.
- Wang Z, Bier EA, Swaminathan A, Parikh K, Nouls J, He M, et al. Diverse cardiopulmonary diseases are associated with distinct xenon magnetic resonance imaging signatures. Eur Respir J. 2019 Dec;54(6).
- Bier EA, Nouls JC, Wang Z, He M, Schrank G, Morales-Medina N, et al. A thermally polarized 129 Xe phantom for quality assurance in multi-center hyperpolarized gas MRI studies. Magn Reson Med. 2019 Nov;82(5):1961–8.
- He M, Zha W, Tan F, Rankine L, Fain S, Driehuys B. A Comparison of Two Hyperpolarized 129Xe MRI Ventilation Quantification Pipelines: The Effect of Signal to Noise Ratio. Acad Radiol. 2019 Jul;26(7):949–59.
- Fenoli J, Rankine L, Driehuys B, Das S. Comparison of 129Xe-MR Ventilation and 4DCT Ventilation Computed From the Deformation Vector Field. In: MEDICAL PHYSICS. WILEY; 2019. p. E246–E246.
- Rankine L, Wang Z, Wang J, He M, McAdams H, Mammarappallil J, et al. Disease Progression in Idiopathic Pulmonary Fibrosis: The Potential for Stratifying Patients Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging. In: MEDICAL PHYSICS. WILEY; 2019. p. E300–E300.
- Nouls JC, Virgincar RS, Culbert AG, Morand N, Bobbert DW, Yoder AD, et al. Applications of 3D printing in small animal magnetic resonance imaging. J Med Imaging (Bellingham). 2019 Apr;6(2):021605.
- Ebner L, Virgincar RS, He M, Choudhury KR, Robertson SH, Christe A, et al. Multireader Determination of Clinically Significant Obstruction Using Hyperpolarized 129Xe-Ventilation MRI. AJR Am J Roentgenol. 2019 Apr;212(4):758–65.
- Mammarappallil JG, Rankine L, Wild JM, Driehuys B. New Developments in Imaging Idiopathic Pulmonary Fibrosis With Hyperpolarized Xenon Magnetic Resonance Imaging. J Thorac Imaging. 2019 Mar;34(2):136–50.
- Coleman E, Wang Z, He M, Bier E, Nouls J, Womack S, et al. Regional Gas Exchange Function Before and After Glycopyrrolate/Formoterol Fumarate Measured by Hyperpolarized Xe-129 MRI in Chronic Obstructive Lung Disease. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC; 2019.
- Bier E, Wang Z, Swaminathan A, Nouls J, He M, Mammarappallil J, et al. 129Xenon MR Imaging and Spectroscopic Signatures to Differentiate Pulmonary Arterial Hypertension from Other Heart and Lung Disease. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC; 2019.
- Mammarappallil J, Coleman E, He M, Wang Z, Bier E, Nouls J, et al. Identification of Gas Exchange Phenotypes Using Hyperpolarized Xe-129 MRI in Patients with Chronic Obstructive Pulmonary Disease (COPD). In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC; 2019.
- Bier EA, Robertson SH, Schrank GM, Rackley C, Mammarappallil JG, Rajagopal S, et al. A protocol for quantifying cardiogenic oscillations in dynamic 129 Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis. NMR Biomed. 2019 Jan;32(1):e4029.
- Wang Z, He M, Bier E, Rankine L, Schrank G, Rajagopal S, et al. Hyperpolarized 129 Xe gas transfer MRI: the transition from 1.5T to 3T. Magn Reson Med. 2018 Dec;80(6):2374–83.
- Virgincar RS, Dahlke J, Robertson SH, Morand N, Qi Y, Degan S, et al. A portable ventilator with integrated physiologic monitoring for hyperpolarized 129Xe MRI in rodents. J Magn Reson. 2018 Oct;295:63–71.
- Rankine LJ, Wang Z, Driehuys B, Marks LB, Kelsey CR, Das SK. Correlation of Regional Lung Ventilation and Gas Transfer to Red Blood Cells: Implications for Functional-Avoidance Radiation Therapy Planning. Int J Radiat Oncol Biol Phys. 2018 Aug 1;101(5):1113–22.
