Biomedical Imaging and Biophotonics

Advancing the physics and mathematical theory of imaging, image acquisition and processing, hardware design, and clinical applications

photoacoustic microscopy of mouse ear vasculature

The Duke BME program is a world leader in development of novel biomedical imaging technologies, with translational and basic science applications.

In the past few decades, our faculty have pushed the boundaries of discovery and innovation in optics and photonics (e.g. optical coherence tomography and low-coherence interferometry), ultrasound (e.g. acoustic radiation force impulse based elasticity imaging), MRI, X-ray, and nuclear medicine-based imaging technologies, developing new diagnostic and treatment tools for ailments ranging from cancer to cardiovascular, neurological, and ophthalmic diseases.

colorful squiggly lines in the general shape of a brain
A colorful, high-resolution look at the blood vessels in a mice brain using technology developed by Pengfei Song and his laboratory. The same technique will soon be used to better image the human lymphatic sytem.

Our research efforts span from advancing the physics and mathematical theory of imaging, image acquisition, and image processing to hardware design and clinical applications. We address longstanding problems in development of multi-dimensional and multi-modality imaging systems with unmatched image acquisition speed, resolution, and penetration depth. We investigate development of complex image-guided clinical tools (e.g., autonomous surgical robots) to cheap and robust image diagnostic technologies (e.g., cellphone cameras).

There are extensive collaborations between our biomedical imaging faculty and Duke University Medical Center clinicians, resulting in the rapid translation of numerous imaging technologies developed at Duke BME to the patient bedside and commercialization.

The Biomedical Imaging research community at Duke is supported and enhanced by numerous centers and programs, including the Fitzpatrick Institute for Photonics, the Duke Center for In Vivo Microscopy, the Center for Global Women’s Health Technologies, and the Duke Medical Imaging Training Program.

Signature Biomedical Imaging Strengths

From bringing real-time and 3D ultrasound imaging into clinical practice to revolutionizing optical coherence tomography (OCT) to guide eye diagnostics and surgery, our researchers have always had an ambitious view of the field’s future.

researcher using 3-D ultrasound machine

3D and Real-Time Ultrasound

Now used in countless clinical settings around the world, our faculty continue to develop these critical technologies for new abilities and applications.

a high-resolution image of a retina

Optical Coherence Tomography

OCT has long been the gold standard for eye care. Our faculty continue to develop its applications from finding early signs of Alzheimer’s disease to marketing low-cost versions for global clinicians.

false-color photoacoustic image of the vasculature of a mouse placenta

Photoacoustic Tomography

PAT for short, this up-and-coming technology uses gentle lasers to generate ultrasound waves from deep tissue, enabling a new way to peer at the complexities of human biology.

The Pocket Colposcope

Cancer Screening and Treatment

Reimagining archaic designs for women’s health technologies, our faculty are building intuitive, less-invasive devices powered by AI to democratize cancer screening and care worldwide.

a closeup of a half dozen blue camera lenses all pushed together with reflections of colorful ant shapes in them

Computational Optics

Stitching together dozens of viewpoints from off-the-shelf cameras can provide rich, comprehensive data for every scale from animal behavior or cellular activity.

Recent Biomedical Imaging News

colorful high-resolution image of a mouse brain
1/28 Pratt School of Engineering

A New Vision for Lymphatic Imaging

Pengfei Song is part of a team led by the University of Alberta, which has received an ARPA-H award to create high-resolution, 3D ultrasound for lymphedema imaging.

Associated Faculty

Alexandra Badea Profile Photo
Alexandra Badea Profile Photo

Alexandra Badea

Associate Professor in Radiology

Al-Hafeez Z Dhalla Profile Photo
Al-Hafeez Z Dhalla Profile Photo

Al-Hafeez Z Dhalla

Assistant Research Professor in the Department of Biomedical Engineering

Bastiaan Driehuys Profile Photo
Bastiaan Driehuys Profile Photo

Bastiaan Driehuys

Professor of Radiology

Timothy Dunn, Ph.D. Profile Photo
Timothy Dunn, Ph.D. Profile Photo

Timothy Dunn, Ph.D.

