Gersbach research image

Drug and Gene Delivery

The field of drug and gene delivery involves development and delivery of drugs, genes, and gene products that ultimately alter protein expression and function of the cells, tissues, and living organisms.

Important areas in this growing field include development of delivery vehicles such as plasmids, nanoparticles, viruses, liposomes, peptide/protein complexes, and biomaterial scaffolds, as well as studies of drug and gene transport, delivery strategies, delivery barriers, and immune response to delivery.

Duke BME is actively involved in understanding and developing new strategies for drug and gene delivery aimed at therapies for cancer, infectious and cardiovascular disease, muscle disease, gastrointestinal disease, and others.

Close collaborations with Duke University School of Medicine faculty and support from the Center for Biomolecular and Tissue Engineering (CBTE) are important contributors to the successful endeavors of this research community.

Primary Faculty

Ashutosh Chilkoti

Ashutosh Chilkoti

Alan L. Kaganov Professor of Biomedical Engineering

Research Interests: Chilkoti's research focuses on biomolecular materials and biointerface science and emphasizes the development of applications that span the range from bioseparations, biosensors, patterned biomaterials, and targeted drug delivery.

Charles Gersbach

Charles Gersbach

Rooney Family Associate Professor of Biomedical Engineering

Research Interests: Dr. Gersbach's research interests are in gene therapy, biomolecular and cellular engineering, regenerative medicine, and synthetic biology.

David F. Katz

David F. Katz

Nello L. Teer, Jr. Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering

Research Interests: Dr. Katz's research interest include methods for prophylaxis against STD's, emphasizing topical microbicides and contraception; biofluid mechanics; rheology and transport phenomena; biophysical aspects of mammalian sperm motility, sperm transport, and fertilization; and biomechanical functioning of...

Michael D Lynch

Michael D Lynch

Assistant Professor in the Department of Biomedical Engineering

Research Interests: Dr. Lynch's research focuses on genetically engineering microbes to shut off their growth circuits and turn on new pathways to produce different compounds. By focusing their energy, he seeks to improve production of biofuels, pharmacological molecules and industrial chemicals.

Robert A. Malkin

Robert A. Malkin

Professor of the Practice in the Department of Biomedical Engineering

Research Interests: Professor Malkin's work on medical instrumentation in the developing world has been supported by Engineering World Health, The National Institutes of Health, The American Heart Association, The Whitaker Foundation, the National Science Foundation and other organizations. The DHT-Lab runs...

Wanda Krassowska Neu

Wanda Krassowska Neu

Professor of Biomedical Engineering

Research Interests: Electroporation-mediated drug delivery and gene therapy; Control of cardiac arrhythmias using nonlinear dynamics

Michael Raphael Tadross

Michael Raphael Tadross

Assistant Professor of Biomedical Engineering

Research Interests: Neural circuits and their dysfunction.

Lingchong You

Lingchong You

Paul Ruffin Scarborough Associate Professor of Engineering

Research Interests: Dr. You's research interest focus on computational systems biology & synthetic biology, including mathematical modeling of cellular networks; mechanisms of information processing by gene networks; design, modeling and construction of robust gene networks for applications in engineering and...

Fan Yuan

Fan Yuan

Professor of Biomedical Engineering

Research Interests: Dr. Yuan's research interests include drug and gene delivery, mechanisms of molecular transport in cells and tissues, and tumor pathophysiology.

Secondary Faculty

Tony Jun Huang

Tony Jun Huang

Professor in the Department of Mechanical Engineering and Materials Science

Research Interests: Acoustofluidics, microfluidics, lab-on-a-chip, biomedical micro-electro-mechanical systems (BioMEMS), optofluidics, plasmofluidics

Research Faculty

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Tarun Saxena

Assistant Research Professor in the Department of Biomedical Engineering