Kam W Leong

Kam Leong

Adjunct Professor of Biomedical Engineering

Professor Leong's research interest focuses on biomaterials design, particularly on synthesis of nanoparticles for DNA-based therapeutics, and nanostructured biomaterials for regenerative medicine

Biomaterials Design:

  • design of self-assembled fibers for tissue engineering
  • microfluidics-mediated synthesis of multifunctional nanoparticles for drug and gene delivery
  • synthesis of novel quantum dots for biomedical applications

Controlled Drug and Gene Delivery:

  • oral gene delivery for hemophilia A and B
  • non-viral gene delivery to the GI tract
  • oral delivery of antigen genes for vaccination

Tissue Engineering:

  • study of response of stem cells to nanotopographical cues
  • expansion of hematopoietic stem cells
  • nerve guidance channels with drug and gene delivery functions
  • microencapsulation of stem cells and genetically-engineered cells
  • development of bioartificial nucleus pulposus device
  • study of interaction of stem cells with synthetic nanostructured biomaterials

Appointments and Affiliations

    Contact Information

    Research Interests

    Leong's research interest focuses on biomaterials design, particularly on synthesis of nanoparticles for DNA-based therapeutics, and nanostructured biomaterials for regenerative medicine.

    Specialties

    Biological Materials
    Drug Delivery
    Tissue Repair, Tissue Engineering
    Biophotonics
    Nanoscience

    Awards, Honors, and Distinctions

    • Clemson Award for Applied Research. Society for Biomaterials. 2012
    • Fellows. American Institute for Medical and Biological Engineering. 1999

    In the News

    Representative Publications

    • Wang, H-X; Li, M; Lee, CM; Chakraborty, S; Kim, H-W; Bao, G; Leong, KW, CRISPR/Cas9-Based Genome Editing for Disease Modeling and Therapy: Challenges and Opportunities for Nonviral Delivery., Chemical Reviews, vol 117 no. 15 (2017), pp. 9874-9906 [10.1021/acs.chemrev.6b00799] [abs].
    • Zhang, J; Li, J; Shi, Z; Yang, Y; Xie, X; Lee, SM; Wang, Y; Leong, KW; Chen, M, pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities, Acta Biomaterialia (2017) [10.1016/j.actbio.2017.04.029] [abs].
    • Lu, M; Ozcelik, A; Grigsby, CL; Zhao, Y; Guo, F; Leong, KW; Huang, TJ, Microfluidic hydrodynamic focusing for synthesis of nanomaterials, Nano Today, vol 11 no. 6 (2016), pp. 778-792 [10.1016/j.nantod.2016.10.006] [abs].
    • Jackman, JG; Juwarker, H; Poveromo, LP; Levinson, H; Leong, KW; Sullenger, BA, Polycationic Nanofibers for Nucleic Acid Scavenging., Biomacromolecules, vol 17 no. 11 (2016), pp. 3706-3713 [10.1021/acs.biomac.6b01236] [abs].
    • Wang, S; Xu, Y; Chan, HF; Kim, H-W; Wang, Y; Leong, KW; Chen, M, Nanoparticle-mediated inhibition of survivin to overcome drug resistance in cancer therapy, Journal of Controlled Release, vol 240 (2016), pp. 454-464 [10.1016/j.jconrel.2016.04.018] [abs].