Bruce Klitzman

Research Themes

Biosensors & Bioinstrumentation, Tissue Engineering & Regenerative Medicine

Research Interests

Blood flow to tissues; Innovation & Entrepreneurship; Medical Device Development; Oxygenation of tissues; Implantable biosensors; Biocompatibility of implanted devices; foreign body response to implants; Intravascular catheter to oxygenate blood

Bio

Our overriding interests are in the fields of tissue engineering, wound healing, biosensors, and long term improvement of medical device implantation. My basic research interests are in the area of physiological mechanisms of optimizing substrate transport to tissue. This broad topic covers studies on a whole animal, whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular level. The current projects include:
1) control of blood flow and flow distribution in the microcirculation,
2) the effects of long-term synthetic and biologic implants on substrate transport to tissues,
3) tissue engineering; combining isolated cells, especially adult stem cells, with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials.
4) decreasing the thrombogenicity of synthetic blood vessels and other blood-contacting devices, and improving their overall performance and biocompatibility.
5) reducing tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage.
6) biosensor function, particularly glucose sensors in normal and diabetics.
7) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential.
8) development of biocompatible materials for soft tissue reconstruction or augmentation.
9) improving performance of glaucoma drainage devices by directing a more favorable foreign body reaction
10) wound healing; particularly internal healing around foreign materials and the effect and prevention of microbes around implanted devices.

Education

• Ph.D. University of Virginia, 1979

Positions

• Associate Professor Emeritus in Surgery
• Associate Research Professor of Biomedical Engineering
• Core Faculty in Innovation & Entrepreneurship

