Peter Edward Fecci
Neurosurgery
Professor of Neurosurgery
Research Interests
Brain Tumor Immunotherapy
Cancer-Induced Immune Dysfunction
Glioblastoma
Brain Metastasis
Bio
As the Director of both the Brain Tumor Immunotherapy Program and the Center for Brain and Spine Metastasis at Duke University, I focus our programmatic interests on the design, optimization, and monitoring of immune-based treatment platforms for patients with intracranial tumors, whether primary or metastatic. Within this broad scope, however, my own group looks more specifically at limitations to immunotherapeutic success, with a particular focus on understanding and reversing T cell dysfunction in patients with glioblastoma (GBM) and brain metastases. We employ a systematic approach to categorizing T cell dysfunction (Woroniecka et al, Clin Cancer Res 2018 Aug 15;24(16):3792-3802), and whereas our earlier work addressed concerns for regulatory T cell-induced tolerance, we now heavily study T cell ignorance and exhaustion, as well. Regarding the former, we recently published the novel phenomenon of S1P1-mediated bone marrow T cell sequestration in patients with intracranial tumors (Chongsathidkiet et al, Nat Medicine 2018 Sep;24(9):1459-1468). Regarding the latter, we have likewise recently identified and characterized exhaustion as a significant limitation to T-cell function within GBM (Woroniecka et al, Clin Cancer Res 2018 Sep 1;24(17):4175-4186). I very much look to collaboratively integrate our approaches with others investigating innovative treatment options. I continue my focus on combining strategies for reversing T cell deficits with current and novel immune-based platforms as a means of deriving and improving rational and precise anti-tumor therapies. It is my sincerest desire to forge a career focused on co-operative, multi-disciplinary, organized brain tumor therapy. Ultimately, my goal is to help coordinate the efforts of a streamlined and effective center for brain tumor research and clinical care. I hope to play some role in ushering in a period where the science and treatment arms of brain tumor therapy suffer no disjoint, but instead represent the convergent efforts of researchers, neuro-oncologists, medical oncologists, radiation oncologists, biomedical engineers, and neurosurgeons alike. I hope to see such synergy become standard of care.
Education
- M.D. Duke University, School of Medicine, 2007
- Ph.D. Duke University, 2007
Trainings & Certifications
- Internship, GENERAL SURGERY (2007 - 2008) Massachusetts General Hospital
- Residency, NEUROSURGERY (2008 - 2013) Massachusetts General Hospital
- Postdoctoral Fellow (2010 - 2012) Dana Farber Cancer Institute
Positions
- Professor of Neurosurgery
- Professor in Pathology
- Associate Professor of Biomedical Engineering
- Associate Professor in Integrative Immunobiology
- Member of the Duke Cancer Institute
Awards, Honors, and Distinctions
- Paper of the Year. American Association of Physicists in Medicine. 2017
- Visting Scholar. National Institutes of Health. 2017
- Duke Health Scholars Award. Duke University School of Medicine. 2016
- Prince Mahidol Youth Mentor Award. Prince Mahidol Award Foundation. 2016
- Sontag Distinguished Scientist Award. Sontag Foundation. 2015
- Resident Advocate Award. Duke University Department of Neurosurgery. 2015
- Alpha Omega Alpha. Alpha Omega Alpha Medical Honor Society. 2015
- Preuss Award for Neuro-Oncologic Research. Congress of Neurological Surgeons. 2013
- Matson Award for Best Basic Science Research. New England Neurosurgical Society. 2013
- NIH Loan Repayment Program Award. National Institutes of Health. 2011
- Resident Teaching Award. Tufts University School of Medicine. 2008
- Neurosurgery Award. Duke University Department of Neurosurgery. 2007
- Keynote Speaker. Society for Neuro-Oncology. 2006
- Eugene A. Stead Scholar. Duke University School of Medicine. 2001
- Medical Scientist Training Program Fellowship. National Institutes of Health. 2001
- Merrill Presidential Scholar. Cornell University. 1999
- Cornell-Diamante Scholarship. Cornell University. 1999
- Nanaline H. Duke Scholar. Duke University School of Medicine. 1999
Courses Taught
- PATHOL 793: Research Independent Study
- PATHOL 293: Research Independent Study
- NEUROSCI 494: Research Independent Study 2
- NEUROSCI 493: Research Independent Study 1
- MOLMED 301B: Research in MOLMED - Oncological Sciences
Publications
- Sperber J, Yoo S, Owolo E, Dalton T, Zachem TJ, Johnson E, et al. Validation of the graded prognostic assessment and recursive partitioning analysis as prognostic tools using a modern cohort of patients with brain metastases. Neurooncol Pract. 2024 Dec;11(6):763–71.
- Hotchkiss KM, Karschnia P, Schreck KC, Geurts M, Cloughesy TF, Huse J, et al. A brave new framework for glioma drug development. Lancet Oncol. 2024 Oct;25(10):e512–9.