Assistant Professor of Biomedical Engineering

Sina Farsiu, Ph.D. Profile Photo
Sina Farsiu, Ph.D. Profile Photo

Sina Farsiu, Ph.D.

Associate Chair for Faculty, Anderson-Rupp Professor of BME

John Hickey Profile Photo
John Hickey Profile Photo

John Hickey

Assistant Professor of Biomedical Engineering

G. Allan Johnson Profile Photo
G. Allan Johnson Profile Photo

G. Allan Johnson

Charles E. Putman University Distinguished Professor of Radiology

David Katz, Ph.D. Profile Photo
David Katz, Ph.D. Profile Photo

David Katz, Ph.D.

Nello L. Teer, Jr. Distinguished Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering

Joseph Yuan-Chieh Lo Profile Photo
Joseph Yuan-Chieh Lo Profile Photo

Joseph Yuan-Chieh Lo

Professor in Radiology

Kathy Nightingale, Ph.D. Profile Photo
Kathy Nightingale, Ph.D. Profile Photo

Kathy Nightingale, Ph.D.

Director of Graduate Studies, Theo Pilkington Distinguished Professor of BME

Mark L. Palmeri Profile Photo
Mark L. Palmeri Profile Photo

Mark L. Palmeri

Professor of the Practice in the Department of Biomedical Engineering

Nimmi Ramanujam, Ph.D. Profile Photo
Nimmi Ramanujam, Ph.D. Profile Photo

Nimmi Ramanujam, Ph.D.

Robert W. Carr, Jr., Distinguished Professor of Biomedical Engineering

Ehsan Samei Profile Photo
Ehsan Samei Profile Photo

Ehsan Samei

Reed and Martha Rice Distinguished Professor of Radiology

Stephen William Smith Profile Photo
Stephen William Smith Profile Photo

Stephen William Smith

Professor Emeritus of Biomedical Engineering

Allen W Song Profile Photo
Allen W Song Profile Photo

Allen W Song

Professor in Radiology

Pengfei Song, Ph.D. Profile Photo
Pengfei Song, Ph.D. Profile Photo

Pengfei Song, Ph.D.

Associate Professor of Biomedical Engineering

Cynthia Ann Toth Profile Photo
Cynthia Ann Toth Profile Photo

Cynthia Ann Toth

Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology

Gregg Trahey, Ph.D. Profile Photo
Gregg Trahey, Ph.D. Profile Photo

Gregg Trahey, Ph.D.

Robert Plonsey Distinguished Professor of Biomedical Engineering

Tuan Vo-Dinh, Ph.D. Profile Photo
Tuan Vo-Dinh, Ph.D. Profile Photo

Tuan Vo-Dinh, Ph.D.

R. Eugene and Susie E. Goodson Distinguished Professor of Biomedical Engineering

Olaf Von Ramm, Ph.D. Profile Photo
Olaf Von Ramm, Ph.D. Profile Photo

Olaf Von Ramm, Ph.D.

Thomas Lord Distinguished Professor of Engineering

Adam Wax, Ph.D. Profile Photo
Adam Wax, Ph.D. Profile Photo

Adam Wax, Ph.D.

Professor of Biomedical Engineering

Patrick D. Wolf Profile Photo
Patrick D. Wolf Profile Photo

Patrick D. Wolf

Associate Professor Emeritus of Biomedical Engineering

Junjie Yao, Ph.D. Profile Photo
Junjie Yao, Ph.D. Profile Photo

Junjie Yao, Ph.D.

Jeffrey N. Vinik Associate Professor of Biomedical Engineering

Other Research Specialties

Explore additional specialty research areas in Duke BME and throughout the Pratt School of Engineering.