William D Stamer

W Daniel Stamer

Joseph A.C. Wadsworth Professor of Ophthalmology

Appointments and Affiliations

  • Joseph A.C. Wadsworth Professor of Ophthalmology
  • Professor of Ophthalmology

Contact Information

  • Office Location: 2608 Erwin Rd, Box 148-145, Durham, NC 27705
  • Office Phone: (919) 684-3745
  • Email Address: william.stamer@duke.edu

Education

  • Ph.D. University of Arizona, 1996
  • B.S. University of Arizona, 1990

Research Interests

The Mechanobiology of Ocular Hypertension in Glaucoma: My laboratory studies the disease of glaucoma, the second leading cause of blindness in the United States, affecting nearly 3 million people (70 million Worldwide). The primary risk factor for developing glaucoma is ocular hypertension (high intraocular pressure, IOP). IOP is a function of aqueous humor moving into and out of the eye. Elevated IOP in glaucoma is a result of disease in the primary efflux route, the "pressure-sensitive" conventional outflow pathway. Controlling IOP in glaucoma patients, whether or not they have ocular hypertension, is important because large clinical trials involving tens of thousands of patients repeatedly demonstrate that significant, sustained IOP reduction slows or halts vision loss. Unfortunately, current daily medical treatments do not target the diseased conventional pathway and do not lower IOP sufficiently in most people with glaucoma. Therefore, finding new, more effective ways to control IOP by targeting the conventional pathway is a central goal the Stamer Laboratory. Using molecular, cellular, organ and living model systems, my laboratory seeks to better understand the mechanobiology of conventional outflow with the ultimate goal to identify and validate targets in the conventional outflow pathway such that novel treatments for ocular hypertension and glaucoma can be developed. We study the dynamic mechanical behavior of the conventional outflow cells and tissues using a variety of approaches including optical coherence tomography, atomic force microscopy, cellular dielectic spectroscopy, ocular perfusions, mechanical stretch and contractility assays.

Representative Publications

  • Reina-Torres, E; Wen, JC; Liu, KC; Li, G; Sherwood, JM; Chang, JYH; Challa, P; Flügel-Koch, CM; Stamer, WD; Allingham, RR; Overby, DR, VEGF as a Paracrine Regulator of Conventional Outflow Facility., Investigative Ophthalmology and Visual Science, vol 58 no. 3 (2017), pp. 1899-1908 [10.1167/iovs.16-20779] [abs].
  • Wen, JC; Reina-Torres, E; Sherwood, JM; Challa, P; Liu, KC; Li, G; Chang, JYH; Cousins, SW; Schuman, SG; Mettu, PS; Stamer, WD; Overby, DR; Allingham, RR, Intravitreal Anti-VEGF Injections Reduce Aqueous Outflow Facility in Patients With Neovascular Age-Related Macular Degeneration., Investigative Ophthalmology and Visual Science, vol 58 no. 3 (2017), pp. 1893-1898 [10.1167/iovs.16-20786] [abs].
  • Chandrawati, R; Chang, JYH; Reina-Torres, E; Jumeaux, C; Sherwood, JM; Stamer, WD; Zelikin, AN; Overby, DR; Stevens, MM, Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma., Advanced Materials (2017) [10.1002/adma.201604932] [abs].
  • Li, G; Cui, G; Dismuke, WM; Navarro, I; Perkumas, K; Woodward, DF; Stamer, WD, Differential response and withdrawal profile of glucocorticoid-treated human trabecular meshwork cells., Experimental Eye Research, vol 155 (2017), pp. 38-46 [10.1016/j.exer.2016.12.002] [abs].
  • Stamer, WD; Schuman, JS, Introduction to Gedenkschrift for David L. Epstein, MD., Experimental Eye Research (2017) [10.1016/j.exer.2017.01.008] [abs].