Courses Taught

• CELLBIO 493: Research Independent Study
• BES 301B: Research in BES

Publications

• Farling S, Klitzman B, Vesel TP, Cheifetz IM, Straube TL, Deshusses MA. Optimization of the IntraVascular Oxygenator Catheter Using Angular Oscillation. Ann Biomed Eng. 2024 Mar;52(3):638–46.
• Straube TL, Farling S, Deshusses MA, Klitzman B, Cheifetz IM, Vesel TP. Intravascular Gas Exchange: Physiology, Literature Review, and Current Efforts. Respir Care. 2022 Apr;67(4):480–93.
• Wu ZJ, Ibrahim MM, Sergesketter AR, Schweller RM, Phillips BT, Klitzman B. The Influence of Topical Vasodilator-Induced Pharmacologic Delay on Cutaneous Flap Viability and Vascular Remodeling. Plast Reconstr Surg. 2022 Mar 1;149(3):629–37.
• Straube T, Farling S, Vesel T, Klitzman B, Deshusses M, Rotta A. DEVELOPMENT OF A NOVEL INTRAVASCULAR OXYGENATOR CATHETER: PILOT EX VIVO STUDY. In: CRITICAL CARE MEDICINE. 2022. p. 540–540.
• Ruppert DS, Mohammed MM, Ibrahim MM, Bachtiar EO, Erning K, Ansari K, et al. Poly(lactide-co-ε-caprolactone) scaffold promotes equivalent tissue integration and supports skin grafts compared to a predicate collagen scaffold. Wound Repair Regen. 2021 Nov;29(6):1035–50.
• Straube T, Farling S, Vesel T, Klitzman B, Deshusses M, Cheifetz I. DEVELOPMENT OF A NOVEL INTRAVASCULAR OXYGENATOR CATHETER: DEMONSTRATION OF TECHNICAL FEASIBILITY. In: CRITICAL CARE MEDICINE. 2021. p. 479–479.
• Farling S, Straube TL, Vesel TP, Bottenus N, Klitzman B, Cheifetz IM, et al. Development of a novel intravascular oxygenator catheter: Oxygen mass transfer properties across nonporous hollow fiber membranes. Biotechnol Bioeng. 2021 Jan;118(1):345–56.
• Bottenus N, Straube T, Farling S, Vesel T, Klitzman B, Deshusses MA, et al. Ultrasonic bubble detection and tracking using spatial coherence and motion modeling. In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2021.
• Ibrahim MM, Patel PS, Wu ZJ, Chien JS, Wisniewski NA, Mohammed MM, et al. Detection of flap tissue ischemia in a rat model: Real-time monitoring of changes in oxygenation and perfusion through injectable biosensors. Surgery. 2020 Nov;168(5):926–34.
• Scheuermann U, Ibrahim MM, Yerxa J, Parker W, Hartwig MG, Klitzman B, et al. Machine Perfusion of Liver Grafts With Implantable Oxygen Biosensors: Proof of Concept Study in a Rodent Model. Transplant Direct. 2019 Jul;5(7):e463.
• Kanick SC, Schneider PA, Klitzman B, Wisniewski NA, Rebrin K. Continuous monitoring of interstitial tissue oxygen using subcutaneous oxygen microsensors: In vivo characterization in healthy volunteers. Microvasc Res. 2019 Jul;124:6–18.
• Patel P, Ibrahim M, Schweller R, Klitzman B. NOVEL IMPLANTABLE BIOSENSORS FOR LIFETIME-BASED MONITORING OF OXYGENATION TO PREDICT WOUND HEALING. In: WOUND REPAIR AND REGENERATION. WILEY; 2019. p. A19–A19.
• Wang HN, Register JK, Fales AM, Gandra N, Strobbia P, Cho EH, et al. Implantable "smart tattoo" SERS nanosensors for in vivo detection of nucleic acid biotargets in a large animal model. In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2019.
• Wang HN, Register JK, Fales AM, Gandra N, Cho EH, Boico A, et al. Surface-enhanced Raman scattering nanosensors for in vivo detection of nucleic acid targets in a large animal model. Nano Research. 2018 Aug 1;11(8):4005–16.
• Blueschke G, Boico A, Negussie AH, Yarmolenko P, Wood BJ, Spasojevic I, et al. Enhanced Drug Delivery to the Skin Using Liposomes. Plast Reconstr Surg Glob Open. 2018 Jul;6(7):e1739.
• Reese AT, Cho EH, Klitzman B, Nichols SP, Wisniewski NA, Villa MM, et al. Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut. Elife. 2018 Jun 19;7.
• Register JK, Fales AM, Wang H-N, Palmer GM, Klitzman B, Vo-Dinh T. In Vivo Sensing Using SERS Nanosensors. In: NANOTECHNOLOGY IN BIOLOGY AND MEDICINE: METHODS, DEVICES, AND APPLICATIONS, 2ND EDITION. 2018. p. 695–701.
• Ibrahim MM, Chien JS, Mohammed MM, King T, Klitzman B. Detection of Acute Vascular Occlusion Using Oxygen Monitoring in Myocutaneous Flaps. In: WOUND REPAIR AND REGENERATION. WILEY; 2018. p. A15–A15.
• Ibrahim MM, Schweller RM, Mohammed MM, Powers DB, Klitzman B. Implantable Oxygen Platform for Continuous, Real-time Detection of Vascular Perfusion and Ischemia. In: WOUND REPAIR AND REGENERATION. WILEY; 2018. p. A8–A8.
• Ibrahim M, Bond J, Medina MA, Chen L, Quiles C, Kokosis G, et al. Characterization of the Foreign Body Response to Common Surgical Biomaterials in a Murine Model. Eur J Plast Surg. 2017 Nov;40(5):383–92.
• Chien JS, Mohammed M, Eldik H, Ibrahim MM, Martinez J, Nichols SP, et al. Injectable Phosphorescence-based Oxygen Biosensors Identify Post Ischemic Reactive Hyperoxia. Sci Rep. 2017 Aug 15;7(1):8255.
• Klitzman B, Chien JS, Mohammed M, Eldik H, ibrahim M, Martinez J, et al. Injectable Phosphorescence-based Oxygen Biosensors Identify Post Ischemic Reactive Hyperoxia. Nature Scientific Reports. 2017 Aug 15;7(1):1–10.
• Ibrahim MM, Schweller RM, Mohammed MM, Powers DB, Klitzman B. NOVEL IMPLANTABLE OXYGEN BIOSENSORS FOR DETECTION OF VASCULAR PERFUSION AND ISCHEMIA. In: WOUND REPAIR AND REGENERATION. WILEY; 2017. p. A40–A40.
• Ibrahim MM, Chien JS, Mohammed MM, King T, Klitzman B. RAPID DETECTION OF ACUTE VASCULAR OCCLUSION USING OXYGEN MONITORING IN A RAT MYOCUTANEOUS FLAP MODEL. In: WOUND REPAIR AND REGENERATION. WILEY; 2017. p. A40–A40.
• Ibrahim MM, Eldik H, Mohammed MM, Wu ZJ, Klitzman B. COMPARISON OF INTRADERMAL AND SUBCUTANEOUS TISSUE OXYGEN TENSION MONITOR TO DETECT FLAP COMPROMISE. In: WOUND REPAIR AND REGENERATION. WILEY; 2017. p. A40–A40.
• Schweller RM, Wu ZJ, Klitzman B, West JL. Stiffness of Protease Sensitive and Cell Adhesive PEG Hydrogels Promotes Neovascularization In Vivo. Ann Biomed Eng. 2017 Jun;45(6):1387–98.
• Wisniewski NA, Nichols SP, Gamsey SJ, Pullins S, Au-Yeung KY, Klitzman B, et al. Tissue-Integrating Oxygen Sensors: Continuous Tracking of Tissue Hypoxia. Adv Exp Med Biol. 2017;977:377–83.
• Chien J, Mohammed M, Eldik H, Ibrahim M, Nichols S, Klitzman B. Implantable Oxygen Biosensors Reveals Post-occlusion Tissue Reactive Hyperoxia. In: JOURNAL OF VASCULAR RESEARCH. KARGER; 2017. p. 37–8.
• Kasili PM, Vo-Dinh T. Monitoring apoptosis and anticancer drug activity in single cells using nanosensors. In: Nanotechnology in Biology and Medicine: Methods, Devices, and Applications, Second Edition. 2017. p. 423–38.
