Kam Leong

Image of Kam Leong

James B. Duke Professor of Biomedical Engineering

Professor Leong's research interest focuses on biomaterials design, particularly on synthesis of nanoparticles for DNA-based therapeutics, and nanostructured biomaterials for regenerative medicine

Biomaterials Design:

  • design of self-assembled fibers for tissue engineering
  • microfluidics-mediated synthesis of multifunctional nanoparticles for drug and gene delivery
  • synthesis of novel quantum dots for biomedical applications

Controlled Drug and Gene Delivery:

  • oral gene delivery for hemophilia A and B
  • non-viral gene delivery to the GI tract
  • oral delivery of antigen genes for vaccination

Tissue Engineering:

  • study of response of stem cells to nanotopographical cues
  • expansion of hematopoietic stem cells
  • nerve guidance channels with drug and gene delivery functions
  • microencapsulation of stem cells and genetically-engineered cells
  • development of bioartificial nucleus pulposus device
  • study of interaction of stem cells with synthetic nanostructured biomaterials

Appointments and Affiliations
  • James B. Duke Professor of Biomedical Engineering
  • Professor of Biomedical Engineering
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Professor in Surgery
  • Member of the Duke Cancer Institute
Contact Information:
Education:

  • Ph.D. University of Pennsylvania, 1987
  • B.S.CH.E. University of California at Santa Barbara, 1977

Curriculum Vitae
Research Interests:

Leong's research interest focuses on biomaterials design, particularly on synthesis of nanoparticles for DNA-based therapeutics, and nanostructured biomaterials for regenerative medicine.

Specialties:

Biological Materials
Drug Delivery
Tissue Repair, Tissue Engineering
Biophotonics
Nanoscience

Awards, Honors, and Distinctions:

  • National Academy of Engineering
  • Stansell Family Distinguished Research Award, 2010
  • 3M Pharmaceuticals Recognition Award, Controlled Release Society, 1996
  • Award for Recognition of Pioneering Contribution in Polymer chemistry and Bioomedical Engineering, Chinese-American Chemical Society, 1995
  • Capsugel Award on Innovative Aspects of Controlled Release Research, Controlled Release Society, 1996, 1997, 1998, 2000, 2001
  • Cygnus Recognition Award, Controlled Release Society, 1997
  • Excellence in Guidance of Graduate Student Research, Controlled Release Society
  • Jorge Heller Manuscript Award, Journal of Controlled Release, 2007
  • Proctor & Gamble Recognition Award, Controlled Release Society, 1993
  • Young Investigator Research Achievement Award, Controlled Release Society, July, 1994

Courses Taught:
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 590: Advanced Topics in Biomedical Engineering
  • BME 590: Special Topics in Biomedical Engineering
  • BME 899: Special Readings in Biomedical Engineering

Representative Publications: (More Publications)
    • Williford, J-M; Wu, J; Ren, Y; Archang, MM; Leong, KW; Mao, H-Q, Recent Advances in Nanoparticle-Mediated siRNA Delivery, Annual Review of Biomedical Engineering, vol 16 no. 1 (2014), pp. 347-370 [10.1146/annurev-bioeng-071813-105119] [abs].
    • Kulangara, K; Adler, AF; Wang, H; Chellappan, M; Hammett, E; Yasuda, R; Leong, KW, The effect of substrate topography on direct reprogramming of fibroblasts to induced neurons., Biomaterials, vol 35 no. 20 (2014), pp. 5327-5336 [10.1016/j.biomaterials.2014.03.034] [abs].
    • Phua, KK; Nair, SK; Leong, KW, Messenger RNA (mRNA) nanoparticle tumour vaccination., Nanoscale, vol 6 no. 14 (2014), pp. 7715-7729 [10.1039/c4nr01346h] [abs].
    • Phua, KK; Boczkowski, D; Dannull, J; Pruitt, S; Leong, KW; Nair, SK, Whole blood cells loaded with messenger RNA as an anti-tumor vaccine., Advanced healthcare materials, vol 3 no. 6 (2014), pp. 837-842 [10.1002/adhm.201300512] [abs].
    • Xing, Q; Vogt, C; Leong, KW; Zhao, F, Highly Aligned Nanofibrous Scaffold Derived from Decellularized Human Fibroblasts, Advanced Functional Materials, vol 24 no. 20 (2014), pp. 3027-3035 [10.1002/adfm.201303460] [abs].