- Zhao J, Vaios E, Wang Y, Yang Z, Cui Y, Reitman ZJ, et al. Dose-Incorporated Deep Ensemble Learning for Improving Brain Metastasis Stereotactic Radiosurgery Outcome Prediction. Int J Radiat Oncol Biol Phys. 2024 Oct 1;120(2):603–13.
- Chiang VL, Pugazenthi S, Leidig WA, Rodriguez A, Prabhu S, Haskell-Mendoza AP, et al. Laser interstitial thermal therapy for new and recurrent meningioma: a prospective and retrospective case series. J Neurosurg. 2024 Sep 1;141(3):642–52.
- Whiteley AE, Ma D, Wang L, Yu S-Y, Yin C, Price TT, et al. Breast cancer exploits neural signaling pathways for bone-to-meninges metastasis. Science. 2024 Jun 21;384(6702):eadh5548.
- Haskell-Mendoza AP, Srinivasan ES, Vo-Dinh T, Fecci PE. Leveraging gold nanostars for precision laser interstitial thermal therapy. Oncotarget. 2024 Jun 14;15:389–91.
- Haskell-Mendoza AP, Reason EH, Gonzalez AT, Jackson JD, Sankey EW, Srinivasan ES, et al. Automated segmentation of ablated lesions using deep convolutional neural networks: A basis for response assessment following laser interstitial thermal therapy. Neuro Oncol. 2024 Jun 3;26(6):1152–62.
- Leng JX, Carpenter DJ, Huang C, Qazi J, Arshad M, Mullikin TC, et al. Determinants of Symptomatic Intracranial Progression After an Initial Stereotactic Radiosurgery Course. Adv Radiat Oncol. 2024 Jun;9(6):101475.
- Neff C, Price M, Cioffi G, Liu Z, Walsh R, Barnholtz-Sloan JS, et al. Atopy improves survival and decreases risk of brain metastasis in cutaneous melanoma. 2024.
- Fairchild A, Salama JK, Godfrey D, Wiggins WF, Ackerson BG, Oyekunle T, et al. Incidence and imaging characteristics of difficult to detect retrospectively identified brain metastases in patients receiving repeat courses of stereotactic radiosurgery. J Neurooncol. 2024 Mar;167(1):219–27.
- Saatian B, Deshpande K, Herrera R, Sedighi S, Eisenbarth R, Iyer M, et al. Breast-to-brain metastasis is exacerbated with chemotherapy through blood-cerebrospinal fluid barrier and induces Alzheimer's-like pathology. J Neurosci Res. 2023 Dec;101(12):1900–13.
- Haskell-Mendoza AP, Radhakrishnan S, Nardin AL, Eilbacher K, Yang LZ, Jackson JD, et al. Utility of Routine Preoperative Urinalysis in the Prevention of Surgical Site Infections. World Neurosurg. 2023 Dec;180:e449–59.
- Singh K, Hotchkiss KM, Parney IF, De Groot J, Sahebjam S, Sanai N, et al. Correcting the drug development paradigm for glioblastoma requires serial tissue sampling. Nat Med. 2023 Oct;29(10):2402–5.
- Lerner EC, Woroniecka KI, D’Anniballe VM, Wilkinson DS, Mohan AA, Lorrey SJ, et al. CD8+ T cells maintain killing of MHC-I-negative tumor cells through the NKG2D-NKG2DL axis. Nat Cancer. 2023 Sep;4(9):1258–72.
- Srinivasan ES, Liu Y, Odion RA, Chongsathidkiet P, Wachsmuth LP, Haskell-Mendoza AP, et al. Gold Nanostars Obviate Limitations to Laser Interstitial Thermal Therapy (LITT) for the Treatment of Intracranial Tumors. Clin Cancer Res. 2023 Aug 15;29(16):3214–24.
- Haskell-Mendoza AP, Srinivasan ES, Lerner EC, Edwards RM, Schwalb AM, Jackson JD, et al. Risk of Tract Seeding Following Laser Interstitial Thermal Therapy for Brain Tumors. Neurosurgery. 2023 Jul 1;93(1):198–205.
- Fairchild AT, Salama JK, Wiggins WF, Ackerson BG, Fecci PE, Kirkpatrick JP, et al. A Deep Learning-Based Computer Aided Detection (CAD) System for Difficult-to-Detect Brain Metastases. Int J Radiat Oncol Biol Phys. 2023 Mar 1;115(3):779–93.
- McCray E, Waguia R, de la Garza Ramos R, Price MJ, Williamson T, Dalton T, et al. Racial disparities in inpatient clinical presentation, treatment, and outcomes in brain metastasis. Neurooncol Pract. 2023 Feb;10(1):62–70.
- Waibl Polania J, Hoyt-Miggelbrink A, Tomaszewski W, Wachsmuth L, Lorrey S, Wilkinson D, et al. Antigen presentation by tumor-associated macrophages mediates progenitor to terminal exhaustion transition in GBM and other solid tumors. bioRxiv. 2023.
