BioE Seminar: From Zip lining to Lego building: Novel Hydrogel Design for Musculoskeletal Tissue Regeneration
Thursday, October 1, 2020 - 12:00pm to 1:00pm
Fan Yang, Ph.D., Associate Professor, Departments of Bioengineering and Orthopaedic Surgery, Stanford University
Hydrogels are attractive choices of biomaterials for 3D cell culture and tissue regeneration given their injectability, ease for minimally invasive delivery, as well as tunable chemical and physical properties. Our research focuses on designing novel hydrogels to enhance stem cell-based tissue regeneration, or for engineering 3D in vitro cancer models to facilitate discovery of new therapeutics or drug screening. In this talk, I'll share two examples of unique hydrogel design from our group with unique structures for enhancing stem cell-based tissue regeneration. I'll introduce a unique sliding hydrogel design that allows cells to "zipline" ligands and crosslinks in 3D, which allowed enhanced stem cell differentiation and faster tissue regeneration. Unlike conventional hydrogels, our sliding hydrogels allow ligands and crosslinks to slide along the hydrogel backbone, enabling cells to "zipline" in 3D with precisely tunable molecular mobility. Our results validate molecular mobility as a novel parameter in biomaterials design to control stem cell differentiation. Sliding hydrogels offers a biomaterials tool to enable elucidating the role of molecular mobility in modulating cell fates in 3D, which cannot be achieved using existing hydrogel tools. Our results validate molecular mobility as a novel parameter in biomaterials design to control stem cell differentiation.