• Shammas RL, Fales AM, Crawford BM, Klitzman B, Hollenbeck ST, VoDinh T. Plasmonic Gold-Nanostars for Tracking of Adult Stem Cells and for Selective Photothermal Ablation. In: Journal of the American College of Surgeons. Ovid Technologies (Wolters Kluwer Health); 2016. p. S100–S100.
• Eldik H, Klitzman B, Ibrahim M, Martinez J, Nichols S, Wisniewksi N. 548 Real-time continuous monitoring of subcutaneous tissue oxygenation. In: Journal of Investigative Dermatology. Elsevier BV; 2016. p. S254–S254.
• Eldik H, Mohamed M, Martinez J, Wisiniewski N, Nichols S, Klitzman B. LB823 Real-time continuous monitoring of tissue oxygenation: Quantifying critically ischemic flap regions. In: Journal of Investigative Dermatology. Elsevier BV; 2016. p. B13–B13.
• Ibrahim M, Levering V, Lanham E, Parra J, Leraas H, Lopez G, et al. MP24-17 PERVASIVE BIOFILM COVERAGE: AN ANALYSIS OF BIOFILM FORMATION IN INDWELLING URINARY CATHETERS. In: Journal of Urology. Ovid Technologies (Wolters Kluwer Health); 2016.
• Ibrahim MM, Medina MA, Bond J, Chen L, Quiles C, Kokosis G, et al. FOREIGN BODY REACTION TO COMMONLY USED SURGICAL BIOMATERIALS. WOUND REPAIR AND REGENERATION. 2016 Mar 1;24(2):A12–3.
• Ibrahim MM, Wu Z, Chien J, Klitzman B. NOVEL IMPLANTABLE OPTICAL OXYGEN MONITOR TO DETECT FLAP VIABILITY. WOUND REPAIR AND REGENERATION. 2016 Mar 1;24(2):A13–A13.
• Lorden E, Ramchal T, Chandra P, Bashirov L, Ibrahim MM, Hammett E, et al. PORE SIZE IMPACTS HYPERTROPHIC SCARRING-RELATED OUTCOMES IN 3D PRINTED POLYURETHANE SCAFFOLDS. WOUND REPAIR AND REGENERATION. 2016 Mar 1;24(2):A16–7.
• Ibrahim MM, Wu Z, Schweller R, Phillips B, Klitzman B. TOPICAL VASODILATOR INDUCES PHARMACOLOGICAL DELAY ON CUTANEOUS FLAP VIABILITY AND VASCULAR REMODELING. WOUND REPAIR AND REGENERATION. 2016 Mar 1;24(2):A13–A13.
• Laux P, Tralau T, Tentschert J, Blume A, Dahouk SA, Bäumler W, et al. A medical-toxicological view of tattooing. Lancet. 2016 Jan 23;387(10016):395–402.
• Vallejo-Heligon SG, Brown NL, Reichert WM, Klitzman B. Porous, Dexamethasone-loaded polyurethane coatings extend performance window of implantable glucose sensors in vivo. Acta Biomater. 2016 Jan;30:106–15.
• Gastrell P, Cho J, Klitzman B. Improving the Biocompatibility of Implants in Irradiated Tissue Using an Adipose-Derived Stromal-Vascular Fraction. In: International Journal of Radiation Oncology*Biology*Physics. Elsevier BV; 2015. p. E544–5.
• Register JK, Fales AM, Wang H-N, Norton SJ, Cho EH, Boico A, et al. In vivo detection of SERS-encoded plasmonic nanostars in human skin grafts and live animal models. Anal Bioanal Chem. 2015 Nov;407(27):8215–24.
• Jung Y, Ji H, Chen Z, Fai Chan H, Atchison L, Klitzman B, et al. Scaffold-free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels. Sci Rep. 2015 Oct 12;5:15116.
• Ibrahim MM, Wu ZJ, Klitzman B. Novel implantable optical oxygen monitor to detect flap viability. In: Journal of the American College of Surgeons. Ovid Technologies (Wolters Kluwer Health); 2015. p. e87–8.
• Jung Y, Ji H, Chen Z, Chan H, Atchison L, Klitzman B, et al. Fabrication of Scaffold-free Tissue Engineered Blood Vessel using Nanopatterned Human Mesenchymal Stem Cell Sheet. In: TISSUE ENGINEERING PART A. MARY ANN LIEBERT, INC; 2015. p. S271–S271.
• Gastrell P, Cho J, Klitzman B. 472. Low-Shear Sodding of an Implantable Expanded Polytetrafluoroethylene Scaffold with a Rat Adipose-Derived Stromal-Vascular Fraction. In: Molecular Therapy. Elsevier BV; 2015. p. S187–S187.
• Liao L, Cho E, Boico A, Register J, Fales A, Helton K, et al. Vascularization of Porous PolyHEMA Scaffolds. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 2015.
• Boico A, Cho E, Liao L, Register J, Fales A, Wisnewski N, et al. Characterization of Inflammatory Cell Response to Implanted Porous P-HEMA in the Dermis Vs Subcutaneous Tissue. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 2015.
• Ibrahim MM, Wu Z, Klitzman B. NOVEL IMPLANTABLE OPTICAL OXYGEN MONITOR TO DETECT FLAP VIABILITY. In: WOUND REPAIR AND REGENERATION. WILEY-BLACKWELL; 2015. p. A26–A26.
• Ibrahim MM, Medina MA, Bond J, Bergeron A, Chen L, Quiles C, et al. FOREIGN BODY RESPONSE TO FIVE COMMON SUBCUTANEOUS IMPLANTS. In: WOUND REPAIR AND REGENERATION. WILEY-BLACKWELL; 2015. p. A27–A27.
• Gastrell P, Cho J, Klitzman B. Low-shear Sodding of an Implantable Expanded Polytetrafluoroethylene Scaffold with a Rat Adipose-derived Stromal-vascular Fraction. In: FASEB JOURNAL. 2015.
• Brown NL, Rose MB, Blueschke G, Cho EH, Schoenfisch MH, Erdmann D, et al. Bioburden after Staphylococcus aureus inoculation in type 1 diabetic rats undergoing internal fixation. Plast Reconstr Surg. 2014 Sep;134(3):412e-419e.
• Cho E, Boico A, Brown N, Wisniewski N, Helton K, Register J, et al. Tissue integration of porous polyHEMA scaffold. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 2014.
• Cho EH, Boico A, Wisniewski NA, Helton KL, Register JK, Fales AM, et al. Abstract 88: microvascular integration into versatile tissue engineering platforms. In: Plast Reconstr Surg. 2014. p. 102.
• Ibrahim MM, Bond J, Bergeron A, Miller KJ, Ehanire T, Quiles C, et al. Abstract 34: a novel immune competent murine hypertrophic scar contracture model: a tool to elucidate disease mechanism and develop new therapies. In: Plast Reconstr Surg. 2014. p. 44–5.
• Ibrahim MM, Bond J, Bergeron A, Miller KJ, Ehanire T, Quiles C, et al. A novel immune competent murine hypertrophic scar contracture model: a tool to elucidate disease mechanism and develop new therapies. Wound Repair Regen. 2014;22(6):755–64.
• Cho EH, Boico A, Wisniewski NA, Gant R, Helton KL, Brown NL, et al. Micovascular integration into porous polyHEMA scaffold. In 2014.
• Radiloff D, Zhao Y, Boico A, Blueschke G, Palmer G, Fontanella A, et al. Anti-hypotensive treatment and endothelin blockade synergistically antagonize exercise fatigue in rats under simulated high altitude. PLoS One. 2014;9(6):e99309.
• Nichols SP, Koh A, Brown NL, Rose MB, Sun B, Slomberg DL, et al. The effect of nitric oxide surface flux on the foreign body response to subcutaneous implants. Biomaterials. 2012 Sep;33(27):6305–12.
• Schroeder T, Wisniewski N, Boico A, Le N, Cho E, Helton K, et al. Long-term tissue integration of porous biopolymers as a material platform for metabolic biosensor. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 2012.