- Rankine L, Wang Z, Kelsey C, Das S, Marks L, Driehuys B. Dose-Dependent Changes in Regional Lung Function Detected 6-12 Weeks After Radiation Therapy: A Novel Application of Hyperpolarized-129Xe MRI. In: MEDICAL PHYSICS. WILEY; 2018. p. E416–7.
- Song EJ, Kelsey CR, Driehuys B, Rankine L. Functional airway obstruction observed with hyperpolarized 129 Xenon-MRI. J Med Imaging Radiat Oncol. 2018 Feb;62(1):91–3.
- Wang JM, Robertson SH, Wang Z, He M, Virgincar RS, Schrank GM, et al. Using hyperpolarized 129Xe MRI to quantify regional gas transfer in idiopathic pulmonary fibrosis. Thorax. 2018 Jan;73(1):21–8.
- Swaminathan A, Bier E, Nouls J, Kennedy K, Womack S, Almeida-Peters S, et al. Non-Invasive Diagnosis of Pulmonary Vascular Disease Using Inhaled 129-XenonMRI. In: CIRCULATION. 2018.
- Huang YT, He M, Wang Z, Rankine L, Womack S, Mammarappallil J, et al. Ventilation and Gas Transfer Measured by 129Xe MRI in Alpha-1 Antitrypsin Heterozygotes: A Pilot Study. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC; 2018.
- Huang YT, Wang Z, He M, Rankine L, Womack S, McAdams P, et al. Ventilation and Gas Transfer Distribution in Alpha-1 Antitrypsin Deficiency After Replacement Therapy. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC; 2018.
- Tighe RM, Rankine L, Wang Z, Wang J, He M, Rackley C, et al. Longitudinal Follow Up After Xe-129 MRI Scan; Potential to Stratify Idiopathic Pulmonary Fibrosis Disease Progression. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC; 2018.
- Robertson SH, Virgincar RS, Bier EA, He M, Schrank GM, Smigla RM, et al. Uncovering a third dissolved-phase 129 Xe resonance in the human lung: Quantifying spectroscopic features in healthy subjects and patients with idiopathic pulmonary fibrosis. Magn Reson Med. 2017 Oct;78(4):1306–15.
- Rankine LJ, Wang Z, Driehuys B, Kelsey CR, Marks LB, Das SK. Is Lung Ventilation Imaging a Reasonable Surrogate for Gas Exchange? Implications for Functionally Guided Radiation Therapy Planning. In: International Journal of Radiation Oncology*Biology*Physics. Elsevier BV; 2017. p. S109–S109.
- Flower C, Freeman MS, Plue M, Driehuys B. Electron microscopic observations of Rb particles and pitting in 129Xe spin-exchange optical pumping cells. J Appl Phys. 2017 Jul 14;122(2):024902.
- Mahmood K, Ebner L, He M, Robertson SH, Wang Z, McAdams HP, et al. Novel Magnetic Resonance Imaging for Assessment of Bronchial Stenosis in Lung Transplant Recipients. Am J Transplant. 2017 Jul;17(7):1895–904.
- Rankine L, Wang Z, Driehuys B, Marks LB, Kelsey C, Das S. BEST IN PHYSICS (JOINT IMAGING-THERAPY): Functional-Guidance for Lung Radiation Therapy Planning: Does Ventilation Imaging Correlate with Gas Exchange? In: MEDICAL PHYSICS. WILEY; 2017. p. 3281–2.
- Wang Z, Robertson SH, Wang J, He M, Virgincar RS, Schrank GM, et al. Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI. Med Phys. 2017 Jun;44(6):2415–28.
- Virgincar RS, Robertson SH, Nouls J, Degan S, Schrank GM, He M, et al. Establishing an accurate gas phase reference frequency to quantify 129 Xe chemical shifts in vivo. Magn Reson Med. 2017 Apr;77(4):1438–45.
- House JS, Nichols CE, Li H, Brandenberger C, Virgincar RS, DeGraff LM, et al. Vagal innervation is required for pulmonary function phenotype in Htr4-/- mice. Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1;312(4):L520–30.
- Ebner L, He M, Virgincar RS, Heacock T, Kaushik SS, Freemann MS, et al. Hyperpolarized 129Xenon Magnetic Resonance Imaging to Quantify Regional Ventilation Differences in Mild to Moderate Asthma: A Prospective Comparison Between Semiautomated Ventilation Defect Percentage Calculation and Pulmonary Function Tests. Invest Radiol. 2017 Feb;52(2):120–7.