- Chan M, Tatter S, Chiang V, Fecci P, Strowd R, Prabhu S, et al. Efficacy of laser interstitial thermal therapy for biopsy-proven radiation necrosis in radiographically recurrent brain metastases. Neurooncol Adv. 2023;5(1):vdad031.
- Haskell-Mendoza AP, Srinivasan ES, Suarez AD, Fecci PE. Laser ablation of a sphenoid wing meningioma: A case report and review of the literature. Surg Neurol Int. 2023;14:138.
- Carpenter DJ, Fairchild AT, Adamson JD, Fecci PE, Sampson JH, Herndon JE, et al. Outcomes in Patients with Intact and Resected Brain Metastasis Treated with 5-Fraction Stereotactic Radiosurgery. Adv Radiat Oncol. 2023;8(2):101166.
- Koga SF, Hodges WB, Adamyan H, Hayes T, Fecci PE, Tsvankin V, et al. Preoperative validation of edema-corrected tractography in neurosurgical practice: translating surgeon insights into novel software implementation. Front Neurol. 2023;14:1322815.
- Wilson Z, Fecci P. T CELL SEQUESTRATION IN POSTERIOR FOSSA TUMORS. In: NEURO-ONCOLOGY. 2023.
- Lerner E, Woroniecka K, D’Anniballe V, Wilkinson D, Lorrey S, Waibl-Polania J, et al. A Novel MHC-Independent Mechanism of Tumor Cell Killing by CD8+T Cells. bioRxiv. 2023.
- Lerner EC, Srinivasan ES, Broadwater G, Haskell-Mendoza AP, Vaios EJ, Edwards RM, et al. Erratum to "E.C. Lerner, E.S. Srinivasan, G. Broadwater, et al. Factors Associated With New-Onset Seizures Following Stereotactic Radiosurgery for Newly Diagnosed Brain Metastases. Adv Radiat Oncol. 2022;7:101054.". Adv Radiat Oncol. 2023;8(2):101187.
- Lorrey SJ, Waibl Polania J, Wachsmuth LP, Hoyt-Miggelbrink A, Tritz ZP, Edwards R, et al. Systemic immune derangements are shared across various CNS pathologies and reflect novel mechanisms of immune privilege. Neurooncol Adv. 2023;5(1):vdad035.
- Schwalb AM, Srinivasan ES, Fecci PE. Commentary: Laser Interstitial Thermal Therapy for First-Line Treatment of Surgically Accessible Recurrent Glioblastoma: Outcomes Compared With a Surgical Cohort. Neurosurgery. 2022 Dec 1;91(6):e160–3.
- Tomaszewski WH, Waibl-Polania J, Chakraborty M, Perera J, Ratiu J, Miggelbrink A, et al. Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma. Nat Commun. 2022 Oct 29;13(1):6483.
- Carpenter DJ, Natarajan B, Arshad M, Natesan D, Schultz O, Moravan MJ, et al. Prognostic Model for Intracranial Progression after Stereotactic Radiosurgery: A Multicenter Validation Study. Cancers (Basel). 2022 Oct 22;14(21).
- Sankey EW, Grabowski MM, Srinivasan ES, Griffin AS, Howell EP, Otvos B, et al. Time to Steroid Independence After Laser Interstitial Thermal Therapy vs Medical Management for Treatment of Biopsy-Proven Radiation Necrosis Secondary to Stereotactic Radiosurgery for Brain Metastasis. Neurosurgery. 2022 Jun 1;90(6):684–90.
- Lerner EC, Edwards RM, Wilkinson DS, Fecci PE. Laser ablation: Heating up the anti-tumor response in the intracranial compartment. Adv Drug Deliv Rev. 2022 Jun;185:114311.
- Lerner EC, Tomaszewski W, D’Anniballe V, Perera J, Cui X, Wilkinson DS, et al. CD8 T cells licensed with immune checkpoint blockade kill murine tumors lacking MHC-I. In: The Journal of Immunology. The American Association of Immunologists; 2022. p. 121.14-121.14.
- Wilkinson DS, Ryan K, Wilson J, Chandramohan V, Landi D, Bigner D, et al. D2C7 CAR: A novel CAR T cell that simultaneously targets wildtype EGFR and its mutant isoform EGFRvIII for treatment of glioma. In: The Journal of Immunology. The American Association of Immunologists; 2022. p. 122.03-122.03.
- Bramall AN, Anton ES, Kahle KT, Fecci PE. Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus. EBioMedicine. 2022 Apr;78:103931.
- Flores C, Dunn G, Fecci P, Lim M, Mitchell D, Reardon DA. Is There a Role for Immunotherapy in Central Nervous System Cancers? Hematol Oncol Clin North Am. 2022 Feb;36(1):237–52.