• Stroncek JD, Ren LC, Klitzman B, Reichert WM. Patient-derived endothelial progenitor cells improve vascular graft patency in a rodent model. Acta Biomater. 2012 Jan;8(1):201–8.
• Hollenbeck ST, Senghaas A, Komatsu I, Zhang Y, Erdmann D, Klitzman B. Tissue engraftment of hypoxic-preconditioned adipose-derived stem cells improves flap viability. Wound Repair Regen. 2012;20(6):872–8.
• Le NN, Rose MB, Levinson H, Klitzman B. Implant healing in experimental animal models of diabetes. J Diabetes Sci Technol. 2011 May 1;5(3):605–18.
• Nichols SP, Le NN, Klitzman B, Schoenfisch MH. Increased in vivo glucose recovery via nitric oxide release. Anal Chem. 2011 Feb 15;83(4):1180–4.
• DeCroos FC, Kondo Y, Mordes D, Lee MR, Ahmad S, Asrani S, et al. In vitro fluid dynamics of the Ahmed glaucoma valve modified with expanded polytetrafluoroethylene. Curr Eye Res. 2011 Feb;36(2):112–7.
• Prichard HL, Schroeder T, Reichert WM, Klitzman B. Bioluminescence imaging of glucose in tissue surrounding polyurethane and glucose sensor implants. J Diabetes Sci Technol. 2010 Sep 1;4(5):1055–62.
• Yang J, Erdmann D, Chang JC, Komatsu I, Zhang Y, Wang D, et al. A model of sequential heart and composite tissue allotransplant in rats. Plast Reconstr Surg. 2010 Jul;126(1):80–6.
• Koschwanez HE, Reichert WM, Klitzman B. Intravital microscopy evaluation of angiogenesis and its effects on glucose sensor performance. J Biomed Mater Res A. 2010 Jun 15;93(4):1348–57.
• Huang X, Zauscher S, Klitzman B, Truskey GA, Reichert WM, Kenan DJ, et al. Peptide interfacial biomaterials improve endothelial cell adhesion and spreading on synthetic polyglycolic acid materials. Ann Biomed Eng. 2010 Jun;38(6):1965–76.
• Schroeder T, Wisniewski N, Boico A, Le N, Cho E, Helton K, et al. Long-term tissue integration of porous biopolymers as a material platform for metabolic biosensor. In: FASEB JOURNAL. 2010.
• Talaat WM, McGraw TA, Klitzman B. Relationship between the canthal-tragus distance and the puncture point in temporomandibular joint arthroscopy. Int J Oral Maxillofac Surg. 2010 Jan;39(1):57–60.
• DeCroos FC, Ahmad S, Kondo Y, Chow J, Mordes D, Lee MR, et al. Expanded polytetrafluoroethylene membrane alters tissue response to implanted Ahmed glaucoma valve. Curr Eye Res. 2009 Jul;34(7):562–7.
• Pradka SP, Ong YS, Zhang Y, Davis SJ, Baccarani A, Messmer C, et al. Increased signs of acute rejection with ischemic time in a rat musculocutaneous allotransplant model. Transplant Proc. 2009 Mar;41(2):531–6.
• Schutte RJ, Xie L, Klitzman B, Reichert WM. In vivo cytokine-associated responses to biomaterials. Biomaterials. 2009 Jan;30(2):160–8.
• Prichard HL, Reichert WM, Klitzman B. Adipose stem cell attachment to glucose sensors. In: 8th World Biomaterials Congress 2008. 2008. p. 2099.
• Koschwanez HE, Yap FY, Klitzman B, Reichert WM. In vitro and in vivo characterization of porous poly-L-lactic acid coatings for subcutaneously implanted glucose sensors. J Biomed Mater Res A. 2008 Dec 1;87(3):792–807.
• Koschwanez HE, Klitzman B, Reichert WM. Percutaneous window chamber method for chronic intravital microscopy of sensor-tissue interactions. J Diabetes Sci Technol. 2008 Nov;2(6):977–83.
• Prichard HL, Reichert W, Klitzman B. IFATS collection: Adipose-derived stromal cells improve the foreign body response. Stem Cells. 2008 Oct;26(10):2691–5.
• Mischen BT, Follmar KE, Moyer KE, Buehrer B, Olbrich KC, Levin LS, et al. Metabolic and functional characterization of human adipose-derived stem cells in tissue engineering. Plast Reconstr Surg. 2008 Sep;122(3):725–38.
• Kovach SJ, Koger KE, Klitzman B, Germann G, Levin LS. Advantages of minimally invasive, balloon-dissector-assisted tissue expander placement: a clinical and experimental study. Ann Plast Surg. 2008 Jan;60(1):89–97.
• Hetrick EM, Prichard HL, Klitzman B, Schoenfisch MH. Reduced foreign body response at nitric oxide-releasing subcutaneous implants. Biomaterials. 2007 Nov;28(31):4571–80.
• Levinson H, Mischen B, Klitzman B, Erdmann D, Levin SL. Non muscle myosin II regulates contractile phenotypes. In: Journal of the American College of Surgeons. Ovid Technologies (Wolters Kluwer Health); 2007. p. S60–1.
• Baccarani A, Yasui K, Olbrich KC, El-Sabbagh A, Kovach S, Follmar KE, et al. Efficacy of ethyl nitrite in reversing surgical vasospasm. J Reconstr Microsurg. 2007 Jul;23(5):257–62.
• Norton LW, Koschwanez HE, Wisniewski NA, Klitzman B, Reichert WM. Vascular endothelial growth factor and dexamethasone release from nonfouling sensor coatings affect the foreign body response. J Biomed Mater Res A. 2007 Jun 15;81(4):858–69.
• Follmar KE, Prichard HL, DeCroos FC, Wang HT, Levin LS, Klitzman B, et al. Combined bone allograft and adipose-derived stem cell autograft in a rabbit model. Ann Plast Surg. 2007 May;58(5):561–5.
• Prichard HL, Reichert WM, Klitzman B. Adult adipose-derived stem cell attachment to biomaterials. Biomaterials. 2007 Feb;28(6):936–46.
• Heitmann C, Khan FN, Erdmann D, Olbrich KC, Adam Sharkawy A, Klitzman B. Vein graft anastomoses with magnets. J Plast Reconstr Aesthet Surg. 2007;60(12):1296–301.
• Lanzen J, Braun RD, Klitzman B, Brizel D, Secomb TW, Dewhirst MW. Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor. Cancer Res. 2006 Feb 15;66(4):2219–23.
• Ko J, Ross J, Awad H, Hurwitz H, Klitzman B. The effects of ZD6474, an inhibitor of VEGF signaling, on cutaneous wound healing in mice. J Surg Res. 2005 Dec;129(2):251–9.
• Nablo BJ, Prichard HL, Butler RD, Klitzman B, Schoenfisch MH. Inhibition of implant-associated infections via nitric oxide release. Biomaterials. 2005 Dec;26(34):6984–90.
• Olbrich KC, Meade R, Bruno W, Heller L, Klitzman B, Levin LS. Halofuginone inhibits collagen deposition in fibrous capsules around implants. Ann Plast Surg. 2005 Mar;54(3):293–6.
• Chan BP, Liu W, Klitzman B, Reichert WM, Truskey GA. In vivo performance of dual ligand augmented endothelialized expanded polytetrafluoroethylene vascular grafts. J Biomed Mater Res B Appl Biomater. 2005 Jan 15;72(1):52–63.
• Kondo Y, Ahmad SI, Lee RM, Asrani S, Olbrich KC, Allingham RR, et al. Outflow facility of a Glaucoma Valve enclosed in expanded polytetrafluoroethylene (ePTFE). In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. ASSOC RESEARCH VISION OPHTHALMOLOGY INC; 2005.
