Lori A. Setton
Adjunct Professor of Biomedical EngineeringResearch in Setton's laboratory is focused on the role of mechanical factors in the degeneration and repair of soft tissues of the musculoskeletal system, including the intervertebral disc, articular cartilage and meniscus. Work in the Laboratory is focused on engineering and evaluating materials for tissue regeneration and drug delivery. Studies combining engineering and biology are also used to determine the role of mechanical factors to promote and control healing of cartilaginous tissues. Research in the Laboratory is funded by The National Institutes of Health, The Coulter Foundation and The North Carolina Biotechnology Center.
Appointments and Affiliations
- Adjunct Professor of Biomedical Engineering
- Faculty Network Member of the Duke Institute for Brain Sciences
- Bass Fellow
- Office Location: Box 90281, Dept. Biomed Engng, Durham, NC 27708
- Office Phone: (919) 660-5131
- Ph.D. Columbia University, 1993
- B.S.E. Princeton University, 1984
Research in Setton's laboratory is focused on the role of mechanical factors in the degeneration and repair of soft tissues of the musculoskeletal system, including the intervertebral disc, articular cartilage and meniscus.
Awards, Honors, and Distinctions
- Van C. Mow Medal. American Society of Mechanical Engineers. 2007
- Fellows. American Institute for Medical and Biological Engineering. 2005
- BME 494: Projects in Biomedical Engineering (GE)
- BME 530: Introduction to Tissue Biomechanics (GE, BB)
- BME 792: Graduate Independent Study
In the News
- New shapeshifting biogel could help heal aging spines (Jul 17, 2013 | Popular Science )
- Duke Bioengineers Develop New Approach to Regenerate Back Discs (Jul 16, 2013)
- Bowles, RD; Karikari, IO; VanDerwerken, DN; Sinclair, MS; Bell, RD; Riebe, KJ; Huebner, JL; Kraus, VB; Sempowski, GD; Setton, LA, In vivo luminescent imaging of NF-κB activity and NF-κB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy., European Journal of Pain, vol 20 no. 3 (2016), pp. 365-376 [10.1002/ejp.732] [abs].
- Adams, SB; Setton, LA; Bell, RD; Easley, ME; Huebner, JL; Stabler, T; Kraus, VB; Leimer, EM; Olson, SA; Nettles, DL, Inflammatory Cytokines and Matrix Metalloproteinases in the Synovial Fluid After Intra-articular Ankle Fracture., Foot & ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society, vol 36 no. 11 (2015), pp. 1264-1271 [10.1177/1071100715611176] [abs].
- Mwangi, TK; Bowles, RD; Tainter, DM; Bell, RD; Kaplan, DL; Setton, LA, Synthesis and characterization of silk fibroin microparticles for intra-articular drug delivery., International Journal of Pharmaceutics, vol 485 no. 1-2 (2015), pp. 7-14 [10.1016/j.ijpharm.2015.02.059] [abs].
- Hwang, PY; Jing, L; Michael, KW; Richardson, WJ; Chen, J; Setton, LA, N-Cadherin-Mediated Signaling Regulates Cell Phenotype for Nucleus Pulposus Cells of the Intervertebral Disc., Cellular and Molecular Bioengineering, vol 8 no. 1 (2015), pp. 51-62 [10.1007/s12195-014-0373-4] [abs].
- Kimmerling, KA; Furman, BD; Mangiapani, DS; Moverman, MA; Sinclair, SM; Huebner, JL; Chilkoti, A; Kraus, VB; Setton, LA; Guilak, F; Olson, SA, Sustained intra-articular delivery of IL-1RA from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis., European cells & materials, vol 29 (2015), pp. 124-139 [abs].