- Peña Pino I, Ma J, Hori YS, Fomchenko E, Dusenbery K, Reynolds M, et al. Stereotactic Laser Ablation (SLA) followed by consolidation stereotactic radiosurgery (cSRS) as treatment for brain metastasis that recurred locally after initial radiosurgery (BMRS): a multi-institutional experience. J Neurooncol. 2022 Jan;156(2):295–306.
- Zhao J, Vaios EJ, Carpenter DJ, Yang Z, Cui Y, Lafata K, et al. A Radiomics-Integrated Deep Learning Model for Identifying Radionecrosis Following Brain Metastasis Stereotactic Radiosurgery (SRS). In: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2022. p. S114–S114.
- Neman J, Saatian B, Deshpande K, Martisorian V, LaViolette P, Boire A, et al. BREAST TO BRAIN METASTASIS IS EXACERBATED WITH CHEMOTHERAPY THROUGH BLOOD-CEREBRAL SPINAL FLUID-BARRIER AND INDUCES ALZHEIMER'S-LIKE PATHOLOGY. In: NEURO-ONCOLOGY. 2022. p. 21–2.
- de Groot JF, Kim AH, Prabhu S, Rao G, Laxton AW, Fecci PE, et al. Efficacy of laser interstitial thermal therapy (LITT) for newly diagnosed and recurrent IDH wild-type glioblastoma. Neurooncol Adv. 2022;4(1):vdac040.
- Fecci PE, Rao G, Brastianos PK, Dunn GP, Anders CK. Editorial: It takes a village: The expanding multi-disciplinary approach to brain metastasis. Front Oncol. 2022;12:1054490.
- Lerner E, D’Anniballe V, Tomaszewski W, Perera J, Cui X, Waibl-Polania J, et al. CD8 T cell mediated killing of MHC class 1 negative tumors requires antigen presenting myeloid cells and interferon gamma. In: CANCER RESEARCH. 2022.
- Lerner EC, Srinivasan ES, Broadwater G, Haskell-Mendoza AP, Edwards RM, Huie D, et al. Factors Associated With New-Onset Seizures Following Stereotactic Radiosurgery for Newly Diagnosed Brain Metastases. In: Adv Radiat Oncol. 2022. p. 101054.
- Fairchild A, Salama JK, Godfrey DJ, Wiggins W, Ackerson B, Niedzwiecki D, et al. Early Imaging Characteristics Associated with Development of Future Brain Metastases in Patients Undergoing Stereotactic Radiosurgery. In: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2022. p. E51–E51.
- Fairchild A, Salama JK, Wiggins W, Ackerson B, Fecci P, Kirkpatrick JP, et al. A Deep Learning-Based Computer Aided Detection (CAD) System for Difficult-to-Detect Brain Metastases (BM). In: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2022. p. S111–2.
- Wilson J, Wilkinson D, Ryan K, Bigner D, Chambramohan V, Fecci P. A NOVEL DUAL-SPECIFIC CHIMERIC ANTIGEN RECEPTOR T CELL WITH HIGH SPECIFICITY FOR EGFR AND EGFRVIII IMPROVES SURVIVAL IN EGFR EXPRESSING MEDULLOBLASTOMA. In: NEURO-ONCOLOGY. 2022. p. 228–9.
- Singh K, Foster M, Miller ES, Gregory S, Weinhold KJ, Ashley DM, et al. A phase 0/surgical window-of-opportunity study in progress, evaluating evolocumab in patients with high-grade glioma or glioblastoma. In: JOURNAL OF CLINICAL ONCOLOGY. 2022. p. TPS2076–TPS2076.
- Carpenter DJ, Fairchild A, Adamson J, Moravan MJJ, Fecci P, Herndon J, et al. Outcomes in Intact and Resected Brain Metastasis Patients Treated with Five-Fraction Stereotactic Radiosurgery. In: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2022. p. E49–50.
- Tucker M, Lacayo M, Joseph S, Ross W, Chongsathidkiet P, Fecci P, et al. Creation of Non-Contact Device for Use in Metastatic Melanoma Margin Identification in ex vivo Mouse Brain. Proc SPIE Int Soc Opt Eng. 2022;11945.
- de Groot J, Kim A, Prabhu S, Rao G, Laxton A, Fecci P, et al. EFFICACY OF LASER INTERSTITIAL THERMAL THERAPY (LITT) FOR NEWLY DIAGNOSED AND RECURRENT IDH WILD-TYPE GLIOBLASTOMA. In: NEURO-ONCOLOGY. 2022. p. 256–7.
- Grabowski MM, Srinivasan ES, Vaios EJ, Sankey EW, Otvos B, Krivosheya D, et al. Combination laser interstitial thermal therapy plus stereotactic radiotherapy increases time to progression for biopsy-proven recurrent brain metastases. Neurooncol Adv. 2022;4(1):vdac086.