• Sorg BS, Peltz CD, Klitzman B, Dewhirst MW. Method for improved accuracy in endogenous urea recovery marker calibrations for microdialysis in tumors. J Pharmacol Toxicol Methods. 2005;52(3):341–9.
• Olbrich KC, Meade RA, Bruno W, Sundin BM, Heller L, Erdmann D, et al. Tempostatin™ (halofuginone) inhibits collagen deposition in fibrous capsules. Transactions - 7th World Biomaterials Congress. 2004. p. 294.
• Dai Q, Huang J, Klitzman B, Dong C, Goldschmidt-Clermont PJ, March KL, et al. Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia. Circulation. 2004 Oct 19;110(16):2467–75.
• Erdmann D, Pippen AM, Moquin KJ, Sweis R, Niklason LE, Levin LS, et al. Immunohistochemical identification of vascular endothelial growth factor in pig latissimus dorsi musculocutaneous flaps following ischemia-reperfusion injury. Ann Plast Surg. 2004 Oct;53(4):398–403.
• Erdmann D, Sweis R, Heitmann C, Yasui K, Olbrich KC, Levin LS, et al. Side-to-side sutureless vascular anastomosis with magnets. J Vasc Surg. 2004 Sep;40(3):505–11.
• Erdmann D, Heitmann C, Pu KCM, Olbrich K, Levin LS, Klitzman B. Anastomoses for vascular shunt, arterial graft, and flap vascularization performed using magnets. In: JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS. ELSEVIER SCIENCE INC; 2004. p. S64–S64.
• Schoenfisch MH, Nablo BJ, Robbins ME, Butler RD, Klitzman B. Nitric oxide release as a means for improving the tissue-compatibility of in vivo subcutaneous glucose biosensors. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. AMER CHEMICAL SOC; 2004. p. U159–60.
• Wong MS, Erdmann D, Sweis R, Pöllmann C, Farrar M, Georgiade GS, et al. Basic fibroblast growth factor expression following surgical delay of rat transverse rectus abdominis myocutaneous flaps. Plast Reconstr Surg. 2004 Jun;113(7):2030–6.
• Erdmann D, Klitzman B. Investigation of TRAM flap oxygenation and perfusion by near-infrared reflection spectroscopy and color-coded duplex sonography: Discussion. Vol. 113, Plastic and Reconstructive Surgery. 2004. p. 153–5.
• Dai QS, Huang JH, Klitzman B, Rokovich J, Rebar E, Johnstone B, et al. A genetically engineered plasmid encoding a zinc finger VEGF-activating transcription factor induces angiogenesis in the rabbits with hind-limb ischemia. In: MOLECULAR THERAPY. ACADEMIC PRESS INC ELSEVIER SCIENCE; 2003. p. S330–1.
• Lockhart AC, Braun RD, Yu D, Ross JR, Dewhirst MW, Humphrey JS, et al. Reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor. Clin Cancer Res. 2003 Feb;9(2):586–93.
• Erdmann D, Sweis R, Wong MS, Niklason LE, du Laney TV, Levin LS, et al. Vascular endothelial growth factor expression in pig latissimus dorsi myocutaneous flaps after ischemia reperfusion injury. Plast Reconstr Surg. 2003 Feb;111(2):775–80.
• Lockhart AC, Braun RD, Yu D, Ross JR, Dewhirst MW, Klitzman B, et al. A clinical model of dermal wound angiogenesis. Wound Repair Regen. 2003;11(4):306–13.
• Stenken JA, Reichert WM, Klitzman B. Magnetic resonance imaging of a tissue/implanted device biointerface using in vivo microdialysis sampling. Anal Chem. 2002 Sep 15;74(18):4849–54.
• Wisniewski N, Klitzman B, Miller B, Reichert WM. Decreased analyte transport through implanted membranes: differentiation of biofouling from tissue effects. J Biomed Mater Res. 2001 Dec 15;57(4):513–21.
• Duncan GT, Lockhart AC, Ross JR, Klitzman B, Olbrich K, Lee VM, et al. Wound angiogenesis in healthy volunteers using OPSI technology: A potential surrogate marker for antiangiogenesis agents. Vol. 7, CLINICAL CANCER RESEARCH. AMER ASSOC CANCER RESEARCH; 2001. p. 3700S-3700S.
• Ettinger SN, Poellmann CC, Wisniewski NA, Gaskin AA, Shoemaker JS, Poulson JM, et al. Urea as a recovery marker for quantitative assessment of tumor interstitial solutes with microdialysis. Cancer Res. 2001 Nov 1;61(21):7964–70.
• Heller L, Levin LS, Klitzman B. Laser Doppler flowmeter monitoring of free-tissue transfers: blood flow in normal and complicated cases. Plast Reconstr Surg. 2001 Jun;107(7):1739–45.
• Ravin AG, Olbrich KC, Levin LS, Usala AL, Klitzman B. Long- and short-term effects of biological hydrogels on capsule microvascular density around implants in rats. J Biomed Mater Res. 2001 May 1;58(3):313–8.
• Klitzman B, Sweis RN, Olbrich KC. Chronic percutaneous intravital microscopy using orthogonal polarization spectral imaging. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 2001. p. A53–A53.
• Wisniewski N, Rajamand N, Reichert W, Klitzman B, Ungerstedt U. Metabolites at a biomaterial-tissue interface sampled by microdialysis - a comparison of the subcutaneous foreign body response in humans and rats over 8 days. Vol. 28, Annals of Biomedical Engineering. 2000.
• Dewhirst MW, Klitzman B, Braun RD, Brizel DM, Haroon ZA, Secomb TW. Review of methods used to study oxygen transport at the microcirculatory level. Int J Cancer. 2000 Oct 20;90(5):237–55.
• Sundin BM, Hussein MA, Glasofer S, El-Falaky MH, Abdel-Aleem SM, Sachse RE, et al. The role of allopurinol and deferoxamine in preventing pressure ulcers in pigs. Plast Reconstr Surg. 2000 Apr;105(4):1408–21.
• Brown SA, Phillips TM, Mathy J, Klitzman B, Levin LS. IL-8 levels in infected bone marrow are modulated by a muscle flap. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 2000. p. A177–A177.
• Olbrich KC, Ravin AG, Usala AL, Levin LS, Klitzman B. Vascular density and capsule thickness around implanted devices. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 2000. p. A445–A445.
• Lockhart AC, Braun RD, Dewhirst MW, Humphrey JS, Yuan F, Grichnick J, et al. Wound angiogenesis inhibition as a marker for anti-angiogenic efficacy. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 2000. p. A35–A35.
• Brown SA, Mayberry AJ, Mathy JA, Phillips TM, Klitzman B, Levin LS. The effect of muscle flap transposition to the fracture site on TNFalpha levels during fracture healing. Plast Reconstr Surg. 2000 Mar;105(3):991–8.
• Wisniewski N, Rajamand N, Reichert W, Klitzman B, Ungerstedt U. Metabolites at a biomaterial-tissue interface sampled by microdialysis - a comparison of the subcutaneous foreign body response in humans and rats over 8 days. Vol. 28, Annals of Biomedical Engineering. 2000. p. 19.
• Klitzman B, Braun RD, Lockhart AC, Heller L, Dewhirst MW, Hurwitz HI. Wound-induced angiogenesis: A clinical model. Messmer K, editor. ORTHOGONAL POLARIZATION SPECTRAL IMAGING. 2000 Jan 1;24:110–4.
