Adjunct Professor of Biomedical Engineering
Professor Leong's research interest focuses on biomaterials design, particularly on synthesis of nanoparticles for DNA-based therapeutics, and nanostructured biomaterials for regenerative medicine
- design of self-assembled fibers for tissue engineering
- microfluidics-mediated synthesis of multifunctional nanoparticles for drug and gene delivery
- synthesis of novel quantum dots for biomedical applications
Controlled Drug and Gene Delivery:
- oral gene delivery for hemophilia A and B
- non-viral gene delivery to the GI tract
- oral delivery of antigen genes for vaccination
- study of response of stem cells to nanotopographical cues
- expansion of hematopoietic stem cells
- nerve guidance channels with drug and gene delivery functions
- microencapsulation of stem cells and genetically-engineered cells
- development of bioartificial nucleus pulposus device
- study of interaction of stem cells with synthetic nanostructured biomaterials
Appointments and Affiliations
- Adjunct Professor of Biomedical Engineering
- Office Phone: (919) 660-8466
- Email Address: email@example.com
- Web Page:
- Ph.D. University of Pennsylvania, 1987
- B.S.CH.E. University of California at Santa Barbara, 1977
Leong's research interest focuses on biomaterials design, particularly on synthesis of nanoparticles for DNA-based therapeutics, and nanostructured biomaterials for regenerative medicine.
Tissue Repair, Tissue Engineering
Awards, Honors, and Distinctions:
- Clemson Award for Applied Research. Society for Biomaterials. 2012
- Fellows. American Institute for Medical and Biological Engineering. 1999
- BME 394: Projects in Biomedical Engineering (GE)
- BME 493: Projects in Biomedical Engineering (GE)
- BME 494: Projects in Biomedical Engineering (GE)
- BME 590: Advanced Topics in Biomedical Engineering
- BME 899: Special Readings in Biomedical Engineering
Representative Publications: (More Publications)
- Huang, S; Srimani, JK; Lee, AJ; Zhang, Y; Lopatkin, AJ; Leong, KW; You, L, Dynamic control and quantification of bacterial population dynamics in droplets., Biomaterials, vol 61 (2015), pp. 239-245 [10.1016/j.biomaterials.2015.05.038] [abs].
- Park, JS; Suryaprakash, S; Lao, Y-H; Leong, KW, Engineering mesenchymal stem cells for regenerative medicine and drug delivery, Methods, vol 84 (2015), pp. 3-16 [10.1016/j.ymeth.2015.03.002] [abs].
- Hong, S; Sycks, D; Chan, HF; Lin, S; Lopez, GP; Guilak, F; Leong, KW; Zhao, X, 3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures., Advanced Materials, vol 27 no. 27 (2015), pp. 4035-4040 [10.1002/adma.201501099] [abs].
- Peng, B; Chen, Y; Leong, KW, MicroRNA delivery for regenerative medicine, Advanced Drug Delivery Reviews, vol 88 (2015), pp. 108-122 [10.1016/j.addr.2015.05.014] [abs].
- Diekman, BO; Thakore, PI; O'Connor, SK; Willard, VP; Brunger, JM; Christoforou, N; Leong, KW; Gersbach, CA; Guilak, F, Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells., Tissue Engineering, Part A, vol 21 no. 7-8 (2015), pp. 1261-1274 [10.1089/ten.tea.2014.0240] [abs].