- Huie D, Lerner EC, Edwards RM, Srinivasan ES, Vaios EJ, Fecci PE. Advanced imaging techniques and planning for laser interstitial thermal therapy. In: Handbook of Neuro-Oncology Neuroimaging. 2022. p. 285–301.
- Tomaszewski WH, Waibl-Polania J, Miggelbrink AM, Chakraborty MA, Fecci PE, Sampson JH, et al. Broad immunophenotyping of the murine brain tumor microenvironment. J Immunol Methods. 2021 Dec;499:113158.
- Batich K, Mitchell D, Healy P, Herndon J, Broadwater G, Michael G, et al. CTIM-10. REPRODUCIBILITY OF CLINICAL TRIALS USING CMV-TARGETED DENDRITIC CELL VACCINES IN PATIENTS WITH GLIOBLASTOMA. In: Neuro-Oncology. Oxford University Press (OUP); 2021. p. vi51–vi51.
- Miggelbrink AM, Jackson JD, Lorrey SJ, Srinivasan ES, Waibl-Polania J, Wilkinson DS, et al. CD4 T-Cell Exhaustion: Does It Exist and What Are Its Roles in Cancer? Clin Cancer Res. 2021 Nov 1;27(21):5742–52.
- Kang JH, Price M, Dalton T, Ramirez L, Fecci PE, Kamal AH, et al. Palliative Care Use for Critically Ill Patients With Brain Metastases. J Pain Symptom Manage. 2021 Nov;62(5):927–35.
- Vaios EJ, Grabowski M, Srinivasan E, Huie D, Sankey E, Otvos B, et al. Combining Laser Interstitial Thermal Therapy With SRS Improves Time to Progression for Recurrent SRS-Treated Brain Metastases. In: International journal of radiation oncology, biology, physics. 2021. p. e583–4.
- Srinivasan ES, Grabowski MM, Nahed BV, Barnett GH, Fecci PE. Laser interstitial thermal therapy for brain metastases. Neurooncol Adv. 2021 Nov;3(Suppl 5):v16–25.
- Chongsathidkiet P, Fecci PE. Cold-inducible RNA-binding protein (CIRBP) as a biomarker to predict recurrence of brain metastases. Neuro Oncol. 2021 Sep 1;23(9):1419–20.
- Price M, Howell EP, Dalton T, Ramirez L, Howell C, Williamson T, et al. Inpatient palliative care utilization for patients with brain metastases. Neurooncol Pract. 2021 Aug;8(4):441–50.
- Nduom EK, Gephart MH, Chheda MG, Suva ML, Amankulor N, Battiste JD, et al. Re-evaluating Biopsy for Recurrent Glioblastoma: A Position Statement by the Christopher Davidson Forum Investigators. Neurosurgery. 2021 Jun 15;89(1):129–32.
- Srinivasan ES, Tsvankin V, Fecci PE. Commentary: A Neurosurgeon's Guide to Cognitive Dysfunction in Adult Glioma. Neurosurgery. 2021 Jun 15;89(1):E1–2.
- Otvos B, Alban TJ, Grabowski MM, Bayik D, Mulkearns-Hubert EE, Radivoyevitch T, et al. Preclinical Modeling of Surgery and Steroid Therapy for Glioblastoma Reveals Changes in Immunophenotype that are Associated with Tumor Growth and Outcome. Clin Cancer Res. 2021 Apr 1;27(7):2038–49.
- Chuntova P, Chow F, Watchmaker PB, Galvez M, Heimberger AB, Newell EW, et al. Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank. Neuro Oncol. 2021 Mar 25;23(3):356–75.
- Srinivasan ES, Tan AC, Anders CK, Pendergast AM, Sipkins DA, Ashley DM, et al. Salting the Soil: Targeting the Microenvironment of Brain Metastases. Mol Cancer Ther. 2021 Mar;20(3):455–66.
- Mohan AA, Tomaszewski WH, Haskell-Mendoza AP, Hotchkiss KM, Singh K, Reedy JL, et al. Targeting Immunometabolism in Glioblastoma. Front Oncol. 2021;11:696402.
- Grabowski MM, Sankey EW, Ryan KJ, Chongsathidkiet P, Lorrey SJ, Wilkinson DS, et al. Immune suppression in gliomas. J Neurooncol. 2021 Jan;151(1):3–12.
- Kim GJ, Buckley ED, Herndon JE, Allen KJ, Dale TS, Adamson JD, et al. Outcomes in Patients With 4 to 10 Brain Metastases Treated With Dose-Adapted Single-Isocenter Multitarget Stereotactic Radiosurgery: A Prospective Study. Adv Radiat Oncol. 2021;6(6):100760.
- Shen E, Van Swearingen AED, Price MJ, Bulsara K, Verhaak RGW, Baëta C, et al. A Need for More Molecular Profiling in Brain Metastases. Front Oncol. 2021;11:785064.