• Wisniewski N, Miller B, Klitzman B, Reichert M. Characterization of analyte transport over time through implantable biosensor membranes using microdialysis. Vol. 2, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 1999. p. 721.
• Dewhirst MW, Ong ET, Braun RD, Smith B, Klitzman B, Evans SM, et al. Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia. Br J Cancer. 1999 Apr;79(11–12):1717–22.
• Brown SA, Phillips T, Mayberry AJ, Mathy JA, Klitzman B, Levin LS. The effect of Staph. aureus on TNFa and IFNg levels during wound healing in a canine open fracture model. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 1999. p. A852–A852.
• Moore FM, Levin LS, Klitzman B, Brown SA. A new wound model for the study of acute soft tissue injury using microdialysis. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 1999. p. A678–A678.
• Sachse RE, Fink SA, Klitzman B. Multimodality evaluation of pressure relief surfaces. Plast Reconstr Surg. 1998 Dec;102(7):2381–7.
• Sachse RE, Fink SA, Klitzman B. Comparison of supine and lateral positioning on various clinically used support surfaces. Ann Plast Surg. 1998 Nov;41(5):513–8.
• Molenaar A. Modulation of ultraviolet light-induced epidermal damage: beneficial effects of tocopherol. Vol. 102, Plast Reconstr Surg. 1998. p. 1785–6.
• Ritter EF, Cronan JC, Rudner AM, Serafin D, Klitzman B. Improved microsurgical anastomotic patency with low molecular weight heparin. J Reconstr Microsurg. 1998 Jul;14(5):331–6.
• Klitzman B, Kalinowski C, Glasofer SL, Rugani L. Pressure ulcers and pressure relief surfaces. Clin Plast Surg. 1998 Jul;25(3):443–50.
• Sharkawy AA, Klitzman B, Truskey GA, Reichert WM. Engineering the tissue which encapsulates subcutaneous implants. II. Plasma-tissue exchange properties. J Biomed Mater Res. 1998 Jun 15;40(4):586–97.
• Sharkawy AA, Klitzman B, Truskey GA, Reichert WM. Engineering the tissue which encapsulates subcutaneous implants. III. Effective tissue response times. J Biomed Mater Res. 1998 Jun 15;40(4):598–605.
• Bhat VD, Klitzman B, Koger K, Truskey GA, Reichert WM. Improving endothelial cell adhesion to vascular graft surfaces: clinical need and strategies. J Biomater Sci Polym Ed. 1998;9(11):1117–35.
• Koger KE, Levin LS, Klitzman B. Effects of internal pressure on blood flow in pig skin. Vol. 12, FASEB Journal. 1998. p. A8.
• Wisniewski N, Klitzman B, Reichert WM. Membrane biofouling measured by microdialysis. Proceedings of the Controlled Release Society. 1998. p. 73–4.
• Ritter EF, Fata MM, Rudner AM, Klitzman B. Heparin bonding increases patency of long microvascular prostheses. Plast Reconstr Surg. 1998 Jan;101(1):142–6.
• Sharkawy AA, Klitzman B, Truskey GA, Reichert WM. Engineering the tissue which encapsulates subcutaneous implants. I. Diffusion properties. J Biomed Mater Res. 1997 Dec 5;37(3):401–12.
• Ritter EF, Kim YB, Reischl HP, Serafin D, Rudner AM, Klitzman B. Heparin coating of vascular prostheses reduces thromboemboli. Surgery. 1997 Nov;122(5):888–92.
• Musselwhite JM, Klitzman B, Maixner W, Burkes EJ. Laser Doppler flowmetry: a clinical test of pulpal vitality. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 Oct;84(4):411–9.
• Ritter EF, Axelrod M, Minn KW, Eades E, Rudner AM, Serafin D, et al. Modulation of ultraviolet light-induced epidermal damage: beneficial effects of tocopherol. Plast Reconstr Surg. 1997 Sep;100(4):973–80.
• Viscardi PJ, Page EA, Clark HG, Serafin D, Klitzman B. Iloprost in alginate decreases the thrombogenicity of expanded polytetrafluoroethylene. J Reconstr Microsurg. 1997 May;13(4):303–6.
• Maynor ML, Moon RE, Klitzman B, Fracica PJ, Canada A. Brown recluse spider envenomation: a prospective trial of hyperbaric oxygen therapy. Acad Emerg Med. 1997 Mar;4(3):184–92.
• Sharkawy A, Klitzman B, Truskey G, Reichert W. Diffusion properties of tissue which encapsulates subcutaneous implants. Vol. 76, Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering. 1997. p. 568–9.
• Skarada DJ, du Laney TV, Steele TM, Ritter EF, Klitzman B. Continual in vivo assessment of 1 mm diameter vascular prostheses. Vol. 1, Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. 1996. p. 278.
• Sharkawy AA, Klitzman B, Truskey GA, Reichert WM. Diffusion properties of capsular tissue. Vol. 2, Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. 1996. p. 132.
• du Laney TV, Truskey GA, Klitzman B. Fibronectin enhances cell spreading and retention on ePTFE under shear in vitro. Vol. 1, Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. 1996. p. 560.
• Sonntag KD, Klitzman B, Burkes EJ, Hoke J, Moshonov J. Pulpal response to cavity preparation with the Er:YAG and Mark III free electron lasers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Jun;81(6):695–702.
• Ritter EF, Anthony JP, Levin LS, Demas CP, Klitzman B, Skarada D, et al. Microsurgical composite tissue transplantation at difficult recipient sites facilitated by preliminary installation of vein grafts as arteriovenous loops. J Reconstr Microsurg. 1996 May;12(4):231–40.
• Zavitsanos G, Huang L, Panza W, Serafin D, Klitzman B. Limiting impairment of muscle function following ischemia and reperfusion in rabbits. J Reconstr Microsurg. 1996 Apr;12(3):183–7.
• Zhang J, Sam AD, Klitzman B, Piantadosi CA. Inhibition of nitric oxide synthase on brain oxygenation in anesthetized rats exposed to hyperbaric oxygen. Undersea Hyperb Med. 1995 Dec;22(4):377–82.
• Kimura H, Wu NZ, Dodge R, Spencer DP, Klitzman BM, McIntyre TM, et al. Inhibition of radiation-induced up-regulation of leukocyte adhesion to endothelial cells with the platelet-activating factor inhibitor, BN52021. Int J Radiat Oncol Biol Phys. 1995 Oct 15;33(3):627–33.
• Skarada DJ, Erickson GR, Warnecke KL, du Laney TV, Greenberg CS, Ritter EF, et al. Assessments of thrombogenicity by three in vitro techniques. Student Research Award in the Undergraduate, Master Candidate, or Health Science Degree Candidate Category, 21st annual meeting of the Society for Biomaterials, San Francisco, CA, March 18-22, 1995. J Biomed Mater Res. 1995 Sep;29(9):1039–45.
• HUSSEIN M, ABDELALEEM S, ELFALAKY M, SERAFIN D, KLITZMAN B. CORRELATION BETWEEN SKELETAL-MUSCLE HIGH-ENERGY ADENINE-NUCLEOTIDE CONTENT AND APPLIED PRESSURE. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 1995. p. A693–A693.
