Rooney Family Associate Professor of Biomedical Engineering
Bursac's research interests include adult and embryonic stem cell therapies for heart and muscle disease. Cardiac and skeletal muscle tissue engineering. Cardiac electrophysiology and arrhythmias. Genetic modifications of stem and somatic cells. Micropatterning of proteins and hydrogels.
The focus of my research is application of stem cells and tissue engineering methodologies in experimental in vitro studies and cell and tissue replacement therapies. Micropatterning of extracellular matrix proteins or protein hydrogels and engineering of synthetic scaffolds are used to build stem cell-derived cardiac and skeletal muscle tissues that replicate the structure-function relationships present in healthy and diseased muscle. These systems are used to separate and systematically study the roles of structural and genetic factors that contribute cardiac and skeletal muscle function and disease at multiple organizational levels (from single cell to 3-dimensional tissue). Optical recordings with voltage and calcium sensitive dyes in synthetic tissues allow us to analyze and optimize normal electrical function as well as study complicated spatio-temporal changes in electrical activity encountered in cardiac arrhythmias and fibrillation. Contractile force measurements allow us to explore factors that would optimize mechanical function of engineered tissues. Examples of the current research projects include: 1) design of co-cultures made of cardiac and different types of stem cells to model and study cell and tissue therapies for cardiac infarction and arrhythmias, 2) local and global gene manipulation in cultures of cardiac and other cell types, 3) engineering of vascularized cardiac and skeletal muscle tissue constructs with controllable structure and function, 4) implantation of stem cell-derived cardiac tissue patches in animal models of cardiac infarction, and 5) design of synthetic excitable tissues for experimental studies and novel cell therapies.
Appointments and Affiliations
- Rooney Family Associate Professor of Biomedical Engineering
- Associate Professor of Biomedical Engineering
- Associate Professor in Medicine
- Office Location: Ciemas 1141, Durham, NC 27708
- Office Phone: (919) 660-5510
- Email Address: firstname.lastname@example.org
- Web Pages:
- Ph.D. Boston University, 2000
- B.S.E. University of Belgrade, 1994
Bursac's research interests include embryonic and adult stem cell therapies for heart and muscle disease. Cardiac and skeletal muscle tissue engineering. Cardiac electrophysiology and arrhythmias. Genetic modifications of stem and somatic cells. Micropatterning of proteins and hydrogels.
Tissue Repair, Tissue Engineering
Awards, Honors, and Distinctions:
- Distinguished Postdoctoral Fellowship, Johns Hopkins University, Biomedical Engineering, 2000-2002
- Honorably Mentioned Finalist, National Association for Sport & Physical Education, 2002
- Merit Award, Biomedical Engineering Society, 2002
- Postdoctoral Fellowship, American Heart Association, 2000-2002
- Scientist Development Grant, American Heart Association, 2005-2008
- Trainee Abstract Grant, American Heart Association, 2002
- BME 301L: Bioelectricity (AC or GE)
- BME 394: Projects in Biomedical Engineering (GE)
- BME 493: Projects in Biomedical Engineering (GE)
- BME 494: Projects in Biomedical Engineering (GE)
- BME 507: Cardiovascular System Engineering, Disease and Therapy (GE, BB, EL)
- BME 578: Quantitative Cell and Tissue Engineering (GE, BB, MC)
- BME 590: Advanced Topics in Biomedical Engineering
- ECE 391: Undergraduate Research in Electrical and Computer Engineering
- GLHLTH 393: Research Independent Study in Global Health
- NEUROSCI 301L: Bioelectricity (AC or GE)
Representative Publications: (More Publications)
- Madden, L; Juhas, M; Kraus, WE; Truskey, GA; Bursac, N, Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs., eLife, vol 4 (2015) [10.7554/elife.04885] [abs].
- Juhas, M; Bursac, N, Roles of adherent myogenic cells and dynamic culture in engineered muscle function and maintenance of satellite cells., Biomaterials, vol 35 no. 35 (2014), pp. 9438-9446 [10.1016/j.biomaterials.2014.07.035] [abs].
- Cheng, CS; Davis, BN; Madden, L; Bursac, N; Truskey, GA, Physiology and metabolism of tissue-engineered skeletal muscle., Experimental biology and medicine (Maywood, N.J.), vol 239 no. 9 (2014), pp. 1203-1214 [10.1177/1535370214538589] [abs].
- Bursac, N, Cardiac fibroblasts in pressure overload hypertrophy: the enemy within?, Journal of Clinical Investigation, vol 124 no. 7 (2014), pp. 2850-2853 [10.1172/jci76628] [abs].
- Hsiai, T; Li, S; Bursac, N, Introduction to the special issue on tissue engineering and regenerative medicine., Annals of Biomedical Engineering, vol 42 no. 7 (2014), pp. 1355-1356 [10.1007/s10439-014-1053-1] [abs].