Kam W Leong

Kam Leong

Adjunct Professor of Biomedical Engineering

Professor Leong's research interest focuses on biomaterials design, particularly on synthesis of nanoparticles for DNA-based therapeutics, and nanostructured biomaterials for regenerative medicine

Biomaterials Design:

  • design of self-assembled fibers for tissue engineering
  • microfluidics-mediated synthesis of multifunctional nanoparticles for drug and gene delivery
  • synthesis of novel quantum dots for biomedical applications

Controlled Drug and Gene Delivery:

  • oral gene delivery for hemophilia A and B
  • non-viral gene delivery to the GI tract
  • oral delivery of antigen genes for vaccination

Tissue Engineering:

  • study of response of stem cells to nanotopographical cues
  • expansion of hematopoietic stem cells
  • nerve guidance channels with drug and gene delivery functions
  • microencapsulation of stem cells and genetically-engineered cells
  • development of bioartificial nucleus pulposus device
  • study of interaction of stem cells with synthetic nanostructured biomaterials

Appointments and Affiliations

  • Adjunct Professor of Biomedical Engineering

Contact Information

Education

  • Ph.D. University of Pennsylvania, 1987
  • B.S.CH.E. University of California at Santa Barbara, 1977

Research Interests

Leong's research interest focuses on biomaterials design, particularly on synthesis of nanoparticles for DNA-based therapeutics, and nanostructured biomaterials for regenerative medicine.

Specialties

Biological Materials
Drug Delivery
Tissue Repair, Tissue Engineering
Biophotonics
Nanoscience

Awards, Honors, and Distinctions

  • Clemson Award for Applied Research. Society for Biomaterials. 2012
  • Fellows. American Institute for Medical and Biological Engineering. 1999

In the News

Representative Publications

  • Lu, M; Ozcelik, A; Grigsby, CL; Zhao, Y; Guo, F; Leong, KW; Huang, TJ, Microfluidic hydrodynamic focusing for synthesis of nanomaterials, Nano Today, vol 11 no. 6 (2016), pp. 778-792 [10.1016/j.nantod.2016.10.006] [abs].
  • Jackman, JG; Juwarker, H; Poveromo, LP; Levinson, H; Leong, KW; Sullenger, BA, Polycationic Nanofibers for Nucleic Acid Scavenging., Biomacromolecules, vol 17 no. 11 (2016), pp. 3706-3713 [10.1021/acs.biomac.6b01236] [abs].
  • Wang, S; Xu, Y; Chan, HF; Kim, H-W; Wang, Y; Leong, KW; Chen, M, Nanoparticle-mediated inhibition of survivin to overcome drug resistance in cancer therapy, Journal of Controlled Release, vol 240 (2016), pp. 454-464 [10.1016/j.jconrel.2016.04.018] [abs].
  • Zhao, X; Yang, K; Zhao, R; Ji, T; Wang, X; Yang, X; Zhang, Y; Cheng, K; Liu, S; Hao, J; Ren, H; Leong, KW; Nie, G, Inducing enhanced immunogenic cell death with nanocarrier-based drug delivery systems for pancreatic cancer therapy, Biomaterials, vol 102 (2016), pp. 187-197 [10.1016/j.biomaterials.2016.06.032] [abs].
  • Perez, RA; Choi, S-J; Han, C-M; Kim, J-J; Shim, H; Leong, KW; Kim, H-W, Biomaterials control of pluripotent stem cell fate for regenerative therapy, Progress in Materials Science, vol 82 (2016), pp. 234-293 [10.1016/j.pmatsci.2016.05.003] [abs].