• Zhang J, Benveniste H, Klitzman B, Piantadosi CA. Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. Stroke. 1995 Feb;26(2):298–304.
• SONNTAG K, BURKES EJ, HOKE J, KLITZMAN B. PULPAL RESPONSE TO CAVITY PREPARATION WITH THE ERYAG LASER. Vol. 74, JOURNAL OF DENTAL RESEARCH. AMER ASSOC DENTAL RESEARCH; 1995. p. 102–102.
• Kim YB, Reisch HP, Serafin D, Klitzman B. Evaluation of the thrombogenecity of microvascular prosthesis by in vivo microscopy. J Korean Med Sci. 1994 Oct;9(5):357–61.
• Hoke JA, Burkes EJ, White JT, Duffy MB, Klitzman B. Blood-flow mapping of oral tissues by laser Doppler flowmetry. Int J Oral Maxillofac Surg. 1994 Oct;23(5):312–5.
• Wu NZ, Ross BA, Gulledge C, Klitzman B, Dodge R, Dewhirst MW. Differences in leucocyte-endothelium interactions between normal and adenocarcinoma bearing tissues in response to radiation. Br J Cancer. 1994 May;69(5):883–9.
• KLITZMAN B, SCHRADER N, MCLENDON RE, DEWHIRST MW. QUANTITATIVE MORPHOLOGY OF RAT CARCINOMA WITH RELEVANCE TO OXYGENATION. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 1994. p. A1046–A1046.
• Klitzman B. Rheology and the regulation of oxygen delivery. Microsurgery. 1994;15(6):369–73.
• Peterseim DS, Meyers CH, Craig DM, Heinle JS, Jayawant AM, Devaney JJ, et al. Enhanced cardiac preservation with oxygenated University of Wisconsin solution. J Surg Res. 1993 Dec;55(6):588–94.
• Wu NZ, Klitzman B, Rosner G, Needham D, Dewhirst MW. Measurement of material extravasation in microvascular networks using fluorescence video-microscopy. Microvasc Res. 1993 Sep;46(2):231–53.
• Wigod MD, Klitzman B. Quantification of in vitro endothelial cell adhesion to vascular graft material. J Biomed Mater Res. 1993 Aug;27(8):1057–62.
• Feldman DL, Sepka RS, Klitzman B. Tissue oxygenation and blood flow on specialized and conventional hospital beds. Ann Plast Surg. 1993 May;30(5):441–4.
• Vann RD, Ritter EF, Plunkett MD, Wyble CW, Bensen CV, Gerth WA, et al. Patency and blood flow in gas denucleated arterial prostheses. J Biomed Mater Res. 1993 Apr;27(4):493–8.
• SONNY M, SAM AD, PIANTADOSI CA, KLITZMAN B. EFFECTS OF HYPERBARIC-OXYGEN ON ARTERIOLAR DIAMETER IN RAT CREMASTER MUSCLE. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 1993. p. A557–A557.
• SAM AD, SONNY M, PIANTADOSI CA, KLITZMAN B. EFFECT OF HYPERBARIC-OXYGEN ON MUSCLE OXYGEN-TENSIONS. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 1993. p. A449–A449.
• WIGOD M, KLITZMAN B. INCREASED MICROVASCULAR ENDOTHELIAL-CELL ADHESION TO BIOMATERIALS. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 1993. p. A241–A241.
• Secomb TW, Hsu R, Dewhirst MW, Klitzman B, Gross JF. Analysis of oxygen transport to tumor tissue by microvascular networks. Int J Radiat Oncol Biol Phys. 1993 Feb 15;25(3):481–9.
• Brizel DM, Klitzman B, Cook JM, Edwards J, Rosner G, Dewhirst MW. A comparison of tumor and normal tissue microvascular hematocrits and red cell fluxes in a rat window chamber model. Int J Radiat Oncol Biol Phys. 1993 Jan 15;25(2):269–76.
• Dewhirst MW, Madwed D, Meyer RE, Ong ET, Klitzman B, Rosner GL, et al. Reduction in tumor blood flow in skin flap tumor after hydralazine is not due to a vascular steal phenomenon. Radiation Oncology Investigations. 1993 Jan 1;1(5):270–8.
• Dewhirst MW, Ong ET, Madwed D, Klitzman B, Secomb T, Brizel D, et al. Effects of the calcium channel blocker flunarizine on the hemodynamics and oxygenation of tumor microvasculature. Radiat Res. 1992 Oct;132(1):61–8.
• Wu NZ, Klitzman B, Dodge R, Dewhirst MW. Diminished leukocyte-endothelium interaction in tumor microvessels. Cancer Res. 1992 Aug 1;52(15):4265–8.
• Dewhirst MW, Vinuya RZ, Ong ET, Klitzman B, Rosner G, Secomb TW, et al. Effects of bradykinin on the hemodynamics of tumor and granulating normal tissue microvasculature. Radiat Res. 1992 Jun;130(3):345–54.
• Dewhirst MW, Ong ET, Klitzman B, Secomb TW, Vinuya RZ, Dodge R, et al. Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber. Radiat Res. 1992 May;130(2):171–82.
• SECOMB TW, HSU R, DEWHIRST MW, KLITZMAN B, GROSS JF. SIMULATION OF OXYGEN-TRANSPORT TO TUMOR-TISSUE BY MICROVASCULAR NETWORKS. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 1992. p. A2084–A2084.
• Minn KW, Serafin D, Mikat E, Klitzman B. Reconstruction of rat femoral veins with microvascular prostheses. Plast Reconstr Surg. 1991 Mar;87(3):536–42.
• Bensen CV, Vann RD, Koger KE, Klitzman B. Quantification of gas denucleation and thrombogenicity of vascular grafts. J Biomed Mater Res. 1991 Mar;25(3):373–86.
• Clinton MS, Sepka RS, Bristol D, Pederson WC, Barwick WJ, Serafin D, et al. Establishment of normal ranges of laser Doppler blood flow in autologous tissue transplants. Plast Reconstr Surg. 1991 Feb;87(2):299–309.
• Axelrod M, Serafin D, Klitzman B. Ultraviolet light and free radicals: an immunologic theory of epidermal carcinogenesis. Plast Reconstr Surg. 1990 Sep;86(3):582–93.
• Perona BP, Bartolome JV, Sepka RS, Serafin D, Klitzman B. Acute difluoromethylornithine treatment increases skin flap survival in rats. Ann Plast Surg. 1990 Jul;25(1):26–8.
• Goldberg M, Serafin D, Klitzman B. Quantification of neutrophil adhesion to skeletal muscle venules following ischemia-reperfusion. J Reconstr Microsurg. 1990 Jul;6(3):267–70.
• Goldberg J, Sepka RS, Perona BP, Pederson WC, Klitzman B. Laser Doppler blood flow measurements of common cutaneous donor sites for reconstructive surgery. Plast Reconstr Surg. 1990 Apr;85(4):581–6.
• Eshbaugh WG, Forley BG, Ritter EF, Serafin D, Klitzman B. Stimulation of DNA synthesis in human epidermis by UVB radiation and its inhibition by difluoromethylornithine. Plast Reconstr Surg. 1990 Apr;85(4):593–6.
• HOKE J, BURKES J, WHITE J, KLITZMAN B. EFFECTS OF HARD AND RESILIENT DENTURE MATERIALS ON TISSUE PERFUSION. In: JOURNAL OF DENTAL RESEARCH. AMER ASSOC DENTAL RESEARCH; 1990. p. 228–228.
• Burk RW, Serafin D, Klitzman B. Toxic effects of catecholamines on skin. Plast Reconstr Surg. 1990 Jan;85(1):92–9.
• Klitzman B. Regional variations of laser doppler blood flow in ischemic skin flaps. In: Plastic and Reconstructive Surgery. 1990. p. 327–8.
• Smith YR, Klitzman B, Ellis MN, Kull FC. The effect of nicotinamide on microvascular density and thermal injury in rats. J Surg Res. 1989 Nov;47(5):465–9.
