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Synthetic and Systems Biology

Drawing from concepts in a wide array of areas, including evolutionary biology, molecular biology, biophysics, and genetic engineering, researchers at Duke are developing methods to read and manipulate genetic code.

This work includes the development of new strategies for regenerative medicine, treatment of genetic disease, and techniques to establish robust gene circuit function. Research in synthetic and systems biology at Duke has provided insight into the design laws of natural biological systems.

The synthetic and systems biology research communities at Duke are supported and enhanced by the Center for Biomolecular and Tissue Engineering (CBTE).

Primary Faculty

Charles Gersbach

Charles Gersbach

Rooney Family Associate Professor of Biomedical Engineering

Research Interests: Dr. Gersbach's research interests are in gene therapy, biomolecular and cellular engineering, regenerative medicine, and synthetic biology.

Michael D Lynch

Michael D Lynch

Assistant Professor in the Department of Biomedical Engineering

Research Interests: Dr. Lynch's research focuses on genetically engineering microbes to shut off their growth circuits and turn on new pathways to produce different compounds. By focusing their energy, he seeks to improve production of biofuels, pharmacological molecules and industrial chemicals.

Amanda Randles

Amanda Randles

Assistant Professor of Biomedical Engineering

Research Interests: Randle's research in biomedical simulation and high performance computing focuses on the development of new computational tools that she uses to provide insight into the localization and development of human diseases ranging from atherosclerosis to cancer.

Xiling Shen

Xiling Shen

Associate Professor in the Department of Biomedical Engineering

Research Interests: Dr. Shen's research integrates systems biology and implantable devices to study non-coding RNA, colon cancer, stem cells, and the enteric nervous system. His multidisciplinary approach provides a new window for developing novel therapeutics against heterogeneous diseases such as cancer.

Lingchong You

Lingchong You

Paul Ruffin Scarborough Associate Professor of Engineering

Research Interests: Dr. You's research interest focus on computational systems biology & synthetic biology, including mathematical modeling of cellular networks; mechanisms of information processing by gene networks; design, modeling and construction of robust gene networks for applications in engineering and...

Research Faculty

Lisa L Satterwhite

Lisa L Satterwhite

Assistant Research Professor in the Department of Biomedical Engineering

Research Interests: Satterwhite studies the genomics and epigenetics of environmental exposures in populations with clear health disparity. Her group identified the first genomic signature for pesticide exposure and is developing simple blood tests to diagnose early stage asymptomatic neurodegenerative disease and...