- Chongsathidkiet P, Waibl Polania J, Lorrey SJ, Grabowski MM, Sankey EW, Wilkinson DS, et al. Cancer Immunotherapy Strategies: Basic Principles. In: Bioanalysis. Springer International Publishing; 2021. p. 29–49.
- Srinivasan E, Lerner E, Edwards R, Huie D, Fecci P. FUNCTIONAL OUTCOMES OF LASER INTERSTITIAL THERMAL THERAPY (LITT) VERSUS RESECTION IN THE TREATMENT OF LESIONS IN OR NEAR THE PRIMARY MOTOR CORTEX. In: NEURO-ONCOLOGY. 2021. p. 195–195.
- Wilkinson D, Ryan K, Chandramohan V, Landi D, Bigner D, Fecci P. GENERATION OF A THIRD GENERATION CAR T CELL THAT SIMULTANEOUSLY TARGETS WILDTYPE EGFR AND ITS MUTANT ISOFORM EGFRVIII FOR TREATMENT OF GLIOBLASTOMA. In: NEURO-ONCOLOGY. 2021. p. 176–176.
- Waibl Polania J, Lerner EC, Wilkinson DS, Hoyt-Miggelbrink A, Fecci PE. Pushing Past the Blockade: Advancements in T Cell-Based Cancer Immunotherapies. Front Immunol. 2021;12:777073.
- Srinivasan E, Chongsathidkiet P, Odion R, Liu Y, Sankey E, Vo-Dinh T, et al. INTEGRATION OF PLASMONIC GOLD NANOSTARS AND LASER INTERSTITIAL THERMAL THERAPY (LITT) FOR SPECIFIC AND AMPLIFIED ABLATION OF BRAIN TUMORS. In: NEURO-ONCOLOGY. 2021. p. 167–167.
- Polania JW, Tomaszweski W, Hoyt-Miggelbrink A, Woroniecka K, Fecci P. INVESTIGATING CD8 T CELL EXHAUSTION STATES GLIOBLASTOMA. In: NEURO-ONCOLOGY. 2021. p. 95–95.
- Kim AH, Tatter S, Rao G, Prabhu S, Chen C, Fecci P, et al. Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System (LAANTERN): 12-Month Outcomes and Quality of Life After Brain Tumor Ablation. In: NEUROSURGERY. 2021. p. S16–S16.
- Liu Y, Chongsathidkiet P, Odion R, Fecci PE, Vo-Dinh T. Multifunctional Gold Nanostars for Sensitive Detection, Photothermal Treatment and Immunotherapy of Brain Tumor. In: Bioanalysis. Springer International Publishing; 2021. p. 235–55.
- Medikonda R, Dunn G, Rahman M, Fecci P, Lim M. A review of glioblastoma immunotherapy. J Neurooncol. 2021 Jan;151(1):41–53.
- Price LS, Adamow M, Attig S, Fecci P, Norberg P, Reap E, et al. Gating Harmonization Guidelines for Intracellular Cytokine Staining Validated in Second International Multiconsortia Proficiency Panel Conducted by Cancer Immunotherapy Consortium (CIC/CRI). Cytometry A. 2021 Jan;99(1):107–16.
- Batich K, Mitchell D, Healy P, Herndon J, Broadwater G, Michael G, et al. REPRODUCIBILITY OF CLINICAL TRIALS USING CMV-TARGETED DENDRITIC CELL VACCINES IN PATIENTS WITH GLIOBLASTOMA. In: NEURO-ONCOLOGY. 2021. p. 51–51.
- Polania JW, Lorrey S, Wilkinson D, Fecci PE. Immune checkpoint blockade therapy in high-grade glioma. In: Immunotherapeutic Strategies for the Treatment of Glioma. 2021. p. 91–108.
- Sankey EW, Srinivasan ES, Mehta VA, Bergin SM, Wang TY, Thompson EM, et al. Perioperative Assessment of Cerebellar Masses and the Potential for Cerebellar Cognitive Affective Syndrome. World Neurosurg. 2020 Dec;144:222–30.
- Adil SM, Hodges SE, Edwards RM, Charalambous LT, Yang Z, Kiyani M, et al. Health care resource utilization and treatment of leptomeningeal carcinomatosis in the United States. Neurooncol Pract. 2020 Dec;7(6):636–45.
- Gastman B, Agarwal PK, Berger A, Boland G, Broderick S, Butterfield LH, et al. Defining best practices for tissue procurement in immuno-oncology clinical trials: consensus statement from the Society for Immunotherapy of Cancer Surgery Committee. J Immunother Cancer. 2020 Nov;8(2).
- Landazuri P, Shih J, Leuthardt E, Ben-Haim S, Neimat J, Tovar-Spinoza Z, et al. A prospective multicenter study of laser ablation for drug resistant epilepsy - One year outcomes. Epilepsy Res. 2020 Nov;167:106473.
- Woroniecka K, Fecci PE. Immuno-synergy? Neoantigen vaccines and checkpoint blockade in glioblastoma. Neuro Oncol. 2020 Sep 29;22(9):1233–4.