• Ritter EF, Vann RD, Wyble C, Barwick WJ, Klitzman B. Hydrostatic pressure reduces thrombogenicity of polytetrafluoroethylene vascular grafts. Am J Physiol. 1989 Oct;257(4 Pt 2):H1076–81.
• Demas CP, Vann R, Ritter E, Sepka RS, Klitzman B, Barwick WJ. Decreased thrombogenicity of vascular prostheses following gas denucleation by hydrostatic pressure. Plast Reconstr Surg. 1988 Dec;82(6):1042–5.
• PERONA B, CLINTON M, KLITZMAN B. INVIVO PLATELET-AGGREGATION IN THE MICROVASCULATURE FOLLOWING ULTRASONIC STIMULATION. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 1988. p. A1876–A1876.
• KLITZMAN B, SCHRADER N, ELIZALDE P. INCREASES IN PERFUSED CAPILLARY DENSITY, CAPILLARY HEMATOCRIT AND SYSTEMIC HEMATOCRIT INDUCED BY CHRONIC EXPOSURE TO HYPOXIA OR COLD. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 1988. p. A1870–A1870.
• RITTER E, VANN R, SEPKA R, KLITZMAN B. REDUCTION IN THROMBOGENICITY OF MICROVASCULAR PROSTHESES. Vol. 2, FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 1988. p. A1877–A1877.
• Forley BG, Huang L, Bartolome J, Serafin D, Klitzman B. The potential role of polyamine inhibition in keloid therapy. Vol. 39, Surgical Forum. 1988. p. 627–8.
• Gelman J, Bartolome JV, Jenkins S, Serafin D, Schanberg SM, Klitzman B. Reduced cell death in skin flaps in rats treated with difluoromethylornithine. FASEB J. 1987 Dec;1(6):474–7.
• Klitzman B. Microvascular determinants of blood flow. J Reconstr Microsurg. 1987 Oct;4(1):77–80.
• Huang L, Privalle CT, Serafin D, Klitzman B. Increased survival of skin flaps by scavengers of superoxide radical. FASEB J. 1987 Aug;1(2):129–32.
• Jenkins SD, Sepka RS, Barwick WJ, Serafin D, Klitzman B. Routine clinical use of laser Doppler flowmeter to monitor free tissue transfer: preliminary results. J Reconstr Microsurg. 1987 Jul;3(4):281–3.
• KLITZMAN B, GELMAN J, SERAFIN D, SEPKA R, SCHANBERG S, BARTOLOME JV. PROTECTION OF RAT SKIN AGAINST ISCHEMIC DAMAGE WITH DIFLUOROMETHYLORNITHINE. Vol. 46, FEDERATION PROCEEDINGS. FEDERATION AMER SOC EXP BIOL; 1987. p. 1120–1120.
• KLITZMAN B, SCHRADER N, SEPKA R, SERAFIN D. RELATIVE EFFECTS OF RED-CELLS AND PLATELETS ON RAT SKIN FLAP SURVIVAL. Vol. 46, FEDERATION PROCEEDINGS. FEDERATION AMER SOC EXP BIOL; 1987. p. 1531–1531.
• Ball R, Serafin D, Klitzman B. Rat skin flap necrosis reduced with topical chlorpromazine. Vol. 38, Surgical Forum. 1987. p. 600–1.
• KLITZMAN B, SEPKA RS, SERAFIN D. EFFECTS OF SYSTEMIC HEMATOCRIT ON RAT SKIN FLAP SURVIVAL. Vol. 23, BIORHEOLOGY. PERGAMON-ELSEVIER SCIENCE LTD; 1986. p. 276–276.
• Fleming BP, Klitzman B, Johnson WO. Measurement of erythrocyte velocity by use of a periodic differential detector. Am J Physiol. 1985 Oct;249(4 Pt 2):H899–905.
• KLITZMAN B. RELATIVE INCREASE IN CAPILLARY HEMATOCRIT FOLLOWING ISOVOLEMIC HEMODILUTION. Vol. 29, MICROVASCULAR RESEARCH. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS; 1985. p. 231–231.
• Klitzman B, Fronczak SJ. Mitochondrial distribution in hamster cremaster muscle. Adv Exp Med Biol. 1984;180:695–700.
• FLEMING BP, KLITZMAN B, JOHNSON WO. A PERIODIC DIFFERENTIAL DETECTOR FOR MICROVASCULAR VELOCIMETRY. Vol. 27, MICROVASCULAR RESEARCH. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS; 1984. p. 243–243.
• KLITZMAN B. RELATIVE VELOCITY OF RED-CELLS AND SUB-MICRON PARTICLES IN MUSCLE CAPILLARIES. Vol. 3, INTERNATIONAL JOURNAL OF MICROCIRCULATION-CLINICAL AND EXPERIMENTAL. KARGER; 1984. p. 386–386.
• FLEMING BP, KLITZMAN B, JOHNSON WO. A PERIODIC DIFFERENTIAL DETECTOR FOR MICROVASCULAR VELOCIMETRY. Vol. 3, INTERNATIONAL JOURNAL OF MICROCIRCULATION-CLINICAL AND EXPERIMENTAL. KARGER; 1984. p. 540–540.
• Klitzman B, Popel AS, Duling BR. Oxygen transport in resting and contracting hamster cremaster muscles: experimental and theoretical microvascular studies. Microvasc Res. 1983 Jan;25(1):108–31.
• KLITZMAN B. EFFECT OF FLUORESCENT LABELING OF RED-CELLS ON FLOW THROUGH CAPILLARIES. Vol. 25, MICROVASCULAR RESEARCH. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS; 1983. p. 241–2.
• Klitzman B, Damon DN, Gorczynski RJ, Duling BR. Augmented tissue oxygen supply during striated muscle contraction in the hamster. Relative contributions of capillary recruitment, functional dilation, and reduced tissue PO2. Circ Res. 1982 Dec;51(6):711–21.
• Klitzman B, Johnson PC. Capillary network geometry and red cell distribution in hamster cremaster muscle. Am J Physiol. 1982 Feb;242(2):H211–9.
• KLITZMAN B, MYERS J, WATTS RP, JOHNSON PC. MEASUREMENT OF MICRO-VASCULAR HEMATOCRIT AND RED-CELL VELOCITY USING STROBOSCOPIC EPI-FLUORESCENCE MICROSCOPY. In: FEDERATION PROCEEDINGS. FEDERATION AMER SOC EXP BIOL; 1982. p. 1759–1759.
• KLITZMAN B, JOHNSON PC. FACTORS AFFECTING THE DISTRIBUTION OF RED-BLOOD-CELLS AT CAPILLARY BIFURCATIONS. Vol. 21, MICROVASCULAR RESEARCH. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS; 1981. p. 247–8.
• KLITZMAN B, JOHNSON PC. HETEROGENEITY OF RED-CELL FLUX AND CAPILLARY HEMATOCRIT IN STRIATED-MUSCLE CAPILLARIES. Vol. 20, MICROVASCULAR RESEARCH. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS; 1980. p. 116–116.
• Duling BR, Klitzman B. Local control of microvascular function: role in tissue oxygen supply. Annu Rev Physiol. 1980;42:373–82.
• Klitzman B, Duling BR. Microvascular hematocrit and red cell flow in resting and contracting striated muscle. Am J Physiol. 1979 Oct;237(4):H481–90.
• KLITZMAN B, DULING BR. CAUSES OF LOW MICRO-VASCULAR HEMATOCRIT IN HAMSTER CREMASTER CAPILLARIES. Vol. 17, MICROVASCULAR RESEARCH. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS; 1979. p. S70–S70.
• Gorczynski RJ, Klitzman B, Duling BR. Interrelations between contracting striated muscle and precapillary microvessels. Am J Physiol. 1978 Nov;235(5):H494–504.
• KLITZMAN B, DULING BR. ACUTE HEMATOCRIT CHANGES IN CAPILLARIES OF STRIATED-MUSCLE DURING FUNCTIONAL HYPEREMIA. Vol. 15, MICROVASCULAR RESEARCH. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS; 1978. p. 267–267.
• Klitzman B, Duling BR. Effects of oxygen and norepinephrine (NE) on capillary blood flow in contracting muscle. Vol. 36, Federation Proceedings. 1977.
• KLITZMAN B, DULING BR. EFFECTS OF OXYGEN AND NOREPINEPHRINE (NE) ON CAPILLARY BLOOD-FLOW IN CONTRACTING MUSCLE. In: FEDERATION PROCEEDINGS. FEDERATION AMER SOC EXP BIOL; 1977. p. 451–451.

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