- Ebner L, Kammerman J, Driehuys B, Schiebler ML, Cadman RV, Fain SB. The role of hyperpolarized 129xenon in MR imaging of pulmonary function. Eur J Radiol. 2017 Jan;86:343–52.
- Nichols C, House J, Li H, Brandenberger C, Virgincar R, Miller L, et al. Htr4 Regulates Pulmonary Function Through Neural Innervation. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC; 2017.
- Driehuys B. Crossing the Chasm(s): Demonstrating the Clinical Value of Hyperpolarized Gas MRI. Acad Radiol. 2017 Jan;24(1):1–3.
- He M, Zha W, Fain SB, Driehuys B. Comparing Quantitative 129xe Ventilation Analysis Pipelines Between Mri Centers. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC; 2017.
- He M, Driehuys B, Que LG, Huang Y-CT. Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution. Acad Radiol. 2016 Dec;23(12):1521–31.
- Subashi E, Liu Y, Robertson S, Segars P, Driehuys B, Yin F, et al. TH-EF-BRA-10: High Spatiotemporal Resolution Self-Sorted 4D MRI. Med Phys. 2016 Jun;43(6):3899.
- Kaushik SS, Robertson SH, Freeman MS, He M, Kelly KT, Roos JE, et al. Single-breath clinical imaging of hyperpolarized (129)Xe in the airspaces, barrier, and red blood cells using an interleaved 3D radial 1-point Dixon acquisition. Magn Reson Med. 2016 Apr;75(4):1434–43.
- Dahhan T, Kaushik SS, He M, Mammarappallil JG, Tapson VF, McAdams HP, et al. Abnormalities in hyperpolarized (129)Xe magnetic resonance imaging and spectroscopy in two patients with pulmonary vascular disease. Pulm Circ. 2016 Mar;6(1):126–31.
- Wang JM, Robertson SH, He M, Virgincar RS, Schrank GM, Smigla R, et al. Using Hyperpolarized 129xe Imaging To Quantify Apical Vs. Basal And Central Vs. Peripheral Gas Exchange Impairment In Idiopathic Pulmonary Fibrosis. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC; 2016.
- He M, Robertson SH, Wang JM, Rackley CR, McAdams HP, Driehuys B. Differentiating Early Stage And Later Stage Ipf Using Hyperpolarized 129xe Ventilation Mri. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC; 2016.
- He M, Robertson SH, Wang JM, Que LG, Mahmood K, Driehuys B, et al. Characterizing The Ventilation Distribution In Healthy Normal Subjects To Establish Robust Quantitative Analysis Of 129xe Mri. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC; 2016.
- He M, Robertson SH, Kaushik SS, Freeman MS, Virgincar RS, Davies J, et al. Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI. Magn Reson Imaging. 2015 Sep;33(7):877–85.
- Robertson SH, Virgincar RS, He M, Freeman MS, Kaushik SS, Driehuys B. Optimizing 3D noncartesian gridding reconstruction for hyperpolarized 129Xe MRI-focus on preclinical applications. Concepts in Magnetic Resonance Part A: Bridging Education and Research. 2015 Jul 1;44(4):190–202.
- Roos JE, McAdams HP, Kaushik SS, Driehuys B. Hyperpolarized Gas MR Imaging: Technique and Applications. Magn Reson Imaging Clin N Am. 2015 May;23(2):217–29.
- Cleveland ZI, Virgincar RS, Qi Y, Robertson SH, Degan S, Driehuys B. 3D MRI of impaired hyperpolarized 129Xe uptake in a rat model of pulmonary fibrosis. NMR Biomed. 2014 Dec;27(12):1502–14.
- He M, Kaushik SS, Robertson SH, Freeman MS, Virgincar RS, McAdams HP, et al. Extending semiautomatic ventilation defect analysis for hyperpolarized (129)Xe ventilation MRI. Acad Radiol. 2014 Dec;21(12):1530–41.
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- Freeman MS, Emami K, Driehuys B. Characterizing and modeling the efficiency limits in large-scale production of hyperpolarized 129Xe. Phys Rev A. 2014 Aug 6;90(2):023406.
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