- Kim AH, Tatter S, Rao G, Prabhu S, Chen C, Fecci P, et al. Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System (LAANTERN): 12-Month Outcomes and Quality of Life After Brain Tumor Ablation. Neurosurgery. 2020 Sep 1;87(3):E338–46.
- Liu Y, Maccarini P, Palmer GM, Inman BA, Fecci PE, Vo-Dinh T. Abstract 6630: Synergistic immuno photothermal nanotherapy (SYMPHONY) for combination cancer therapy. In: Cancer Research. American Association for Cancer Research (AACR); 2020. p. 6630–6630.
- Srinivasan ES, Sankey EW, Grabowski MM, Chongsathidkiet P, Fecci PE. The intersection between immunotherapy and laser interstitial thermal therapy: a multipronged future of neuro-oncology. Int J Hyperthermia. 2020 Jul;37(2):27–34.
- Shen SH, Woroniecka K, Barbour AB, Fecci PE, Sanchez-Perez L, Sampson JH. CAR T cells and checkpoint inhibition for the treatment of glioblastoma. Expert Opin Biol Ther. 2020 Jun;20(6):579–91.
- Grabowski MM, Sankey E, Srinivasan E, Howell E, Scott A, Olufawo M, et al. Laser Interstitial Thermal Therapy Followed By SRS Increases Time to Progression of Recurrent Brain Metastases Initially Treated With SRS. In: JOURNAL OF NEUROSURGERY. AMER ASSOC NEUROLOGICAL SURGEONS; 2020. p. 111–111.
- Rennert RC, Khan U, Bartek J, Tatter SB, Field M, Toyota B, et al. Laser Ablation of Abnormal Neurological Tissue Using Robotic Neuroblate System (LAANTERN): Procedural Safety and Hospitalization. Neurosurgery. 2020 Apr 1;86(4):538–47.
- Moravan MJ, Fecci PE, Anders CK, Clarke JM, Salama AKS, Adamson JD, et al. Current multidisciplinary management of brain metastases. Cancer. 2020 Apr 1;126(7):1390–406.
- Woroniecka KI, Rhodin KE, Dechant C, Cui X, Chongsathidkiet P, Wilkinson D, et al. 4-1BB Agonism Averts TIL Exhaustion and Licenses PD-1 Blockade in Glioblastoma and Other Intracranial Cancers. Clin Cancer Res. 2020 Mar 15;26(6):1349–58.
- Kemeny HR, Elsamadicy AA, Farber SH, Champion CD, Lorrey SJ, Chongsathidkiet P, et al. Targeting PD-L1 Initiates Effective Antitumor Immunity in a Murine Model of Cushing Disease. Clin Cancer Res. 2020 Mar 1;26(5):1141–51.
- Huang M-N, Nicholson LT, Batich KA, Swartz AM, Kopin D, Wellford S, et al. Antigen-loaded monocyte administration induces potent therapeutic antitumor T cell responses. J Clin Invest. 2020 Feb 3;130(2):774–88.
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- Cheema TA, Fecci PE, Ning J, Rabkin SD. Immunovirotherapy for the treatment of glioblastoma. Oncoimmunology. 2014 Jan 1;3(1):e27218.
- Akbay EA, Koyama S, Carretero J, Altabef A, Tchaicha JH, Christensen CL, et al. Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. Cancer Discov. 2013 Dec;3(12):1355–63.
- Fecci PE, Koyama S, Chen C, Cheema T, Dranoff G, Martuza R, et al. Lost And Found: Therapeutic Implications Of Bone Marrow As Harbor For Missing T-Cells In Glioma. In: JOURNAL OF NEUROSURGERY. AMER ASSOC NEUROLOGICAL SURGEONS; 2013. p. A564–A564.
- Fecci P, Chen C, Koyama S, Dranoff G, Martuza RL, Curry WT. 198 Of Mice and Men. In: Neurosurgery. Ovid Technologies (Wolters Kluwer Health); 2013. p. 185–6.
- Cheema TA, Wakimoto H, Fecci PE, Ning J, Kuroda T, Jeyaretna DS, et al. Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12006–11.
- Reardon DA, Wucherpfennig KW, Freeman G, Wu CJ, Chiocca EA, Wen PY, et al. An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma. Expert Rev Vaccines. 2013 Jun;12(6):597–615.
- Choi BD, Fecci PE, Sampson JH. Regulatory T cells move in when gliomas say "I Do". Clin Cancer Res. 2012 Nov 15;18(22):6086–8.
- Dunn GP, Fecci PE, Curry WT. Cancer immunoediting in malignant glioma. Neurosurgery. 2012 Aug;71(2):201–22.
- Agarwalla P, Barnard Z, Fecci P, Dranoff G, Curry WT. Sequential immunotherapy by vaccination with GM-CSF-expressing glioma cells and CTLA-4 blockade effectively treats established murine intracranial tumors. J Immunother. 2012 Jun;35(5):385–9.
- Chatterjee N, Domoto-Reilly K, Fecci PE, Schwamm LH, Singhal AB. Licorice-associated reversible cerebral vasoconstriction with PRES. Neurology. 2010 Nov 23;75(21):1939–41.
- Hahn B, Fecci A, Jacobs C. Renal artery aneurysm. J Emerg Med. 2010 Jun;38(5):654–5.
- Curry WT, Barnard ZR, Agarwalla PK, Fecci P, Dranoff G. CTLA-4 BLOCKADE AUGMENTS VACCINE-INDUCED ANTITUMOR IMMUNITY AGAINST INTRACRANIAL GLIOMA. In: NEURO-ONCOLOGY. DUKE UNIV PRESS; 2009. p. 618–618.
- Mitchell DA, Fecci PE, Sampson JH. Immunotherapy of malignant brain tumors. Immunol Rev. 2008 Apr;222:70–100.
- Selznick LA, Shamji MF, Fecci P, Gromeier M, Friedman AH, Sampson J. Molecular strategies for the treatment of malignant glioma--genes, viruses, and vaccines. Neurosurg Rev. 2008 Apr;31(2):141–55.
- Fecci PE, Ochiai H, Mitchell DA, Grossi PM, Sweeney AE, Archer GE, et al. Systemic CTLA-4 blockade ameliorates glioma-induced changes to the CD4+ T cell compartment without affecting regulatory T-cell function. Clin Cancer Res. 2007 Apr 1;13(7):2158–67.
- Learn CA, Fecci PE, Schmittling RJ, Xie W, Karikari I, Mitchell DA, et al. Profiling of CD4+, CD8+, and CD4+CD25+CD45RO+FoxP3+ T cells in patients with malignant glioma reveals differential expression of the immunologic transcriptome compared with T cells from healthy volunteers. Clin Cancer Res. 2006 Dec 15;12(24):7306–15.
- Fecci PE, Sweeney AE, Grossi PM, Nair SK, Learn CA, Mitchell DA, et al. Systemic anti-CD25 monoclonal antibody administration safely enhances immunity in murine glioma without eliminating regulatory T cells. Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4294–305.
- Unger JM, Fecci P, Ochiai H, Mitchell DA, Schmittling R, Chewning TA, et al. Radiotherapy with regulatory T-cell depletion is synergistic for treatment of experimental model of malignant glioma. In: JOURNAL OF NEUROSURGERY. AMER ASSOC NEUROLOGICAL SURGEONS; 2006. p. A637–8.
- Fecci PE, Mitchell DA, Whitesides JF, Xie W, Friedman AH, Archer GE, et al. Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma. Cancer Res. 2006 Mar 15;66(6):3294–302.
- Learn CA, Schmittling RJ, Fecci PE, Mitchell DA, Archer GE, Sampson JH. Expression profiling of CD4+ and CD8+ T cells in malignant glioma. In: CLINICAL CANCER RESEARCH. AMER ASSOC CANCER RESEARCH; 2005. p. 8999S-8999S.
- Fecci PE, Mitchell DA, Archer GE, Morse MA, Lyerly HK, Bigner DD, et al. The history, evolution, and clinical use of dendritic cell-based immunization strategies in the therapy of brain tumors. J Neurooncol. 2003;64(1–2):161–76.
- Mitchell DA, Fecci PE, Sampson JH. Adoptive immunotherapy for malignant glioma. Cancer J. 2003;9(3):157–66.
- Fecci PE, Sampson JH. Clinical immunotherapy for brain tumors. Neuroimaging Clin N Am. 2002 Nov;12(4):641–64.
- Fecci PE, Gromeier M, Sampson JH. Viruses in the treatment of brain tumors. Neuroimaging Clin N Am. 2002 Nov;12(4):553–70.
- Desjardins A, Randazzo D, Chandramohan V, Peters K, Johnson MO, Threatt S, et al. Dose escalation study of D2C7-IT administered intratumorally via convection-enhanced delivery for recurrent malignant glioma. In.
- Desjardins A, Randazzo D, Chandramohan V, Peters KB, Johnson MO, Threatt S, et al. Dose escalation study of D2C7-IT administered intratumorally via convection-enhanced delivery for recurrent malignant glioma. In.
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- When Cancer Spreads to the Brain and Spine (Aug 29, 2022 | School of Medicine)
- Searching for A Higher Gear in the Fight Against Brain Cancer (Dec 2, 2021 | The Graduate School)
- Cohen-Wolkowiez, Fecci, and Herman Elected Members of American Society for Clinical Investigation (May 5, 2021 | School of Medicine )
- A Duke Team Just Found Missing Immune Cells That Could Fight Lethal Brain Tumors (Aug 13, 2018 | Duke Health News)
- Duke neurosurgeon: Many factors in McCain's favor as he undergoes cancer treatment (Jul 20, 2017 | )